84 Results for "

Adipogenesis

" in MedChemExpress (MCE) Product Catalog:
Products (84)

84 Results for "Adipogenesis" in MCE Product Catalog:

25
Beta-Sitosterol (purity>98%)
Beta-Sitosterol (purity>98%)
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25 Publications Verification
Cat. No.: HY-N0171A
CAS No.: 83-46-5
Synonyms: β-Sitosterol (purity>98%); 22,23-Dihydrostigmasterol (purity>98%)
Category:  

Steroids

Target:  

Bacterial Apoptosis Reactive Oxygen Species (ROS) MDM-2/p53 Caspase PARP MMP Bcl-2 Family HIF/HIF Prolyl-Hydroxylase TNF Receptor Interleukin Related NF-κB mTOR Lactate Dehydrogenase CDK Glutathione Peroxidase SOD

Beta-Sitosterol (purity>98%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc .
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25
Beta-Sitosterol (purity>80%)
Beta-Sitosterol (purity>80%)
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25 Publications Verification
Cat. No.: HY-N0171
CAS No.: 83-46-5
Category:  

Endogenous metabolite

Target:  

Apoptosis Endogenous Metabolite

Beta-Sitosterol (purity≥80%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc .
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4
Isoxanthohumol
Isoxanthohumol
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4 Cited Publications
Cat. No.: HY-N2584A
CAS No.: 521-48-2
Category:  

Infection Flavonoids Anti-aging Humulus lupulus L. Moraceae Extract Flavonones Plants Disease Research Fields Cancer

Target:  

HSV Apoptosis Reactive Oxygen Species (ROS) Autophagy CMV Fungal Integrin S100 Protein

Isoxanthohumol is an orally active flavonoid compound. Isoxanthohumol has biological activities such as anti-tumor, anti-inflammatory, antioxidant, antiviral, antifungal, and inhibition of adipogenesis. Isoxanthohumol can induce apoptosis, autophagy, and migration of tumor cells. Isoxanthohumol is active against viruses such as HSV, BVDV, CMV, and Rhino. Isoxanthohumol can be used for the research of tumors, metabolic, and inflammatory diseases .
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3
Fucosterol
Fucosterol
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3 Cited Publications
Cat. No.: HY-N4103
CAS No.: 17605-67-3
Category:  

Metabolic Disease Disease Research Fields Steroids

Target:  

PARP Endogenous Metabolite

Fucosterol is a sterol isolated from algae, seaweed or diatoms. Fucosterol exhibits various biological activities, including antioxidant, anti-adipogenic, blood cholesterol reducing, anti-diabetic and anti-cancer activities . Fucosterol regulates adipogenesis via inhibition of PPARα and C/EBPα expression and can be used for anti-obesity agents development research .
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3
Eriocalyxin B
Eriocalyxin B
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3 Cited Publications
Cat. No.: HY-N2303
CAS No.: 84745-95-9
Category:  

Natural Products Senna sophera (L.) Roxb. Plants Disease Research Fields Inflammation/Immunology Labiatae Extract

Target:  

Apoptosis NF-κB Autophagy Reactive Oxygen Species (ROS) CDK PPAR FABP Akt mTOR

Eriocalyxin B is a diterpenoid compound that can be isolated from Chinese herb Isodon eriocalyx. Eriocalyxin B exhibits multiple activities, such as anti-cancer, anti-inflammatory, and inhibition of adipogenesis. Eriocalyxin B is capable of inducing apoptosis and autophagy in tumor cells. Eriocalyxin B can be used in the research of cancers, autoimmune diseases, and other conditions .
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3
Desmethylglycitein
Desmethylglycitein
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3 Cited Publications
Cat. No.: HY-N5072
CAS No.: 17817-31-1
Synonyms: 4',6,7-Trihydroxyisoflavone
Category:  

Flavonoids Glycine max (L.) merr Phenols Polyphenols Leguminosae Extract Plants Disease Research Fields Cancer Isoflavones

Target:  

