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1320

Inhibitors & Agonists

Screening Libraries

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Peptides

Inhibitory Antibodies

176

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N1150

Thymidine 20+ Cited Publications DThyd; NSC 21548	DNA/RNA Synthesis Endogenous Metabolite Orthopoxvirus	Cancer
Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication .

HY-10241

Simeprevir 40+ Cited Publications TMC435; TMC435350	HCV HCV Protease SARS-CoV DNA/RNA Synthesis	Infection
Simeprevir (TMC435; TMC435350) is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a K_i of 0.36 nM. Simeprevir inhibits HCV replication with an EC₅₀ of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (M ^pro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses .

HY-W011834

2'-O-Methylcytidine	HCV DNA/RNA Synthesis	Infection
2'-O-Methylcytidine is an orally active 2'-substituted nucleoside as a inhibitor of HCV replication with antiviral activity. 2'-O-Methylcytidine inhibits RNA-dependent RNA polymerase (NS5B)-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate .

HY-129983

5-Hydroxymethyl-2'-deoxyuridine	HSV	Infection Cancer
5-Hydroxymethyl-2'-deoxyuridine is a nucleoside analog. 5-Hydroxymethyl-2'-deoxyuridine inhibits the replication of multiple human leukemia cell lines with IC₅₀ values of 1.7-5.8 μM. 5-Hydroxymethyl-2'-deoxyuridine prolongs the survival of mice carrying L1210 leukemia. 5-Hydroxymethyl-2'-deoxyuridine can be used for the research of cell replication and leukemia .

HY-N0457A

L-Chicoric Acid 3 Publications Verification (-)-Chicoric acid; trans-Caffeoyltartaric acid	HIV Integrase HIV Endogenous Metabolite	Infection Cancer
L-Chicoric Acid ((-)-Chicoric acid) is a dicaffeoyltartaric acid and a potent, selective and reversible HIV-1 integrase inhibitor with an IC₅₀ of ~100 nM. L-Chicoric Acid inhibits HIV-1 replication in tissue culture .

HY-128370

Calcium trinatrium diethylenetriaminepentaacetic acid hydrate Ca-DTPA trisodium salt hydrate	CMV	Infection
Calcium trinatrium diethylenetriaminepentaacetic acid hydrate (Ca-DTPA trisodium salt hydrate) is a metal chelator and a useful antidote (such as acute cadmium intoxication). Diethylenetriaminepentaacetic acid calcium trisodium salt hydrate is a nontoxic inhibitor of CMV replication .

HY-107760

Decanoyl-RVKR-CMK 1 Publications Verification DecRVKRcmk	HIV	Infection Inflammation/Immunology
Decanoyl-RVKR-CMK (DecRVKRcmk) inhibits over-expressed gp160 processing and HIV-1 replication .

HY-W011100

Cyclofenil	Dengue Virus Estrogen Receptor/ERR Flavivirus	Infection Endocrinology
Cyclofenil is a selective estrogen receptor modulator and an ovulation-inducing agent. Cyclofenil shows an inhibitory effect on dengue virus replication in Vero cells with an EC₅₀ of 1.62 μM. Cyclofenil has anti-dengue-virus activity .

HY-50001

Nucleozin 5+ Cited Publications	Influenza Virus	Infection
Nucleozin, a potent inhibitor of influenza A virus infection, induces the formation of nucleoprotein (NP) aggregates and antagonizes its nuclear accumulation, leading to cessation of viral replication. Nucleozin impedes influenza A virus replication in vitro with a nanomolar EC₅₀ .

HY-B0738

Dithranol Anthralin	DNA/RNA Synthesis	Inflammation/Immunology
Dithranol (Anthralin) is an anthraquinone derivative, with potent anti-psoriatic effects. Dithranol can inhibit DNA replication and repair .

HY-111397

Bizelesin 1 Publications Verification NSC 615291; U-77779	DNA Alkylator/Crosslinker	Cancer
Bizelesin (NSC 615291; U-77779) is an AT-specific DNA alkylating agent that can generate DNA interstrand crosslinks, effectively inhibit DNA replication, and has potential anticancer activity .

