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Cat. No.: HY-119112A

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LY 379196

LY 379196 is a PKC-β inhibitor (IC₅₀: 50 nM and 30 nM for PKC βI and βII respectively). LY 379196 inhibits the VEGF, IGF-1 and bFGF-induced proliferation of bovine retinal microvascular endothelial cells (BREC). LY 379196 is an antiproliferatory agentfor proliferative retinopathy.

For research use only. We do not sell to patients.

Formula: C₃₀H₃₄N₄O₅S
Molecular Weight:562.68

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

LY 379196 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All PKC Isoforms :

Chemical Information

Molecular Weight 562.68
Formula C₃₀H₃₄N₄O₅S
SMILES

O=C1NC(C2=C1C(C3=CC=CC=C34)=CN4CCC[C@H](CN(C)C)CCN5C6=CC=CC=C6C2=C5)=O.O=S(O)(C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lin WW, et al. Distinct PKC isoforms mediate the activation of cPLA2 and adenylyl cyclase by phorbol ester in RAW264.7 macrophages. Br J Pharmacol. 1998 Dec;125(7):1601-9. [Content Brief]

[2]. G.E. Lang, et al. Effect of the PKC ß Inhibitor LY 379196 in Combination with Growth Factors on Proliferation of Bovine Retinal Vascular Endothelial Cells. ARVO Annual Meeting Abstract. May 2003

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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LY 379196

All PKC Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

LY 379196 Related Classifications

HY-119112A Related Classifications