ML 10302
Based on 1 Customer Validation
ML 10302 is a potent agonist 5-HT4 receptor with Ki of 1.07 nM. 5-Hydroxytryptamine (5-HT4) receptor agonists stimulate gut motility through cholinergic pathways. ML10302 induces significant prokinesia both in the small bowel and colon through activation of cholinergic pathways. ML 10302 also has the potential for the research of neurology diseases.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 98.95%
- CAS No.: 148868-55-7
- 화학식: C15H21ClN2O3
- 분자량:312.79
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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All 5-HT Receptor Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| C6 | EC50 |
51 nM
Compound: ML-10302
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Agonist activity at human 5HT4 isoform E receptor expressed in rat C6 cells assessed as cAMP accumulation by radio-immunoassay relative to 5HT
Agonist activity at human 5HT4 isoform E receptor expressed in rat C6 cells assessed as cAMP accumulation by radio-immunoassay relative to 5HT
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[PMID: 19334715] |
| CHO | EC50 |
2.5 nM
Compound: ML-10302
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Agonist activity at human 5HT4e receptor expressed in CHO cells assessed as cAMP level after 4 hrs by luciferase reporter gene assay
Agonist activity at human 5HT4e receptor expressed in CHO cells assessed as cAMP level after 4 hrs by luciferase reporter gene assay
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[PMID: 26363507] |
Chemical Information
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CAS No. 148868-55-7
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Appearance Solid
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분자량 312.79
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화학식 C15H21ClN2O3
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Color White to off-white
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SMILES
O=C(OCCN1CCCCC1)C2=CC(Cl)=C(N)C=C2OC
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 125 mg/mL (399.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Cachard-Chastel M, et al. 5-HT4 receptor agonists increase sAPPalpha levels in the cortex and hippocampus of male C57BL/6j mice. Br J Pharmacol. 2007;150(7):883-892. [Content Brief]
[2]. Yang D, et al. New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors. J Med Chem. 1997;40(4):608-621. [Content Brief]
[3]. De Ponti F, et al. Intestinal motor stimulation by the 5-HT4 receptor agonist ML10302: differential involvement of tachykininergic pathways in the canine small bowel and colon. Neurogastroenterol Motil. 2001;13(6):543-553. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1970 mL | 15.9852 mL | 31.9703 mL | 79.9258 mL |
| 5 mM | 0.6394 mL | 3.1970 mL | 6.3941 mL | 15.9852 mL | |
| 10 mM | 0.3197 mL | 1.5985 mL | 3.1970 mL | 7.9926 mL | |
| 15 mM | 0.2131 mL | 1.0657 mL | 2.1314 mL | 5.3284 mL | |
| 20 mM | 0.1599 mL | 0.7993 mL | 1.5985 mL | 3.9963 mL | |
| 25 mM | 0.1279 mL | 0.6394 mL | 1.2788 mL | 3.1970 mL | |
| 30 mM | 0.1066 mL | 0.5328 mL | 1.0657 mL | 2.6642 mL | |
| 40 mM | 0.0799 mL | 0.3996 mL | 0.7993 mL | 1.9981 mL | |
| 50 mM | 0.0639 mL | 0.3197 mL | 0.6394 mL | 1.5985 mL | |
| 60 mM | 0.0533 mL | 0.2664 mL | 0.5328 mL | 1.3321 mL | |
| 80 mM | 0.0400 mL | 0.1998 mL | 0.3996 mL | 0.9991 mL | |
| 100 mM | 0.0320 mL | 0.1599 mL | 0.3197 mL | 0.7993 mL |
ML 10302 Related Classifications
HY-14441 Related Classifications
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