HY-N3242

Moronic acid 1 Publications Verification (+)-Moronic acid	HIV Reactive Oxygen Species (ROS) NOD-like Receptor (NLR)	Infection Inflammation/Immunology
Moronic Acid is a triterpenoid compound, which is an orally available anti-HIV agent with anti-inflammatory activity. Moronic Acid can inhibit viral replication, with an EC₅₀ value of <1 μg/mL. Moronic Acid can be isolated from Brazilian propolis .

HY-107760A

Decanoyl-RVKR-CMK TFA 1 Publications Verification DecRVKRcmk TFA	HIV	Infection Inflammation/Immunology
Decanoyl-RVKR-CMK (DecRVKRcmk) TFA inhibits over-expressed gp160 processing and HIV-1 replication .

HY-131603

Lamivudine triphosphate 3TCTP	Reverse Transcriptase HCV HBV SARS-CoV Drug Derivative	Infection
Lamivudine triphosphate (3TCTP) is a phosphorylated Lamivudine (HY-B0250) (a nucleoside analogue). Lamivudine triphosphate inhibits the reverse transcriptase of HIV or HBV viruses to block viral replication by chain termination. Lamivudine triphosphate is also an inhibitor of the RdRp activity of the NS5B subunit of the HCV. Lamivudine triphosphate can be incorporated into the nascent RNA by the SARS-CoV-2 RdRp, thus halting mutations in the nascent SARS-CoV-2 RNA .

HY-19743

Triazavirin 1 Publications Verification	Nucleoside Antimetabolite/Analog Influenza Virus DNA/RNA Synthesis	Infection
Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent. Triazavirin works by inhibiting the synthesis of viral RNA and DNA and replication of genomic fragments. Triazavirin is also an effective protective agent on the transmission stage of influenza .

HY-116887

N6-Methyladenine	Endogenous Metabolite Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Cancer
N6-Methyladenine is a DNA epigenetic modification that involves the addition of a methyl group to the sixth position of adenine. N6-Methyladenine plays an important role in distinguishing host DNA from exogenous DNA and controls many biological functions, such as DNA replication, transcription, mismatch repair, and chromosome replication. N6-Methyladenine can be used for the kidney diseases .

HY-150785

TAS1553	Apoptosis	Cancer
TAS1553 is a potent, orally active protein-protein interaction (PPI) inhibitor with an IC₅₀ values of 0.0396 μM. TAS1553 inhibits DNA replication and reduces intracellular dATP pool. TAS1553 induces apoptosis. TAS1553 can be used for cancer research .

HY-U00124B

Tromantadine hydrochloride 1 Publications Verification	HSV	Infection
Tromantadine hydrochloride, an Amantadine derivative with antiherpetic activity, inhibits herpes simplex virus type 1 (HSV-1) and HSV-2 replication .

HY-N1150R

Thymidine (Standard) DThyd (Standard); NSC 21548 (Standard)	Reference Standards DNA/RNA Synthesis Endogenous Metabolite Orthopoxvirus	Cancer
Thymidine (Standard) is the analytical standard of Thymidine. This product is intended for research and analytical applications. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication .

HY-135327

Amphotericin B methyl ester	HIV Fungal	Infection
Amphotericin B methyl ester is the methyl ester derivative of the polyene antibiotic Amphotericin B (A634250). Amphotericin B methyl ester is the cholesterol-binding compound possesses significant antifungal activity. Amphotericin B methyl ester disrupts HIV-1 particle production and potently inhibits HIV-1 replication .

HY-15591A

TMC647055 Choline salt 2 Publications Verification	HCV	Infection
TMC647055 (Choline salt) is a potent nonnucleoside NS5B polymerase inhibitor of HCV replication. TMC647055 Choline salt has potent HCV combine activity with an IC₅₀ value of 82 nM. TMC647055 Choline salt can be used for the research of Hepatitis C virus (HCV) .