CDK PI3K PKC

Desmethylglycitein (4',6,7-Trihydroxyisoflavone), a metabolite of daidzein, sourced from Glycine max with antioxidant, and anti-cancer activities. Desmethylglycitein binds directly to CDK1 and CDK2 in vivo, resulting in the suppresses CDK1 and CDK2 activity . Desmethylglycitein is a direct inhibitor of protein kinase C (PKC)α, against solar UV (sUV)-induced matrix matrix metalloproteinase 1 (MMP1) . Desmethylglycitein binds to PI3K in an ATP competitive manner in the cytosol, where it inhibits the activity of PI3K and downstream signaling cascades, leading to the suppression of adipogenesis in 3T3-L1 preadipocytes .
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2
2"-O-Galloylhyperin
2'-O-Galloylhyperin
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2 Cited Publications
Cat. No.: HY-N0526
CAS No.: 53209-27-1
Category:  

Flavonols Pyrolaceae Extract Plants Flavonoids Pyrola calliantha H. Andr. Phenols Polyphenols Disease Research Fields Inflammation/Immunology Pyrola incarnata Fisch. ex DC.

Target:  

Sirtuin Keap1-Nrf2 NF-κB ERK p38 MAPK JNK TSH Receptor Reactive Oxygen Species (ROS) SOD

2''-O-Galloylhyperin is an active natural compound with anti‑inflammatory, antioxidant, anti‑adipogenic, antifibrotic, and cytostatic activities. 2''-O-Galloylhyperin upregulates SIRT1/Nrf2 signaling, inhibits NF-κB and MAPK (ERK1/2, p38, JNK) phosphorylation, suppresses TSHR activation, reduces ROS accumulation, and enhances SOD and GSH-Px activities. 2''-O-Galloylhyperin protects against LPS-induced tissue injury, enhances survival, and inhibits adipogenesis and fibrosis. 2"-O-Galloylhyperin can be used for the research of sepsis, acute lung injury, and thyroid eye disease .
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2
Beta-Sitosterol (Standard)
Beta-Sitosterol (Standard)
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2 Cited Publications
Cat. No.: HY-N0171R
CAS No.: 83-46-5
Synonyms: β-Sitosterol (Standard); 22,23-Dihydrostigmasterol (Standard))
Category:  

Cardiovascular Disease Leguminosae Extract Plants Other Families Extract Endogenous metabolite Disease Research Fields Glycyrrhiza uralensis Fisch. Inflammation/Immunology Steroids

Target:  

Reference Standards Apoptosis Endogenous Metabolite

Beta-Sitosterol (Standard) is the analytical standard of Beta-Sitosterol. This product is intended for research and analytical applications. Beta-Sitosterol (purity≥80%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc.
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2
N-Oleoyl glycine
N-Oleoyl glycine
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2 Cited Publications
Cat. No.: HY-113204
CAS No.: 2601-90-3
Purity:  ≥99.0%
Category:  

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite Cannabinoid Receptor Akt

N-Oleoyl glycine is a lipoamino acid, which stimulates adipogenesis associated with activation of CB1 receptor and Akt signaling pathway in 3T3-L1 adipocyte.
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1
SGC-SMARCA-BRDVIII
SGC-SMARCA-BRDVIII
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1 Cited Publications
Cat. No.: HY-145446
CAS No.: 1997319-84-2
Purity:  99.84%
Target:  

SWI/SNF Complex

Research Areas:  

Metabolic Disease

SGC-SMARCA-BRDVIII, a chemical probe, is a potent and selective inhibitor of SMARCA2/4 and PB1(5), with Kds of 35 nM, 36 nM, and 13 nM, respectively. SGC-SMARCA-BRDVIII also inhibits PB1(2) and PB1(3), with Kds of 3.7 and 2.0 μM, respectively. SGC-SMARCA-BRDVIII can block adipogenesis of 3T3-L1 murine fibroblasts .
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1
Rebaudioside D
Rebaudioside D
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1 Cited Publications
Cat. No.: HY-N0468
CAS No.: 63279-13-0
Category:  

