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By Targets:	ADC Antibody (3) ADC Payload (14) Adrenergic Receptor (1) Aldehyde Dehydrogenase (ALDH) (1) Amino Acid Derivatives (3) Amyloid-β (5) Antibiotic (4) Antibody-Drug Conjugates (ADCs) (2) Apoptosis (14) Bacterial (6) BCRP (1) Biochemical Assay Reagents (31) Btk (5) c-Myc (2) Cadherin (1) Caspase (8) CD19 (1) CD3 (4) Claudin (1) Constitutive Androstane Receptor (1) Cytochrome P450 (4) Dengue Virus (1) DNA Alkylator/Crosslinker (17) DNA Glycosylase (1) DNA Stain (1) DNA/RNA Synthesis (12) Dopamine Receptor (1) Drug Derivative (9) Drug Intermediate (14) Drug Isomer (2) Drug Metabolite (6) Drug-Linker Conjugates for ADC (7) EGFR (16) Endogenous Metabolite (13) Environmental Pollutants (3) Factor Xa (1) Ferroptosis (2) Fluorescent Dye (6) Fungal (3) Gap Junction Protein (1) GLP Receptor (3) Glycosidase (1) HBV (3) HIV (3) HIV Integrase (2) HSP (2) HSV (1) iGluR (1) Insulin Receptor (1) Integrin (1) Interleukin Related (3) Isotope-Labeled Compounds (9) Keap1-Nrf2 (3) Kinesin (1) Leukotriene Receptor (1) Liposome (1) LOX-1 (1) LXR (1) mAChR (1) MDM-2/p53 (2) Microtubule/Tubulin (5) Mitophagy (1) MMP (1) MOFs (1) Molecular Glues (2) NAMPT (1) Neurokinin Receptor (1) NF-κB (10) NO Synthase (3) Notch (1) Nucleoside Antimetabolite/Analog (1) Opioid Receptor (2) Orphan Receptor (1) Oxytocin Receptor (4) P-glycoprotein (1) P2X Receptor (1) PANK (1) Parasite (2) PARP (1) PD-1/PD-L1 (5) Phosphodiesterase (PDE) (2) Phosphoramidites (2) PINK1/Parkin (1) PKC (2) Potassium Channel (2) PROTAC Linkers (2) Proton Pump (1) Pyroptosis (1) Radionuclide-Drug Conjugates (RDCs) (1) Raf (3) RAR/RXR (2) Ras (1) Reactive Oxygen Species (ROS) (5) Reference Standards (17) SARS-CoV (1) SOD (1) Sodium Channel (1) Somatostatin Receptor (1) STAT (1) STING (6) Survivin (1) Tau Protein (1) TGF-beta/Smad (1) TNF Receptor (2) Vasopressin Receptor (2) Virus Protease (1) β-catenin (1)
By Research Areas:	Cancer (104) Cardiovascular Disease (16) Endocrinology (10) Infection (28) Inflammation/Immunology (41) Metabolic Disease (18) Neurological Disease (24)
Click Chemistry:	PROTAC Synthesis (2) Azide (1) Alkynes (4)
Oligonucleotides:	Thymine (1) Cytosine (1) Phospholipids (1) Phosphoramidites (2)

274

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D0844

Glutathione oxidized 5+ Cited Publications L-Glutathione oxidized; GSSG; Oxiglutatione	Endogenous Metabolite Reactive Oxygen Species (ROS)	Metabolic Disease
Glutathione oxidized (L-Glutathione oxidized) is produced by the oxidation of glutathione. Detoxification of reactive oxygen species is accompanied by production of glutathione oxidized. Glutathione oxidized can be used for the research of sickle cells and erythrocytes .

HY-101161

SG3199 3 Publications Verification	DNA Alkylator/Crosslinker ADC Payload	Cancer
SG3199 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer. SG3199 is the released warhead component of the ADC payload Tesirine (SG3249) .

HY-128952

Tesirine 5+ Cited Publications SG3249	Drug-Linker Conjugates for ADC DNA Alkylator/Crosslinker	Cancer
Tesirine (SG3249) is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. SG3199 (HY-101161) is the released warhead component of the ADC payload Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines. PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity .

HY-101127

SGD-1882 PBD Dimer	ADC Payload	Cancer
SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs.

HY-77490A

1,3-Butanediol 1 Publications Verification	Environmental Pollutants Endogenous Metabolite	Cardiovascular Disease Neurological Disease
1,3-Butanediol, an orally active ethanol dimer providing a source of calories for human nutrition. 1,3-Butanediol administeration can stimulate the biosynthesis of the ketone body, β-hydroxybutyrate (βHB). 1,3-Butanediol has cerebral protective and hypoglycaemic effect .

HY-114348

N,N'-Diacetyl-L-cystine DiNAC; (Ac-Cys-OH)2	Amino Acid Derivatives	Cardiovascular Disease
N,N'-diacetyl-L-cystine (DiNAC) is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N,N'-diacetyl-L-cystine is a potent, orally active modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents. N,N'-diacetyl-L-cystine also has antiatherosclerotic effects in Watanabe-heritable hyperlipidemic rabbit (WHHL) rabbits .

HY-101160

SG2057 DRG16	DNA Alkylator/Crosslinker ADC Payload	Cancer
SG2057 (DRG16) is a PBD dimer containing a pentyldioxy linkage which binds sequence selectively in the minor groove of DNA forming DNA interstrand and intrastrand cross-linked adducts. SG2057 is a highly active antitumor agent .