HY-145932

DMA-135 hydrochloride	Enterovirus	Infection
DMA-135 hydrochloride inhibits enterovirus 71 (EV71) IRES-dependent translation and replication. DMA-135 hydrochloride binds to enterovirus 71 (EV71) SLII domain with moderately high affinity (K_D= 520 nM). DMA-135 hydrochloride has no significant toxicity in cell-based studies .

HY-156215

NCI-B16	HCV	Infection
NCI-B16 is a small molecule RNA binder and inhibits HCV viral replication .

HY-135570

hDHODH-IN-3	Influenza Virus Dihydroorotate Dehydrogenase DNA/RNA Synthesis	Infection
hDHODH-IN-3 (compound 21d) is a human dihydroorotate dehydrogenase (HsDHODH) inhibitor, inhibits measles virus replication with a pMIC₅₀ value of 8.6 .

HY-128787

hDHODH-IN-4	Dihydroorotate Dehydrogenase DNA/RNA Synthesis Influenza Virus	Infection
hDHODH-IN-4 is a potent human dihydroorotate dehydrogenase (DHODH) inhibitor, with a pIC₅₀ of 7.8 for human recombinant DHODH. hDHODH-IN-4 inhibits measles virus replication, with a pMIC₅₀ of 8.8 .

HY-16784

Samatasvir 1 Publications Verification IDX719; IDX18719	HCV HCV Protease	Infection
Samatasvir (IDX71) is a potent, orally active NS5A inhibitor of HCV replication. Samatasvir is effective and selective against infectious HCV and replicons, with EC₅₀s falling within a tight range of 2 to 24 pM in genotype 1 through 5 replicons .

HY-N1150S11

Thymidine-13C10 DThyd-¹³C₁₀; NSC 21548-¹³C₁₀	Isotope-Labeled Compounds DNA/RNA Synthesis Endogenous Metabolite Orthopoxvirus	Cancer
Thymidine- ¹³C₁₀ (DThyd- ¹³C₁₀; NSC 21548- ¹³C₁₀) is ¹³C-labeled Thymidine (HY-N1150). Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication.

HY-W009245

Bz-RS-iSer(3-Ph)-OMe	HIV	Infection Cancer
Bz-RS-iSer(3-Ph)-OMe (compound 2), a Taxol derivative, inhibits HSV replication cycle at low cytotoxicity, blocks mitotic divisions of Vero cells, influences M-MSV induced tumor size and affects immune response by inhibiting PHA-induced T lymphocyte proliferation .

HY-W011834R

2'-O-Methylcytidine (Standard)	Reference Standards HCV DNA/RNA Synthesis	Infection
2'-O-Methylcytidine (Standard) is the analytical standard of 2'-O-Methylcytidine. This product is intended for research and analytical applications. 2'-O-Methylcytidine is an orally active 2'-substituted nucleoside as a inhibitor of HCV replication with antiviral activity. 2'-O-Methylcytidine inhibits RNA-dependent RNA polymerase (NS5B)-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate .

HY-W190976

5-Vinyl-2'-deoxyuridine 5-VINYL-DURD	DNA/RNA Synthesis Apoptosis	Cancer
5-Vinyl-2'-deoxyuridine (5-VINYL-DURD), a thymidine analogue, is incorporated into cellular DNA during DNA replication. 5-Vinyl-2'-deoxyuridine is a click chemistry reagent, it contains an Alkyne group and induces DNA damage leads to apoptosis in human cultured cells .

HY-Y0426

2,4-Dihydroxypyridine 3-Deazauracil	HIV	Infection
2,4-Dihydroxypyridine (compound 2) is a pyridine derivative which is active against both Topo IIKHIV activity and HIV-1 replication, with a pIC50 of 5.05 and 4.07 against Topo IIKHIV and HIV-1 replication, reespectively .

