Recilisib sodium
Based on 45 publication(s) in Google Scholar
Recilisib sodium (ON 01210) is a radioprotectant, which can activate AKT, PI3K activities in cells.
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- CAS No.: 922139-31-9
- Formule: C16H12ClNaO4S
- Masse moléculaire:358.77
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) Recilisib sodium
More- Phytomedicine. 2025 Nov:147:157215. [Abstract]
- Phytomedicine. 2025 Apr:139:156464. [Abstract]
- Phytomedicine. 2024 Dec:135:156022. [Abstract]
- Phytomedicine. 2023 Apr:112:154684. [Abstract]
- Phytomedicine. 2022 Sep:104:154323. [Abstract]
- J Pharm Anal. 2023 May;13(5):463-482. [Abstract]
- J Transl Med. 2025 Oct 7;23(1):1062. [Abstract]
- Int J Biol Macromol. 2020 Mar 15:147:79-88. [Abstract]
- Cell Prolif. 2024 Nov;57(11):e13700. [Abstract]
- Cell Mol Neurobiol. 2023 Oct;43(7):3623-3637. [Abstract]
- Lipids Health Dis. 2024 Sep 4;23(1):282. [Abstract]
- J Ethnopharmacol. 2026 Sep 15:368:121836. [Abstract]
- J Ethnopharmacol. 2026 Sep 15:368:121766. [Abstract]
- J Ethnopharmacol. 2026 Mar 1:358:120973. [Abstract]
- J Ethnopharmacol. 2022 Jun 28:292:115212. [Abstract]
- J Agric Food Chem. 2025 Jul 23;73(29):18176-18185. [Abstract]
- Biochem Pharmacol. 2026 May:247:117804. [Abstract]
- Biochem Pharmacol. 2025 Sep 4;242(Pt 3):117305. [Abstract]
- Biochem Pharmacol. 2025 Sep 10;242(Pt 2):117329. [Abstract]
- Inflammopharmacology. 2025 Apr;33(4):2165-2178. [Abstract]
- Drug Des Devel Ther. 2025 Jun 17:19:5123-5141. [Abstract]
- Int Immunopharmacol. 2023 Feb:115:109677. [Abstract]
- mBio. 2025 Aug 13;16(8):e0097625. [Abstract]
- Sci Rep. 2023 Aug 11;13(1):13072. [Abstract]
- J Cell Mol Med. 2025 Jul;29(13):e70691. [Abstract]
- J Cell Mol Med. 2020 Dec;24(24):14316-14324. [Abstract]
- Biomedicines. 2026 Mar 17;14(3):692. [Abstract]
- Biol Trace Elem Res. 2024 Feb;202(2):701-712. [Abstract]
- J Cell Commun Signal. 2026 Feb 23;20(1):e70067. [Abstract]
- Naunyn Schmiedebergs Arch Pharmacol. 2025 Jul 8. [Abstract]
- J Cell Physiol. 2024 Jun;239(6):e31267. [Abstract]
- J Cell Commun Signal. 2022 Dec;16(4):579-599. [Abstract]
- J Pharm Pharmacol. 2024 Nov 4;76(11):1508-1520. [Abstract]
- Parasit Vectors. 2024 Aug 19;17(1):347. [Abstract]
- Toxicol Appl Pharmacol. 2025 Aug 21:117531. [Abstract]
- Cell Biol Int. 2022 Sep;46(9):1519-1529. [Abstract]
- Mol Cell Endocrinol. 2022 May 1:547:111598. [Abstract]
- Food Chem Toxicol. 2025 Oct:204:115628. [Abstract]
- BMC Anesthesiol. 2021 Aug 30;21(1):210. [Abstract]
- Tissue Cell. 2026 Jun 12:103:103696. [Abstract]
- Neurosci Lett. 2023 Jan 18:794:136995. [Abstract]
- Dev Biol. 2022 Jul;487:122-133. [Abstract]
- SSRN. 2025 Apr 4.
- Research Square Print. 2023 Jan 13.