HY-148424

*PBD dimer-2*	ADC Payload DNA Alkylator/Crosslinker	Cancer
PBD dimer-2 (compound 2c) is a C8-linked pyrrolobenzodiazepine dimer. PBD dimer-2 can span an extra base pair and cross-link the 5′-Pu-GA(T/A)TC-Py sequence. PBD dimer-2 can be used as a payload for antibody–agent conjugates (ADCs), and it can be used for the research of cancer .

HY-W033577

Tricarbonyldichlororuthenium(II) dimer 2 Publications Verification CORM-2	P2X Receptor Potassium Channel NO Synthase STAT Interleukin Related	Inflammation/Immunology
Tricarbonyldichlororuthenium(II) dimer (CORM-2) is a CO-releasing molecule. Tricarbonyldichlororuthenium(II) dimer exhibits anti-inflammatory, antioxidant, and gastric mucosa-protective activities. Additionally, Tricarbonyldichlororuthenium(II) dimer has CO-independent functional effects on multiple potassium channels .

HY-B2224

Thiamine disulfide	HIV Endogenous Metabolite	Infection Metabolic Disease
Thiamine disulfide, a vitamin B1 derivative, is an oxidized dimer of Thiamine. Thiamine disulfide is a potent HIV-1 inhibitor. Thiamine disulfide significantly depresses HIV-1 transactivator (Tat) activity .

HY-16182

Ecamsule 1 Publications Verification	Biochemical Assay Reagents	Others
Ecamsule is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression. Ecamsule has the potential for the research of polymorphous light eruption (PMLE) .

HY-141514

MSA-2 dimer 1 Publications Verification	STING	Inflammation/Immunology Cancer
MSA-2 dimer is a selective, orally active non-nucleotide STING agonist (K_d=145 μM) with long-term antitumor and immunogenic activity. MSA-2 dimer is bound to STING as a non-covalent dimer exhibiting higher permeability than cyclic dinucleotide .

HY-153804

Naphthyridine carbamate dimer NCD	Molecular Glues	Others Cancer
Naphthyridine caebamate dimer (NCD) is a DNA molecular glue that induces designed structural changes in target functional DNA to modulate function .

HY-16182A

Ecamsule disodium 1 Publications Verification	Biochemical Assay Reagents	Others
Ecamsule disodium is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression .

HY-D0916

*Thiazole orange dimer* YOYO 1** YOYO 1; YOYO1	Fluorescent Dye	Others
Thiazole orange dimer YOYO 1 (YOYO 1) is a cell-impermeable cyanine dimer with no inherent fluorescence, and its fluorescence intensity increases significantly upon binding to double-stranded DNA (dsDNA) . Thiazole orange dimer YOYO 1 can serve as a nuclear counterstain or a dead cell indicator (Ex/Em = 505/512 nm).

HY-W441004

DSPE-Thiol	Liposome	Others
DSPE-Thiol is a phophalipid capped with thiol group. The thiol capped head can selectively react with maleimide. DSPE-Thiol can also be used for the preparation of phospholipid dimers .

HY-Y1109

Dichloro(p-cymene)ruthenium(II) dimer Tetrachlorobis(mu-4-cymene)diruthenium(II)	Biochemical Assay Reagents	Cancer
Dichloro(p-cymene)ruthenium(II) dimer (Tetrachlorobis(mu-4-cymene)diruthenium(II)) is a ruthenium-based organometallic catalyst precursor, which is widely applied in the field of organic synthesis .

HY-P3432

DfTat	Biochemical Assay Reagents	Others
DfTat is a dimer of the prototypical cell-penetrating peptide TAT. DfTat can deliver small molecules, peptides and proteins into live cells with a particularly high efficiency. DfTat labeled with the rhodamine can be used as a tracer for easy detection .

HY-111009

Swinholide A	Fungal	Infection
Swinholide A is the actin-binding marine polyketide and dimerizes actin with the K_d of ~ 50 nM . Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments. Swinholide A disrupts the actin cytoskeleton of cells.Antifungal activity .

HY-W033466

Dichloro(benzene)ruthenium(II) dimer Benzeneruthenium(II) chloride Dimer	Biochemical Assay Reagents	Others
Benzeneruthenium(II) Chloride Dimer (Benzeneruthenium(II) chloride dimer) is a dinuclear complex. Benzeneruthenium(II) Chloride Dimer undergoes a hydrolysis reaction to generate a mixture of mononuclear ruthenium complexes in equilibrium .

HY-P3215

Oxytocin parallel dimer	Oxytocin Receptor	Endocrinology
Oxytocin parallel dimer is the disulfide-bridged homo peptide dimer. Oxytocin dimer has oxytocin and vasopressin-like activity with less toxic than oxytocin .

HY-W097819

Divanillin Dehydrodivanillin	Endogenous Metabolite	Others
Divanillin is a dimer composed of two vanillins (HY-N0098) covalently linked .

HY-79986

Diiodo(p-cymene)ruthenium(II) dimer	Drug Intermediate	Others
Diiodo(p-cymene)ruthenium(II) dimer is a drug intermediate for synthesis of various active compounds.

HY-W020887

[IrCl(COE)2]2 Chlorobis(cyclooctene)iridium(I)Dimer	Biochemical Assay Reagents Endogenous Metabolite
[IrCl(COE)2]2 (Chlorobis(cyclooctene)iridium(I)dimer) is a transition metal catalyst with remarkable catalytic activity. It is widely used in catalyzing a variety of organic reactions, especially in the synthesis of unsaturated compounds. In addition, [IrCl(COE)2]2 has shown potential anti-tumor properties in biochemical research.

HY-120397

Bis-propargyl-PEG4	PROTAC Linkers	Infection Cancer
Bis-propargyl-PEG4 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG4 is used for the synthesis of demethylvancomycin dimers . Bis-propargyl-PEG4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-E70377

Cu/Zn Superoxide dismutase Cu/Zn SOD	SOD	Inflammation/Immunology Cancer
Cu/Zn Superoxide dismutase (Cu/Zn SOD; SOD1) is a cytosolic copper-zinc dimer form of superoxide dismutase enzyme. Cu/Zn Superoxide dismutase has oxygen radical enzymatic dismutation .