HY-19558

IDX184	HCV HCV Protease	Infection
IDX184 is a potent and orally bioavailable inhibitor of HCV replication. IDX184 potently inhibits HCV polymerase (IC₅₀=0.31 μM, K_i=52.3 nM) .

HY-106382

PMEDAP	HIV CMV	Infection Cancer
PMEDAP is a potent inhibitor of human immunodeficiency virus (HIV) replication. PMEDAP has anti-murine cytomegalovirus (MCMV) activity. PMEDAP is a very potent inhibitor of Moloney murine sarcoma virus (MSV)-induced tumor formation and associated mortality .

HY-W011834S

2'-O-Methylcytidine-d3	Isotope-Labeled Compounds HCV	Infection
2'-O-Methylcytidine-d₃ is deuterium labeled 2'-O-Methylcytidine (HY-W011834). 2'-O-Methylcytidine is a 2'-substituted nucleoside as a inhibitor of HCV replication. 2'-O-Methylcytidine inhibits RNA-dependent RNA polymerase (NS5B)-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate.

HY-111296

YM 53403	RSV	Infection
YM 53403 is an anti-respiratory syncytial virus (RSV) agent, with an EC₅₀ of 0.20 μM. YM 53403 potently inhibits the replication of RSV strains belonging to both A and B subgroups .

HY-116887R

N6-Methyladenine (Standard)	Endogenous Metabolite Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Reference Standards	Cancer
N6-Methyladenine (Standard) is the analytical standard of N6-Methyladenine (HY-116887). This product is intended for research and analytical applications. N6-Methyladenine is a modified purine that is widely present in prokaryotes. In prokaryotes, N6-Methyladenine plays an important role in distinguishing host DNA from exogenous DNA and controls many biological functions, such as DNA replication, transcription, mismatch repair, and chromosome replication. N6-Methyladenine can be used for the kidney diseases .

HY-P4030

Herpes virus inhibitor 2	HIV Protease	Infection
Herpes virus inhibitor 2 is a herpes virus inhibitor and disrupts herpes virus ribonucleotide reductase quaternary structure. Herpes virus inhibitor 2 inhibits viral replication .

HY-N9340

Hypoglaunine D	HIV	Infection
Hypoglaunine D is an analogue of Triptonine B and acts as an anti-HIV compound. Hypoglaunine D inhibits HIV* replication* in H9 lymphocytes with an EC₅₀ value of 22 μg/ml .

HY-N1150S10

Thymidine-d14 DThyd-d₁₄; NSC 21548-d₁₄	Isotope-Labeled Compounds DNA/RNA Synthesis Endogenous Metabolite Orthopoxvirus	Cancer
Thymidine-d₁₄ (DThyd-d₁₄; NSC 21548-d₁₄) is deuterium labeled Thymidine (HY-N1150). Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication.

HY-148167

2'-Deoxy-2'-fluoro-l-uridine	DNA/RNA Synthesis Virus Protease	Infection
2'-Deoxy-2'-fluoro-l-uridine is an L-nucleoside compound. 2'-Deoxy-2'-fluoro-l-uridine is a potent, selective viral RNA polymerase inhibitor, thereby inhibiting RNA virus replication .

HY-W704973

F-ara-EdU	DNA/RNA Synthesis	Cancer
F-ara-EdU is a low-toxic, highly stable probe for DNA synthesis that is used as a marker for cell proliferation and DNA replication by binding to DNA or RNA in cells. F-ara-EdU can also be used to detect the rate of DNA synthesis within cells, as well as to study the mechanisms of DNA repair and damage .

HY-114437

Fusion Inhibitory Peptide Z-D-Phe-Phe-Gly-OH; FIP; Virus Replication Inhibitory Peptide	Influenza Virus	Infection
Fusion Inhibitory Peptide (Z-D-Phe-Phe-Gly-OH, FIP, Virus Replication Inhibitory Peptide) is a potent inhibitor of the virus replication, by inhibiting the membrane fusing activity of a viral glycoprotein .

