2. Immunology/Inflammation GPCR/G Protein Apoptosis
  3. IFNAR CXCR TNF Receptor
  4. mDF6002

mDF6002 is a IL-12R-Fc fusion protein. mDF6002 induces sustained IFNγ production. mDF6002 exerts tumor-suppressive effects in mouse models of colon cancer and melanoma. mDF6002 can be used for research on solid tumors such as colon cancer and melanoma.

For research use only. We do not sell to patients.

mDF6002

mDF6002 Chemical Structure

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mDF6002 Related Antibodies

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Description

mDF6002 is a IL-12R-Fc fusion protein. mDF6002 induces sustained IFNγ production. mDF6002 exerts tumor-suppressive effects in mouse models of colon cancer and melanoma. mDF6002 can be used for research on solid tumors such as colon cancer and melanoma[1].

In Vitro

mDF6006 (0.006-6250 pM; 60 h) potently induces IFN-γ production in naive Balb/c mouse splenocytes with an EC50 of 2.07 pM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

mDF6002 Related Antibodies
Parmacokinetics
Species Dose Route T1/2 AUC0-t Cmax Tmax AUC
Mice[1] 10 μg/mL i.v. 29.85 h 5,637 ng·h/mL 258 ng/mL 0.19 h /
Mice[1] 10 μg/mL s.c. / / / / 6.33 ng·h/mL
In Vivo

mDF6006 (1 μg; s.c.; once weekly; 7 weeks) achieves 100% complete tumor regression in advanced large CT26 colon carcinoma-bearing BALB/cJ mice and induces protective T cell memory in 90% of treated mice[1].
mDF6006 (0.5 μg; i.p.; once weekly) induces partial responses in 90% of B16F10 melanoma-bearing C57BL/6J mice and drives sustained pharmacodynamic responses in both tumor and serum[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/cJ mice (female, 7-9 weeks old, subcutaneous inoculation with CT26 cells, advanced large tumors averaging 815 mm3)[1]
Dosage: 1 μg (equimolar to 1 μg rmIL-12)
Administration: s.c.; once weekly; 7 weeks
Result: Induced complete tumor regression in all 10 treated mice.
Was well tolerated with no body weight loss.
Enabled 9/10 complete responders to reject tumor rechallenge and remain tumor-free, while age-matched naive controls developed progressive tumors.
Animal Model: C57BL/6J mice (female, 7-9 weeks old, subcutaneous inoculation with B16F10 cells)[1]
Dosage: 0.5 μg (equimolar to 0.5 μg rmIL-12)
Administration: i.p.; once weekly
Result: Induced partial responses in 9/10 treated mice.
Significantly improved survival compared to rmIL-12.
Significantly elevated and protracted levels of IFNγ, CXCL9, CXCL10, CCL5, and TNF-α were detected in both tumor lysates and serum at 72 hours post-dose.
Storage

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Purity & Documentation
References
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mDF6002 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

mDF6002mDF 6002mDF-6002IFNARCXCRTNF ReceptorInterferon-α/β receptorInterferon-alpha/beta receptor CXC chemokine receptorsC-X-C motif chemokine receptorsTumor Necrosis Factor ReceptorTNFRIL-12 receptordendritic cellsCD4+ T cellsIL-12Rinterferon gammaIFNγsolid tumorsCD8+ T cellsimmune cellstumor microenvironmentInhibitorinhibitorinhibit

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