- Environ Toxicol. 2020 Dec;35(12):1299-1307. [Abstract]
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Activité biologique
Description
In Vitro
Recilisib sodium (up to 50 μM) shows a normal distribution of cells throughout the cell cycle, with a slight reduction in the number of cells in S-phase at 50 μM. Continuous exposure of Recilisib sodium (100 μM) does not result in cell death. Recilisib sodium treatment does not inhibit the colony forming potential of human bone marrow cells. Recilisib sodium provides dose dependent protection of human bone marrow cells at all three doses of IR. Recilisib sodium activates the phosphorylation of AKT and GSK3α/β in HFL cells. Recilisib sodium increases PI3K activity in HFL-1 cells and murine bone marrow cells in response to radiation exposure. Recilisib sodium treatment in combination with radiation alters the MAPK signaling pathway[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 922139-31-9
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Masse moléculaire 358.77
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Formule C16H12ClNaO4S
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SMILES
O=C(C1=CC=C(C=C1)/C=C/S(=O)(CC2=CC=C(C=C2)Cl)=O)O[Na]
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Synonyms
ON 01210 sodium
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (45)
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Journal Impact Factor
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Most Recent
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Phytomedicine
Dendrobin A inhibits gastric cancer: Mechanistic insights supported by integrated evidence. [Abstract]2025 Nov:147:157215. PMID: 40913985 -
Phytomedicine
Brusatol inhibits malignant phenotypes and lipid metabolism of osteosarcoma cells by regulating PI3K/AKT and MAPK pathways. [Abstract]2025 Apr:139:156464. PMID: 39970856
Recilisib sodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Apr:139:156464. [Abstract]
Recilisib significantly reversed BRU-induced suppression of lipid metabolism in 143B, U2OS cells.
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Phytomedicine
Hypocrellin A against intrahepatic Cholangiocarcinoma via multi-target inhibition of the PI3K-AKT-mTOR, MAPK, and STAT3 signaling pathways. [Abstract]2024 Dec:135:156022. PMID: 39284270
Recilisib sodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Dec:135:156022. [Abstract]
Recilisib partially reversed the proliferation inhibitory effect of HA in RBE and HuccT1 cells.
Recilisib sodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Dec:135:156022. [Abstract]
Recilisib indeed elevated the protein expression of P-mTOR (Ser2448), P-PI3K (Tyr607), and P-AKT (S473) following HA-induced inhibition PI3K-AKT-mTOR activator recilisib reversed the effect of HA on ICC.
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Phytomedicine
Hydroxysafflor yellow A regulates lymphangiogenesis and inflammation via the inhibition of PI3K on regulating AKT/mTOR and NF-κB pathway in macrophages to reduce atherosclerosis in ApoE-/- mice. [Abstract]2023 Apr:112:154684. PMID: 36738477 -
Phytomedicine
2022 Sep:104:154323. PMID: 35858516 -
J Pharm Anal
Ginsenoside Rk3 is a novel PI3K/AKT-targeting therapeutics agent that regulates autophagy and apoptosis in hepatocellular carcinoma. [Abstract]2023 May;13(5):463-482. PMID: 37305788
Recilisib sodium purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2023 May;13(5):463-482. [Abstract]
Recilisib (10 μM) activated the PI3K/AKT pathway (via recilisib), leading to an increased HCC cell viability in the cotreatment group compared to the Rk3 only group.
Recilisib sodium purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2023 May;13(5):463-482. [Abstract]
Recilisib (10 μM) increased the protein expression of CDK4, cyclin D1 and P62, as well as decreased the protein expression of Bax, c-PARP and LC3II/LC3I in HepG2 and HCC-LM3 cells with 100 μM Rk3.
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J Transl Med
Hispidulin suppresses osteosarcoma by directly targeting FABP4 to disrupt lipid metabolism and inhibit the PI3K/AKT pathway. [Abstract]2025 Oct 7;23(1):1062. PMID: 41057878 -
Int J Biol Macromol
A polysaccharide from Grifola frondosa fruit body induces HT-29 cells apoptosis by PI3K/AKT-MAPKs and NF-κB-pathway. [Abstract]2020 Mar 15:147:79-88. PMID: 31923503
Recilisib sodium purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2020 Mar 15:147:79-88. [Abstract]
Measurement of ERK1/2 and NF-κB p65. Effect of GFP-A and Recilisib (activator of Akt) (10 μmol/L) on the expression of phosphorylated ERK1/2 in HT-29 cells. Cells are treated with 180 μg/mL GFP-A in the presence or absence of Recilisib for different durations of time.