HY-138291

Ethoxyquin dimer	Orphan Receptor Constitutive Androstane Receptor Keap1-Nrf2 Drug Metabolite	Inflammation/Immunology
Ethoxyquin dimer is a dimer of Ethoxyquin (HY-B1425). Ethoxyquin dimer is an antioxidant. Ethoxyquin dimer can more readily accumulate in liver and adipose tissue compared with Ethoxyquin. Ethoxyquin above 10 mg/kg shows hepatotoxicity in mice .

HY-175004

*PBD dimer-4*	ADC Payload DNA Alkylator/Crosslinker	Cancer
PBD dimer-4 (Compound 7) is a C1-subsitituted PBD dimer. PBD dimer-4 has high DNA-binding affinity, DNA cross-linking ability and potent cytotoxicity against MDA-MB-231 cells (IC₅₀: 236 nM). PBD dimer-4 can be used as a payload of ADC Loncastuximab tesirine (HY-P99349) to treat several different cancer types .

HY-136113

Ibrutinib dimer	Btk	Cancer
Ibrutinib dimer is a Dimer of Ibrutinib. Ibrutinib dimer is an impurity of Ibrutinib . Ibrutinib is a selective, irreversible Btk inhibitor with an IC₅₀ of 0.5 nM .

HY-N10638

*N-Acetyldopamine dimer-2*	Reactive Oxygen Species (ROS) NF-κB	Inflammation/Immunology
N-Acetyldopamine dimer-2 (compound 2) is a N-acetyldopamine dimer that can be isolated from the yellow powder form Periostracum Cicadae with antioxidant and anti-inflammatory activities. N-Acetyldopamine dimer-2 inhibits oxidized low-density lipoprotein (LDL) oxidation, ROS generation, NO production, and NF-κB activity .

HY-W020940

Allylpalladium(II) chloride dimer	Biochemical Assay Reagents	Others
Allylpalladium(II) chloride dimer is an organometallic Pd complexe that can be used as a protein scaffold .

HY-W587729

Ethylene terephthalate cyclic dimer	Drug Intermediate	Others
Ethylene terephthalate cyclic dimer is a intermediate of polyethylene terephthalate (PET). PET is a common plastic used in fibers and packaging materials.

HY-W033831

Rhodium(II) triphenylacetate dimer Rh2(TPA)4	Endogenous Metabolite Biochemical Assay Reagents
Rhodium(II) triphenylacetate dimer (Rh2(TPA)4) is an important catalyst with high C–H activation reaction activity. Rhodium(II) triphenylacetate dimer is widely used in organic synthesis to achieve the construction of complex molecules. Rhodium(II) triphenylacetate dimer can also be used to catalyze the synthesis of certain biologically active molecules and improve the preparation efficiency of compounds. Rhodium(II) triphenylacetate dimer exhibits excellent selectivity and reaction rate in catalytic reactions.

HY-133022

trans-2-Undecenoic acid (E)-2-Undecenoic acid; (E)-Undec-2-enoic acid	Drug Isomer	Metabolic Disease
trans-2-Undecenoic acid ((E)-2-Undecenoic acid) is an α,β-unsaturated carboxylic acid and is characterized by acid dimers. The corresponding dimers are connected via intermolecular hydrogen bonds of the carboxylic groups C=O···H-O .

HY-E70578

T4 Endonuclease V	DNA Glycosylase	Others
T4 Endonuclease V is a dual-activity DNA glycosylase that combines the activities of DNA N-glycosylase and AP lyase. T4 Endonuclease V can repair ultraviolet (UV)-induced cyclobutane pyrimidine dimers in DNA .

HY-Y1094

[Rh(cod)Cl]2 Chloro(1,5-cyclooctadiene)rhodium(I) Dimer	Biochemical Assay Reagents	Cardiovascular Disease
[Rh(cod)Cl]2 (Chloro(1,5-cyclooctadiene)rhodium(I) dimer) is a rhodium (I) organometallic dimer complex. [Rh(cod)Cl]2 can inhibit platelet-activating factor-mediated platelet aggregation with IC₅₀ values of 5.2 and 43.3 μM in washed rabbit platelets and human platelet-rich plasmas. [Rh(cod)Cl]2 also can inhibit thrombin-, ADP (HY-W010918)- and collagen-induced aggregation with IC₅₀ values of 16.7, 162 and 69.8 μM. [Rh(cod)Cl]2 can be used for the research of cardiovascular disease, such as thrombosis .

HY-178338

STING agonist-47	STING	Cancer
STING agonist-47 is a STING agonist with an EC₅₀ of 0.72 μM and a K_d of 176 nM. STING agonist-47 is a dimer of MSA-2 (HY-136927). STING agonist-47 can be used for the research of cancer, such as breast cancer .

HY-174293

Osimertinib dimer	Drug Derivative	Cancer
Osimertinib dimer is a dimer of Osimertinib (HY-15772). Osimertinib (AZD9291) is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC₅₀ of 12 nM against L858R and 1 nM against L858R/T790M, respectively. Osimertinib overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer .

HY-N10637

*N-Acetyldopamine dimer-1*	Others	Others
N-Acetyldopamine dimer-1 is a 2-(3',4'-dihydroxyphenyl)-1,4-benzodioxane derivative. N-Acetyldopamine dimer-1 is optically active, can be isolated from crude agent "Zentai," a cast-off shell of the cicada of Cryptotympana sp. (Cicadidae) .

