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Cat. No.: HY-187844

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FL113

FL113 is a racemate of FL118 (HY-12486). FL113 is less effective than FL118 in inhibiting the expression of Survivin, Mcl-1, XIAP, and cIAP2. FL113 exhibits weaker antitumor activity than FL118 in colon tumor xenograft models. FL113 can be used for research on colon cancer and head and neck cancer.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 104155-89-7
화학식: C₂₁H₁₆N₂O₆
분자량:392.37

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

FL113 Chemical Structure

CAS No.: 104155-89-7

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

Mcl-1

XIAP

cIAP2

All Bcl-2 Family Isoforms :

All IAP Isoforms :

In Vitro

Anti-cancerApoptosis

Anti-cancer

Apoptosis

FL113 (10 nM; 48-96 h) is far less effective than FL118 (HY-12486) in inhibiting the expression of survivin, Mcl-1, XIAP, and cIAP2 in head and neck FaDu cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

FaDu
Concentration:

10 nM
Incubation Time:

48, 72, and 96 h
Result:

Inhibited survivin, Mcl-1, XIAP, and cIAP2 protein expression less effectively than FL118.

In Vivo

Anti-cancer

FL113 (1.5 mg/kg; i.p.; single injection) is less effective than FL118 in downregulating survivin, Mcl-1, and cIAP2 in mice^[1].
FL113 (1 mg/kg; weekly × 4 schedule) exhibits much weaker antitumor activity than FL118 in colon tumor xenograft models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

SCID mice (female, 6-12 weeks old)^[1]
Dosage:

1.5 mg/kg
Administration:

i.p.; single injection
Result:

Resulted in less effective inhibition of survivin, Mcl-1, and cIAP2 expression compared to FL118.
Showed no inhibitory effect on XIAP in the in vivo tumor tissues.

Related Protocols :

Chemical Information

CAS No. 104155-89-7
분자량 392.37
화학식 C₂₁H₁₆N₂O₆
SMILES

O=C1OCC=2C(=O)N3C(=CC2C1(O)CC)C=4N=C5C=C6OCOC6=CC5=CC4C3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Zhao J, et al. Antitumor activity of FL118, a survivin, Mcl-1, XIAP, and cIAP2 selective inhibitor, is highly dependent on its primary structure and steric configuration. Molecular pharmaceutics. 2014 Feb 03;11(2):457-67.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

FL113

All Bcl-2 Family Isoforms

All IAP Isoforms