Roridin H
Roridin H (Verrucarin H) is a cytostatic antibiotic present in the Myrothecium verrucaria strain and the marine-derived Myrothecium sp. TUF 02F6. The IC50 of Roridin H against mouse leukemia cells is 0.12 mM. Roridin H can be used in leukemia-related research.
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- CAS No.: 29953-50-2
- 화학식: C29H36O8
- 분자량:512.59
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L1210 | IC50 |
0.12 μM
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Cytotoxicity against murine leukemia L1210 cells by XTT method, incubated for 72 h.
Cytotoxicity against murine leukemia L1210 cells by XTT method, incubated for 72 h.
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17080680 |
Roridin H (compound 1) undergoes complete catalytic hydrogenation to form Octahydrororidin H[1].
Roridin H undergoes base-catalyzed hydrolysis, which cleaves the macrocyclic diester to produce Verrucarol and Myrothecinic acid[1].
Roridin H (72 h) potently inhibits the proliferation of mouse leukemia L1210 cells, with an IC50 of 0.12 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 29953-50-2
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Appearance Solid
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분자량 512.59
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화학식 C29H36O8
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Color White to off-white
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SMILES
CC1=C[C@]2([H])[C@]([C@]3(C)[C@@]4(OC4)[C@](C[C@H]3OC(/C=C\C=C\C(O5)C(C)OC5C/C(C)=C\6)=O)([H])O2)(COC6=O)CC1
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Synonyms
Verrucarin H
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Structure Classification
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Initial Source
Myrothecium verrucaria
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
순도&문서
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Data Sheet (290 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Roridin H Related Classifications
HY-N12908 Related Classifications
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