HY-P5213

*Vasopressin Dimer* (parallel) TFA**	Vasopressin Receptor Oxytocin Receptor	Endocrinology
Vasopressin Dimer (parallel) TFA is a parallel dimer of Vasopressin (HY-B1811). Vasopressin Dimer (parallel) TFA can activate four G protein-coupled receptors, V1aR, V1bR, V2R, and OTR .

HY-P3223A

Biphalin acetate	Opioid Receptor	Neurological Disease
Biphalin acetate, a BBB-penetrable opioid peptide analog, contains two active enkephalin pharmacophores.Biphalin acetate has high affinity for opioid receptors. Biphalin acetate shows analgesic effect in acute, neuropathic, and chronic animal pain models. Biphalin acetate is also an antiviral, antiproliferative, anti-inflammatory, and neuroprotective agent .

HY-126678

Dimethyl-SGD-1882 Dimethyl-PBD Dimer	ADC Payload	Cancer
Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly potent DNA alkylator, and is used as an antibody-drug conjugate (ADC) cytotoxin. PBD Dimer is a DNA alkylator which inhibits DNA replication .

HY-W025817

Citrazinic acid	Fluorescent Dye	Others
Citrazinic acid is a weakly fluorescent compound whose optical properties are dependent on aggregation states and chemical environment. Citrazinic acid strongly tends to form dimers at high concentrations .

HY-N10766

Ampelopsin F	Others	Others
Ampelopsins F is a bridged plant oligostilbene that can be isolated from Ampelopsis brevipedunculata var. hancei roots. Ampelopsins F is a resveratrol dimer .

HY-B2224R

Thiamine disulfide (Standard)	Reference Standards HIV Endogenous Metabolite	Infection Metabolic Disease
Thiamine disulfide (Standard) is the analytical standard of Thiamine disulfide. This product is intended for research and analytical applications. Thiamine disulfide, a vitamin B1 derivative, is an oxidized dimer of Thiamine. Thiamine disulfide is a potent HIV-1 inhibitor. Thiamine disulfide significantly depresses HIV-1 transactivator (Tat) activity .

HY-164492

LSN3074753	Raf	Cancer
LSN3074753, an analog of LY3009120 (HY-12558), is a pan-RAF and Raf dimer inhibitor. LSN3074753 demonstrates activity against tumor cells with MAPK pathway activation driven by BRAF monomer or RAF dimers including BRAF- or KRAS-mutant colorectal cancer. LSN3074753 combined with Cetuximab (HY-P9905) shows additive and synergistic effects for colorectal cancer PDX models, particularly those with KRAS or BRAF mutation .

HY-D1660

Acridine homodimer NSC 219743	DNA Stain	Others
Acridine homodimer (NSC 219743), acridine dimer, is a fluorescence dye. Acridine homodimer emits a blue-green fluorescence when bound to DNA. Acridine homodimer has extremely high affinity for AT-rich regions of nucleic acids, can be used for chromosome banding .

HY-112636

Astrophloxine	Amyloid-β	Others
Astrophloxine is a fluorescent imaging probe capable of targeting antiparallel dimers. Astrophloxine can be used to detect aggregated Aβ in brain tissue and cerebrospinal fluid samples of Alzheimer's disease (AD) mice .

HY-N7980

Rubipodanone A	NF-κB	Cancer
Rubipodanone A, a naphthohydroquinone dimer, shows cytotoxicity against A549, BEL-7402, HeLa, HepG2, SGC-7901 and U251 cells. Rubipodanone A also shows obvious activating effect at 20 and 40 μM for NF-κB .

HY-139673

BG dimer	Fluorescent Dye	Others
BG dimer is a molecular dimer organic luminogen with aggregation-induced emission.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-D0844

Glutathione oxidized 5+ Cited Publications L-Glutathione oxidized; GSSG; Oxiglutatione	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Reactive Oxygen Species (ROS)
Glutathione oxidized (L-Glutathione oxidized) is produced by the oxidation of glutathione. Detoxification of reactive oxygen species is accompanied by production of glutathione oxidized. Glutathione oxidized can be used for the research of sickle cells and erythrocytes .

HY-N0282

Demecolcine 5+ Cited Publications	Alkaloids other families Classification of Application Fields Other Alkaloids Plants Inflammation/Immunology Disease Research Fields Source Classification	Microtubule/Tubulin Apoptosis
Demecolcine is a potent mitotic inhibitor with an IC₅₀ value of 2.4 μM for inhibition of tubulin polymerization. Colcemid (Demecolcine) can interact with tubulin dimers to induce anti-mitotic action and inhibit microtubule growth. Colcemid (Demecolcine) can be used for inflammatory disorders and cancer research .

HY-77490A

1,3-Butanediol 1 Publications Verification	Cardiovascular Disease Structural Classification Natural Products Neurological Disease Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Endogenous Metabolite
1,3-Butanediol, an orally active ethanol dimer providing a source of calories for human nutrition. 1,3-Butanediol administeration can stimulate the biosynthesis of the ketone body, β-hydroxybutyrate (βHB). 1,3-Butanediol has cerebral protective and hypoglycaemic effect .

HY-W040129

Chromomycin A3 1 Publications Verification	Microorganisms Source Classification	DNA Alkylator/Crosslinker DNA/RNA Synthesis Apoptosis Caspase
Chromomycin A3 is an inhibitor that selectively binds to GC-rich DNA sequences. Chromomycin A3 targets the DNA minor groove after forming a dimer with Mg ²⁺. Chromomycin A3 inhibits DNA replication and transcription, blocks the binding of Sp1 transcription factor to target gene promoters, downregulates the expression of anti-apoptotic proteins such as FLIP, Mcl-1, and XIAP, and induces S-phase cycle arrest and caspase-dependent apoptosis in tumor cells. Chromomycin A3 can antagonize oxidative stress induced by glutathione depletion and neuronal apoptosis induced by Camptothecin (HY-15660). Chromomycin A3 can be used in basic research on malignant tumors such as cholangiocarcinoma, and is a potential chemosensitizer and GC-rich region probe .

