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Results for "

HSV inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HSV (146) Acetyl-CoA Carboxylase (2) Acyltransferase (2) Akt (5) AMPK (2) Androgen Receptor (1) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (24) Apoptosis (35) Autophagy (23) Bacterial (46) Caspase (3) Cathepsin (3) CCR (1) CD3 (1) CD47 (1) CDK (4) CMV (22) COX (10) CXCR (1) Cyclic GMP-AMP Synthase (1) Cytochrome P450 (1) DNA Methyltransferase (1) DNA/RNA Synthesis (38) Drug Derivative (2) Drug Metabolite (2) DYRK (1) EBV (4) Endogenous Metabolite (31) Enterovirus (2) Environmental Pollutants (5) ERK (5) FAK (1) FASTK (1) Fatty Acid Synthase (FASN) (2) Ferroptosis (5) FGFR (2) Flavivirus (4) Fungal (10) GSK-3 (3) HBV (1) HIF/HIF Prolyl-Hydroxylase (1) Histone Demethylase (3) HIV (22) HPV (2) HSP (4) IFNAR (1) Influenza Virus (8) Integrin (3) Interleukin Related (5) Isotope-Labeled Compounds (14) JNK (2) Mitochondrial Metabolism (1) Mitophagy (2) MMP (2) Monoamine Oxidase (2) NF-κB (12) NO Synthase (8) NOD-like Receptor (NLR) (5) Nucleoside Antimetabolite/Analog (22) Orthopoxvirus (10) p38 MAPK (3) PAK (1) Parasite (8) PARP (1) Phosphatase (2) PI3K (2) PKC (2) PPAR (9) PROTACs (1) Proton Pump (2) Reactive Oxygen Species (ROS) (5) Reference Standards (31) RSV (1) SARS-CoV (5) Ser/Thr Protease (2) Sirtuin (2) STAT (7) STING (1) Tau Protein (3) Thrombopoietin Receptor (1) Thymidylate Synthase (3) TNF Receptor (3) Toll-like Receptor (TLR) (4) TRP Channel (1) Tyrosinase (2) VEGFR (3) Virus Protease (5) VSV (2) VZV (2) YB-1 (1)
By Research Areas:	Cancer (72) Cardiovascular Disease (5) Infection (157) Inflammation/Immunology (38) Metabolic Disease (13) Neurological Disease (16)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Guanosine (1) Nucleoside Analogs (3) Uridine (1) Antisense Oligonucleotides (2) Cholesterol (1)

171

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: HSV

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16592

Brefeldin A Maximum Cited Publications 153 Publications Verification BFA; Cyanein; Decumbin	Autophagy Mitophagy HSV Antibiotic Bacterial	Infection Cancer
Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus . Brefeldin A is also an autophagy and mitophagy inhibitor . Brefeldin A inhibits *HSV-1* and has anti-cancer activity .

HY-13605

Cytarabine 90+ Cited Publications Cytosine β-D-arabinofuranoside; Cytosine Arabinoside; Ara-C	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog HSV Autophagy Apoptosis Endogenous Metabolite Orthopoxvirus	Infection Cancer
Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC₅₀ of 16 nM. Cytarabine has antiviral effects against *HSV*. Cytarabine shows anti-orthopoxvirus activity.

HY-B1773A

Sodium propionate 3 Publications Verification	Environmental Pollutants Apoptosis Endogenous Metabolite Bacterial Autophagy HSV PPAR NF-κB COX NO Synthase	Infection Neurological Disease Inflammation/Immunology Cancer
Sodium propionate is an orally active short-chain fatty acid. Sodium propionate can be produced by intestinal bacteria from the metabolism of dietary fiber. Sodium propionate increases PPAR-γ, inhibits NF-κB activation, and reduces COX-2 expression and NO production. Sodium propionate also induces Apoptosis and Autophagy. Sodium propionate reduces *HSV-1*-induced keratitis. Sodium propionate has anticancer effects against glioblastoma. Sodium propionate exhibits neuroprotective, antioxidant, and anti-inflammatory activities. Sodium propionate can be used in the research of spinal cord injury and Alzheimer's disease .

HY-N1067

Xanthohumol 15+ Cited Publications	COX Acyltransferase Apoptosis HSV CMV Influenza Virus	Infection Cancer
Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, *HSV-1, HSV-2* and cytomegalovirus (CMV).

HY-13605A

Cytarabine hydrochloride 90+ Cited Publications Cytosine β-D-arabinofuranoside hydrochloride; Cytosine Arabinoside hydrochloride; Ara-C hydrochloride	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog HSV Autophagy	Infection Cancer
Cytarabine hydrochloride, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC₅₀ of 16 nM. Cytarabine hydrochloride has antiviral effects against *HSV*.

HY-15486

Salubrinal 35+ Cited Publications	Phosphatase HSV Autophagy Apoptosis	Infection Inflammation/Immunology Cancer
Salubrinal is a cell-permeable and selective inhibitor of eIF2α dephosphorylation . Salubrinal acts as a dual-specificity phosphatase 2 (Dusp2) inhibitor and suppresses inflammation in anti-collagen antibody-induced arthritis . Salubrinal has antiviral activity against *HSV-1* and inhibits dephosphorylation of eIF2α mediated by the *HSV-1* protein ICP34.5 .

HY-14809

Amenamevir 5+ Cited Publications ASP2151	HSV	Infection
Amenamevir is a helicase-primase inhibitor which has potent antiviral activity against *HSVs* with an EC₅₀ of 14 ng/mL.

HY-118122

Fialuridine FIAU; DRG-0098; NSC 678514	HSV HBV DNA/RNA Synthesis Orthopoxvirus Nucleoside Antimetabolite/Analog	Infection
Fialuridine (FIAU), a nucleoside analog, is a *HSV-1* and *HSV-2* inhibitor with K_is of 0.14 μM and 0.95 μM, respectively. Fialuridine shows anti-orthopoxvirus and anti-hepatitis B virus (HBV) activities. Fialuridine inhibits duck HBV DNA replication with IC₅₀ values of 0.075 μM and 156 μM in human hepatoma cells and in chicken liver cells, respectively .

HY-N1430

Oxyresveratrol 3 Publications Verification trans-Oxyresveratrol	Tyrosinase HSV Autophagy	Others
Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC₅₀ of 28.9 µM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive tyrosinase inhibitor with an IC₅₀ value of 1.2 µM for mushroom tyrosinase. Oxyresveratrol is effective against *HSV-1, HSV-2* and varicella-zoster virus, and has neuroprotective effects .

HY-17425A

Valacyclovir hydrochloride 1 Publications Verification Valaciclovir hydrochloride	HSV Antibiotic Bacterial	Infection Cancer
Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an orally active antiviral agent for herpes simplex, herpes zoster, and herpes B. Valacyclovir hydrochloride inhibits *HSV-1* W (₅₀=2.9 μg/ml). Valacyclovir hydrochloride is a proagent of Aciclovir (HY-17422) .

HY-P2310

Defensin HNP-1 human	Bacterial Parasite Apoptosis HIV HSV CMV TNF Receptor NOD-like Receptor (NLR) DNA/RNA Synthesis Influenza Virus	Cardiovascular Disease Infection
Defensin HNP-1 human is a type of human neutrophil peptide (HNPs). Defensin HNP-1 human possesses immunomodulatory functions and can delay the apoptosis of neutrophils. Defensin HNP-1 human inhibits DNA/RNA/protein synthesis and interferes with metabolic pathways, thus exhibiting broad antibacterial activity. Defensin HNP-1 human has direct inactivation effects on HIV, HSV-1, HSV-2, CMV, influenza virus, etc. Defensin HNP-1 human has antileishmanial activity. Defensin HNP-1 human is involved in endothelial cell dysfunction during the early development of atherosclerosis .

HY-113289

Brassicasterol 1 Publications Verification	Akt Androgen Receptor Bacterial Drug Metabolite HSV	Infection Cardiovascular Disease Neurological Disease Cancer
Brassicasterol is a metabolite of Ergosterol and has cardiovascular protective effects. Brassicasterol exerts anticancer effects in prostate cancer through dual targeting of AKT and androgen receptor signaling pathways. Brassicasterol inhibits *HSV-1* (IC₅₀=1.2 μM) and Mycobacterium tuberculosis. Brassicasterol also inhibits sterol δ 24-reductase, slowing the progression of atherosclerosis. Brassicasterol is also a cerebrospinal fluid biomarker for Alzheimer's disease .

HY-15303

Pritelivir 5+ Cited Publications AIC316; BAY 57-1293	DNA/RNA Synthesis HSV	Infection
Pritelivir (AIC316), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir is active against herpes simplex virus types 1 and 2 (HSV-1 and *HSV-2) with the IC₅₀ of 0.02 μM against HSV*1-2 .

HY-122704A

Surfen dihydrochloride 2 Publications Verification Aminoquinuride dihydrochloride	FGFR HSV Tau Protein	Infection Neurological Disease Inflammation/Immunology
Surfen dihydrochloride is a potent heparan sulfate antagonist. Surfen inhibits FGF2 binding and signal transduction. Surfen binds to glycosaminoglycans and reduces tau hyperphosphorylation. Surfen dihydrochloride inhibits the activity of recombinant uronyl 2-O-sulfotransferase with an IC₅₀ of approximately 2 μM. Surfen dihydrochloride inhibits *HSV-1* viral infection. Surfen dihydrochloride inhibits neural differentiation, delays remyelination, and alleviates EAE .