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Cell Prolif
MCL restrained ROS/AKT/ASAH1 pathway to therapy tamoxifen resistance breast cancer by stabilizing NRF2. [Abstract]2024 Nov;57(11):e13700. PMID: 38924190 -
Cell Mol Neurobiol
Inhibiting PI3K/Akt-Signaling Pathway Improves Neurobehavior Changes in Anti-NMDAR Encephalitis Mice by Ameliorating Blood-Brain Barrier Disruption and Neuronal Damage. [Abstract]2023 Oct;43(7):3623-3637. PMID: 37314618 -
Lipids Health Dis
MG-132 activates sodium palmitate-induced autophagy in human vascular smooth muscle cells and inhibits senescence via the PI3K/AKT/mTOR axis. [Abstract]2024 Sep 4;23(1):282. PMID: 39232759 -
J Ethnopharmacol
2026 Sep 15:368:121836. PMID: 42106019 -
J Ethnopharmacol
Elucidation of the mechanisms and therapeutic effects of Sini Decoction on anxiety induced by forced swimming stress in mice. [Abstract]2026 Sep 15:368:121766. PMID: 42044778 -
J Ethnopharmacol
Methanol extract of Artemisia argyi against influenza a virus via inhibition of PI3K-AKT pathway activation. [Abstract]2026 Mar 1:358:120973. PMID: 41317814 -
J Ethnopharmacol
Huang Bai Jian Pi decoction alleviates diarrhea and represses inflammatory injury via PI3K/Akt/NF-κB pathway: In vivo and in vitro studies. [Abstract]2022 Jun 28:292:115212. PMID: 35331876 -
J Agric Food Chem
PI3K-Mediated Regulation of Glycogen Metabolism To Facilitate Tomato chlorosis Virus Transmission by Bemisia tabaci MED. [Abstract]2025 Jul 23;73(29):18176-18185. PMID: 40626897 -
Biochem Pharmacol
ATF5 activates LPAR5 to enhance macrophage pro-inflammatory responses to exacerbate rheumatoid arthritis. [Abstract]2026 May:247:117804. PMID: 41690415 -
Biochem Pharmacol
Sappanone A, a potential natural inhibitor of PI3K, alleviates metabolic dysfunction-associated steatohepatitis in experimental models. [Abstract]2025 Sep 4;242(Pt 3):117305. PMID: 40914217 -
Biochem Pharmacol
TEA domain transcription factor 3 suppresses aortic and left ventricular remodeling via transcriptional activation of PDZ domain containing 1. [Abstract]2025 Sep 10;242(Pt 2):117329. PMID: 40939874 -
Inflammopharmacology
Curcumol attenuates hyperproliferation and inflammatory response in a psoriatic HaCaT keratinocyte model by inhibiting the PI3K-Akt pathway and ameliorates skin lesions and inflammatory status in psoriasis-like mice. [Abstract]2025 Apr;33(4):2165-2178. PMID: 40063187 -
Drug Des Devel Ther
Exploring the Therapeutic Potential of FSGTC for Osteoarthritis: A Comprehensive Study Combining Nested Case Analysis, Network Pharmacology, and Experimental Validation. [Abstract]2025 Jun 17:19:5123-5141. PMID: 40546656 -
Int Immunopharmacol
2023 Feb:115:109677. PMID: 36634415 -
mBio
The swine acute diarrhea syndrome coronavirus spike protein promotes syncytial formation via upregulation of cellular cholesterol synthesis. [Abstract]2025 Aug 13;16(8):e0097625. PMID: 40586601 -
Sci Rep
Taraxasterol suppresses the proliferation and tumor growth of androgen-independent prostate cancer cells through the FGFR2-PI3K/AKT signaling pathway. [Abstract]2023 Aug 11;13(1):13072. PMID: 37567936 -
J Cell Mol Med
Modified Qianghuo Shengshi Decoction Ameliorates Osteoarthritis via Inhibiting PI3K/Akt Pathway-Related Ferroptosis. [Abstract]2025 Jul;29(13):e70691. PMID: 40586853 -
J Cell Mol Med
Tumour necrosis factor-α promotes BMHSC differentiation by increasing P2X7 receptor in oestrogen-deficient osteoporosis. [Abstract]2020 Dec;24(24):14316-14324. PMID: 33169524 -
Biomedicines
Quercetin Ameliorates Comorbid Insomnia in Diarrhea-Predominant Irritable Bowel Syndrome via the PI3K/AKT/NF-κB Signaling Pathway. [Abstract]2026 Mar 17;14(3):692. PMID: 41898339 -
Biol Trace Elem Res
Antagonizing Effects of Chromium Against Iron-Decreased Glucose Uptake by Regulating ROS-Mediated PI3K/Akt/GLUT4 Signaling Pathway in C2C12. [Abstract]2024 Feb;202(2):701-712. PMID: 37156991 -