HY-N3841

ε-Viniferin 1 Publications Verification epsilon-Viniferin	Stilbenes Classification of Application Fields Vitis vinifera cv. Zalema Phenols Polyphenols Plants Vitaceae Inflammation/Immunology Disease Research Fields Source Classification	Cytochrome P450
ε-Viniferin (epsilon-Viniferin), the dimer of Resveratrol and can be isolated from Vitis vinifera, displays a potent inhibitory for all the CYP activities, with K_i values from 0.5-20 μM. ε-Viniferin possesses potent antioxidant, anti-inflammatory, anti-diabetic, and anti-neurodegenerative capacity .

HY-B2224

Thiamine disulfide	Infection Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	HIV Endogenous Metabolite
Thiamine disulfide, a vitamin B1 derivative, is an oxidized dimer of Thiamine. Thiamine disulfide is a potent HIV-1 inhibitor. Thiamine disulfide significantly depresses HIV-1 transactivator (Tat) activity .

HY-N2083

Handelin	Classification of Application Fields Terpenoids Sesquiterpenes Genista vuralii A.Duran & Dural Plants Compositae Inflammation/Immunology Disease Research Fields	NF-κB
Handelin is a guaianolide dimer from Chrysanthemum boreale that has potent anti-inflammatory activity by down-regulating NF-κB signaling and pro-inflammatory cytokine production .

HY-N2344

Procyanidin A1 2 Publications Verification Proanthocyanidin A1	Flavonoids other families Functional Molecules Classification of Application Fields Research of Health Products Phenols Polyphenols Plants Biflavones Inflammation/Immunology Disease Research Fields Source Classification	PKC
Procyanidin A1 (Proanthocyanidin A1) is a procyanidin dimer, which inhibits degranulation downstream of protein kinase C activation or Ca ²⁺ influx from an internal store in RBL-213 cells. Procyanidin A1 has antiallergic effects .

HY-130778

N,N'-Diacetylchitobiose	Microorganisms Animals Classification of Application Fields Other Diseases Disease Research Fields Saccharides Source Classification	Endogenous Metabolite
N,N'-Diacetylchitobiose is a dimer of β(1,4) linked N-acetyl-D glucosamine. N,N'-Diacetylchitobiose is the hydrolysate of chitin and can be used as alternative carbon source by E. coli. N,N'-Diacetylchitobiose also reverses myocardial depression .

HY-111009

Swinholide A	Infection Natural Products Classification of Application Fields Animals Marine natural products Sponge Disease Research Fields Source Classification	Fungal
Swinholide A is the actin-binding marine polyketide and dimerizes actin with the K_d of ~ 50 nM . Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments. Swinholide A disrupts the actin cytoskeleton of cells.Antifungal activity .

HY-W034065

3,5-Dihydroxyacetophenone	Classification of Application Fields Phenols Polyphenols Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Drug Intermediate
3,5-Dihydroxyacetophenone is a drug intermediate that can be used in the synthesis of the active stilbene dimer dehydro-δ-viniferin .

HY-W097819

Divanillin Dehydrodivanillin	Styrax suberifolius Hook. et Arn. Styracaceae Phenols Plants Source Classification	Endogenous Metabolite
Divanillin is a dimer composed of two vanillins (HY-N0098) covalently linked .

HY-N3393

Lethedioside A	Aquilaria agallocha Roxb. Structural Classification Flavonoids Flavones Thymelaeaceae Plants Source Classification	β-catenin
Lethedioside A is a Enhancer of split 1 (Hes1) inhibitor with an IC₅₀ of 9.5 μM. Lethedioside A inhibits Hes1 dimer formation. Lethedioside A exhibits weak inhibition of TCF4/β-catenin complex formation. Lethedioside A inhibits nitric oxide production by activated immune cells .

HY-N0282R

Colcemid (Standard)	Alkaloids Structural Classification other families Other Alkaloids Plants Source Classification	Reference Standards Microtubule/Tubulin Apoptosis
Colcemid (Standard) is the analytical standard of Colcemid. This product is intended for research and analytical applications. Colcemid (Demecolcine) is a potent mitotic inhibitor with an IC₅₀ value of 2.4 μM for inhibition of tubulin polymerization. Colcemid (Demecolcine) can interact with tubulin dimers to induce anti-mitotic action and inhibit microtubule growth. Colcemid (Demecolcine) can be used for inflammatory disorders and cancer research .

HY-N3841R

ε-Viniferin (Standard) epsilon-Viniferin (Standard)	Structural Classification Stilbenes Vitis vinifera cv. Zalema Phenols Polyphenols Plants Vitaceae Source Classification	Reference Standards Cytochrome P450
ε-Viniferin (Standard) is the analytical standard of ε-Viniferin. This product is intended for research and analytical applications. ε-Viniferin (epsilon-Viniferin), the dimer of Resveratrol and can be isolated from Vitis vinifera, displays a potent inhibitory for all the CYP activities, with Ki values from 0.5-20 μM. ε-Viniferin possesses potent antioxidant, anti-inflammatory, anti-diabetic, and anti-neurodegenerative capacity .

