Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
126 Results for "
17β-HSD isoenzymes
" in MedChemExpress (MCE) Product Catalog:
Products (126)
126 Results for "17β-HSD isoenzymes" in MCE Product Catalog:
19
Target:
19
16
16 Cited Publications
Synonyms: APTA-2217; BYK 20869; B9302-107
Target:
Research Areas:
Roflumilast (APTA-2217) is a selective PDE4 inhibitor with IC50s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDE4A4, PDE4B1, and PDE4B2, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells.
11
11 Cited Publications
Cat. No.: HY-D0845
CAS No.: 57564-91-7
Synonyms: GSNO; RVC-588; S-Nitroso-L-glutathione
Research Areas:
Nitrosoglutathione (GSNO), a exogenous NO donor and a substrate for rat alcohol dehydrogenase class III isoenzyme, inhibits cerebrovascular angiotensin II-dependent and -independent AT1 receptor responses .
7
7 Cited Publications
Research Areas:
BCATc Inhibitor 2 is a selective branched-chain aminotransferase (BCAT) inhibitor for research of neurodegenerative diseases. The IC50s of 0.2 μM, 0.8 μM and 3.0 μM for rat cytosolic isoenzyme rBCATc, human cytosolic isoenzyme hBCATc and rat mitochondrial isoenzyme rBCATm, respectively. BCATc, also called BCAT1, is in the cytoplasm .
4
4 Cited Publications
Target:
Research Areas:
Nefazodone is an orally active phenylpiperazine antidepressant. Nefazodone can potently and selectively block postsynaptic 5-HT2A receptors, and moderately inhibit 5-HT and noradrenaline reuptake. Nefazodone can also relieve the adverse effects of stress on the the immune system of mice. Nefazodone has a high affinity for CYP3A4 isoenzyme, which indicates that it has certain risk of agent-agent interaction .
3
Target:
Research Areas:
Ticlopidine (PCR 5332), an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC50 of 81.7 μM. Ticlopidine blocks several NTPDase isoenzymes with IC50s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively. Ticlopidine is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine inhibits CYP2C9 and CYP3A4 with IC50s of 26.0 and 32.3 μM, respectively.
3
3 Cited Publications
Synonyms: ONO-9302; SKF105657
Target:
Research Areas:
Epristeride (ONO-9302) is a selective, specific and orally active uncompetitive inhibitor of human steroid 5 alpha-reductase isoform 2. Epristeride has inhibitory effects for SR isoenzymes types 2 with Ki value of 0.7-2 nM. Epristeride can be used for the research of prostatic hyperplasia and acne .
3
3 Cited Publications
Cat. No.: HY-B0153A
CAS No.: 53885-35-1
Target:
Research Areas:
Ticlopidine (PCR 5332) hydrochloride, an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC50 of 81.7 μM. Ticlopidine hydrochloride blocks several NTPDase isoenzymes with IC50s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively. Ticlopidine hydrochloride is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine hydrochloride inhibits CYP2C9 and CYP3A4 with IC50s of 26.0 and 32.3 μM, respectively .
