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Cat. No.: HY-173631

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(S)-dHTC1

(S)-dHTC1 is a molecular glue degrader targeting the transcriptional co-activator ENL. (S)-dHTC1 binds the ligase with high affinity only after forming the ENL:dHTC1 complex with an IC₅₀ value of 93 nM. (S)-dHTC1 degrades ENL in MV4;11 cells with a DC₅₀ value of 26 nM. (S)-dHTC1 can be used for acute myeloid leukemia study.

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CAS No.: 3081383-46-9
화학식: C₃₃H₄₀N₈O₆S
분자량:676.79

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

(S)-dHTC1 Chemical Structure

CAS No.: 3081383-46-9

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

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Chemical Information

CAS No. 3081383-46-9
분자량 676.79
화학식 C₃₃H₄₀N₈O₆S
SMILES

O=C(NC1CCC1)C(C=C2)=CN(C2=N3)C=C3C4=CC=CC(C(NCCN5CCC(NS(=O)(N6C[C@@]7(CC(NC7=O)=O)CC6)=O)CC5)=O)=C4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. JB Shaum, et al. High-throughput diversification of protein-ligand surfaces to discover chemical inducers of proximity. bioRxiv. September 30, 2024.

Calculators

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Molecular Weight Molecular Weight

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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(S)-dHTC1

All PROTACs Isoforms