J Cell Commun Signal
Structural maintenance of chromosome protein 1A exacerbates liver fibrosis by enhancing hepatic stellate cell activation and extracellular matrix synthesis via laminin subunit gamma 2 activation. [Abstract]2026 Feb 23;20(1):e70067. PMID: 41737731 -
Naunyn Schmiedebergs Arch Pharmacol
Ononin induces ferroptosis in colorectal cancer cells via the PI3K/AKT/Nrf2 pathway to enhance anti-cancer immunotherapy. [Abstract]2025 Jul 8. PMID: 40627200 -
J Cell Physiol
FNDC5 inhibits malignant growth of human cervical cancer cells via restraining PI3K/AKT pathway. [Abstract]2024 Jun;239(6):e31267. PMID: 38558303 -
J Cell Commun Signal
Lysine demethylase 5A promotes prostate adenocarcinoma progression by suppressing microRNA-330-3p expression and activating the COPB2/PI3K/AKT axis in an ETS1-dependent manner. [Abstract]2022 Dec;16(4):579-599. PMID: 35581421 -
J Pharm Pharmacol
Targeting the PI3K/AKT signaling pathway with PNU120596 protects against LPS-induced acute lung injury. [Abstract]2024 Nov 4;76(11):1508-1520. PMID: 39288376 -
Parasit Vectors
Ac-HSP20 regulates autophagy and promotes the encystation of Acanthamoeba castellanii by inhibiting the PI3K/AKT/mTOR signaling pathway. [Abstract]2024 Aug 19;17(1):347. PMID: 39160562 -
Toxicol Appl Pharmacol
Chrysin enhances sunitinib sensitivity in renal cell carcinoma by inducing ferroptosis via targeting PI3K/Akt/GPX4 pathway. [Abstract]2025 Aug 21:117531. PMID: 40848919 -
Cell Biol Int
2022 Sep;46(9):1519-1529. PMID: 35731168 -
Mol Cell Endocrinol
Stanniocalcin2 inhibits the epithelial-mesenchymal transition and invasion of trophoblasts via activation of autophagy under high-glucose conditions. [Abstract]2022 May 1:547:111598. PMID: 35157929 -
Food Chem Toxicol
Mechanistic insights into AKT1/GSK3β/CD36 axis regulation in ZLY06-induced hepatic lipid metabolism dysfunction and protective intervention via AKT activation strategies. [Abstract]2025 Oct:204:115628. PMID: 40633829 -
BMC Anesthesiol
The expression of kappa-opioid receptor promotes the migration of breast cancer cells in vitro. [Abstract]2021 Aug 30;21(1):210. PMID: 34461834 -
Tissue Cell
Liensinine induces autophagy and apoptosis in hepatocellular carcinoma via reactive oxygen species-mediated inhibition of the PI3K/AKT/mTOR pathway. [Abstract]2026 Jun 12:103:103696. PMID: 42314534 -
Neurosci Lett
Inhibiting specificity protein 1 attenuated sevoflurane-induced mitochondrial stress and promoted autophagy in hippocampal neurons through PI3K/Akt/mTOR and α7-nAChR signaling. [Abstract]2023 Jan 18:794:136995. PMID: 36464148 -
Dev Biol
Autophagy participates in germline cyst breakdown and follicular formation by modulating glycolysis switch via Akt signaling in newly-hatched chicken ovaries. [Abstract]2022 Jul;487:122-133. PMID: 35525303 -
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Environ Toxicol
Acylglycerol kinase promotes the stemness of nasopharyngeal carcinoma cells by promoting β-catenin translocation to the nucleus through activating PI3K/Akt pathway. [Abstract]2020 Dec;35(12):1299-1307. PMID: 32652857
Recilisib sodium purchased from MedChemExpress. Usage Cited in: Environ Toxicol. 2020 Dec;35(12):1299-1307. [Abstract]
FaDu cells with AGK overexpression is treated with the PI3K inhibitor LY294002, and Cal27 cells with AGK knockdown is treated with PI3K activator Recilisib (50 μM). The inhibitory effect of LY294002 and promoting effects of Recilisib on PI3K/Akt signaling is confirmed by Western blot analysis.
Pureté et documentation
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Recilisib sodium Related Classifications
HY-101625A Related Classifications
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