NSC-134754

NSC-134754 inhibits heat shock-induced Hsp72 induction in CHO cells with an IC₅₀ of 1 μM and has a cellular toxicity IC₅₀ of 5 μM^[1].
NSC-134754 (1-2 μM; 16 h prior to heat shock) potently inhibits heat shock-induced Hsp72 induction in CHO cells at concentrations of 1 μM and completely inhibits this induction at 2 μM^[1].
NSC-134754 (1-2 μM; 24 h) does not inhibit general protein synthesis in CHO cells^[1].
NSC-134754 (2 μM; 5 h pre-incubation) partially inhibits HSF-1-dependent transcription (40% reduction) in heat-shocked PC-3 cells^[1].
NSC-134754 (2 μM; 5 h pre-incubation) does not inhibit heat shock-induced Hsp72 mRNA transcription in PC-3 cells^[1].
NSC-134754 (2 μM) potently inhibits heat shock-induced Hsp72 induction across multiple cell lines, with 100% inhibition in MM.1S and MEF cells, 99% inhibition in CHO cells, and 85% inhibition in PC-3 cells^[1].
NSC-134754 (2 μM; 5 h) completely inhibits proteasome inhibitor (Velcade)-induced Hsp72 induction in MM.1S cells^[1].
NSC-134754 (2 μM; 5 h) inhibits Hsp90 inhibitor (radicicol)-induced Hsp72 induction by 90% in MM.1S cells^[1].
NSC-134754 (2 μM) inhibits proteasome inhibitor (MG132)-induced Hsp72 induction by 90% in PC-3 cells^[1].
NSC-134754 (2 μM) inhibits Hsp90 inhibitor (17-AAG)-induced Hsp72 induction by 70% in PC-3 cells^[1].
NSC-134754 (2 μM; 5 h pre-incubation) sensitizes MM.1S multiple myeloma cells to Hsp90 inhibitor (Radicicol HY-N6769)-induced apoptosis, as measured by increased PARP cleavage^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.