HY-131606B

Cidofovir diphosphate tritriethylamine	Drug Metabolite DNA/RNA Synthesis	Infection
Cidofovir diphosphate tri triethylamine is an active intracellular metabolite of Cidofovir. Cidofovir diphosphate tri triethylamine is a selective inhibitor of viral DNA polymerases with K_i values of 6.6, 0.86 and 1.4 μM for HCMV, HSV-1 and HSV-2 DNA polymerase, respectively .

HY-N2004

Isoborneol 1 Publications Verification (±)-Isoborneol	Environmental Pollutants HSV	Infection Neurological Disease
Isoborneol ((±)-Isoborneol) is a monoterpenoid alcohol present in the essential oils of numerous medicinal plants and has antioxidant and antiviral properties. Isoborneol is a potent inhibitor of herpes simplex virus type 1 *(HSV-1)* .

HY-120427

Cosalane 1 Publications Verification NSC 658586	CCR CXCR HIV HSV	Infection Inflammation/Immunology
Cosalane (NSC 658586) is a CCR7 (IC₅₀ = 2.43 μM) and CXCR2 antagonist (IC₅₀ = 0.66 μM). Cosalane is an inhibitor of HIV replication with a wide range of activity against HIV-1 isolates, HIV-2, Rauscher murine leukemia virus, *HSV-1, HSV-2* and human cytomegalovirus. Cosalane inhibits both attachment of gp120 to CD4. Cosalane inhibits human and murine CCR7 in response to both CCL19 and CCL21 agonists. Cosalane can be studied in research for HIV or attenuating acute graft-versus-host disease (aGVHD) in allogeneic hematopoietic stem cell transplantation (HSCT) .

HY-17425

Valacyclovir 1 Publications Verification Valaciclovir	HSV Antibiotic Bacterial	Infection Cancer
Valacyclovir (Valaciclovir) is an orally active antiviral agent for herpes simplex, herpes zoster, and herpes B. Valacyclovir inhibits *HSV-1* W (₅₀=2.9 μg/ml). Valacyclovir is a proagent of Aciclovir (HY-17422) .

HY-P2310A

Defensin HNP-1 human TFA	Bacterial Parasite Apoptosis HIV HSV CMV TNF Receptor Interleukin Related NOD-like Receptor (NLR) DNA/RNA Synthesis Influenza Virus	Cardiovascular Disease Infection
Defensin HNP-1 human TFA is a type of human neutrophil peptide (HNPs). Defensin HNP-1 human TFA possesses immunomodulatory functions and can delay the apoptosis of neutrophils. Defensin HNP-1 human TFA inhibits DNA/RNA/protein synthesis and interferes with metabolic pathways, thus exhibiting broad antibacterial activity. Defensin HNP-1 human TFA has direct inactivation effects on HIV, HSV-1, HSV-2, CMV, influenza virus, etc. Defensin HNP-1 human TFA has antileishmanial activity. Defensin HNP-1 human TFA is involved in endothelial cell dysfunction during the early development of atherosclerosis .

HY-113431

Arabinosylhypoxanthine	Nucleoside Antimetabolite/Analog HSV DNA/RNA Synthesis	Infection
Arabinosylhypoxanthine is a purine nucleoside analog. Arabinosylhypoxanthine selectively inhibits viral DNA synthesis. Arabinosylhypoxanthine exhibits anti-HSV activity. Arabinosylhypoxanthine can be used in studies related to herpes simplex virus infection .

HY-128744

Phosphonoacetic acid 2 Publications Verification	Endogenous Metabolite Orthopoxvirus HSV DNA/RNA Synthesis	Infection
Phosphonoacetic acid is an endogenous metabolite and antiviral agent. Phosphonoacetic acid is active against orthopoxviruses and herpes viruses. Phosphonoacetic acid can inhibit *HSV* DNA synthesis and virus-specific DNA polymerase activity, and affect the synthesis of late viral proteins .

HY-W291131

Isatin-β-thiosemicarbazone IBT	HSV Orthopoxvirus	Infection
Isatin-β-thiosemicarbazone is a potent anti-poxvirus agent (including monkeypox virus, orthopoxvirus, vaccinia virus, etc). Isatin-β-thiosemicarbazone also is a potent herpes simplex virus (HSV) inhibitor. Isatin-β-thiosemicarbazone exhibits

HY-148852

PNU-183792	HSV	Infection
PNU-183792, a 4-oxo-dihydroquinoline, is an orally active HSV polymerases inhibitor. PNU-183792 shows a broad-spectrum antiviral activity, with IC₅₀ values of 0.69 μM, 0.37 μM and 0.58 μM for human cytomegalovirus (HCM), varicella zoster virus and HSV polymerases, respectively. PNU-183792 is inactive against human α, γ and δ polymerases. PNU-183792 also inhibits simian varicella virus (SVV), murine cytomegalovirus (MCMV) and rat cytomegalovirus (RCMV) .

HY-160222

HSV-60mer sodium	HSV STING IFNAR NF-κB	Infection
HSV-60mer sodium is a 60 bp double-stranded DNA oligonucleotide derived from the HSV-1 genome, and also an IFNβ inducer. HSV-60mer sodium colocalizes with endogenous cytoplasmic IFI16 in immune cells. HSV-60mer sodium activates the transcription factors IRF3 and NF-κB, induces the production of proinflammatory cytokines, and inhibits HSV-1 replication in immune cells. HSV-60mer sodium can be used in studies related to herpes simplex virus type 1 infection .

HY-150306

Adibelivir IM-250	DNA/RNA Synthesis HSV	Infection
Adibelivir (IM-250) is an orally active helicase-primase inhibitor. Adibelivir is effective against *HSV* infection and reduces reactivation of latent HSV. Adibelivir inhibits HSV-1 infection in Vero cells (IC₅₀: ~20 nM). Adibelivir can be used for the study of recurrent herpes disease^[1][2]_.

HY-18944

FIT-039	CDK HSV CMV DNA/RNA Synthesis	Infection
FIT-039 is a selective, ATP-competitive and orally active CDK9 inhibitor with an IC₅₀ of 5.8 μM for CKD9/cyclin T1. FIT-039 does not inhibit other CDKs and other kinases. FIT-039 inhibits replication of *HSV-1* (IC₅₀ of 0.69 μM), *HSV-2, human adenovirus, and human CMV. FIT-039 is a promising antiviral agent for inhibiting* drug-resistant *HSVs* and other DNA viruses.

HY-18684

SIBA 5'-Isobutylthioadenosine; 5'-Deoxy-5'-isobutylthioadenosine	Nucleoside Antimetabolite/Analog HSV Parasite	Infection Metabolic Disease Cancer
SIBA (5'-Isobutylthioadenosine) is a transmethylation inhibitor (SAH (HY-19528) analogue), with potent anti-proliferative activity. SIBA reversibly inhibits the production of HSV-1 by blocking methylation, specifically by blocking the 5' end-capping of viral mRNA. SIBA also inhibits the growth of tumour cells in vitro and metastatic spread in vivo. SIBA can be used in cancer, HSV-1 infection and anti-malaria studies .

HY-17422S1

Acyclovir-d4 Aciclovir-d₄; Acycloguanosine-d₄	Isotope-Labeled Compounds HSV Bacterial Apoptosis Antibiotic	Infection Cancer
Acyclovir-d₄ is the deuterium labeled Acyclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent. Acyclovir inhibits HSV-1 (IC₅₀ of 0.85 μM), HSV-2 (IC₅₀ of 0.86 μM) and varicella-zoster virus. Acyclovir can be phosphorylated by viral thymidine kinase (TK), and Acyclovir triphosphate interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate and obligatory chain termination . Acyclovir prevents bacterial infections during induction therapy for acute leukaemia .

HY-110354

UCM05 2 Publications Verification G28UCM	Fatty Acid Synthase (FASN) Bacterial	Infection
UCM05 (G28UCM) is a fatty acid synthase (FASN) and filamentous temperature-sensitive protein Z (Ftsz) inhibitor. UCM05 inhibits fatty acid synthesis, viral replication, and Gram-positive bacterial growth. UCM05 binds to FtsZ GTP-binding sites, inhibits GTPase activity, and disrupts Z-ring localization. UCM05 can be used for the research of HSV-1/2 infection, HIV-1 infection, and Gram-positive bacterial infections^[1][2][3].

HY-U00124B

Tromantadine hydrochloride 1 Publications Verification	HSV	Infection
Tromantadine hydrochloride, an Amantadine derivative with antiherpetic activity, inhibits herpes simplex virus type 1 (HSV-1) and *HSV-2* replication .

HY-P5997

XQ2B	Autophagy Cyclic GMP-AMP Synthase	Inflammation/Immunology
XQ2B is a specific cGAS inhibitor targeting protein-DNA interaction and phase separation. XQ2B markedly reduces ISD-induced Autophagy. XQ2B inhibits herpes simplex virus 1 (HSV-1)-induced antiviral immune responses and enhances HSV-1 infection .

