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Cat. No.: HY-117948A

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(S)-ML399

(S)-ML399 (Compound 18S) is the enantiomer of ML399 (HY-117948). (S)-ML399 acts as a Menin-MLL interaction inhibitor with an IC₅₀ of 1400 nM. (S)-ML399 can be used to investigate acute leukemias with MLL translocations, including acute myeloid leukemia and acute lymphoblastic leukemia.

For research use only. We do not sell to patients.

CAS No.: 1560968-51-5
Formula: C₂₇H₂₈FN₃O₂
Molecular Weight:445.53

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Please store the product under the recommended conditions in the Certificate of Analysis.

(S)-ML399 Chemical Structure

CAS No.: 1560968-51-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Chemical Information

CAS No. 1560968-51-5
Molecular Weight 445.53
Formula C₂₇H₂₈FN₃O₂
SMILES

O[C@](C1CCN(CC1)CCCOC2=CC=C(C=C2)C#N)(C3=CC=CC=N3)C4=CC(F)=CC=C4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. He S, et al. High-affinity small-molecule inhibitors of the menin-mixed lineage leukemia (MLL) interaction closely mimic a natural protein-protein interaction. J Med Chem. 2014;57(4):1543-1556. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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(S)-ML399

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(S)-ML399 Related Classifications

HY-117948A Related Classifications