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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
296 Results for "
Dimer
" in MedChemExpress (MCE) Product Catalog:
Products (296)
296 Results for "Dimer" in MCE Product Catalog:
39
39 Publications Verification
Target:
Forschungsgebiete:
MSA-2, a potent and orally available non-nucleotide STING agonist, is bound to STING as a noncovalent dimer with nanomolar affinity. MSA-2 shows EC50s of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. MSA-2 stimulates interferon-β secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models .
16
16 Cited Publications
Target:
Forschungsgebiete:
SN-011 is a potent and selective mouse and human STING inhibitor, with an IC50 of 76 nM for STING signaling. SN-011 competes with cyclic dinucleotide (CDN) for the binding pocket of the STING dimer, blocking CDN binding and STING activation. SN-011 can be used for the research of STING-driven autoimmune and inflammatory disease .
10
10 Cited Publications
Art. -Nr.: HY-D0844
CAS. Nr.: 27025-41-8
Synonyms: L-Glutathione oxidized; GSSG; Oxiglutatione
8
Category:
Alkaloids Plant Other Alkaloids Other Families Extract Disease Research Fields Inflammation/Immunology
Target:
7
Forschungsgebiete:
Tesirine (SG3249) is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. SG3199 (HY-101161) is the released warhead component of the ADC payload Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines. PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity .
7
HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition .
5
5 Cited Publications
Forschungsgebiete:
SG3199 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer. SG3199 is the released warhead component of the ADC payload Tesirine (SG3249) .
4
Forschungsgebiete:
Tricarbonyldichlororuthenium(II) dimer (CORM-2) is a CO-releasing molecule. Tricarbonyldichlororuthenium(II) dimer exhibits anti-inflammatory, antioxidant, and gastric mucosa-protective activities. Additionally, Tricarbonyldichlororuthenium(II) dimer has CO-independent functional effects on multiple potassium channels .
3
Target:
Forschungsgebiete:
BI-0115 is a selective inhibitor of LOX-1 (IC50=5.4 μM) that blocks cellular uptake of oxLDL. BI-0115 binding triggers receptor inhibition by formation of dimers of the homodimeric ligand binding domain .
3
Category:
Other Families Extract Plant Flavonoids Functional Molecules Research of Health Products Phenols Polyphenols Disease Research Fields Inflammation/Immunology Biflavones
Target:
3
3 Cited Publications
Target:
Forschungsgebiete:
IL-17A antagonist 1 is an interleukin-17A (IL-17A) antagonist with an IC50 of 1.14 μM and a Kd of 0.66 μM. IL-17A antagonist 1 binds specifically and exclusively to the IL-17A homodimer at its central dimer interface pocket, induces a large conformational change that widens the pocket, and disrupts the IL-17A/IL-17RA interaction. IL-17A antagonist 1 does not bind to IL-17F or IL-17RA .
2
Forschungsgebiete:
Dixanthogen is a dimer of xanthate, which forms via the oxidation of xanthate. Dixanthogen can decompose peroxides, which are key radical initiators for the oxidative degradation of polypropylene. Dixanthogen serves as a stabilizer for polypropylene, a pediculicide, and is also used in studies related to metal recovery .
2
Target:
Forschungsgebiete:
Allophycocyanin (APC Dye) is a light-harvesting protein, containing strongly coupled dimers of chromophores. Allophycocyanin serve as a minimal system to examine photosynthetic energy transfer. Allophycocyanin strongly absorbs far-red light (FRL), and expresses during acclimation to low light, likely associates with chlorophyll a-containing photosystem I .
The product specifications provided below refer solely to the active content of Allophycocyanin.
The product specifications provided below refer solely to the active content of Allophycocyanin.
2
2 Cited Publications
Synonyms: Bisacrylamide; MBA; Methylenebisacrylamide; N,N-Methylenebisacrylamide
1
1 Cited Publications
Target:
Forschungsgebiete:
MSA-2 dimer is a selective, orally active non-nucleotide STING agonist (Kd=145 μM) with long-term antitumor and immunogenic activity. MSA-2 dimer is bound to STING as a non-covalent dimer exhibiting higher permeability than cyclic dinucleotide .
1
1 Cited Publications
Art. -Nr.: HY-N2083
CAS. Nr.: 62687-22-3
Category:
Plant Chrysanthemum boreale Extract Terpenoids Sesquiterpenes Compositae/Asteraceae Extract Disease Research Fields Inflammation/Immunology
Target:
1
1 Cited Publications
Art. -Nr.: HY-16182A
CAS. Nr.: 90458-75-6
Target:
Forschungsgebiete:
Ecamsule disodium is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression .
1
1 Cited Publications
Art. -Nr.: HY-16182
CAS. Nr.: 92761-26-7
Target:
Forschungsgebiete:
Ecamsule is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression. Ecamsule has the potential for the research of polymorphous light eruption (PMLE) .
1
1
Category:
Vitaceae Extract Plant Stilbenes Phenols Polyphenols Disease Research Fields Inflammation/Immunology Vitis vinifera cv. Zalema Extract
Target:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