HY-W011950

Acridin-9-amine hydrochloride hydrate 4 Publications Verification	DNA/RNA Synthesis	Others
Acridin-9-amine (9-Aminoacridine) hydrochloride hydrate is a mutagen and DNA modifier. Acridin-9-amine hydrochloride hydrate induces mutagenic lesions during DNA replication .

HY-N8361

Glycoborinine	HIV Apoptosis	Infection Cancer
Glycoborinine, a natural carbazole alkaloid, can be isolated from Glycosmis pentaphylla. Glycoborinine induces HepG2 cell apoptosis through mitochondrial pathway. Glycoborinine also inhibits HIV replication in cells .

HY-124052

AZ-27	RSV	Infection
AZ-27 is a respiratory syncytial virus (RSV) inhibitor. AZ-27 can differentially suppress various RSV polymerase activities at the promoter, thereby inhibiting the early stages of mRNA transcription and genome replication by targeting the promoter .

HY-172553

AS-0017445	Virus Protease SARS-CoV	Infection
AS-0017445 is an inhibitor targeting the main protease of both the current coronavirus and the virus that caused the Middle East Respiratory Syndrome (MERS) outbreak. AS-0017445 inhibits the viral protein processing in host cells and thus prevents viral replication .

HY-105721

Aranotin	SARS-CoV	Infection
Aranotin strongly binds to Nsp15 viral protein. Aranotin can be used as promising SARS-CoV-2 replication strong inhibitor. Aranotin has the potential for COVID-19 research .

HY-U00124

Tromantadine	HSV	Infection
Tromantadine hydrochloride, an Amantadine derivative with antiherpetic activity, inhibits herpes simplex virus type 1 (HSV-1) and HSV-2 replication .

HY-138061

DENV-IN-2	Flavivirus Dengue Virus DNA/RNA Synthesis	Infection
DENV-IN-2 is a potent dengue viral replication inhibitor extracted from patent WO2018215315A1, compound 6AB, has an EC₅₀ of 0.016 nM. DENV-IN-2 shows high potent activity against all four serotypes of the Dengue virus with EC₅₀s ranging from 0.013 to 0.029 nM .

HY-106920

Kynostatin 272 KNI 272; Kynostatin; NSC 651714	HIV Protease	Infection
Kynostatin 272 (KNI 272) is a potent HIV protease inhibitor. Kynostatin 272 inhibits the activity of the HIV protease by simulating the substrate transition state of the HIV protease, thus preventing a key step in the replication of the HIV virus. Kynostatin 272 provides an important research foundation for the development of drugs for HIV and AIDS .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13629

Etoposide Maximum Cited Publications 173 Publications Verification VP-16; VP-16-213	Infection Monophenols Classification of Application Fields Sinopodophyllum hexandrum (Royle) Ying Lignans Phenols Phenylpropanoids Plants Berberidaceae Disease Research Fields Source Classification	Topoisomerase Autophagy Mitophagy Bacterial Apoptosis Antibiotic
Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy .

HY-13433

Thapsigargin 135+ Cited Publications	Infection Classification of Application Fields Terpenoids Diterpenoids Umbelliferae Plants Disease Research Fields Source Classification Thapsia garganica L. Cancer	Calcium Channel SARS-CoV Apoptosis
Thapsigargin, an endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal Ca ²⁺-ATPase. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types .

HY-N1150

Thymidine 20+ Cited Publications DThyd; NSC 21548	Structural Classification Natural Products Immune System Disorder Microorganisms Classification of Application Fields Disease markers Other Diseases Endogenous metabolite Disease Research Fields Source Classification	DNA/RNA Synthesis Endogenous Metabolite Orthopoxvirus
Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication .

HY-N6707

Triacsin C 5+ Cited Publications WS 1228A; FR 900190	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	ACSL Family Parasite
Triacsin C (WS 1228A), is an orally active and intracellular long-chain acyl-CoA synthetases (ACSL) inhibitor, which can be isolated from Streptomyces aureofaciens. Triacsin C inhibits TAG accumulation into lipid droplets (LD) by suppressing ACSL activity . Triacsin C exhibits highly inhibitory effect against rotavirus replication .

