FOXP
Forkhead Box P Protein
Forkhead box proteins (FOXPs) are transcription factors composed of FOXP1 (3p14.1), FOXP2 (7q31), FOXP3 (Xp11.23), and FOXP4 (6p21.1). They all possess a similar 110-amino acid DNA-binding domain, termed the winged helix/forkhead domain. FOXP1 regulates development of B cells, FOXP2 controls language development and FOXP4 mediates development of T cell. FOXP3, so called scurfin, is critically involved in differentiation and function of regulatory T cells or CD4+/CD25+ regulatory T (Treg) cells for cancer immunotherapy. FOXP proteins play important roles in the regulation of gene transcription in associated with immune function, carcinogenesis, differentiation and angiogenesis[1][2].
FOXP Isoform Specific Products
All Product Categories
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FOXP Related Products (11)
Related Products (11)
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FOXP Isoform Comparison
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Epirubicin hydrochloride
0 ImagesSynonyms: 4'-Epidoxorubicin hydrochlorideEpirubicin hydrochloride (4'-Epidoxorubicin hydrochloride), a semisynthetic L-arabino derivative of doxorubicin, has an antineoplastic agent by inhibiting Topoisomerase. Epirubicin hydrochloride inhibits DNA and RNA synthesis. Epirubicin hydrochloride is a Forkhead box protein p3 (Foxp3) inhibitor and inhibits regulatory T cell activity.
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Epirubicin
0 ImagesSynonyms: 4'-EpidoxorubicinEpirubicin (4'-Epidoxorubicin), a semisynthetic L-arabino derivative of doxorubicin, has an antineoplastic agent by inhibiting Topoisomerase. Epirubicin inhibits DNA and RNA synthesis. Epirubicin is a Forkhead box protein p3 (Foxp3) inhibitor and inhibits regulatory T cell activity.
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Peptide P60
0 ImagesSynonyms: FOXP3 inhibitor P60Peptide P60 is a FOXP3 inhibitor. Peptide P60 reduces the nuclear translocation of FOXP3 and impairs FOXP3-mediated inhibition of NF-κB and NFAT activity. Peptide P60 inhibits the immunosuppressive activity of regulatory T cells and restores the proliferation and activation of effector T cells. Peptide P60 induces lymphoproliferative autoimmune syndrome in neonatal ICR mice and reduces the number of CD4+CD25+Foxp3+ T cells in the spleen. Peptide P60 enhances the efficacy of AH1 (HY-P4193) peptide vaccine and recombinant adenovirus-based HCV NS3 vaccine in BALB/c mice, including protective effects against CT26 tumor implantation. Peptide P60 can be used in studies related to tumor immunity, viral infection and lymphoproliferative autoimmune syndrome.
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DS-437
0 ImagesDS-437 is a dual PRMT5/7 inhibitor (IC50s of PRMT5/7=6 μM). DS-437 is selective for PRMT5 and PRMT7 over 29 other human protein-, DNA-, and RNA-methyltransferases. DS-437 is a S-adenosylmethionine (SAM)-competitive inhibitor of PRMT5. DS-437 also inhibits DNMT3A and DNMT3B, with IC50s of 52 and 62 μM, respectively. DS-437 inhibits the methylation of FOXP3.
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AZD8701
0 ImagesCat. No.: HY-159692CAS No.: 2603457-08-3Synonyms: IONIS-1063734AZD8701 (IONIS-1063734) is an antisense oligonucleotide targeting FOXP3 in regulatory T cells (Tregs), with a human IC50 of 65.2 nM. AZD8701 binds to intronic sites of all FOXP3 pre-mRNA isoforms and mediates dose-dependent FOXP3 knockdown via free uptake. AZD8701 can be used in cancer-related research.
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Epirubicin hydrochloride (Standard)
0 ImagesSynonyms: 4'-Epidoxorubicin hydrochloride (Standard)Epirubicin (hydrochloride) (Standard) is the analytical standard of Epirubicin (hydrochloride). This product is intended for research and analytical applications. Epirubicin hydrochloride (4'-Epidoxorubicin hydrochloride), a semisynthetic L-arabino derivative of doxorubicin, has an antineoplastic agent by inhibiting Topoisomerase. Epirubicin hydrochloride inhibits DNA and RNA synthesis. Epirubicin hydrochloride is a Forkhead box protein p3 (Foxp3) inhibitor and inhibits regulatory T cell activity.
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AZD8701 sodium
0 ImagesCat. No.: HY-159692ASynonyms: IONIS-1063734 sodiumAZD8701 (IONIS-1063734) sodium is an antisense oligonucleotide targeting FOXP3 in regulatory T cells (Tregs). AZD8701 sodium can relieve immunosuppression in cancer.
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