HY-17425AR

Valacyclovir hydrochloride (Standard) Valaciclovir hydrochloride (Standard)	Reference Standards HSV Antibiotic Bacterial	Infection Cancer
Valacyclovir (hydrochloride) (Standard) is the analytical standard of Valacyclovir (hydrochloride). This product is intended for research and analytical applications. Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an orally active antiviral agent for herpes simplex, herpes zoster, and herpes B. Valacyclovir hydrochloride inhibits *HSV-1* W (₅₀=2.9 μg/ml). Valacyclovir hydrochloride is a proagent of Aciclovir (HY-17422) .

HY-117025A

Manzamine A hydrochloride 2 Publications Verification Keramamine A hydrochloride	GSK-3 CDK Parasite Proton Pump HSV Autophagy	Infection Neurological Disease Cancer
Manzamine A hydrochloride, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC₅₀s of 10.2 μM and 1.5 μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride has antimalarial and anticancer activities. Manzamine A hydrochloride also shows potent activity against *HSV-1* .

HY-117025

Manzamine A Keramamine A	GSK-3 CDK Parasite Proton Pump HSV Autophagy	Infection Neurological Disease Cancer
Manzamine A, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC₅₀s of 10.2 μM and 1.5 μM, respectively. Manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A has antimalarial and anticancer activities. Manzamine A also shows potent activity against *HSV-1* .

HY-15303A

Pritelivir mesylate 5+ Cited Publications AIC316 mesylate; BAY 57-1293 mesylate	DNA/RNA Synthesis HSV	Infection
Pritelivir mesylate (BAY 57-1293 mesylate), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir mesylate is active against herpes simplex virus types 1 and 2 (HSV-1 and *HSV-2) with the IC₅₀ of 0.02 μM against HSV*1-2 .

HY-50735

Fiacitabine NSC 382097; FIAC; FOAC	HSV EBV DNA/RNA Synthesis	Infection
Fiacitabine (NSC 382097; FIAC; FOAC) is a potent and highly selective anti-herpesvirus agent. Fiacitabine acts as an inhibitor of *HSV* DNA polymerase, with a K_i of 0.26 μM for HSV-1 and 0.42 μM for HSV-2, respectively. Fiacitabine can be efficiently phosphorylated by thymidine kinase encoded by the virus itself to generate FIACTP, an active triphosphate metabolite. Fiacitabine is applicable to research related to herpesvirus infections .

HY-148169

2'-Deoxy-L-guanosine	Nucleoside Antimetabolite/Analog	Infection
2'-Deoxy-L-guanosine selectively inhibits D-Thymidine phosphorylation catalyzed by HSV 1 thymidine kinase. 2'-Deoxy-L-guanosine is the L-configuration of 2'-Deoxyguanosine (HY-17563) .

HY-106892

BW 348U87 348U87	DNA/RNA Synthesis	Infection
BW 348U87 is an inhibitor for ribonucleotide reductase, which exhibits synergistic effect with Acyclovir (HY-17422), potentiate the antiviral activity of Acyclovir against herpes simplex virus (HSV) in athymic nude mouse model .

HY-163529

HN0037	HSV Cytochrome P450	Infection
HN0037 is a selective, orally active Helicase-primase inhibitor. HN0037 is mainly metabolized by CYP3A4. HN0037 inhibits *HSV* replication by targeting the viral helicase-primase complex, which consists of three proteins encoded by UL5 (helicase), UL52 (primase), and UL8 (scaffold protein that promotes primer synthesis) .

HY-131606

Cidofovir diphosphate	HSV CMV DNA/RNA Synthesis	Infection
Cidofovir diphosphate is an active intracellular metabolite of Cidofovir. Cidofovir diphosphate is a selective inhibitor of viral DNA polymerases with K_i values of 6.6, 0.86 and 1.4 μM for HCMV, HSV-1 and HSV-2 DNA polymerase, respectively .

HY-129861

5'-Ethynyl-2'-deoxycytidine	HSV	Infection Cancer
5'-Ethynyl-2'-deoxycytidine is an inhibitor for *HSV, that inhibits* the cytopathic effect of HSV-1 in primary rabbit kidney cell with a MIC of 0.2 μg/mL. 5'-Ethynyl-2'-deoxycytidine inhibits the proliferation of leukemia L1210 cell with an IC₅₀ of 64.5 μg/mL .

HY-122920

Soyasaponin II	HSV CMV Influenza Virus HIV NOD-like Receptor (NLR) YB-1	Infection Inflammation/Immunology
Soyasaponin II is a saponin with antiviral activity. Soyasaponin II inhibits the replication of HSV-1, HCMV, influenza virus, and HIV-1. Soyasaponin II shows potent inhibition on HSV-1 replication. Soyasaponin II serves as a inhibitor for YB-1 phosphorylation and NLRP3 inflammasome priming and could protect mice against LPS/GalN induced acute liver failure .

HY-W002008

5-Nitrobarbituric acid	HSV	Infection Inflammation/Immunology
5-Nitrobarbituric acid is a herpes simplex virus type-1 (HSV-1) inhibitor (IC₅₀=1.7 μM) .

HY-16592R

Brefeldin A (Standard) BFA (Standard); Cyanein (Standard); Decumbin (Standard)	Reference Standards Autophagy Mitophagy HSV Antibiotic Bacterial	Infection Cancer
Brefeldin A (Standard) (BFA (Standard)) is the analytical standard of Rutin. This product is intended for research and analytical applications. Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus. Brefeldin A is also an autophagy and mitophagy inhibitor. Brefeldin A inhibits HSV-1 and has anti-cancer activity.

HY-N11097

FK-3000	Apoptosis HSV HIV	Infection Cancer
FK-3000 is a potent anti-tumor agent that inhibits the growth of carcinoma cells through apoptosis and induction cell cycle arrest. FK-3000 also exhibit antiviral effects against *HSV-1* and HIV-1 .

HY-122704

Surfen Aminoquinuride	FGFR HSV Tau Protein	Infection Neurological Disease Inflammation/Immunology
Surfen is a potent heparan sulfate antagonist. Surfen inhibits FGF2 binding and signal transduction. Surfen binds to glycosaminoglycans and reduces tau hyperphosphorylation. Surfen inhibits the activity of recombinant uronyl 2-O-sulfotransferase with an IC₅₀ of approximately 2 μM. Surfen inhibits *HSV-1* viral infection. Surfen inhibits neural differentiation, delays remyelination, and alleviates EAE .

HY-14743B

Golotimod hydrochloride SCV 07 hydrochloride; Gamma-D-glutamyl-L-tryptophan hydrochloride	Bacterial STAT	Infection Inflammation/Immunology Cancer
Golotimod hydrochloride (SCV 07 hydrochloride), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod hydrochloride (SCV 07 hydrochloride) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod hydrochloride (SCV 07 hydrochloride) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2) .

HY-100272

B220	HSV CMV	Infection Cancer
B220 is an antiviral agent which can inhibit the growth of *HSV-1, HSV-2* and human cytomegalovirus (CMV).

HY-15303B

Pritelivir mesylate hydrate 5+ Cited Publications AIC316 mesylate hydrate; BAY 57-1293 mesylate hydrate	DNA/RNA Synthesis HSV	Infection
Pritelivir mesylate hydrate (BAY 57-1293 mesylate hydrate), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir mesylate hydrate is active against herpes simplex virus types 1 and 2 (HSV-1 and *HSV-2) with the IC₅₀ of 0.02 μM against HSV*1-2 .

HY-170547

DNA polymerase-IN-6	DNA/RNA Synthesis HSV EBV CMV	Infection
DNA polymerase-IN-6 is an antiviral agent and a DNA polymerase inhibitor. DNA polymerase-IN-6 inhibits the replication of HCMV, *HSV-1, HSV-2* and EBV. DNA polymerase-IN-6 exhibits low cytotoxicity in mammalian cells. DNA polymerase-IN-6 can be used in research related to viral infections .

Cat. No.	Product Name	Type

HY-B1773A

Sodium propionate

3 Publications Verification

Biochemical Assay Reagents

Sodium propionate is an orally active short-chain fatty acid. Sodium propionate can be produced by intestinal bacteria from the metabolism of dietary fiber. Sodium propionate increases PPAR-γ, inhibits NF-κB activation, and reduces COX-2 expression and NO production. Sodium propionate also induces Apoptosis and Autophagy. Sodium propionate reduces HSV-1-induced keratitis. Sodium propionate has anticancer effects against glioblastoma. Sodium propionate exhibits neuroprotective, antioxidant, and anti-inflammatory activities. Sodium propionate can be used in the research of spinal cord injury and Alzheimer's disease .

HY-125474

Carrageenan

1 Publications Verification

Biochemical Assay Reagents

Carrageenan is an antiviral and anticancer agent. Carrageenan inhibits herpes simplex virus (HSV), HIV, and hepatitis A virus (HAV) by directly binding to the viral capsid to block the attachment of viruses such as HPV to HSPG factors on the cell surface. Carrageenan delays and arrests cell cycle progression, exhibits cytotoxicity against HeLa cancer cells, and can be applied to studies related to cervical cancer, genital warts, hepatitis A, and other conditions. Carrageenan also induces acute non-immune inflammation, triggers a three-phase inflammatory response involving the release of multiple proinflammatory mediators, and causes persistent edema, hyperalgesia, and neutrophil recruitment in mice .

