LCK - LCK proto-oncogene, Src family tyrosine kinase Gene

Also Known as LSK; YT16; IMD22; p56lck; pp58lck

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3932

About LCK

Cytogenetic location: 1p35.2 Genomic coordinates (GRCh38): 1:32,251,265-32,286,165 (from NCBI)

This gene has 14 transcripts (splice variants), 120 orthologues, 32 paralogues and is associated with 67 phenotypes. Biased expression in lymph node (RPKM 46.5), appendix (RPKM 22.7) and 9 other tissues.

Summary

This gene is a member of the Src family of Protein Tyrosine Kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and Other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Aug 2016]

LCK Products (3)

mRNA	Protein	Name
NM_001042771.3	NP_001036236.1	tyrosine-protein kinase Lck isoform a
NM_001330468.2	NP_001317397.1	tyrosine-protein kinase Lck isoform b
NM_005356.5	NP_005347.3	tyrosine-protein kinase Lck isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	15671290	GOA
enables CD4 receptor binding	IPI IPI: Inferred from physical interaction	7486703	GOA
enables CD8 receptor binding	IPI IPI: Inferred from physical interaction	2470098	GOA
enables SH2 domain binding	IPI IPI: Inferred from physical interaction	7852312	GOA
enables T cell receptor binding	IPI IPI: Inferred from physical interaction	8681956	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	17118402	GOA
enables non-membrane spanning protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	8681956	GOA
enables phosphatidylinositol 3-kinase binding	IPI IPI: Inferred from physical interaction	7504174	GOA
enables phospholipase activator activity	IDA IDA: Inferred from direct assay	11606584	GOA
enables phospholipase binding	IPI IPI: Inferred from physical interaction	11606584	GOA
enables phosphotyrosine residue binding	IPI IPI: Inferred from physical interaction	20624904	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7507203	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	8618896	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	22080863	GOA
enables protein serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	8506364	GOA
enables protein tyrosine kinase activity	EXP EXP: Inferred from Experiment	1381360	GOA
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	214242	GOA
enables protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	8681956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in CD27 signaling pathway	IDA IDA: Inferred from direct assay	38354704	GOA
involved in Fc-gamma receptor signaling pathway	IDA IDA: Inferred from direct assay	8478617	GOA
involved in T cell activation	IDA IDA: Inferred from direct assay	38354704	GOA
involved in T cell differentiation	IMP IMP: Inferred from mutant phenotype	1579166	GOA
involved in T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	8943371	GOA
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	16116473	GOA
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	8681956	GOA
involved in intracellular zinc ion homeostasis	IEP IEP: Inferred from expression pattern	11739864	GOA
involved in peptidyl-tyrosine autophosphorylation	IDA IDA: Inferred from direct assay	8478617	GOA
involved in peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	8681956	GOA
involved in positive regulation of T cell activation	IDA IDA: Inferred from direct assay	8943371	GOA
involved in positive regulation of heterotypic cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	27400149	GOA
involved in positive regulation of intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	16116473	GOA
involved in positive regulation of leukocyte cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	27400149	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	214242	GOA
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	16116473	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in immunological synapse	IDA IDA: Inferred from direct assay	20007709	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	12150984	GOA
located in pericentriolar material	IDA IDA: Inferred from direct assay	7513706	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	12218089	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12150984	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LCK Protein Structure

SH3_1

SH2

Pkinase_Tyr

0
100
200
300
400
509 a.a.

Protein Preferred Names	Protein Names
tyrosine-protein kinase Lck	T-lymphocyte specific protein tyrosine kinase p56lck

