AM12
AM12 inhibits Lanthanide-evoked TRPC5 activity with an IC50 of 0.28 μM.
For research use only. We do not sell to patients.
- CAS No.: 2387510-84-9
- Formula: C15H9BrO5
- Molecular Weight:349.13
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
IC50: 0.28 μM (TRPC5)[1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
0.28 μM
Compound: 20; AM12
|
Inhibition of human TRPC5 expressed in HEK293 cells assessed as reduction in gadolinium-induced calcium entry after 30 mins by fura-2 dye based fluorescence assay
Inhibition of human TRPC5 expressed in HEK293 cells assessed as reduction in gadolinium-induced calcium entry after 30 mins by fura-2 dye based fluorescence assay
|
[PMID: 30943030] |
AM12 also inhibits TRPC5 activity evoked by the agonist (-)-Englerin A[1].
AM12 also inhibits TRPC4 channels similarly. AM12 inhibits TRPC5 and TRPC4 channels via a site accessible from the extracellular face of the membrane, acting directly on either the channel or a site closely associated with it[1].
AM12 also inhibits Ca2+ entry evoked by Gd3+. AM12 inhibits the Gd3+-evoked Ca2+ signal with an IC50 of 0.28 μM. AM12 is slightly more potent than the natural product Galangin as an inhibitor of the Gd3+-evoked signal[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2387510-84-9
-
Molecular Weight 349.13
-
Formula C15H9BrO5
-
SMILES
O=C1C(O)=C(C2=CC=CC=C2Br)OC3=C1C(O)=CC(O)=C3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz