251 Results for "

anticancer properties

" in MedChemExpress (MCE) Product Catalog:
Products (251)

251 Results for "anticancer properties" in MCE Product Catalog:

7
Quinine hemisulfate hydrate
Quinine hemisulfate hydrate
0 Images
7 Cited Publications
Cat. No.: HY-D0143B
CAS No.: 207671-44-1
Category:  

Infection Alkaloids Rubiaceae Cinchona calisaya Wedd. Quinoline Alkaloids Plants Disease Research Fields

Target:  

Parasite Potassium Channel Dengue Virus Flavivirus

Quinine hemisulfate hydrate is an orally active alkaloid extracted from cinchona bark, possessing various biological activities including antimalarial, antidengue virus (DENV), and anticancer properties. Quinine hemisulfate hydrate acts as a potassium channel inhibitor that suppresses the +100 mV current of MT mSlo3 (KCa5.1) channels induced by voltage pulses, with an IC50 value of 169 μM. Quinine hemisulfate hydrate serves as a fluorescence standard reference substance with fluorescence spectrum calibration and validation activity .
loading...
    loading...
View All Sizes
6
Bendamustine hydrochloride
Bendamustine hydrochloride
0 Images
6 Cited Publications
Cat. No.: HY-B0077
CAS No.: 3543-75-7
Synonyms: SDX-105
Target:  

DNA Alkylator/Crosslinker Apoptosis

Research Areas:  

Neurological Disease Inflammation/Immunology Cancer

Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties .
loading...
    loading...
View All Sizes
6
Bendamustine
Bendamustine
0 Images
6 Cited Publications
Cat. No.: HY-13567
CAS No.: 16506-27-7
Purity:  ≥98.0%
Synonyms: SDX-105 free base
Target:  

DNA Alkylator/Crosslinker Apoptosis

Research Areas:  

Neurological Disease Inflammation/Immunology Cancer

Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties .
loading...
    loading...
View All Sizes
5
Licochalcone D
Licochalcone D
0 Images
5 Cited Publications
Cat. No.: HY-N4187
CAS No.: 144506-15-0
Category:  

Metabolic Disease Plants Flavonoids Chalcones Leguminosae Phenols Polyphenols Disease Research Fields Glycyrrhiza uralensis Fisch. Inflammation/Immunology

Target:  

NF-κB Apoptosis Reactive Oxygen Species (ROS)

Licochalcone D, a flavonoid compound mainly existing in the root of Glycyrrhiza uralensis, is a potent and orally active inhibitor of NF-kappaB (NF-κB) p65. Licochalcone D possesses antioxidant, anti-inflammatory, anti-cancer properties .
loading...
    loading...
View All Sizes
5
Didymin
Didymin
0 Images
5 Cited Publications
Cat. No.: HY-N2068
CAS No.: 14259-47-3
Category:  

Flavonoids Monophenols Flavonones Rutaceae Phenols Plants Disease Research Fields Citrus Cancer

Target:  

Apoptosis

Didymin, a flavonoid glycoside, possesses antioxidant and anticancer properties. Didymin induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma .
loading...
    loading...
View All Sizes
5
Atractylenolide I
Atractylenolide I
0 Images
5 Cited Publications
Cat. No.: HY-N0201
CAS No.: 73069-13-3
Category:  

Terpenoids Sesquiterpenes Astragalus caprinus L. Plants Compositae Disease Research Fields Cancer

Target:  

TNF Receptor Toll-like Receptor (TLR) JAK STAT

Atractylenolide I is a sesquiterpene derived from the rhizome of Atractylodes macrocephala, possesses diverse bioactivities, such as neuroprotective, anti-allergic, anti-inflammatory and anticancer properties. Atractylenolide I reduces protein levels of phosphorylated JAK2 and STAT3 in A375 cells, and acts as a TLR4-antagonizing agent.
loading...
    loading...
View All Sizes
5
Proanthocyanidins
Proanthocyanidins
0 Images
5 Cited Publications
Cat. No.: HY-N0794
CAS No.: 20347-71-1
Category:  

Cardiovascular Disease Plants Infection other families Flavonoids Functional Molecules Research of Health Products Phenols Polyphenols Disease Research Fields Inflammation/Immunology Biflavones

Target:  

Bacterial Fungal

Proanthocyanidin (Procyanidin) are a class of polyphenolic that are widely distributed in higher plants, consisted of an electrophilic flavanyl unit. Proanthocyanidin can be used as antioxidant and anti-cancers agent. Proanthocyanidin also exhibit anti-inflammatory, cardioprotective, antibacterial and antifungal properties, which can be used in the treatment of chronic venous insufficiency, capillary fragility, sunburn and retinopathy. .
loading...
    loading...
View All Sizes
5
Bruceine D
Bruceine D
0 Images
5 Cited Publications
Cat. No.: HY-N3014
CAS No.: 21499-66-1
Category:  

Infection Simaroubaceae Terpenoids Diterpenoids Plants Disease Research Fields Brucea javanica (L.) Merr.

