Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
961 Results for "
Nucleic
" in MedChemExpress (MCE) Product Catalog:
Products (961)
961 Results for "Nucleic" in MCE Product Catalog:
1
1
Miravirsen sodium is a potent miR-122 inhibitor and inhibits the biogenesis of miR-122. Miravirsen sodium is a 15-nucleotide locked nucleic acid-modified phosphorothioate antisense oligonucleotide. Miravirsen sodium inhibits HCV replication, and can be used in research of HCV infection .
1
Research Areas:
Miravirsen (SPC-3649) is a potent miR-122 inhibitor and inhibits the biogenesis of miR-122. Miravirsen is a 15-nucleotide locked nucleic acid-modified phosphorothioate antisense oligonucleotide. Miravirsen inhibits HCV replication. Miravirsen can be used in research of HCV infection .
1
1 Cited Publications
Cat. No.: HY-P74649
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PCBP1; Nucleic Acid-Binding Protein SUB2.3; Poly(RC) Binding Protein 1; Epididymis Secretory Protein Li 85; Heterogeneous Nuclear Ribonucleoprotein E1; Alpha-CP1; Poly(RC)-Binding Protein 1; HEL-S-85; HnRNP-E1; Heterogenous Nuclear Ribonucleoprotein E1; H
Species:
Human
Source:
E. coli
1
1 Cited Publications
1
1 Cited Publications
Synonyms: Lumi-Phos Plus; Lumigen PPD; PPD
1
1 Cited Publications
Target:
1
1
Category:
Alkaloids Human Gut Microbiota Metabolites Neurological Disease Other Alkaloids Endogenous metabolite Disease Research Fields Cancer
Target:
1
1 Cited Publications
Cat. No.: HY-172705
Research Areas:
DSPE-PEG2000-RVG29 is a PEG conjugate composed of DSPE and rabies virus glycoprotein 29 (RVG29). RVG29 specifically binds to nicotinic acetylcholine receptors (nAChR) at the blood-brain barrier (BBB), crosses the BBB, and mediates receptor-dependent transcytosis. DSPE-PEG2000-RVG29 can be used for brain-targeted drug delivery, surface modification of nanocarriers, as well as gene and nucleic acid delivery. DSPE-PEG2000-RVG29 is applicable to research related to hypoxic-ischemic brain injury, Parkinson's disease, and other conditions .
1
Target:
Research Areas:
Edelfosine (ET-18-OCH3) is an orally active lipid raft modulator and apoptosis inducer that alters membrane fluidity and preferentially inserts into tumor cell membranes. Edelfosine recruits death receptor ligands (FasL/CD95L, TRAIL) and Bid to lipid rafts to form death-inducing signaling complexes, thereby initiating mitochondria-dependent apoptosis and inducing cytochrome c release. Edelfosine also exerts anti-inflammatory effects, promotes L-Selectin shedding, and causes no gastrointestinal or organ toxicity. In addition, Edelfosine inhibits nucleic acid and protein synthesis in Leishmania donovani and exhibits antiproliferative activity. Edelfosine can be used in research on multiple myeloma, inflammatory bowel diseases (such as ulcerative colitis and Crohn's disease), and visceral leishmaniasis .
1
1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (1,2-POPE; 16:0-18:1 PE) is a phosphatidylethanolamine (PE) lipid. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can induce lipid bilayer to form a hexagonal phase (HII) structure in an acidic environment and promote membrane fusion. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can enhance the endosomal escape ability of lipid nanoparticles (LNPs) and improve the cellular delivery efficiency of nucleic acid drugs such as mRNA. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can be used for LNP carrier targeting of gene therapy and mRNA vaccines .
1
1 Cited Publications
Target:
Research Areas:
BTYNB is a structure-specific nucleic acid binder and IGF2BP1 inhibitor (with an IC50 of 5 μM against hBTYNB). BTYNB disrupts the IGF2BP1-RNA interaction and blocks its binding to oncogenic mRNAs such as c-Myc, MDM2, PD-L1. BTYNB completely blocks the INHBA-Smad2/3 pathway, disrupts the MYCN/IGF2BP1 loop, and thereby induces apoptosis and cell cycle arrest, effectively inhibiting the proliferation and survival of cancer cells. In addition, BTYNB acts as an immune activator and tumor microenvironment modulator, enhances T cell-mediated tumor killing, and produces significant synergistic effects with inhibitors of PD-1, BRD and BIRC5. BTYNB can be used in relevant research on various malignant tumors including ovarian cancer, neuroblastoma, leukemia and melanoma .
DLin-K-C3-DMA, a cationic lipid, can be used in the synthesis of nucleic acid-lipid particle to delivery of nucleic acid .
Cat. No.: HY-N3013
CAS No.: 25514-29-8
Synonyms: Brucein B
Category:
Simaroubaceae Extract Ketones, Aldehydes, Acids Plants Disease Research Fields Inflammation/Immunology Brucea javanica (L.) Merr.
Target:
Cat. No.: HY-160439
CAS No.: 2763904-72-7
Target:
Research Areas:
Ionizable lipid-2 is a cationic lipid for nucleic acid delivery, with the ability to form lipid nanoparticle mRNA vaccines that exhibit in vitro stability and immunostimulatory activity. Ionizable lipid-2 can be used in studies related to herpes zoster, mRNA vaccines and nucleic acid delivery .
Cat. No.: HY-148389
CAS No.: 68141-38-8
Synonyms: Sialylglycoasparaginate
Target:
Research Areas:
Disialo-Asn (Sialylglycoasparaginate) is an asparagine oligosaccharide. Disialo-Asn can be used for nucleic acid modification .
Cat. No.: HY-111807
CAS No.: 206055-71-2
Research Areas:
Locked nucleic acid 1 is a derivative of LNA-type nucleoside.
Target:
Research Areas:
3′-Deoxyadenosine 5′-triphosphateCan be used for nucleic acid synthesis.
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
