2. PROTAC PI3K/Akt/mTOR
  3. PROTACs Akt
  4. MS15 TFA

MS15 TFA is a potent and selective AKT PROTAC degrader. MS15 TFA inhibits the AKT1, -2, and -3 activities, with IC50 values of 798 nM, 90 nM, and 544 nM, respectively.

For research use only. We do not sell to patients.

MS15 TFA Chemical Structure

MS15 TFA Chemical Structure

Size Price Stock Quantity
1 mg USD 380 In-stock
5 mg USD 930 In-stock
10 mg   Get quote  
50 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of MS15 TFA:

MS15 TFA Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MS15 TFA is a potent and selective AKT PROTAC degrader. MS15 TFA inhibits the AKT1, -2, and -3 activities, with IC50 values of 798 nM, 90 nM, and 544 nM, respectively[1].

IC50 & Target

798 nM (AKT-1), 90 nM (AKT-2), 544 nM (AKT-3)[1]
In Vivo

MS15 (75 mg/kg, IP, once) is bioavailable in mice through intraperitoneal administration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

1228.47

Formula

C66H80F3N11O7S
Appearance

Solid

Color

White to yellow

SMILES

NC1(CCC1)C(C=C2)=CC=C2N3C4=NC(C5=CC(CCC(NCCCCCCCCCCC(N[C@H](C(N6C[C@@H](C[C@H]6C(N[C@@H](C)C7=CC=C(C=C7)C8=C(N=CS8)C)=O)O)=O)C(C)(C)C)=O)=O)=CC=C5)=CC=C4N=C3C9=CC=CN=C9N.OC(C(F)(F)F)=O
Shipping

Shipping with dry ice.
Storage

-80°C, protect from light, stored under nitrogen
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (81.40 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8140 mL 4.0701 mL 8.1402 mL
5 mM 0.1628 mL 0.8140 mL 1.6280 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.86%

COA (250 KB) HNMR (268 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8140 mL 4.0701 mL 8.1402 mL 20.3505 mL
5 mM 0.1628 mL 0.8140 mL 1.6280 mL 4.0701 mL
10 mM 0.0814 mL 0.4070 mL 0.8140 mL 2.0351 mL
15 mM 0.0543 mL 0.2713 mL 0.5427 mL 1.3567 mL
20 mM 0.0407 mL 0.2035 mL 0.4070 mL 1.0175 mL
25 mM 0.0326 mL 0.1628 mL 0.3256 mL 0.8140 mL
30 mM 0.0271 mL 0.1357 mL 0.2713 mL 0.6784 mL
40 mM 0.0204 mL 0.1018 mL 0.2035 mL 0.5088 mL
50 mM 0.0163 mL 0.0814 mL 0.1628 mL 0.4070 mL
60 mM 0.0136 mL 0.0678 mL 0.1357 mL 0.3392 mL
80 mM 0.0102 mL 0.0509 mL 0.1018 mL 0.2544 mL
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MS15 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MS15MS 15MS-15PROTACsAktPKBProtein kinase BKRAS/BRAFcancerSW620 cellsColo205HT-29SKMEL 239PANC-1 cellsInhibitorinhibitorinhibit

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