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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
394 Results for "
Chelator
" in MedChemExpress (MCE) Product Catalog:
Products (394)
394 Results for "Chelator" in MCE Product Catalog:
438
Deferoxamine mesylate (Deferoxamine B mesylate) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine mesylate upregulates HIF-1α levels with good antioxidant activity. Deferoxamine mesylate also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine mesylate can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19 .
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438 Publications Verification
別名: Deferoxamine B; Deferriferrioxamine B; Deferrioxamine
Deferoxamine (Deferoxamine B) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine upregulates HIF-1α levels with good antioxidant activity. Deferoxamine also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19 .
146
146 Cited Publications
37
37 Cited Publications
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37 Cited Publications
Target:
研究分野:
BAPTA tetrasodium is a selective and cell-impermeant chelator for calcium. BAPTA tetrasodium has high selectivity against magnesium and calcium. BAPTA can also inhibit phospholipase C activity independently of their role as Ca 2+ chelators .
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37 Cited Publications
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31 Cited Publications
製品番号: HY-D0836
CAS 番号: 25102-12-9
別名: Ethylenediaminetetraacetic acid dipotassium dihydrate
28
研究分野:
TPEN (TPEDA) is a specific cell-permeable heavy metal chelator. TPEN has a higher affinity for Zn 2+, but a lower affinity for Mg 2+ and Ca 2+. TPEN induces DNA damage and increases intracellular ROS production. TPEN also inhibits cell proliferation and induces apoptosis .
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28 Cited Publications
製品番号: HY-W018746
CAS 番号: 139-33-3
別名: Ethylenediaminetetraacetic acid disodium
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27 Cited Publications
製品番号: HY-D0861A
CAS 番号: 13368-13-3
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27 Cited Publications
製品番号: HY-W087947
CAS 番号: 65501-24-8
別名: Ethylenediaminetetraacetic acid dihydrate tripotassium
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27
27 Cited Publications
製品番号: HY-W127774
CAS 番号: 85715-60-2
別名: Ethylenediaminetetraacetic acid hydrate sodium
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27
27 Cited Publications
製品番号: HY-W250119
CAS 番号: 23411-34-9
別名: EDTA disodium calcium salt hydrate; Ethylenediaminetetraacetic acid disodium calcium salt hydrate
17
Target:
研究分野:
Vipivotide tetraxetan (PSMA-617) is a high potent prostate-specific membrane antigen (PSMA) inhibitor, with a Ki of 0.37 nM. Vipivotide tetraxetan (PSMA-617) is designed consisting of three components: the pharmacophore Glutamate-urea-Lysine, the chelator DOTA able to complex both 68Ga or 177Lu, and a linker connecting these two entities. Glutamate-urea-Lysine is the selective pharmacophore to bind to prostate specific membrane antigen.
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17 Cited Publications
別名: PGSK diacetate (5/6-mixture)
Target:
研究分野:
Phen green SK (PGSK) diacetate (PGSK diacetate (5/6-mixture)) is a metal ion-sensitive fluorescent probe that can penetrate cell membranes. Phen green SK (PGSK) diacetate can react with a variety of metal ions, including Fe 2+, Cd 2+, Co 2+, Ni 2+, Zn 2+, etc. Phen green SK (PGSK) diacetate chelates Fe 2+, resulting in fluorescence quenching, which can be restored when a membrane-permeable chelator is added, thereby reflecting the changes in the intracellular chelatable iron pool. The excitation/emission maxima of Phen green SK diacetate are 507/532 nm, respectively .
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Target:
研究分野:
Deferasirox (ICL 670) is an orally available iron chelator used for the management of transfusional iron overload .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