HY-N3841A

δ-Viniferin	Vitis vinifera cv. Zalema Phenols Polyphenols Plants Vitaceae Source Classification	Cytochrome P450
δ-Viniferin is a resveratrol dehydrodimer, an isomer of ε-Viniferin (HY-N3841) . ε-Viniferin (epsilon-Viniferin), the dimer of Resveratrol, displays a potent inhibitory for all the CYP activities, with K_i values from 0.5-20 μM. ε-Viniferin possesses potent antioxidant, anti-inflammatory, anti-diabetic, and anti-neurodegenerative capacity.

HY-N10766

Ampelopsin F	Vitis amurensis Rupr. Phenols Polyphenols Plants Vitaceae Source Classification	Others
Ampelopsins F is a bridged plant oligostilbene that can be isolated from Ampelopsis brevipedunculata var. hancei roots. Ampelopsins F is a resveratrol dimer .

HY-B2224R

Thiamine disulfide (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards HIV Endogenous Metabolite
Thiamine disulfide (Standard) is the analytical standard of Thiamine disulfide. This product is intended for research and analytical applications. Thiamine disulfide, a vitamin B1 derivative, is an oxidized dimer of Thiamine. Thiamine disulfide is a potent HIV-1 inhibitor. Thiamine disulfide significantly depresses HIV-1 transactivator (Tat) activity .

HY-N7980

Rubipodanone A	Quinones Classification of Application Fields Rubia podantha Rubiaceae Plants Naphthalene Quinones Disease Research Fields Source Classification Cancer	NF-κB
Rubipodanone A, a naphthohydroquinone dimer, shows cytotoxicity against A549, BEL-7402, HeLa, HepG2, SGC-7901 and U251 cells. Rubipodanone A also shows obvious activating effect at 20 and 40 μM for NF-κB .

HY-N16567

Acrofolione A	Structural Classification Acronychia haplophylla Ketones, Aldehydes, Acids Rutaceae Plants Source Classification	Apoptosis Caspase PARP Survivin
Acrofolione A is an acetophenone dimer isolated from Acronychia pendunculata with anticancer effects. Acrofolione A induces G0/G1 phase cell cycle arrest and apoptosis in human NALM-6 pre-B cell leukaemia cells. Acrofolione A can be used for leukaemia research .

HY-N16543

Bisisorhapontigenin A	Structural Classification Phenols Polyphenols Gnetaceae Plants Gnetum montanum Markgr. Source Classification	Leukotriene Receptor
Bisisorhapontigenin A is a dimer of isorhapontigenin. Bisisorhapontigenin A exhibits antagonistic activity against LTD4 and can be used for research on anti-inflammatory effects .

HY-N3574

Chloramultilide B	Structural Classification Chloranthus serratus (Thunb.) Roem. et Schult. Terpenoids Sesquiterpenes Chloranthaceae Plants Source Classification	Fungal
Chloramultilide B is a lindenane dimer that can be isolated from Chloranthus serratus. Chloramultilide B has inhibitory activities against Candida albicans and C.parapsilosis with a MIC value of 0.068 μM .

HY-N4299

Caesappanin C	Structural Classification Classification of Application Fields Leguminosae Caesalpinia sappan L. Other Phenylpropanoids Phenols Polyphenols Metabolic Disease Phenylpropanoids Plants Disease Research Fields Source Classification	HSV HSP
Caesappanin C, a biphenyl dimer from the ethanolic extract of the heartwood of Indonesian Caesalpinia sappan L., shows strong proliferation stimulating activity against the primary osteoblastic cells in vitro. Caesappanin C has the potential to stimulate bone formation and regeneration . Caesappanin C can effectively deactivate HSV particles and bind HSV surface glycoprotein B (gB) to inhibit membrane fusion .

HY-126640

Phomoxanthone A	Quinones Microorganisms Anthraquinones Source Classification	Parasite
Phomoxanthone A is a xanthone dimer, which can be isolated from Phomopsis. Phomoxanthone A exhibits antimalarial and antitubercular activities against Plasmodium falciparum (K1, multidrug-resistant strain, IC₅₀ is 0.11 µg/mL) and Mycobacterium tuberculosis (H37Ra strain, MIC is 0.50 µg/mL). Phomoxanthone A exhibits cytotoxicity in cells KB, BC-1 and Vero, IC₅₀ is 0.99, 0.51 and 1.4 µg/mL, respectively .

HY-123350

Saroaspidin B	Antibiotics Guttiferae Plants Hypericum japonicum Thunb. ex Murray Other Antibiotics Source Classification	Antibiotic
Saroaspidin B, a dimer of a phloroglucinol moiety, is an antibiotic compound .

HY-N9150

Shizukaol A	Terpenoids Sesquiterpenes Chloranthaceae Chloranthus japonicus Sieb. Plants Source Classification	Others
Shizukaol A is an sesquiterpene dimer that can be isolated from Chloranthus japonicas .

HY-N8404

Chlorahololide C	Classification of Application Fields Chloranthus holostegius (Hand.-Mazz.) Pei et Shan Terpenoids Sesquiterpenes Chloranthaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	Potassium Channel
Chlorahololide C, a lindenane sesquiterpenoid dimer, is isolated from Chloranthus holostegius. Chlorahololide C is a potent and selective potassium channel blocker, with an IC₅₀ of 3.6 μM .

HY-N6310

Talaromycesone A	Infection Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Phenols Disease Research Fields Source Classification	Bacterial
Talaromycesone A is an oxaphenalenone dimer compound. Talaromycesone A exhibits potent antibacterial activities with an IC₅₀ of 3.70 μM, against human pathogenic Staphylococcus strains. Talaromycesone A displays potent acetylcholinesterase inhibitory activities with an IC₅₀ of 7.49 μM .

HY-77490AR

1,3-Butanediol (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
1,3-Butanediol (Standard) is the analytical standard of 1,3-Butanediol. This product is intended for research and analytical applications. 1,3-Butanediol, an ethanol dimer providing a source of calories for human nutrition. 1,3-Butanediol is converted in the body to β-hydroxybutyrate and has cerebral protective and hypoglycaemic effect .

