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Cat. No.: HY-145813

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MU1656

MU1656 is a potent and selective inhibitor of histone methyltransferase DOT1L, with an IC₅₀ of 2 nM. MU1656 can be used for the research of hematological malignancies.

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CAS No.: 2766698-38-6
화학식: C₃₂H₄₅N₇O₂
분자량:559.75

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

MU1656 Chemical Structure

CAS No.: 2766698-38-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

MU1656 is a potent and selective inhibitor of histone methyltransferase DOT1L, with an IC₅₀ of 2 nM. MU1656 can be used for the research of hematological malignancies^[1].

IC₅₀ & Target^[1]

DOT1L

2 nM (IC₅₀)

All Histone Methyltransferase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MOLM-13	EC₅₀	7.7 μM Compound: (-)-53; MU1656	Cytotoxicity against human MOLM-13 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay Cytotoxicity against human MOLM-13 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay	[PMID: 35302777]
MV4-11	EC₅₀	1.7 μM Compound: (-)-53; MU1656	Cytotoxicity against human MV4-11 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay Cytotoxicity against human MV4-11 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay	[PMID: 35302777]
SK-N-MC	EC₅₀	8.8 μM Compound: (-)-53; MU1656	Cytotoxicity against human SK-N-MC cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay Cytotoxicity against human SK-N-MC cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay	[PMID: 35302777]
SU-DHL-5	EC₅₀	9 μM Compound: (-)-53; MU1656	Cytotoxicity against human SU-DHL-5 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay Cytotoxicity against human SU-DHL-5 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay	[PMID: 35302777]

Chemical Information

CAS No. 2766698-38-6
분자량 559.75
화학식 C₃₂H₄₅N₇O₂
SMILES

O[C@H]1[C@@H](C[C@@H]([C@H]1O)CN([C@H]2C[C@H](C2)CCC(NC3=C4)=NC3=CC=C4C(C)(C)C)C(C)C)C5=CC=C6N5N=CN=C6N
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Khirsariya P, et, al. Synthesis and Profiling of Highly Selective Inhibitors of Methyltransferase DOT1L Based on Carbocyclic C-Nucleosides. J Med Chem. 2022 Apr 14;65(7):5701-5723. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
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CAS No.:
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Purity:
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MU1656

All Histone Methyltransferase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

MU1656 Related Classifications

HY-145813 Related Classifications