HY-B1773AR

Sodium propionate (Standard)

Biochemical Assay Reagents

Sodium propionate (Standard) is the analytical standard of Sodium propionate. This product is intended for research and analytical applications. Sodium propionate is an orally active short-chain fatty acid. Sodium propionate can be produced by intestinal bacteria from the metabolism of dietary fiber. Sodium propionate increases PPAR-γ, inhibits NF-κB activation, and reduces COX-2 expression and NO production. Sodium propionate also induces Apoptosis and Autophagy. Sodium propionate reduces HSV-1-induced keratitis. Sodium propionate has anticancer effects against glioblastoma. Sodium propionate exhibits neuroprotective, antioxidant, and anti-inflammatory activities. Sodium propionate can be used in the research of spinal cord injury and Alzheimer's disease .

Cat. No.	Product Name	Target	Research Area

HY-P2310

Defensin HNP-1 human	Bacterial Parasite Apoptosis HIV HSV CMV TNF Receptor NOD-like Receptor (NLR) DNA/RNA Synthesis Influenza Virus	Cardiovascular Disease Infection
Defensin HNP-1 human is a type of human neutrophil peptide (HNPs). Defensin HNP-1 human possesses immunomodulatory functions and can delay the apoptosis of neutrophils. Defensin HNP-1 human inhibits DNA/RNA/protein synthesis and interferes with metabolic pathways, thus exhibiting broad antibacterial activity. Defensin HNP-1 human has direct inactivation effects on HIV, HSV-1, HSV-2, CMV, influenza virus, etc. Defensin HNP-1 human has antileishmanial activity. Defensin HNP-1 human is involved in endothelial cell dysfunction during the early development of atherosclerosis .

HY-P2310A

Defensin HNP-1 human TFA	Bacterial Parasite Apoptosis HIV HSV CMV TNF Receptor Interleukin Related NOD-like Receptor (NLR) DNA/RNA Synthesis Influenza Virus	Cardiovascular Disease Infection
Defensin HNP-1 human TFA is a type of human neutrophil peptide (HNPs). Defensin HNP-1 human TFA possesses immunomodulatory functions and can delay the apoptosis of neutrophils. Defensin HNP-1 human TFA inhibits DNA/RNA/protein synthesis and interferes with metabolic pathways, thus exhibiting broad antibacterial activity. Defensin HNP-1 human TFA has direct inactivation effects on HIV, HSV-1, HSV-2, CMV, influenza virus, etc. Defensin HNP-1 human TFA has antileishmanial activity. Defensin HNP-1 human TFA is involved in endothelial cell dysfunction during the early development of atherosclerosis .

HY-P5997

XQ2B	Autophagy Cyclic GMP-AMP Synthase	Inflammation/Immunology
XQ2B is a specific cGAS inhibitor targeting protein-DNA interaction and phase separation. XQ2B markedly reduces ISD-induced Autophagy. XQ2B inhibits herpes simplex virus 1 (HSV-1)-induced antiviral immune responses and enhances HSV-1 infection .

HY-14743

Golotimod SCV 07; Gamma-D-glutamyl-L-tryptophan	Bacterial STAT	Infection Inflammation/Immunology Cancer
Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod (SCV-07) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod (SCV-07) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2) .

HY-P5642

Retrocyclin-101 RC-101	Bacterial Ser/Thr Protease Influenza Virus HSV SARS-CoV Toll-like Receptor (TLR) Fungal HIV Flavivirus	Infection Inflammation/Immunology
Retrocyclin-101 (RC-101) is a synthetic cyclic θ-defensin, a broad-spectrum antimicrobial peptide with anti-pathogen (covering viruses, bacteria and fungi) activity and anti-inflammatory activity. Retrocyclin-101 exhibits significant inhibitory activity against HIV, SARS-CoV-2, flaviviruses, influenza viruses, HSV-1/2, Staphylococcus aureus and others. Retrocyclin-101 inhibits TLR4 and TLR2-mediated signal transduction and reduces pro-inflammatory cytokine expression .

HY-P10371

PKHB1 txCD47	Reactive Oxygen Species (ROS) Thrombopoietin Receptor Mitochondrial Metabolism HSP HSV CD47	Infection Inflammation/Immunology Cancer
PKHB1 (txCD47) is a CD47 agonist and Thrombospondin-1 peptide mimetic. PKHB1 activates CD47 and triggers Caspase-independent, calcium-dependent cell death via mitochondrial alterations, ROS production, endoplasmic reticulum morphological changes, and dissipation of mitochondrial membrane potential. PKHB1 induces the exposure of Calreticulin, HSP70, and HSP90, thereby driving immunogenic cell death. PKHB1 promotes intratumoral CD8 ⁺T cell infiltration and inhibits breast tumorigenesis. PKHB1 reduces *HSV-1* levels and alleviates the severity of herpes simplex keratitis. PKHB1 can be used in research related to breast cancer, herpes simplex keratitis, and T-cell acute lymphoblastic leukemia .

HY-P5693

HBA(111–142)	Bacterial CMV HSV	Infection
HBA(111-142), an antimicrobial peptide, is a C-terminal 32-mer fragment of alpha-hemoglobin. HBA(111-142) has antibacterial activity against the ESKAPE panel of pathogens. HBA(111-142) forms amyloid fibrils, and has antiviral activities. HBA(111-142) inhibits measles and herpes viruses (HSV-1, HSV-2, HCMV) .

HY-14743R

Golotimod (Standard) SCV 07 (Standard); Gamma-D-glutamyl-L-tryptophan (Standard)	Bacterial STAT Reference Standards	Infection Inflammation/Immunology Cancer
Golotimod (Standard) is the analytical standard of Golotimod. This product is intended for research and analytical applications. Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod (SCV-07) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod (SCV-07) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2) .

HY-P11022

TL-119 A-3302-B	Endogenous Metabolite HSV TRP Channel	Infection Cancer
TL-119 (A-3302-B) is a polypeptide. TL-119 can be isolated from the bacteria Micromonospora sp. MAG 9-7 and Saccharomonospora sp. CNQ-490. TL-119 inhibits TRPV-1. TL-119 exhibits antiviral activity against *HSV-2*. TL-119 possesses anticancer activity against gastric cancer and colorectal cancer .

HY-P5642A

Retrocyclin-101 TFA RC-101 TFA	HIV SARS-CoV Influenza Virus Flavivirus HSV Bacterial Fungal Toll-like Receptor (TLR) Ser/Thr Protease	Infection Inflammation/Immunology
Retrocyclin-101 (RC-101) TFA is an artificially synthesized, cyclic-structured θ-defensin, a broad-spectrum agent with antimicrobial (covering viruses, bacteria, and fungi) activity and anti-inflammatory activity. Retrocyclin-101 TFA can inhibit the serine protease activity of ZIKV NS2B-NS3, with an IC₅₀ of 7.20 μM. Retrocyclin-101 TFA has significant inhibitory activity against HIV, SARS-CoV-2, flaviviruses, influenza viruses, HSV-1/2, Staphylococcus aureus, etc. Retrocyclin-101 TFA inhibits the signal transduction mediated by TLR4 and TLR2, reducing the expression of pro-inflammatory cytokines .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99147

Anti-Mouse TCR V gamma 2 Antibody (UC3-10A6)	CD3	Infection Inflammation/Immunology
Anti-Mouse TCR V gamma 2 Antibody (UC3-10A6) is an Armenian Hamster-derived IgG antibody inhibitor, targeting to mouse TCR V gamma 2. Anti-Mouse TCR V gamma 2 Antibody (UC3-10A6) reacts with an epitope on the delta chain of the mouse Vγ2 TCR (V gamma 2 T cell receptor). Anti-Mouse TCR V gamma 2 Antibody (UC3-10A6) can deplete γδ T cell. Anti-Mouse TCR V gamma 2 Antibody (UC3-10A6) can be used for the researches of infection and immunology, such as herpes simplex virus-1 (HSV-1) infection .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-16592

Brefeldin A Maximum Cited Publications 153 Publications Verification BFA; Cyanein; Decumbin	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Antiviral Disease Research Anticancer Disease Research Fields Source Classification	Autophagy Mitophagy HSV Antibiotic Bacterial
Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus . Brefeldin A is also an autophagy and mitophagy inhibitor . Brefeldin A inhibits *HSV-1* and has anti-cancer activity .

HY-13605

Cytarabine 90+ Cited Publications Cytosine β-D-arabinofuranoside; Cytosine Arabinoside; Ara-C	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Marine natural products Sponge Endogenous metabolite Disease Research Fields Source Classification	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog HSV Autophagy Apoptosis Endogenous Metabolite Orthopoxvirus
Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC₅₀ of 16 nM. Cytarabine has antiviral effects against *HSV*. Cytarabine shows anti-orthopoxvirus activity.

HY-N0469

L-Lysine 5+ Cited Publications	Microorganisms Classification of Application Fields Anti-aging Disease markers Endocrine diseases Amino acids Nervous System Disorder Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification Cancer	Endogenous Metabolite Virus Protease HSV
L-lysine is an essential amino acid for humans with orally activity. L-lysine can inhibit the occurrence of *HSV* infections and is used in herpes research. L-lysine increases calcium absorption, reduces diabetes-related diseases, improves gut health, and alleviates pancreatic inflammation. L-lysine can be used in research on metabolism, infection, and inflammation .