HY-N10577

Chlorfortunone A	Terpenoids Sesquiterpenes Chloranthaceae Plants Chloranthus fortunei (A. Gray) Solms-Laub	TGF-beta/Smad
Chlorfortunone A is a novel sesquiterpenoid dimers, can be isolated from the roots of Chloranthus fortunei. Chlorfortunone A inhibits transforming growth factor (TGF)-β activity .

HY-N12704

N-Acetyldopamine dimers B	Animals Phenols Polyphenols Source Classification	Others
N-Acetyldopamine dimers B is the dimer form of N-Acetyldopamine (HY-N7493) .

HY-N9054

Ageratochromene dimer Precocene II Dimer	Structural Classification Other Phenylpropanoids Lupinus perennis L. Phenylpropanoids Plants Compositae Source Classification	Drug Derivative
Ageratochromene dimer (Precocene II dimer) is a natural phenolic compound.

HY-N1350

Riligustilide	Natural Products Plants Umbelliferae Echinacea angustifolia DC. Source Classification	Others
Riligustilide (compound 2) is a kind of phthalide dimer. Riligustilide can be isolated from the radix of Angelica sinensis .

HY-N3671

Cycloshizukaol A	Chloranthus serratus (Thunb.) Roem. et Schult. Terpenoids Sesquiterpenes Chloranthaceae Plants Source Classification	Others
Cycloshizukaol A is a symmetrical cyclic lindenane dimer with C2 symmetry. Cycloshizukaol A can be isolated from the root of Chloranthus serratus .

HY-N12478

Ainsliadimer A	Caesalpinia crista L. Terpenoids Sesquiterpenes Plants Compositae Source Classification	NO Synthase
Ainsliadimer A is a sesquiterpene lactone dimer with an unusual carbon skeleton. Ainsliadimer A can be obtained from from Ainsliaea macrocephala. Ainsliadimer A inhibits the production of nitric oxide in cells stimulated by LPS .

HY-N12235

Sarglaroids F	Ketones, Aldehydes, Acids Sarcandra glabra (Thunb.) Nakai Chloranthaceae Plants Source Classification	Caspase
Sarglaroids F (compound 6) is an anti-inflammatory agent isolated from the roots of Grass Coral. Sarglaroids F inhibits LPS/ATP-induced IL-1β release by affecting K+ efflux and reducing Caspase-1(P20) levels. Sarglaroids F is not cytotoxic to RAW264.7 cells .

HY-N11894

1,3,6-Trihydroxy-2-methyl-9,10-anthraquinone-3-O-(6'-O-acetyl)-beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranoside	Quinones Rubia podantha Anthraquinones Rubiaceae Plants Source Classification	Others
1,3,6-Trihydroxy-2-methyl-9,10-anthraquinone-3-O-(6'-O-acetyl)-beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranoside ( Compound 20) is a quinone compound that can be isolated from the roots and rhizomes of Madder .

HY-N2344R

Procyanidin A1 (Standard) Proanthocyanidin A1 (Standard)	Structural Classification Flavonoids other families Phenols Polyphenols Plants Biflavones Source Classification	Reference Standards PKC
Procyanidin A1 (Standard) is the analytical standard of Procyanidin A1. This product is intended for research and analytical applications. Procyanidin A1 (Proanthocyanidin A1) is a procyanidin dimer, which inhibits degranulation downstream of protein kinase C activation or Ca2+ influx from an internal store in RBL-213 cells. Procyanidin A1 has antiallergic effects .

HY-130778R

N,N'-Diacetylchitobiose (Standard)	Microorganisms Animals Saccharides Source Classification	Endogenous Metabolite Reference Standards
N,N'-Diacetylchitobiose (Standard) is the analytical standard of N,N'-Diacetylchitobiose. This product is intended for research and analytical applications. N,N'-Diacetylchitobiose is a dimer of β(1,4) linked N-acetyl-D glucosamine. N,N'-Diacetylchitobiose is the hydrolysate of chitin and can be used as alternative carbon source by E. coli. N,N'-Diacetylchitobiose also reverses myocardial depression .

HY-W040129R

Chromomycin A3 (Standard)	Microorganisms Source Classification	Reference Standards Bacterial Fungal Apoptosis Antibiotic
Chromomycin A3 (Standard) is the analytical standard of Chromomycin A3 (HY-W040129). This product is intended for research and analytical applications. Chromomycin A3 is an inhibitor that selectively binds to GC-rich DNA sequences. Chromomycin A3 targets the DNA minor groove after forming a dimer with Mg ²⁺. Chromomycin A3 inhibits DNA replication and transcription, blocks the binding of Sp1 transcription factor to target gene promoters, downregulates the expression of anti-apoptotic proteins such as FLIP, Mcl-1, and XIAP, and induces S-phase cycle arrest and caspase-dependent apoptosis in tumor cells. Chromomycin A3 can antagonize oxidative stress induced by glutathione depletion and neuronal apoptosis induced by Camptothecin (HY-15660). Chromomycin A3 can be used in basic research on malignant tumors such as cholangiocarcinoma, and is a potential chemosensitizer and GC-rich region probe .

HY-N13773

Quercetin dimer	Structural Classification Flavonoids Liliaceae Allium cepa L. Plants Other Flavonoids Source Classification	Drug Derivative
Quercetin dimer is a natural flavonoid.

HY-N18090

Voacamidine	Apocynaceae Structural Classification Alkaloids Voacanga africana Stapf Other Alkaloids Plants Source Classification	Drug Derivative
Voacamidine is an iboga-vobasinyl dimeric monoterpenoid indole alkaloid found in the root bark of Voacanga africana. Voacamidine undergoes cleavage in acid media to produce Voacangine (HY-N7536) .