Terpenoids Metabolic Disease Diterpenoids Plants Other Families Extract Disease Research Fields Sweeteners Food Research

Target:  

FXR Acetyl-CoA Carboxylase

Rebaudioside D is an orally active sweetener that targets and activates FXR, modulates Acetyl-CoA Carboxylase, and inhibits 3-hydroxy-3-methylglutaryl-CoA reductase. Rebaudioside D regulates bile acid homeostasis and lipid metabolism, reduces the synthesis rates of fatty acids and cholesterol, and exerts multiple effects including anti-adipogenesis, hepatoprotection, anti-steatosis, gut microbiota modulation, enhancement of secondary bile acid metabolism, anti-endotoxin activity, regulation of bile acid transport, and inhibition of bile acid efflux. Rebaudioside D also reduces body weight gain, visceral fat accumulation, hepatic triglyceride and cholesterol accumulation, hepatic lipid peroxidation, and decreases the circulating level of lipopolysaccharide-binding protein. Rebaudioside D additionally enhances the secondary bile acid metabolic pathway of intestinal bacteria, upregulates the gene expression of ileal organic solute transporter α, and downregulates the gene expression of hepatic bile salt export pump. Rebaudioside D does not affect glucose homeostasis, alter total caloric intake or fecal energy excretion, induce weight gain, exacerbate obesity, promote hepatic steatosis, impair brown adipose tissue function, nor change skeletal muscle metabolism-related proteins. Rebaudioside D can be used in diet-induced obesity and obesity-related research .
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1
Kahweol
Kahweol
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1 Cited Publications
Cat. No.: HY-N6258
CAS No.: 6894-43-5
Category:  

Terpenoids Metabolic Disease Diterpenoids Plants Other Families Extract Disease Research Fields Coffea arabica L. Rubiaceae Extract

Target:  

AMPK Apoptosis

Kahweol is one of the consituents of the coffee from Coffea Arabica with anti-inflammatory anti-angiogenic, and anti-cancerous activities. Kahweol inhibits adipogenesis and increase glucose uptake by AMP-activated protein kinase (AMPK) activation. Kahweol induces apoptosis.
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1
(10E,12Z)-Octadeca-10,12-dienoic acid
(10E,12Z)-Octadeca-10,12-dienoic acid
0 Images
1 Cited Publications
Cat. No.: HY-116538
CAS No.: 2420-56-6
Purity:  99.10%
Synonyms: trans-10,cis-12 CLA2
Target:  

Endogenous Metabolite PPAR NF-κB Stearoyl-CoA Desaturase (SCD) Lipase

Research Areas:  

Metabolic Disease Inflammation/Immunology Cancer

(10E,12Z)-Octadeca-10,12-dienoic acid (trans-10,cis-12 CLA2) is an orally active PPARα activator and inhibits adipocyte differentiation. (10E,12Z)-Octadeca-10,12-dienoic acid and its downstream metabolites have various antioxidant and antitumor activities. (10E,12Z)-Octadeca-10,12-dienoic acid can induce proinflammatory cytokines and chemokines, which would lead to decreased adipogenesis and insulin resistance in adipose tissue. (10E,12Z)-Octadeca-10,12-dienoic acid can affect many aspects of milk fat synthesis. (10E,12Z)-Octadeca-10,12-dienoic acid reduces expression of lipogenic enzymes and inhibits the desaturation of fatty acids. (10E,12Z)-Octadeca-10,12-dienoic acid can reduce lipoprotein lipase (LPL) activity in cultured 3T3-L1 adipocytes and enhance triacylglycerol release from these cells. (10E,12Z)-Octadeca-10,12-dienoic acid decreases the expression of hepatic stearoyl-CoA desatyrase mRNA in mice. (10E,12Z)-Octadeca-10,12-dienoic acid is associated with changes in mucosal NF-κB and Cyclin D1 protein levels in mice .
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1
BpV(pic) potassium hydrate
BpV(pic) potassium hydrate
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1 Cited Publications
Cat. No.: HY-18764
CAS No.: 148556-27-8
Target:  