HY-N1067

Xanthohumol 15+ Cited Publications	Infection Chalcones Flavonoids Classification of Application Fields Humulus lupulus L. Phenols Polyphenols Plants Moraceae Disease Research Fields Source Classification	COX Acyltransferase Apoptosis HSV CMV Influenza Virus
Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, *HSV-1, HSV-2* and cytomegalovirus (CMV).

HY-N0415

Trigonelline chloride 5+ Cited Publications Trigonelline hydrochloride	Infection Alkaloids Erythrophleum fordii Oliv. Classification of Application Fields Labiatae Pyridine Alkaloids Metabolic Disease Plants Disease Research Fields Source Classification	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal
Trigonelline chloride is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline chloride is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline chloride also has anti-HSV-1, antibacterial, and antifungal activity, and induces ferroptosis.

HY-N0414

Trigonelline 5+ Cited Publications Trigenolline	Alkaloids Microorganisms other families Classification of Application Fields Leguminosae Pyridine Alkaloids Metabolic Disease Plants Endogenous metabolite Trigonella foenum-graecum Linn. Disease Research Fields Source Classification	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal
Trigonelline is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline also has anti-HSV-1, antibacterial, and antifungal activity and induces ferroptosis.

HY-N1992

Theaflavin 3,3'-digallate 5+ Cited Publications TF-3; ZP10	Infection Flavonoids Classification of Application Fields Flavanols Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Disease Research Fields Source Classification Theaceae	Virus Protease HSV HIV Flavivirus
Theaflavin 3,3'-digallate (TF-3) is a potent Zika virus (ZIKV) protease inhibitor with an IC₅₀ of 2.3 μM. Theaflavin 3,3'-digallat directly binds to ZIKVpro (K_d=8.86 μM) and inhibits ZIKV replication. Theaflavin 3,3'-digallat inhibits the activity of gp41 and NS2B-3 protease and has antiviral activity against *HSV* and HIV-1 . Theaflavin 3,3'-digallate, the typical pigment in black tea, is a potent antitumor agent .

HY-B0275

Oxytetracycline 5+ Cited Publications	Structural Classification Classification of Application Fields Antibacterial Disease Research Endogenous metabolite Other Antibiotics Plant agriculture research Infection Monophenols Microorganisms Antibiotics Resistance Selection Animal Husbandry Phenols Disease Research Fields Source Classification	Environmental Pollutants Antibiotic Endogenous Metabolite Bacterial HSV
Oxytetracycline is an antibiotic belonging to the tetracycline class. Oxytetracycline potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline also possesses anti-HSV-1 activity .

HY-N1430

Oxyresveratrol 3 Publications Verification trans-Oxyresveratrol	other families Stilbenes Classification of Application Fields Anti-aging Other Diseases Phenols Polyphenols Plants Disease Research Fields Source Classification	Tyrosinase HSV Autophagy
Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC₅₀ of 28.9 µM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive tyrosinase inhibitor with an IC₅₀ value of 1.2 µM for mushroom tyrosinase. Oxyresveratrol is effective against *HSV-1, HSV-2* and varicella-zoster virus, and has neuroprotective effects .

HY-17425A

Valacyclovir hydrochloride 1 Publications Verification Valaciclovir hydrochloride	Infection Classification of Application Fields Disease Research Fields	HSV Antibiotic Bacterial
Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an orally active antiviral agent for herpes simplex, herpes zoster, and herpes B. Valacyclovir hydrochloride inhibits *HSV-1* W (₅₀=2.9 μg/ml). Valacyclovir hydrochloride is a proagent of Aciclovir (HY-17422) .

HY-113289

Brassicasterol 1 Publications Verification	Infection Animals Classification of Application Fields Disease Research Fields Steroids Source Classification Cancer	Akt Androgen Receptor Bacterial Drug Metabolite HSV
Brassicasterol is a metabolite of Ergosterol and has cardiovascular protective effects. Brassicasterol exerts anticancer effects in prostate cancer through dual targeting of AKT and androgen receptor signaling pathways. Brassicasterol inhibits *HSV-1* (IC₅₀=1.2 μM) and Mycobacterium tuberculosis. Brassicasterol also inhibits sterol δ 24-reductase, slowing the progression of atherosclerosis. Brassicasterol is also a cerebrospinal fluid biomarker for Alzheimer's disease .

HY-B0275A

Oxytetracycline hydrochloride 5+ Cited Publications	Structural Classification Classification of Application Fields Antibacterial Disease Research Endogenous metabolite Other Antibiotics Infection Monophenols Microorganisms Antibiotics Phenols Disease Research Fields Source Classification	Environmental Pollutants Antibiotic Endogenous Metabolite Bacterial HSV
Oxytetracycline hydrochloride is an antibiotic belonging to the tetracycline class. Oxytetracycline hydrochloride potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline hydrochloride is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline hydrochloride also possesses anti-HSV-1 activity .

HY-N2004

Isoborneol 1 Publications Verification (±)-Isoborneol	Structural Classification Other Monoterpenes Terpenoids Curcuma aromatica Salisb. cv. Wenyujin Plants Source Classification Zingiberaceae	Environmental Pollutants HSV
Isoborneol ((±)-Isoborneol) is a monoterpenoid alcohol present in the essential oils of numerous medicinal plants and has antioxidant and antiviral properties. Isoborneol is a potent inhibitor of herpes simplex virus type 1 *(HSV-1)* .

HY-128744

Phosphonoacetic acid 2 Publications Verification	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Orthopoxvirus HSV DNA/RNA Synthesis
Phosphonoacetic acid is an endogenous metabolite and antiviral agent. Phosphonoacetic acid is active against orthopoxviruses and herpes viruses. Phosphonoacetic acid can inhibit *HSV* DNA synthesis and virus-specific DNA polymerase activity, and affect the synthesis of late viral proteins .

HY-B0275B

Oxytetracycline dihydrate 5+ Cited Publications	Infection Monophenols Microorganisms Classification of Application Fields Antibiotics Phenols Antibacterial Disease Research Endogenous metabolite Disease Research Fields Other Antibiotics Source Classification	Bacterial HSV Antibiotic Endogenous Metabolite
Oxytetracycline dihydrate is an antibiotic belonging to the tetracycline class. Oxytetracycline dihydrate potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline dihydrate is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline dihydrate also possesses anti-HSV-1 activity .

HY-N0772

Isomangiferin 4 Publications Verification	Infection Structural Classification Liliaceae Xanthones Classification of Application Fields Phenols Polyphenols Anemarrhena asphodeloides Bunge Plants Disease Research Fields Source Classification	VEGFR NOD-like Receptor (NLR) NF-κB Bacterial AMPK Acetyl-CoA Carboxylase Apoptosis Reactive Oxygen Species (ROS) HSV Drug Derivative
Isomangiferin is an orally active xanthone C-glucoside, and its chemical structure is similar to Mangiferin (HY-N0290). Isomangiferin is an effective VEGFR-2 kinase inhibitor, which can induces cell apoptosis, inhibit the growth, metastasis and angiogenesis of breast cancer. Isomangiferin exerts anti-inflammatory effects by inhibiting the HMGB1/NLRP3/NF-κB signaling pathway, thereby improving the renal function indicators of diabetic mice. Isomangiferin exhibits inhibitory effects on various bacteria and herpes simplex virus type 1 (HSV-1). Isomangiferin promotes the migration and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and reduces cell apoptosis and the production of ROS by activating the AMPK/ACC pathway, thereby facilitating fracture healing .

HY-N7719

Oosporein	Quinones Microorganisms Classification of Application Fields Other Diseases Benzene Quinones Disease Research Fields Source Classification	Endogenous Metabolite Bacterial Fungal Parasite Apoptosis Reactive Oxygen Species (ROS) Caspase HSV
Oosporein is a microbial metabolite and a red crystalline toxin produced by various fungi. Oosporein can promote the reproduction of fungi in host bodies by inhibiting insect immunity, and possesses multiple activities such as antibacterial, antiviral (HSV), and insecticidal effects. Oosporein can inhibit plant growth. In addition, Oosporein can also induce apoptosis, cell membrane damage, oxidative stress, and mitochondrial damage. Oosporein has certain antitumor activity .

HY-N2110

Phellopterin	Structural Classification Classification of Application Fields Coumarins Phenylpropanoids Umbelliferae Helogyne apaloidea Nutt. Plants Inflammation/Immunology Disease Research Fields Source Classification	Akt Sirtuin Integrin STAT PI3K Apoptosis ERK PPAR PKC Toll-like Receptor (TLR) HIV
Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating SIRT1, downregulating ICAM-1 (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the PU.1/CLEC5A/PI3K-AKT loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus .

HY-B0275AR

Oxytetracycline hydrochloride (Standard)	Structural Classification Monophenols Microorganisms Antibiotics Phenols Antibacterial Disease Research Endogenous metabolite Other Antibiotics Source Classification	Reference Standards Bacterial HSV Antibiotic Endogenous Metabolite
Oxytetracycline (hydrochloride) (Standard) is the analytical standard of Oxytetracycline (hydrochloride). This product is intended for research and analytical applications. Oxytetracycline hydrochloride is an antibiotic belonging to the tetracycline class. Oxytetracycline hydrochloride potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline hydrochloride is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline hydrochloride also possesses anti-HSV-1 activity .

