Copy Link Print Information

Tepoditamab

(Synonyms: MCLA 117)
고객리뷰

Based on 1 Customer Validation

Tepoditamab (MCLA-117) is a full-length human IgG1 bispecific monoclonal antibody that binds to CLEC12A of myeloid cells and CD3 of cytotoxic T cells. Among others, CLEC12A is a myeloid differentiation antigen. Tepoditamab kills AML leukaemia mother cells and AML leukaemia stem cells, induces T cell-mediated proliferative lysis of AML cells. Tepoditamab induces upto 30-fold T-cell expansion. Tepoditamab results in moderate to strong cytokine (IFNγ, IL-6, IL-8, IL-10, and TNFα) and IFNγ release in human whole blood and PBMC, respectively. Tepoditamab can be used in acute myeloid leukaemia (AML) research.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

  • Purity: ≥99%
  • CAS No.: 2044679-53-8
  • 분자량:144.787 kDa
  • 보관:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Tepoditamab
  • Experimental Validation Results for Tepoditamab
  • Experimental Validation Results for Tepoditamab
  • Experimental Validation Results for Tepoditamab
  • Experimental Validation Results for Tepoditamab
  • Tepoditamab Chemical Structure
    Tepoditamab Chemical Structure
CAS No.: 2044679-53-8
사이즈
가격
재고
수량
Amount: USD 0.00
Please select quantity
or
or

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download
Tepoditamab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
주변의 대리점 찾기 Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Chemical Information
  • 순도&문서
  • References
  • Help & FAQs
You May Still Need
Top Publications Citing

Use of MCE Products

All Interleukin Related Isoforms

More

All TNF Receptor Isoforms

More
Keywords
MOQ
Minimum order quantity
100 mg

견적 받기 해외재고보유

Other size
견적 받기
Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress 로그인
Register
Sign in to MedChemExpress
회원가입

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Loaded Tepoditamab on AHC2 biosensor, can bind CLEC12A/MICL Protein, Human (Biotinylated, HEK293, His-Avi, HY-P77633) with an affinity constant of 1.185E-08 M as determined in BLI assay.

  • 1/16

    Immobilized CD3 epsilon Protein, Human (HEK293, His, HY-P70506) can bind Tepoditamab. The EC50 for this effect is 74.47 ng/mL.

  • 1/16

    Immobilized CLEC12A/MICL Protein, Human (HEK293, Fc, HY-P77631) can bind Tepoditamab. The EC50 for this effect is 67.71 ng/mL.

  • 1/16

    Flow cytometric analysis of 1×106 Jurkat cells labelling CD3E (red) with Tepoditamab (HY-P99390). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control.

  • Tepoditamab Chemical Structure
    1/16
  • Tepoditamab
  • Loaded Tepoditamab on AHC2 biosensor, can bind CLEC12A/MICL Protein, Human (Biotinylated, HEK293, His-Avi, HY-P77633) with an affinity constant of 1.185E-08 M as determined in BLI assay.
  • Immobilized CD3 epsilon Protein, Human (HEK293, His, HY-P70506) can bind Tepoditamab. The EC50 for this effect is 74.47 ng/mL.
  • Immobilized CLEC12A/MICL Protein, Human (HEK293, Fc, HY-P77631) can bind Tepoditamab. The EC50 for this effect is 67.71 ng/mL.
  • Flow cytometric analysis of 1×106 Jurkat cells labelling CD3E (red) with Tepoditamab (HY-P99390). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control.