Target:  

Notch Apoptosis Parasite

Bruceine D is a Notch inhibitor with anti-cancer activity and induces apoptosis in several human cancer cells. Bruceine D is an effective botanical insect antifeedant with outstanding systemic properties, causing potent pest growth inhibitory activity . Bruceine D has strong anthelmintic activity against D. intermedius with an EC50 value of 0.57 mg/L .
loading...
    loading...
View All Sizes
5
Esculin
Esculin
0 Images
5 Cited Publications
Cat. No.: HY-N0188
CAS No.: 531-75-9
Category:  

other families Monophenols Coumarins Phenols Phenylpropanoids Plants Disease Research Fields Cancer

Target:  

p38 MAPK

Esculin is a fluorescent coumarin glucoside, the active ingredient in ash bark. Esculin has antidiabetic effects, improves cognitive impairment in experimental diabetic nephropathy (DN) via the MAPK signaling pathway, and exerts antioxidant stress and anti-inflammatory effects. Esculin also has anticancer, antibacterial, antiviral, neuroprotective, antithrombotic, and therapeutic properties for eye diseases .
loading...
    loading...
View All Sizes
5
Garcinol
Garcinol
0 Images
5 Cited Publications
Cat. No.: HY-107569
CAS No.: 78824-30-3
Purity:  ≥99.0%
Category:  

Guttiferae Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology Garcinia indica

Target:  

Cholinesterase (ChE) Histone Acetyltransferase Apoptosis Endogenous Metabolite

Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 μM and 7.39 μM, respectively . Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity .
loading...
    loading...
View All Sizes
5
8-Gingerol
8-Gingerol
0 Images
5 Cited Publications
Cat. No.: HY-N0447
CAS No.: 23513-08-8
Category:  

Zingiber officinale Roscoe Monophenols Phenols Plants Disease Research Fields Inflammation/Immunology Cancer Zingiberaceae

Target:  

TRP Channel Bacterial Apoptosis Autophagy STAT PERK EGFR PI3K Akt mTOR Caspase MMP

8-Gingerol can be found in the rhizome of ginger (Z. officinale) and has oral bioactivity. It activates TRPV1, with an EC50 value of 5.0 µM. 8-Gingerol inhibits COX-2 and also suppresses the growth of H. pylori in vitro. Additionally, 8-Gingerol exhibits anticancer, antioxidant, and anti-inflammatory properties by inhibiting the epidermal growth factor receptor (EGFR) and modulating its downstream STAT3/ERK pathway to suppress the proliferation, migration, and invasion of colorectal cancer cells. 8-Gingerol also exerts immunosuppressive effects by inhibiting oxidative stress, inducing cell cycle arrest, promoting apoptosis, and regulating autophagy. Furthermore, 8-Gingerol has cardioprotective effects. 8-Gingerol is promising for research in the fields of cancer, infection, immunosuppression, and cardiovascular diseases.
loading...
    loading...
View All Sizes
4
IR-783
IR-783
0 Images
4 Cited Publications
Cat. No.: HY-139109
CAS No.: 115970-66-6
Purity:  99.87%
Synonyms: ADS 780WS
IR-783 (ADS 780WS) is a heptamethine cyanine dye. IR-783 induces Mitochondrial membrane potential loss, ATP depletion, mitochondrial permeability transition pore opening, Cytochrome c release and Apoptosis in breast cancer cells. IR-783 promotes the translocation of Drp1 from the cytosol to mitochondria. IR-783 increases the expression of mitochondrial fission proteins such as MFF and Fission-1. IR-783 possesses imaging, cancer-targeting and anticancer properties. IR-783 exerts anticancer effects against breast cancer. IR-783 can be used in breast cancer-related research .
loading...
    loading...
View All Sizes
3
Prodigiosin
Prodigiosin
0 Images
3 Cited Publications
Cat. No.: HY-100711
CAS No.: 82-89-3
Purity:  99.89%
Synonyms: Prodigiosine; NSC47147
Category:  

Antifungal Anti-inflammation/Immunoregulatory Disease Research Antibacterial Other Antibiotics Food Research Infection Microorganisms Antibiotics Pigments Anticancer Disease Research Fields Inflammation/Immunology

Target:  

Bacterial Apoptosis Wnt Fungal Parasite

Prodigiosin (Prodigiosine) is a red pigment produced by bacteria as a bioactive secondary metabolite. Prodigiosin is a potent inhibitor of the Wnt/β-catenin pathway. Prodigiosin has antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties .
loading...
    loading...
View All Sizes
3
Prodigiosin hydrochloride
Prodigiosin hydrochloride
0 Images
3 Cited Publications
Cat. No.: HY-100711A
CAS No.: 56144-17-3
Purity:  98.00%
Synonyms: Prodigiosine hydrochloride
Category:  

Infection Alkaloids Microorganisms Pyrrole Alkaloids Pigments Disease Research Fields Inflammation/Immunology Food Research

Target:  