HY-117025A

Manzamine A hydrochloride 2 Publications Verification Keramamine A hydrochloride	Infection Alkaloids Piperidine Alkaloids Neurological Disease Classification of Application Fields Animals Marine natural products Pyridine Alkaloids Sponge Disease Research Fields Indole Alkaloids Source Classification	GSK-3 CDK Parasite Proton Pump HSV Autophagy
Manzamine A hydrochloride, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC₅₀s of 10.2 μM and 1.5 μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride has antimalarial and anticancer activities. Manzamine A hydrochloride also shows potent activity against *HSV-1* .

HY-117025

Manzamine A Keramamine A	Infection Alkaloids Neurological Disease Classification of Application Fields Animals Marine natural products Sponge Disease Research Fields Cancer	GSK-3 CDK Parasite Proton Pump HSV Autophagy
Manzamine A, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC₅₀s of 10.2 μM and 1.5 μM, respectively. Manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A has antimalarial and anticancer activities. Manzamine A also shows potent activity against *HSV-1* .

HY-N12717

Casuarinin	Terminalia arjuna (Roxb. ex DC.) Wight & Arn. Structural Classification Combretaceae Phenols Polyphenols Plants Source Classification	PAK FASTK HSP p38 MAPK NF-κB NO Synthase COX HSV Caspase TNF Receptor Fungal Apoptosis
Casuarinin is an orally active antiproliferative, anti-inflammatory, antifungal, virucidal and gastroprotective agent. Casuarinin upregulates the expression of p21/WAF1, Fas/APO‑1, mFasL, sFasL and HSP‑70, arrests cell cycle, induces apoptosis and inhibits cancer cell proliferation. Casuarinin inhibits TNF‑α-induced phosphorylation of MAPK and activation of NF‑κB, downregulates the expression of iNOS, NF‑κB, COX‑2 and ICAM‑1, and reduces the production of proinflammatory mediators. Casuarinin attenuates ethanol-induced activation of caspase‑3 and elevation of TNF‑α, inhibits the growth of *Candida albicans, and inhibits* *HSV‑2*. Casuarinin can be used in research related to mammary adenocarcinoma, inflammatory skin diseases, gastric ulcers, candidiasis and herpes simplex virus infections .

HY-N0469R

L-Lysine (Standard)	Structural Classification Microorganisms Disease markers Endocrine diseases Amino acids Nervous System Disorder Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Virus Protease HSV
L-Lysine (Standard) is the analytical standard of L-Lysine. This product is intended for research and analytical applications. L-lysine is an essential amino acid for humans with orally activity. L-lysine can inhibit the occurrence of *HSV* infections and is used in herpes research. L-lysine increases calcium absorption, reduces diabetes-related diseases, improves gut health, and alleviates pancreatic inflammation. L-lysine can be used in research on metabolism, infection, and inflammation . IC₅₀ & Target:L-lysine (150 mg/kg) promotes, but not initiates, bladder cancer. The administration of L-lysine to rats submitted to colovesical cystoplasty accelerates the development of transitional metaplasia of the intestinal epithelium . L-lysine (10 mg/kg) treatment attenuates pancreatic tissue injury induced by L-arginine by inhibiting the release of the inflammatory cytokine IL-6 and enhance antioxidant activity . In Vivo:L-lysine (10?mg/kg, p.o., pre-treated or post-treated, administration duration 15 days) treatment attenuates pancreatic tissue injury induced by L-arginine by inhibiting the release of the inflammatory cytokine IL-6 and enhance antioxidant activity in acute pancreatitis mice model . L-lysine (5 or 10?mg/kg, p.o., 45 days) ameliorates sepsis-induced acute lung injury in a lipopolysaccharide (HY-D1056)-induced mouse model .

HY-13605R

Cytarabine (Standard) Cytosine β-D-arabinofuranoside (Standard); Cytosine Arabinoside (Standard); Ara-C (Standard)	Structural Classification Natural Products Microorganisms Marine natural products Sponge Endogenous metabolite Source Classification	Reference Standards DNA/RNA Synthesis Nucleoside Antimetabolite/Analog HSV Autophagy Apoptosis Endogenous Metabolite Orthopoxvirus
Cytarabine (Standard) is the analytical standard of Cytarabine. This product is intended for research and analytical applications. Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC₅₀ of 16 nM. Cytarabine has antiviral effects against *HSV*. Cytarabine shows anti-orthopoxvirus activity.

HY-N0414R

Trigonelline (Standard) Trigenolline (Standard)	Alkaloids Structural Classification Microorganisms other families Leguminosae Pyridine Alkaloids Plants Endogenous metabolite Trigonella foenum-graecum Linn. Source Classification	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal Reference Standards
Trigonelline (Standard) is the analytical standard of Trigonelline. This product is intended for research and analytical applications. Trigonelline is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline also has anti-HSV-1, antibacterial, and antifungal activity and induces ferroptosis.

HY-122920

Soyasaponin II	Triterpenes Classification of Application Fields Leguminosae Terpenoids Plants Inflammation/Immunology Disease Research Fields Glycine soja Sieb. Et Zucc. Source Classification	HSV CMV Influenza Virus HIV NOD-like Receptor (NLR) YB-1
Soyasaponin II is a saponin with antiviral activity. Soyasaponin II inhibits the replication of HSV-1, HCMV, influenza virus, and HIV-1. Soyasaponin II shows potent inhibition on HSV-1 replication. Soyasaponin II serves as a inhibitor for YB-1 phosphorylation and NLRP3 inflammasome priming and could protect mice against LPS/GalN induced acute liver failure .

HY-16592R

Brefeldin A (Standard) BFA (Standard); Cyanein (Standard); Decumbin (Standard)	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Antiviral Disease Research Anticancer Source Classification	Reference Standards Autophagy Mitophagy HSV Antibiotic Bacterial
Brefeldin A (Standard) (BFA (Standard)) is the analytical standard of Rutin. This product is intended for research and analytical applications. Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus. Brefeldin A is also an autophagy and mitophagy inhibitor. Brefeldin A inhibits HSV-1 and has anti-cancer activity.

HY-N11097

FK-3000	Alkaloids Piperidine Alkaloids Plants Stephania delavayi Diels Menispermaceae Source Classification	Apoptosis HSV HIV
FK-3000 is a potent anti-tumor agent that inhibits the growth of carcinoma cells through apoptosis and induction cell cycle arrest. FK-3000 also exhibit antiviral effects against *HSV-1* and HIV-1 .

HY-N7719R

Oosporein (Standard)	Quinones Microorganisms Benzene Quinones Source Classification	Endogenous Metabolite Reference Standards Bacterial Fungal Parasite Apoptosis Reactive Oxygen Species (ROS) Caspase HSV
Oosporein (Standard) is the analytical standard of Oosporein (HY-N7719). This product is intended for research and analytical applications. Oosporein is a microbial metabolite and a red crystalline toxin produced by various fungi. Oosporein can promote the reproduction of fungi in host bodies by inhibiting insect immunity, and possesses multiple activities such as antibacterial, antiviral (HSV), and insecticidal effects. Oosporein can inhibit plant growth. In addition, Oosporein can also induce apoptosis, cell membrane damage, oxidative stress, and mitochondrial damage. Oosporein has certain antitumor activity .

HY-N1067R

Xanthohumol (Standard)	Structural Classification Chalcones Flavonoids Humulus lupulus L. Phenols Polyphenols Plants Moraceae Source Classification	Reference Standards COX Acyltransferase Apoptosis HSV CMV Influenza Virus
Xanthohumol (Standard) is the analytical standard of Xanthohumol. This product is intended for research and analytical applications. Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2 and cytomegalovirus (CMV).

HY-N1430R

Oxyresveratrol (Standard) trans-Oxyresveratrol (Standard)	Structural Classification other families Stilbenes Phenols Polyphenols Plants Source Classification	Reference Standards Tyrosinase HSV Autophagy
Oxyresveratrol (Standard) is the analytical standard of Oxyresveratrol. This product is intended for research and analytical applications. Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC50 of 28.9 μM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive tyrosinase inhibitor with an IC50 value of 1.2 μM for mushroom tyrosinase. Oxyresveratrol is effective against HSV-1, HSV-2 and varicella-zoster virus, and has neuroprotective effects .

HY-N4299

Caesappanin C	Structural Classification Classification of Application Fields Leguminosae Caesalpinia sappan L. Other Phenylpropanoids Phenols Polyphenols Metabolic Disease Phenylpropanoids Plants Disease Research Fields Source Classification	HSV HSP
Caesappanin C, a biphenyl dimer from the ethanolic extract of the heartwood of Indonesian Caesalpinia sappan L., shows strong proliferation stimulating activity against the primary osteoblastic cells in vitro. Caesappanin C has the potential to stimulate bone formation and regeneration . Caesappanin C can effectively deactivate HSV particles and bind HSV surface glycoprotein B (gB) to inhibit membrane fusion .

HY-N2812

Epipodophyllotoxin acetate 4-O-Epipodophyllotoxinyl acetate	Cupressaceae Lignans Phenylpropanoids Plants Source Classification	HSV VSV
Epipodophyllotoxin acetate (4-O-Epipodophyllotoxinyl acetate; compound 4) is a cyclolignan that exhibits antineoplastic and antiviral activities. Epipodophyllotoxin acetate inhibits *HSV* and VSV, with IC₅₀s of 0.2 and 0.1 μg/mL, respectively .