HY-N16526

Juncatrin B	Quinones Structural Classification Juncus effusus Linn. Juncaceae Juncus articulatus L. Plants Phenanthrenequinones Source Classification	Bacterial
Juncatrin B is a type of dihydrophenanthrene compound. Juncatrin B exhibits inhibitory activity against both Methicillin (HY-121544)-sensitive Staphylococcus aureus (MSSA) and Methicillin-resistant Staphylococcus aureus (MRSA). Juncatrin B can inhibit the formation of biofilms in MSSA and MRSA. Juncatrin B has no significant activity against Gram-negative bacteria. Juncatrin B can be used in the research of anti-Staphylococcus aureus .

HY-N16691

Acrovestone	Structural Classification Ketones, Aldehydes, Acids Rutaceae Phenols Plants Acronychia pedunculata (L.) Miq. Source Classification	Others
Acrovestone (compound 4) is an Acronychia-type acetophenone dimer and a selective anticancer agent. Acrovestone has IC₅₀ values ??of 0.38 μM and 0.93 μM against A2058 melanoma cells and DU145 prostate cancer cells, respectively. Acrovestone shows low inhibitory activity against normal human dermal fibroblasts (NHDF), with an IC₅₀ >5 μM. Acrovestone can be used in anticancer research related to prostate cancer and melanoma. Acrovestone can be naturally extracted from the trunk bark of Acronychia pedunculata .

HY-N16857

Didendronbiline A	Structural Classification Orchidaceae Phenols Plants Dendrobium nobile Lindl. Source Classification	Drug Derivative
Didendronbiline A is a natural phenolic compound.

HY-N18470

Gadusol	Structural Classification Natural Products Animals Source Classification	DNA/RNA Synthesis Apoptosis Reactive Oxygen Species (ROS)
Gadusol is a potent, maternally supplied natural sunscreen. Gadusol is synthesized by the mother during oogenesis and stored in eggs, representing the primary sunscreen mechanism during the early developmental stages of fish. Gadusol directly prevents UVB-induced DNA damage and reduces the generation of ROS thereby avoiding cellular stress and apoptosis. Gadusol does not exert antioxidant functions in zebrafish embryos. Gadusol can be used in studies related to topical photoprotective cosmetics .

HY-N18192

Kuwanon L	Structural Classification Flavonoids Flavonones Morus alba L. Plants Moraceae Source Classification	HIV HIV Integrase
Kuwanon L is an HIV-1 integrase (HIV-1 integrase) inhibitor, with IC₅₀ values of 42 μM and 34 μM for LEDGF-dependent and LEDGF-independent integrase, respectively. Kuwanon L blocks the interaction between HIV-1 integrase and LEDGF/p75, with an IC₅₀ of 22 μM. Kuwanon L inhibits HIV-1 replication in immune cells. Kuwanon L is applicable to research related to HIV-1 infection .

Cat. No.	Product Name	Chemical Structure

HY-143859S

*Metoprolol dimer-d10*
Metoprolol dimer-d₁₀ is the deuterium labeled Metoprolol dimer .

HY-141736S

*Acetaminophen dimer-d6*
Acetaminophen dimer-d₆ is the deuterium labeled Acetaminophen dimer .

HY-142217S

*Quetiapine dimer* impurity-d8**
Quetiapine dimer impurity-d₈ is the deuterium labeled Quetiapine dimer impurity .

HY-132770S

*Propafenone Dimer* Impurity-d10**
Propafenone Dimer Impurity-d₁₀ is the deuterium labeled Propafenone Dimer Impurity .

HY-W749231

*Ethylene Terephthalate Cyclic Dimer-d8*
Ethylene Terephthalate Cyclic Dimer-d₈ is the deuterium labeled 3,6,13,16-Tetraoxatricyclo[16.2.2.28,11]tetracosa-8,10,18,20,21,23-hexaene-2,7,12,17-tetrone (HY-W587729).

HY-W710827

N,N'-Methylenebisacrylamide-d6

N,N'-Methylenebisacrylamide-d₆ is the deuterium labeled N,N'-Methylenebisacrylamide (HY-D0848). N,N'-Methylenebisacrylamide (Bisacrylamide) is an orally active acrylamide dimer and crosslinker. N,N'-Methylenebisacrylamide increases CYP2E1, P53, cleaved caspase-3. N,N'-Methylenebisacrylamide promotes hepatic cancer. N,N'-Methylenebisacrylamide changes sperm abnormality rate and sperm count. N,N'-Methylenebisacrylamide decreases the number of various cells in the blood as well as induces liver and testicular damage. N,N'-Methylenebisacrylamide is used to prepare polyacrylamide gel .

HY-157825S

*Sildenafil dimer-d8*
Sildenafil dimer-d₈ (Sildenafil dimer impurity-d₈) is the deuterium labeled Sildenafil dimer.

HY-Z8715S

*Albuterol dimer-d18*
Albuterol dimer-d₁₈ is the deuterium labeled Albuterol dimer.

HY-101161S

SG3199-d6
SG3199-d₆ is the deuterium labeled SG3199 (HY-101161). SG3199 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer. SG3199 is the released warhead component of the ADC payload Tesirine (SG3249).

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-128952G

Tesirine SG3249	Drug-Linker Conjugates for ADC DNA Alkylator/Crosslinker	Cancer
Tesirine (GMP) (SG3249 (GMP)) is Tesirine (HY-128952) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Tesirine (SG3249) is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. SG3199 (HY-101161) is the released warhead component of the ADC payload Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines. PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity .

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