2
2 Cited Publications
Cat. No.: HY-P3252A
Target:
Research Areas:
1
1 Cited Publications
Synonyms: Theophyllineacetic acid; Theophylline-7-acetic acid
1
1 Cited Publications
Cat. No.: HY-15455S
CAS No.: 1398065-69-4
Synonyms: APTA-2217-d4; BYK 20869-d4; B9302-107-d4
1
1 Cited Publications
Cat. No.: HY-P7604
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: AKR1C3; Aldo-Keto Reductase Family 1, Member C3 (3-Alpha Hydroxysteroid Dehydrogenase, Type II), Isoform CRA_a; Prev. HSD17B5; Trans-1,2-Dihydrobenzene-1,2-Diol Dehydrogenase; PGFS; Type IIb 3-Alpha Hydroxysteroid Dehydrogenase; Prostaglandin F Synthase; 3-Alpha-Hydroxysteroid Dehydrogenase Type 2; KIAA0119; 17-Beta-Hydroxysteroid Dehydrogenase Type 5; HAKRB; Hydroxysteroid (17-Beta) Dehydrogenase 5; DDX; Dihydrodiol Dehydrogenase Type I; 3-Alpha Hydroxysteroid Dehydrogenase, Type II; Indanol Dehydrogenase; Testosterone 17-Beta-Dehydrogenase 5; 3-Alpha-HSD Type 2; Chlordecone Reductase Homolog HAKRb; 17-Beta-HSD 5; Dihydrodiol Dehydrogenase X; HluPGFS; Dihydrodiol Dehydrogenase 3; HAKRe; 3-Alpha-HSD Type II, Brain; DD-3; HA1753; DDH1; DD3; Aldo-Keto Reductase Family 1 Member C3; Aldo-Keto Reductase Family 1, Member C3 (3-Alpha Hydroxysteroid Dehydrogenase, Type II)
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-19754A
CAS No.: 847459-98-7
CRA-026440 hydrochloride is a potent, broad-spectrum HDAC (HDAC) inhibitor. The Ki values against recombinant HDAC isoenzymes HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10 are 4 nM, 14 nM, 11 nM, 15 nM, 7 nM, and 20 nM respectively. CRA-026440 hydrochloride shows antitumor and antiangiogenic activities . CRA-026440 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
1
1 Cited Publications
Research Areas:
4-Hydroxyretinoic acid (4-HRA) is a derivative of Retinoic acid (HY-14649). 4-Hydroxyretinoic acid is formed via the catalysis of retinol by cytochrome P-450 isoenzymes. 4-Hydroxyretinoic acid also serves as a substrate for UDP-glucuronosyltransferase (s) and recombinant UGT2B7. 4-Hydroxyretinoic acid binds to the nuclear receptor RAR (Retinoic Acid Receptor), activates RAR and RXR-alpha, subsequently regulates gene expression and cell differentiation, and induces cancer cell apoptosis (Apoptosis). 4-Hydroxyretinoic acid also participates in multiple physiological processes such as immunoregulation, neuroprotection and antioxidation .
1
Target:
Research Areas:
Creatine Kinase MB (rCK-MB), Recombinant Human (CK-MB) is a cytoplasmic creatine kinase isoenzyme composed of M and B subunits, belonging to the phosphotransferase family. Creatine Kinase MB (rCK-MB), Recombinant Human catalyzes the transfer of phosphate groups between creatine and phosphocreatine, and consumes phosphocreatine immobilized on the surface of the biosensor, resulting in a decrease in the electrochemical peak current that is proportional to its concentration. Creatine Kinase MB (rCK-MB), Recombinant Human can be used in studies of acute myocardial infarction, coronary artery disease with atherosclerotic plaques, autoimmune myocarditis, and malignant tumors .
Cat. No.: HY-122277
CAS No.: 57704-16-2
Synonyms: Ro 03-7410
Target:
Research Areas:
1'-Hydroxy bufuralol is the main metabolite of Bufuralol (HY-105124) by the cytochrome P450 isoenzymes 2D1 and 2D2 (CYP2D1/2). 1'-Hydroxy bufuralol can be used to determine CYP2D1/2 enzyme activity .
Category:
Persea americana Mill Lauraceae Extract Metabolic Disease Plants Disease Research Fields Saccharides Monosaccharides
Target:
Cat. No.: HY-A0165
CAS No.: 22345-47-7
Target:
Research Areas:
Tofisopam, a 2,3-benzodiazepine compound, is an orally active anxiolytic agent. Tofisopam can inhibit phosphodiesterase PDE isoenzyme activity, withIC50 values of 2.11 μM, 1.98 μM, 0.42 μM, and 0.92 μM for PDE-2A3, PDE-3A, PDE-4A1, and PDE-10A1, respectively. Tofisopam can be used for the study of anxiety .
Target:
Research Areas:
Carbonic anhydrase isoenzyme is an isoform of Carbonic anhydrase (HY-P1775). Carbonic anhydrase isoenzymes are a class of widely distributed metalloenzymes that catalyze the reversible hydration-dehydration reaction of the carbon dioxide-bicarbonate system, and also exhibit acetaldehyde hydration and ester hydrolysis activities. Carbonic anhydrase isoenzyme is associated with epithelial ion transport processes involving sodium, potassium, anions, and ammonia. Carbonic anhydrase isoenzyme can be used in research on cancer, glaucoma, obesity, and epilepsy .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