LCK Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LCK	P06239	CDKAL1	Homo sapiens	Q5VV42	Validated Y2H	25416956
Intra	LCK	P06239	CDKAL1	Homo sapiens	Q5VV42	Y2H Prey Pooling	25416956
Intra	LCK	P06239	MET	Homo sapiens	P08581	FPS	24728074
Intra	LCK	P06239	ZAP70	Homo sapiens	P43403	Anti Tag CoIP	10318843
Intra	LCK	P06239	LAT	Homo sapiens	O43561	Protein Kinase Assay	16938345
Intra	LCK	P06239	PTPRC	Homo sapiens	P08575	Phosphatase Assay	7507203
Intra	LCK	P06239	PTPRC	Homo sapiens	P08575	Anti Bait CoIP	7507203
Intra	LCK	P06239	PTPRC	Homo sapiens	P08575	Affinity Chrom	8576115
Intra	LCK	P06239	PTPRC	Homo sapiens	P08575	Phosphatase Assay	19167335
Intra	LCK	P06239	KHDRBS1	Homo sapiens	Q07666	Pull Down	7852312
Intra	LCK	P06239	KIT	Homo sapiens	P10721	FPS	24728074
Intra	LCK	P06239	THEMIS	Homo sapiens	Q8N1K5-1	Protein Kinase Assay	23460737
Intra	LCK	P06239	HSP90AA1	Homo sapiens	P07900	Anti Tag CoIP	31980649
Intra	LCK	P06239	HSP90AA1	Homo sapiens	P07900	Anti Bait CoIP	16888650
Intra	LCK	P06239	UBC	Homo sapiens	P0CG48	Pull Down	18539162
Intra	LCK	P06239	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	31980649
Intra	LCK	P06239	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	LCK	P06239	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	22939624
Intra	LCK	P06239	CD4	Homo sapiens	P01730	Anti Bait CoIP	16888650
Intra	LCK	P06239	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	LCK	P06239	PRKCQ	Homo sapiens	Q04759	Anti Tag CoIP	21964608
Intra	LCK	P06239	SH2D2A	Homo sapiens	Q9NP31	Pull Down	16839418
Intra	LCK	P06239	SH2D2A	Homo sapiens	Q9NP31	Anti Tag CoIP	15827961
Intra	LCK	P06239	SH2D2A	Homo sapiens	Q9NP31	Pull Down	15827961
Intra	LCK	P06239	SH2D2A	Homo sapiens	Q9NP31	Anti Bait CoIP	16839418
Intra	LCK	P06239	NR3C1	Homo sapiens	P04150	Imaging	16888650
Intra	LCK	P06239	MED28	Homo sapiens	Q9H204	Y2H	10656681
Intra	LCK	P06239	MED28	Homo sapiens	Q9H204	Pull Down	16899217
Intra	LCK	P06239	GAB1	Homo sapiens	Q13480	FPS	24728074
Intra	LCK	P06239	AR	Homo sapiens	P10275	FPS	24728074
Intra	LCK	P06239	GATA3	Homo sapiens	P23771	Validated Y2H	26871637
Intra	LCK	P06239	GATA3	Homo sapiens	P23771	Y2H Array	26871637
Intra	LCK	P06239	GATA3	Homo sapiens	P23771	Y2H Prey Pooling	26871637
Intra	LCK	P06239	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	25416956
Cross	LCK	P06239	tio_athv3	Ateline herpesvirus 3	Q9YJQ8	Anti Tag CoIP	16051843
Intra	LCK	P06239	ADAM15	Homo sapiens	Q13444	Pull Down	11741929
Intra	LCK	P06239	PTPN6	Homo sapiens	P29350	Phosphatase Assay	19167335
Intra	LCK	P06239	SYK	Homo sapiens	P43405	Far-WB	8798676
Intra	LCK	P06239	SYK	Homo sapiens	P43405	Y2H	15536084
Intra	LCK	P06239	SYK	Homo sapiens	P43405	Y2H	8798676
Intra	LCK	P06239	SYK	Homo sapiens	P43405	CoIP	8621719
Intra	LCK	P06239	SYK	Homo sapiens	P43405	Pull Down	8798676
Intra	LCK	P06239	BCL3	Homo sapiens	P20749	Anti Bait CoIP	16099425
Intra	LCK	P06239	BCL3	Homo sapiens	P20749	Anti Tag CoIP	16099425
Cross	LCK	P06239	tip_shv2c	Saimiriine herpesvirus 2	P22575	Anti Bait CoIP	17005671
Cross	LCK	P06239	tip_shv2c	Saimiriine herpesvirus 2	P22575	NMR	15554700

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LCK Proteins

Cat. No.	상품명	Accession	Purity
HY-P73269	Lck Protein, Human (Active, sf9, GST)	P06239-1 (M1-P509)	≥ 90%, as determined by reducing SDS-PAGE.