PTEN

Research Areas:  

Metabolic Disease

BpV(pic) potassium hydrate is a PTEN inhibitor with IC50 31 nM. BpV(pic) potassium hydrate is also an insulin simulator that activates insulin receptor kinase in cultured liver cancer cells, stimulates adipogenesis in adipocytes, and inhibits the dephosphorylation of autophosphorylated insulin receptors and epidermal growth factor receptors in rat hepatosomes .
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IL-11 Protein, Human (CHO)
IL-11 Protein, Human (CHO)
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1 Cited Publications
Cat. No.: HY-P7031A
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL11; Adipogenesis Inhibitory Factor; Interleukin 11; Interleukin-11; IL-11; Oprelvekin; AGIF
Species:  
Human
Source:  
CHO
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Gnetol
Gnetol
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Cat. No.: HY-126052
CAS No.: 86361-55-9
Purity:  99.86%
Category:  

Gnetaceae Extract Stilbenes Metabolic Disease Phenols Polyphenols Plants Disease Research Fields Gnetum montanum Markgr.

Target:  

COX Tyrosinase HDAC

Gnetol is a phenolic compound isolated from the root of Gnetum montanum . Gnetol potently inhibits COX-1 (IC50 of 0.78 μM) and HDAC. Gnetol is a potent tyrosinase inhibitor with an IC50 of 4.5 μM for murine tyrosinase and suppresses melanin biosynthesis. Gnetol has antioxidant, antiproliferative, anticancer and hepatoprotective activity. Gnetol also possesses concentration-dependent α-Amylase, α-glucosidase, and adipogenesis activities .
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Turanose
Turanose
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Cat. No.: HY-113334
CAS No.: 547-25-1
Purity:  99.91%
Category:  

Microorganisms Animals Endogenous metabolite Disease Research Fields Inflammation/Immunology Saccharides

Target:  

Endogenous Metabolite

Turanose is an isomer of Sucrose that naturally exists in honey. Turanose has anti-inflammatory and regulates adipogenesis effect. Turanose has potential for obesity and related chronic diseases research .
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Drupanin
Drupanin
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Cat. No.: HY-N10361
CAS No.: 53755-58-1
Category:  

Monophenols Animals Phenols Disease Research Fields Cancer

Drupanin is an orally active and selective AKR1C3 enzyme inhibitor and an RXRα agonist with an EC50 value of 4.8 μM, which is found in green propolis. Drupanin also activates PPARγ moderately. Drupanin induces adipogenesis and elevates aP2 mRNA levels in 3T3-L1 fibroblasts Drupanin has the potential for the research of breast and prostate cancers .
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Netoglitazone
Netoglitazone
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Cat. No.: HY-100428
CAS No.: 161600-01-7
Purity:  99.88%
Synonyms: MCC-555; Isaglitazone
Target:  

PPAR

Research Areas:  

Metabolic Disease

Netoglitazone (MCC-555) is an orally active PPARγ ligand with an EC50 of 8 μM. Netoglitazone mediates cell type-specific functional regulation, and modulates the transcriptional activity of PPARγ as a full agonist, partial agonist or antagonist. Netoglitazone induces adipogenesis, inhibits osteoblastogenesis, alters the weight of extramedullary fat depots and enhances insulin sensitivity. Netoglitazone reduces blood glucose levels. Netoglitazone can be used in research related to type 2 diabetes and non-insulin-dependent diabetes mellitus .
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Desmethylicaritin
Desmethylicaritin
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Cat. No.: HY-N2785
CAS No.: 28610-31-3
Category:  

Flavanonols Flavonoids Epimedium brevicornu Maxim. Plants Berberidaceae Extract

Target:  

Wnt

Desmethylicaritin is a phytoestrogenic molecule, has inducible effect on directional differentiation of embryonic stem cells into cardiomyocytes. Desmethylicaritin also suppresses adipogenesis via Wnt/β-catenin signaling pathway .
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