Bacterial Apoptosis Fungal Wnt Parasite

Prodigiosin (Prodigiosine) hydrochloride is a red pigment produced by bacteria as a bioactive secondary metabolite. Prodigiosin hydrochloride is a potent proapoptotic agent, and inhibits Wnt/β-catenin pathway. Prodigiosin hydrochloride has antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties .
loading...
    loading...
View All Sizes
3
Solasonine
Solasonine
0 Images
3 Cited Publications
Cat. No.: HY-N0070
CAS No.: 19121-58-5
Category:  

Alkaloids Piperidine Alkaloids Solanum nigrum Linn. Plants Solanaceae Disease Research Fields Cancer

Target:  

Ferroptosis Glutathione Peroxidase Reactive Oxygen Species (ROS)

Solasonine is a ferroptosis inducer which can be isolated from Solanum melongena that has anti-infection, anti-cancer, and neurogenesis promoting properties. Solasonine promotes ferroptosis of HCC cells via destruction of the glutathione redox system induced by inhibiting GPX4, and can be used for cancer research .
loading...
    loading...
View All Sizes
3
Falcarindiol
Falcarindiol
0 Images
3 Cited Publications
Cat. No.: HY-N0364
CAS No.: 55297-87-5
Category:  

Infection Natural Products Chrysanthemum × morifolium (Ramat.) Hemsl. Metabolic Disease Plants Umbelliferae Disease Research Fields Inflammation/Immunology

Target:  

Apoptosis Autophagy PPAR

Falcarindiol, an orally active polyacetylenic oxylipin, activates PPARγ and increases the expression of the cholesterol transporter ABCA1 in cells. Falcarindiol induces apoptosis and autophagy. Falcarindiol has anti-inflammatory, antifungal, anticancer and antidiabetic properties . Falcarindiol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
loading...
    loading...
View All Sizes
3
Polygalacin D
Polygalacin D
0 Images
3 Cited Publications
Cat. No.: HY-N6064
CAS No.: 66663-91-0
Category:  

Triterpenes Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Plants Disease Research Fields Cancer

Target:  

Apoptosis IAP

Polygalacin D (PGD) is a bioactive compound isolated from Platycodon grandiflorum with anticancer and anti-proliferative properties. PGD suppresses the expression of the IAP family of proteins including survivin, cIAP-1 and cIAP-2 and blocks the PI3K/Akt pathway by inhibiting the phosphorylation of GSK3β, Akt and the expression of PI3K. Polygalacin D induces apoptosis
loading...
    loading...
View All Sizes
3
β-Carotene
β-Carotene
0 Images
3 Cited Publications
Cat. No.: HY-N0411
CAS No.: 7235-40-7
Synonyms: Provitamin A; beta-Carotene
Category:  

Metabolic Disease Endocrine diseases Plants Endogenous metabolite Food Research Other Terpenoids other families Immune System Disorder Terpenoids Disease markers Pigments Disease Research Fields Cancer

Target:  

Environmental Pollutants Endogenous Metabolite Reactive Oxygen Species (ROS) Apoptosis

β-Carotene (Provitamin A), a carotenoid compound, is a naturally-occurring vitamin A precursor. β-Carotene is a modulator of reactive oxygen species (ROS), with antioxidant and antiinflammatory activities. β-Carotene may serve as an antioxidant or as a prooxidant, depending on its intrinsic properties as well as on the redox potential of the biological environment in which it acts. β-Carotene induces breast cancer cells apoptosis, with anticancer activities .
loading...
    loading...
View All Sizes
3
C6 Ceramide
C6 Ceramide
0 Images
3 Cited Publications
Cat. No.: HY-19542
CAS No.: 124753-97-5
Synonyms: C6-Cer; N-Hexanoylsphingosine
Target:  

Apoptosis

Research Areas:  

Cancer

C6 Ceramide (C6-Cer) is a short-chain, cell-permeable ceramide pathway activator with anticancer activity. C6 Ceramide-mediated miR-29b expression participates in the progression of multiple myeloma through suppressing the proliferation, migration and angiogenesis of endothelial cells by targeting Akt signal pathway. C6 Ceramide exhibits multiple anti-cancer properties including cell cycle arrest, Apoptosis, inhibition of tumor growth and enhances the effects of chemotherapy in drug-resistant cancer cells. C6-ceramide can be used as an adjuvant for chemotherapeutic agents, to enhance anti-tumor effects .
loading...
    loading...
View All Sizes
3
Bryostatin 1
Bryostatin 1
0 Images
3 Cited Publications
Cat. No.: HY-105231
CAS No.: 83314-01-6
Purity:  99.70%
Category:  

Neurological Disease Anti-inflammation/Immunoregulatory Marine natural products Other marine organisms Disease Research Infection Animals Macrolide Antibiotics Antibiotics Anticancer Disease Research Fields Inflammation/Immunology

Target:  

PKC HIV Bacterial

Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a potent and central nervous system (CNS)-permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein with Kis of 8.07 nM and 0.45 nM, respectively. Bryostatin 1 has anti-cancer, anti-inflammatory, neuroprotective, anti-HIV-1 infection properties .
loading...
    loading...
View All Sizes
Assay Types