2. Neuronal Signaling Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. α-synuclein Caspase Reactive Oxygen Species (ROS)
  4. NPT100-18A

NPT100-18A is an αSyn oligomerization inhibitor. NPT10018A rescues cleaved caspase-3 levels to control levels. NPT10018A attenuates mitochondrial oxidative stress probe levels in a compartment-specific manner and, at higher concentrations, increases ATP signals. NPT100-18A can be used for the study of Parkinson’s disease (PD).

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NPT100-18A

NPT100-18A Chemical Structure

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NPT100-18A Related Antibodies

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α-synuclein α-synuclein Aggregation α-synuclein/CHMP2B

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Description

NPT100-18A is an αSyn oligomerization inhibitor. NPT10018A rescues cleaved caspase-3 levels to control levels. NPT10018A attenuates mitochondrial oxidative stress probe levels in a compartment-specific manner and, at higher concentrations, increases ATP signals. NPT100-18A can be used for the study of Parkinson’s disease (PD)[1][2].

IC50 & Target

Caspase 3

 

In Vitro

NPT100-18A (10 nM) reduces the amount of Triton-X100 insoluble αSyn aggregated conformers in iPSC-derived mDANs[1].
NPT100-18A (10 nM) specifically reduces mitochondrial ROS in iPSC-derived mDANs without affecting total intracellular ROS[1].
NPT100-18A (1 µM) significantly increases ATP signaling in iPSC-derived mDANs[1].
NPT100-18A (10 nM, 21 days) significantly reduces the proportion of cCasp3⁺ neurons in iPSC-derived mDANs and inhibits the αSyn-related early neuronal apoptosis pathway[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NPT100-18A Related Antibodies
In Vivo

NPT100-18A (1-20 mg/kg, i.p., once daily for 90 days) significantly improved motor dysfunction in mThy1–wt–α-syn transgenic mice and reduced α-syn oligomers and related neurodegenerative pathology[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: mThy1-wt-α-syn transgenic mice[2].
Dosage: 1 mg/kg, 5 mg/kg, 10 mg/kg, 20 mg/kg
Administration: I.p., once daily for 90 days
Result: 10 and 20 mg/kg significantly reduced foot slips.
10 mg/kg significantly improved the error rate in the Challenger beam test.
Accumulation of α-synuclein in neurons and neurites was reduced.
SDS-resistant α-synuclein oligomers were reduced.
α-synuclein changed from a membrane component to a cytoplasmic component.
Animal Model: mThy1-E57K-α-syn transgenic mice[2].
Dosage: 20 mg/kg
Administration: I.p., once daily for 90 days
Result: Significantly reduced α-syn dimer/trimer/polymers.
Oligomer accumulation decreased markedly.
Molecular Weight

493.64

Formula

C28H39N5O3
SMILES

O=C1N(CC2CCNCC2)CC(N(C(CCC3=CNC4=C3C=CC=C4)=O)CCC5=O)N5C1CCCC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NPT100-18A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NPT100-18Aα-synucleinCaspaseReactive Oxygen Species (ROS)α-SynParkinson’s diseaseAlpha-synucleinAggregationOxidative stressROSiPSCDopaminergic neuronsMitochondriaInhibitorinhibitorinhibit

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