HY-N15215

Antiviral agent 64	Structural Classification Monophenols Phenols Alpinia officinarum Hance Plants Source Classification Zingiberaceae	Enterovirus Influenza Virus RSV HSV
Antiviral agent 64 (Compound 12) is a diarylheptanoid that can be isolated from Alpinia officinarum. Antiviral agent 64 exhibits cytotoxicity in human neuroblastoma cell IMR-32 with an IC₅₀ of 0.23 μM. Antiviral agent 64 exhibits antiviral efficacy, that inhibits RSV, poliovirus, measles virus, *HSV-1, and influenza virus H1N1, with EC₅₀* of 13.3, 3.7, 6.3, 5.7, and <10 μg/mL, respectively .

HY-B0275C

Oxytetracycline calcium	Infection Quinones Classification of Application Fields Anthraquinones Endogenous metabolite Disease Research Fields Source Classification	Bacterial HSV Antibiotic Endogenous Metabolite
Oxytetracycline calcium is an antibiotic belonging to the tetracycline class. Oxytetracycline calcium potently inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline calcium is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline calcium also possesses anti-HSV-1 activity .

HY-B0275R

Oxytetracycline (Standard)	Structural Classification Antibacterial Disease Research Endogenous metabolite Other Antibiotics Plant agriculture research Monophenols Microorganisms Antibiotics Resistance Selection Animal Husbandry Phenols Source Classification	Reference Standards Bacterial HSV Endogenous Metabolite Antibiotic
Oxytetracycline (Standard) is the analytical standard of Oxytetracycline. This product is intended for research and analytical applications. Oxytetracycline is an antibiotic belonging to the tetracycline class. Oxytetracycline potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline also possesses anti-HSV-1 activity .

HY-N0415R

Trigonelline chloride (Standard) Trigonelline hydrochloride (Standard)	Alkaloids Structural Classification Erythrophleum fordii Oliv. Labiatae Pyridine Alkaloids Plants Source Classification	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal Reference Standards
Trigonelline (chloride) (Standard) is the analytical standard of Trigonelline (chloride). This product is intended for research and analytical applications. Trigonelline chloride is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline chloride is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline chloride also has anti-HSV-1, antibacterial, and antifungal activity, and induces ferroptosis.

HY-N1992R

Theaflavin 3,3'-digallate (Standard) TF-3 (Standard); ZP10 (Standard)	Structural Classification Flavonoids Flavanols Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Source Classification Theaceae	Reference Standards Virus Protease HSV HIV Flavivirus
Theaflavin 3,3'-digallate (Standard) is the analytical standard of Theaflavin 3,3'-digallate. This product is intended for research and analytical applications. Theaflavin 3,3'-digallate (TF-3) is a potent Zika virus (ZIKV) protease inhibitor with an IC₅₀ of 2.3 μM. Theaflavin 3,3'-digallat directly binds to ZIKVpro (Kd=8.86 μM) and inhibits ZIKV replication. Theaflavin 3,3'-digallat inhibits the activity of gp41 and NS2B-3 protease and has antiviral activity against HSV and HIV-1 . Theaflavin 3,3'-digallate, the typical pigment in black tea, is a potent antitumor agent .

HY-N2110R

Phellopterin (Standard)	Structural Classification Coumarins Phenylpropanoids Umbelliferae Helogyne apaloidea Nutt. Plants Source Classification	Reference Standards Akt Sirtuin Integrin STAT PI3K Apoptosis ERK PPAR PKC Toll-like Receptor (TLR) HIV
Phellopterin (Standard) is the analytical standard of Phellopterin. Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating SIRT1, downregulating ICAM-1 (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the PU.1/CLEC5A/PI3K-AKT loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus.

HY-N14446

Karalicin	Natural Products Microorganisms Source Classification	HSV
Karalicin inhibits herpes simplex virus HSV-1, HSV-2, vaccinia virus, polio virus type I with the IC₅₀s (μg/mL) of 0.004, 0.008, 0.016 and 0.016 .

HY-N10177

Peniterphenyl A	Infection Microorganisms Classification of Application Fields Phenols Polyphenols Disease Research Fields Source Classification	HSV
Peniterphenyl A is a natural product obtained from a deep-sea-derived Penicillium sp. Peniterphenyl A inhibits *HSV-1/2* virus entry into cells and may block HSV-1/2 infection through direct interaction with virus envelope glycoprotein D to interfere with virus adsorption and membrane fusion. Peniterphenyl A is a promising lead compound against HSV-1/2 .

HY-111801

Woodorien	Blechnaceae Plants Woodwardia orientalis Sw. Saccharides Monosaccharides Source Classification	HSV
Woodorien is a potent *HSV-1* inhibitor. Woodorien also is a glucoside that can be isolated from Woodwardia orientalis .

HY-N2004R

Isoborneol (Standard) (±)-Isoborneol (Standard)	Structural Classification Natural Products Curcuma aromatica Salisb. cv. Wenyujin Plants Source Classification Zingiberaceae	Reference Standards HSV
Isoborneol (Standard) is the analytical standard of Isoborneol. This product is intended for research and analytical applications. Isoborneol ((±)-Isoborneol) is a monoterpenoid alcohol present in the essential oils of numerous medicinal plants and has antioxidant and antiviral properties. Isoborneol is a potent inhibitor of herpes simplex virus type 1 (HSV-1) .

HY-128744R

Phosphonoacetic acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Orthopoxvirus HSV DNA/RNA Synthesis
Phosphonoacetic acid (Standard) is the analytical standard of Phosphonoacetic acid (HY-128744). This product is intended for research and analytical applications. Phosphonoacetic acid is an endogenous metabolite and antiviral agent. Phosphonoacetic acid is active against orthopoxviruses and herpes viruses. Phosphonoacetic acid can inhibit *HSV* DNA synthesis and virus-specific DNA polymerase activity, and affect the synthesis of late viral proteins .

HY-N0772R

Isomangiferin (Standard)	Structural Classification Liliaceae Xanthones Phenols Polyphenols Anemarrhena asphodeloides Bunge Plants Source Classification	Reference Standards VEGFR NF-κB NOD-like Receptor (NLR) AMPK Acetyl-CoA Carboxylase Apoptosis Reactive Oxygen Species (ROS) HSV Drug Derivative
Isomangiferin (Standard) is the analytical standard of Isomangiferin (HY-N0772). This product is intended for research and analytical applications. Isomangiferin is an orally active xanthone C-glucoside, and its chemical structure is similar to Mangiferin (HY-N0290). Isomangiferin is an effective VEGFR-2 kinase inhibitor, which can induces cell apoptosis, inhibit the growth, metastasis and angiogenesis of breast cancer. Isomangiferin exerts anti-inflammatory effects by inhibiting the HMGB1/NLRP3/NF-κB signaling pathway, thereby improving the renal function indicators of diabetic mice. Isomangiferin exhibits inhibitory effects on various bacteria and herpes simplex virus type 1 (HSV-1). Isomangiferin promotes the migration and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and reduces cell apoptosis and the production of ROS by activating the AMPK/ACC pathway, thereby facilitating fracture healing.

HY-B0275BR

Oxytetracycline dihydrate (Standard)	Structural Classification Monophenols Microorganisms Antibiotics Phenols Antibacterial Disease Research Endogenous metabolite Other Antibiotics Source Classification	Reference Standards Bacterial HSV Antibiotic Endogenous Metabolite
Oxytetracycline (dihydrate) (Standard) is the analytical standard of Oxytetracycline (dihydrate). This product is intended for research and analytical applications. Oxytetracycline dihydrate is an antibiotic belonging to the tetracycline class. Oxytetracycline dihydrate potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline dihydrate is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline dihydrate also possesses anti-HSV-1 activity .

Cat. No.	Product Name	Chemical Structure

HY-B1773AS3

Sodium propionate-13C3

Sodium propionate- ¹³C-3 is the ¹³C-labeled Propionate sodium (HY-B1773A). Sodium propionate is an orally active short-chain fatty acid. Sodium propionate can be produced by intestinal bacteria from the metabolism of dietary fiber. Sodium propionate increases PPAR-γ, inhibits NF-κB activation, and reduces COX-2 expression and NO production. Sodium propionate also induces Apoptosis and Autophagy. Sodium propionate reduces HSV-1-induced keratitis. Sodium propionate has anticancer effects against glioblastoma. Sodium propionate exhibits neuroprotective, antioxidant, and anti-inflammatory activities. Sodium propionate can be used in the research of spinal cord injury and Alzheimer's disease .

HY-17422S1

Acyclovir-d4

Acyclovir-d₄ is the deuterium labeled Acyclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent. Acyclovir inhibits HSV-1 (IC₅₀ of 0.85 μM), HSV-2 (IC₅₀ of 0.86 μM) and varicella-zoster virus. Acyclovir can be phosphorylated by viral thymidine kinase (TK), and Acyclovir triphosphate interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate and obligatory chain termination . Acyclovir prevents bacterial infections during induction therapy for acute leukaemia .

HY-B0275S

Oxytetracycline-d6
Oxytetracycline-d₆ is deuterium labeled Oxytetracycline. Oxytetracycline is an antibiotic belonging to the tetracycline class. Oxytetracycline potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline also possesses anti-HSV-1 activity .