LCK Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P80743	Lck Antibody (YA712)	WB	Human
HY-P80743A	Lck Antibody (YA712)(PBS only)	WB	Human
HY-P83970	Lck Antibody (YA3667)	WB, ELISA	Human
HY-P83970A	Lck Antibody (YA3667)(PBS only)	WB, ELISA	Human
HY-P85255	Lck Antibody (YA4947)	WB; IHC-P; IHC-F; ICC/IF; IF-Tissue; IP; FC	Human
HY-P85555	Lck Antibody (YA5247)	WB	Human
HY-P86477	Lck Antibody (YA6169)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Immunodeficiency 22	Severe Combined Immunodeficiency Due To Lck Deficiency IMD22 Scid Due To Lck Deficiency Scid Due To Lymphocyte-Specific Protein Tyrosine Kinase Deficiency Severe Combined Immunodeficiency Due To Lymphocyte-Specific Protein Tyrosine Kinase Deficiency Immunodeficiency, Type 22
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Thymoma	Primary Thymic Epithelial Neoplasm Primary Thymic Epithelial Tumor Thymus Neoplasms
Immunodeficiency 17	IMD17 Cd3-Gamma Deficiency Scid-Like Immunodeficiency, T Cell-Partial, B Cell-Positive, Nk Cell-Positive Combined Immunodeficiency Due To Cd3gamma Deficiency Immunodeficiency 17, Cd3 Gamma Deficient Cd3gamma Deficiency Immunodeficiency, Type 17
Lymphopenia	Lymphocytopenia
Cd45 Deficiency
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Common Variable Immune Deficiency Acquired Hypogammaglobulinemia Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Immunodeficiency 13	Idiopathic Cd4 Lymphopenia IMD13 Icl Immunodeficiency, Type 13
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Thymus Gland Disease	Disease Of Thymus Gland
Thymus Cancer	Thymic Neoplasm Thymic Tumor Thymus Neoplasm Thymus Neoplasms Malignant Neoplasm Of Thymus Neoplasm Of Thymus Thymic Neoplasms Thymoma, Familial Thymic Carcinoma Thymoma, Type C Cancer Of Thymus Malignant Tumour Of Thymus Primary Malignant Neoplasm Of Thymus Thymic Glandular Cancer Thymus Gland Cancer
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Complement Component 7 Deficiency	C7 Deficiency C7D
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Co-Trimoxazole Allergy	Bactrim Allergy Cotrimoxazol Allergy Tmp/Smx Allergy Trimethoprim/Sulfamethoxazole Allergy
Epidermodysplasia Verruciformis 1	Epidermodysplasia Verruciformis Epidermodysplasia Verruciformis, Susceptibility To, 1 Lutz-Lewandowsky Epidermodysplasia Verruciformis EV1 Lewandowsky-Lutz Syndrome Ev
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	상품명	효과	Purity	Phase
HY-132166	Velzatinib	Inhibitor	99.40%	Phase 3
HY-157442	GLPG3312	Inhibitor	98.63%	Phase 1

Pre-clinical Phase

Bioactive Molecules (23)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-15323	PRT062607 Hydrochloride	Inhibitor	98.07%	Unkown
HY-13561	AZM475271	Inhibitor	99.89%	Unkown
HY-107447	N-Deshydroxyethyl Dasatinib	Ligand	97.19%	Unkown
HY-112291	SB 220025	Inhibitor	99.90%	Unkown
HY-10644	Lck inhibitor 2	Inhibitor	99.73%	Unkown
HY-15324	PRT062607 acetate	Inhibitor	99.83%	Unkown
HY-180888	Lck-IN-5	Inhibitor	98.09%	Unkown
HY-118105	RK-20448	Inhibitor	99.38%	Unkown
HY-175463	LCK degrader-2	Degrader	/	Unkown
HY-112448	Lck-IN-6	Inhibitor	/	Unkown
HY-175281	SJ11646	Degrader	/	Unkown
HY-175916	LCK ligand-1	Ligand	/	Unkown
HY-12299G	WH-4-023 (GMP)	Inhibitor	/	Unkown
HY-180928	LCK degrader-3	Degrader	/	Unkown
HY-179948	BTK-IN-45	Inhibitor	/	Unkown
HY-114980	BMS-279700	Inhibitor	/	Unkown
HY-163278	Lck-IN-2	Inhibitor	/	Unkown
HY-175437	MRT-7612	Degrader	/	Unkown
HY-175193	N-Deshydroxyethyl Dasatinib-C3-NH2	Inhibitor	/	Unkown
HY-176194	Antifibrotic agent 1	Inhibitor	/	Unkown
HY-133184	Aminogenistein	Inhibitor	/	Unkown
HY-178014	SIK1-IN-1	Inhibitor	/	Unkown
HY-120622	BMS-243117	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LCK	VGNC	VGNC:99997
Mus musculus	LCK	MGD	MGI:96756
Canis familiaris	LCK	VGNC	VGNC:42607
Felis catus	LCK	VGNC	VGNC:68023
Rattus norvegicus	LCK	RGD	RGD:2994
Bos taurus	LCK	VGNC	VGNC:30810
Others	LCK	NCBI