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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
404 Results for "
GMP
" in MedChemExpress (MCE) Product Catalog:
Products (404)
404 Results for "GMP" in MCE Product Catalog:
321
321 Publications Verification
Synonyms: CHIR-99021; CT99021
Laduviglusib (CHIR-99021) is a potent, selective and orally active GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib enhances mouse and human embryonic stem cells self-renewal. Laduviglusib induces autophagy .
87
Target:
Research Areas:
RU.521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation. RU.521 suppresses dsDNA-activated reporter activity with an IC50 of 0.7 μM. RU.521 reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS) .
44
44 Cited Publications
Synonyms: 2'-3'-cyclic GMP-AMP
Target:
44
44 Cited Publications
Synonyms: 2'-3'-cyclic GMP-AMP sodium
Target:
28
28 Cited Publications
Synonyms: Cyclic GMP-AMP; 3',3'-cGAMP
Target:
Research Areas:
cGAMP (Cyclic GMP-AMP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators .
28
28 Cited Publications
Synonyms: Cyclic GMP-AMP disodium; 3',3'-cGAMP disodium
Category:
Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology
Target:
28
28 Cited Publications
Cat. No.: HY-110385A
Purity: 95.19%
Synonyms: Cyclic GMP-AMP diammonium; 3',3'-cGAMP diammonium
Target:
9
9 Cited Publications
Synonyms: c-di-GMP diammonium; cyclic diguanylate diammonium; 5GP-5GP diammonium
Target:
9
9 Cited Publications
Synonyms: c-di-GMP disodium; cyclic diguanylate disodium; 5GP-5GP disodium
Target:
9
9 Cited Publications
Target:
Research Areas:
G150 is a highly selective human cyclic GMP-AMP synthase (h-cGAS) inhibitor with an IC50 of 10.2 nM. G150 represses dsDNA-triggered interferon expression, and G150 can be used for the research of inflammatory .
7
7 Cited Publications
Target:
Research Areas:
G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS), with IC50s of 14.0 nM and 442 nM for h-cGAS and m-cGAS, respectively. G140 has anti-inflammatory activity .
5
3
3 Cited Publications
Cat. No.: HY-P78549
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL4; B_cell Stimulatory Factor 1; Interleukin 4; B-Cell Stimulatory Factor 1; IL-4; B Cell Growth Factor 1; Lymphocyte Stimulatory Factor 1; Binetrakin; Interleukin-4; Pitrakinra; BCGF-1; MGC79402; BCGF1; BSF-1; BSF1
Species:
Human
Source:
E. coli
3
3 Cited Publications
Target:
Research Areas:
PF-06928215 is a cGAS (cyclic GMP-AMP Synthase) inhibitor with an IC50 of 4.9 μΜ. PF-06928215 has a high binding affinity of 0.2 μM (Kd) .
3
3 Cited Publications
3
3 Cited Publications
Cat. No.: HY-P72337
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CGAS; D4; Prev. C6orf150; DANGER Family Member 4; Prev. MB21D1; CGAMP Synthase; H-CGAS; Chromosome 6 Open Reading Frame 150; Mab-21 Domain-Containing Protein 1; Protein MB21D1; 2'3'-CGAMP Synthase; Cyclic GMP-AMP Synthase; Mab-21 Domain Containing 1
Species:
Human
Source:
E. coli
2
2 Cited Publications
Cat. No.: HY-10182G
CAS No.: 252917-06-9
Synonyms: CHIR-99021 (GMP); CT99021 (GMP)
2
2 Cited Publications
Cat. No.: HY-P7044G
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL6; Hybridoma Growth Factor; Prev. IFNB2; IFN-Beta-2; IL-6; BSF-2; Interleukin-6; CDF; BSF2; Interleukin 6 (Interferon, Beta 2); HGF; B-Cell Differentiation Factor; HSF; Truncated Interleukin 6; B-Cell Stimulatory Factor 2; Interferon, Beta 2; CTL Differ
Species:
Human
Source:
E. coli
2
2 Cited Publications
Cat. No.: HY-W010759
CAS No.: 20813-76-7
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
