1. Epigenetics
    Apoptosis
  2. Histone Methyltransferase
    Apoptosis
  3. PRMT6-IN-3

PRMT6-IN-3 

Cat. No.: HY-152236
Handling Instructions

PRMT6-IN-3 (compound 25) is a selective PRMT6 inhibitor with an IC50 value of 192 nM. PRMT6-IN-3 can induce apoptosis in cancer cells and has anticancer activity.

For research use only. We do not sell to patients.

PRMT6-IN-3 Chemical Structure

PRMT6-IN-3 Chemical Structure

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Description

PRMT6-IN-3 (compound 25) is a selective PRMT6 inhibitor with an IC50 value of 192 nM. PRMT6-IN-3 can induce apoptosis in cancer cells and has anticancer activity[1].

In Vitro

PRMT6-IN-3(compound 25) (80 μM, 3-7 days) has anti-proliferative activity against HCC827 and MDA-MB-435 cells[1].
PRMT6-IN-3(compound 25) (0-40 μM, 72 h) significantly induces apoptosis of cancer cells in a dose-dependent manner. Among them, a concentration of 40 μM could induce apoptosis in 43.44% and 35.08% of HCC827 and MDA-MB-435 cells, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The pharmacokinetic parameters of PRMT6-IN-3(compound 25) in rat

Parameters iv (2 mg/kg) po (10 mg/kg)
Tmax (h) 0.08 0.33
T1/2 (h) 1.46 1.63
AUC(0-t)(ng*h/mL) 661.50 123.53
MRT(0-t) (h) 1.24 1.86
Cmax (ng/mL) - 88.32
F (%) - 3.73

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

374.50

Formula

C19H26N4O2S

SMILES

O=S(C1CC1)(NC2=CC=C(C3=CC(CN(C)CCNC)=CN=C3)C=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
PRMT6-IN-3
Cat. No.:
HY-152236
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