HY-B1773AS4

Sodium propionate-d5

Sodium propionate-d₅ is the deuterium labeled Propionate sodium (HY-B1773A). Sodium propionate is an orally active short-chain fatty acid. Sodium propionate can be produced by intestinal bacteria from the metabolism of dietary fiber. Sodium propionate increases PPAR-γ, inhibits NF-κB activation, and reduces COX-2 expression and NO production. Sodium propionate also induces Apoptosis and Autophagy. Sodium propionate reduces HSV-1-induced keratitis. Sodium propionate has anticancer effects against glioblastoma. Sodium propionate exhibits neuroprotective, antioxidant, and anti-inflammatory activities. Sodium propionate can be used in the research of spinal cord injury and Alzheimer's disease .

HY-B1773AS

Sodium propionate-13C

Sodium propionate- ¹³C is the ¹³C labeled Propionate sodium (HY-B1773A). Sodium propionate is an orally active short-chain fatty acid. Sodium propionate can be produced by intestinal bacteria from the metabolism of dietary fiber. Sodium propionate increases PPAR-γ, inhibits NF-κB activation, and reduces COX-2 expression and NO production. Sodium propionate also induces Apoptosis and Autophagy. Sodium propionate reduces HSV-1-induced keratitis. Sodium propionate has anticancer effects against glioblastoma. Sodium propionate exhibits neuroprotective, antioxidant, and anti-inflammatory activities. Sodium propionate can be used in the research of spinal cord injury and Alzheimer's disease .

HY-13637S

Ganciclovir-d5

Ganciclovir-d₅ is the deuterium labeled Ganciclovir. Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC₅₀ of 5.2 μM for feline herpesvirus type-1 (FHV-1) .

HY-B0275S1

Oxytetracycline-d3

Oxytetracycline-d₃ is the deuterium labeled Oxytetracycline (HY-B0275). Oxytetracycline is an antibiotic belonging to the tetracycline class. Oxytetracycline potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline also possesses anti-HSV-1 activity .

HY-B1773AS5

Sodium propionate-d3

Sodium propionate-d₃ is the deuterium labeled Propionate sodium (HY-B1773A). Sodium propionate is an orally active short-chain fatty acid. Sodium propionate can be produced by intestinal bacteria from the metabolism of dietary fiber. Sodium propionate increases PPAR-γ, inhibits NF-κB activation, and reduces COX-2 expression and NO production. Sodium propionate also induces Apoptosis and Autophagy. Sodium propionate reduces HSV-1-induced keratitis. Sodium propionate has anticancer effects against glioblastoma. Sodium propionate exhibits neuroprotective, antioxidant, and anti-inflammatory activities. Sodium propionate can be used in the research of spinal cord injury and Alzheimer's disease .

HY-17425AS

Valacyclovir-d8 hydrochloride
Valacyclovir-d₈ (hydrochloride) is the deuterium labeled Valacyclovir hydrochloride. Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an orally active antiviral agent for herpes simplex, herpes zoster, and herpes B. Valacyclovir hydrochloride inhibits HSV-1 W (50=2.9 μg/ml). Valacyclovir hydrochloride is a proagent of Aciclovir (HY-17422) .

HY-17425AS1

Valacyclovir-d4 hydrochloride
Valacyclovir-d₄ (hydrochloride) is the deuterium labeled Valacyclovir hydrochloride. Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an orally active antiviral agent for herpes simplex, herpes zoster, and herpes B. Valacyclovir hydrochloride inhibits HSV-1 W (50=2.9 μg/ml). Valacyclovir hydrochloride is a proagent of Aciclovir (HY-17422) .

HY-A0061S

Trifluridine-13C,15N2
Trifluridine- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Trifluridine . Trifluridine (Trifluorothymidine;5-Trifluorothymidine;TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral agent for herpes simplex virus (HSV) infection. Trifluorothymidine also has anti-orthopoxvirus activity .

HY-W755036

Oxytetracycline-13C,d3 hydrochloride

Oxytetracycline-13C,d3 hydrochloride is the 13C- and deuterium labeled Oxytetracycline hydrochloride (HY-B0275A). Oxytetracycline hydrochloride is an antibiotic that exhibits board-spectrum antibacterial activity. Oxytetracycline hydrochloride is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline hydrochloride also possesses anti-HSV-1 activity .

HY-W766548

Floxuridine-13C,15N2

Floxuridine- ¹³C, ¹⁵N₂ (5-Fluorouracil 2'-deoxyriboside- ¹³C, ¹⁵N₂) is the ¹³C- and ¹⁵N-labeled labeled Floxuridine (HY-B0097). Floxuridine (5-Fluorouracil 2'-deoxyriboside) is a pyrimidine analog and known as an oncology antimetabolite. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage by activating the ATM and ATR checkpoint signaling pathways in vitro. Floxuridine is a extreamly potent inhibitor for S. aureus infection and induces cell apoptosis . Floxuridine has antiviral effects against HSV and CMV .

HY-15303S

Pritelivir-d4-1
Pritelivir-d₄-1 (AIC316-d₄-1) is deuterium labeled Pritelivir. Pritelivir (AIC316), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir is active against herpes simplex virus types 1 and 2 (HSV-1 and *HSV-2) with the IC₅₀ of 0.02 μM against HSV*1-2 .

HY-13605S

Cytarabine-d2
Cytarabine-d₂ is the deuterium labeled Cytarabine. Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC₅₀ of 16 nM. Cytarabine has antiviral effects against HSV .

HY-B1773AS1

Sodium propionate-13C-1

Sodium propionate- ¹³C-1 is the ¹³C-labeled Propionate sodium (HY-B1773A). Sodium propionate is an orally active short-chain fatty acid. Sodium propionate can be produced by intestinal bacteria from the metabolism of dietary fiber. Sodium propionate increases PPAR-γ, inhibits NF-κB activation, and reduces COX-2 expression and NO production. Sodium propionate also induces Apoptosis and Autophagy. Sodium propionate reduces HSV-1-induced keratitis. Sodium propionate has anticancer effects against glioblastoma. Sodium propionate exhibits neuroprotective, antioxidant, and anti-inflammatory activities. Sodium propionate can be used in the research of spinal cord injury and Alzheimer's disease .

HY-N0415S1

Trigonelline-d3-1 chloride

Trigonelline-d₃-1 chloride (Trigonelline-d₃-1 hydrochloride) is the deuterium labeled Trigonelline chloride (HY-N0415). Trigonelline chloride is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline chloride is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline chloride also has anti-HSV-1, antibacterial, and antifungal activity, and induces ferroptosis.

Cat. No.	Product Name		Classification

HY-129861

5'-Ethynyl-2'-deoxycytidine		Alkynes
5'-Ethynyl-2'-deoxycytidine is an inhibitor for *HSV, that inhibits* the cytopathic effect of HSV-1 in primary rabbit kidney cell with a MIC of 0.2 μg/mL. 5'-Ethynyl-2'-deoxycytidine inhibits the proliferation of leukemia L1210 cell with an IC₅₀ of 64.5 μg/mL .

Cat. No.	Product Name		Classification

HY-113289

Brassicasterol 1 Publications Verification		Cholesterol
Brassicasterol is a metabolite of Ergosterol and has cardiovascular protective effects. Brassicasterol exerts anticancer effects in prostate cancer through dual targeting of AKT and androgen receptor signaling pathways. Brassicasterol inhibits *HSV-1* (IC₅₀=1.2 μM) and Mycobacterium tuberculosis. Brassicasterol also inhibits sterol δ 24-reductase, slowing the progression of atherosclerosis. Brassicasterol is also a cerebrospinal fluid biomarker for Alzheimer's disease .

HY-113431

Arabinosylhypoxanthine		Nucleoside Analogs
Arabinosylhypoxanthine is a purine nucleoside analog. Arabinosylhypoxanthine selectively inhibits viral DNA synthesis. Arabinosylhypoxanthine exhibits anti-HSV activity. Arabinosylhypoxanthine can be used in studies related to herpes simplex virus infection .

HY-148169

2'-Deoxy-L-guanosine		Nucleoside Analogs Guanosine
2'-Deoxy-L-guanosine selectively inhibits D-Thymidine phosphorylation catalyzed by HSV 1 thymidine kinase. 2'-Deoxy-L-guanosine is the L-configuration of 2'-Deoxyguanosine (HY-17563) .

HY-177638

ISIS 1082		Antisense Oligonucleotides
ISIS 1082 is an antisense oligonucleotide targeted to the translation initiation codon of herpes simplex virus (HSV) type 1 and 2 virion capsid protein. It has been shown to inhibit HSV-1 replication in vitro

HY-W011079

5-Iodouridine 1 Publications Verification		Nucleoside Analogs Uridine
5-Iodouridine is an iodine-containing pyrimidine nucleoside analog. 5-Iodouridine inhibits dihydroorotase with a K_i value of 340 µM. 5-Iodouridine significantly enhances the cell-killing effect of gamma irradiation. 5-Iodouridine can be used in the research of HSV-1 infection and leukemia .

HY-177638A

ISIS 1082 sodium		Antisense Oligonucleotides
ISIS 1082 sodium is an antisense oligonucleotide targeted to the translation initiation codon of herpes simplex virus (HSV) type 1 and 2 virion capsid protein. It has been shown to inhibit HSV-1 replication in vitro

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