HY-10572

Efavirenz 15+ Cited Publications DMP 266; EFV; L-743726	Infection Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Reverse Transcriptase HIV Autophagy Endogenous Metabolite Parasite
Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a K_i of 2.93 nM and exhibits an IC₉₅ of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture .

HY-B1192

Estradiol benzoate 15+ Cited Publications β-Estradiol 3-benzoate; 17β-Estradiol 3-benzoate	Classification of Application Fields Disease Research Fields Cancer	Estrogen Receptor/ERR HBV Bcl-2 Family
Estradiol benzoate (β-Estradiol 3-benzoate) is a HBx protein inhibitor and inhibits androgen and hepatitis B virus (HBV) transcription, replication. Estradiol benzoate shows antifertility effects, anti- Toxoplasma gondii activity and can improve memory behavior of Ovariectomy (Ovx) female mice .

HY-N0102

Isoliquiritigenin 30+ Cited Publications GU17; ISL; Isoliquiritigen; SJ000286237	Classification of Application Fields Plants Infection Chalcones Flavonoids Microorganisms Leguminosae Phenols Polyphenols Glycyrrhiza uralensis Fisch. Inflammation/Immunology Disease Research Fields Source Classification	Aldose Reductase Influenza Virus Autophagy Apoptosis
Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza uralensis Fisch., which inhibits aldose reductase with an IC₅₀ of 320 nM. Isoliquiritigenin is a potent inhibitor of influenza virus replication with an EC₅₀ of 24.7 μM.

HY-17438

Cidofovir 10+ Cited Publications GS 0504; HPMPC; (S)-HPMPC	Infection Structural Classification Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	CMV Apoptosis DNA/RNA Synthesis Orthopoxvirus Endogenous Metabolite
Cidofovir (GS 0504) is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer . Cidofovir also has anti-orthopoxvirus and anti-variola activities .

HY-N1992

Theaflavin 3,3'-digallate 5+ Cited Publications TF-3; ZP10	Infection Flavonoids Classification of Application Fields Flavanols Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Disease Research Fields Source Classification Theaceae	Virus Protease HSV HIV Flavivirus
Theaflavin 3,3'-digallate (TF-3) is a potent Zika virus (ZIKV) protease inhibitor with an IC₅₀ of 2.3 μM. Theaflavin 3,3'-digallat directly binds to ZIKVpro (K_d=8.86 μM) and inhibits ZIKV replication. Theaflavin 3,3'-digallat inhibits the activity of gp41 and NS2B-3 protease and has antiviral activity against HSV and HIV-1 . Theaflavin 3,3'-digallate, the typical pigment in black tea, is a potent antitumor agent .

HY-N0158

Oxymatrine 15+ Cited Publications	Infection Alkaloids Piperidine Alkaloids Classification of Application Fields Leguminosae Sophora flavescens Aiton Plants Inflammation/Immunology Disease Research Fields Source Classification	TGF-beta/Smad Apoptosis
Oxymatrine, an alkaloid from Sophora flavescens Alt. with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway. Oxymatrine inhibits bocavirus minute virus of canines (MVC) replication, reduces viral gene expression and decreases apoptosis induced by viral infection .

HY-N2022

Castanospermine 4 Publications Verification	Alkaloids other families Classification of Application Fields Plants Disease Research Fields Indole Alkaloids Source Classification Cancer	Glycosidase
Castanospermine is a natural alkaloid that can be extracted from black beans or the Moreton Bay chestnut tree (Castanospermum australae). Castanospermine is an α/ β-glucosidase inhibitor. Castanospermine has anti-inflammatory, antiviral replication and anti-metastatic effects on prostate cancer. Castanospermine can be used as an immunosuppressant to prevent transplant rejection .

HY-I0660

Picolinic acid 1 Publications Verification PCL 016	Infection Structural Classification Classification of Application Fields Anti-aging Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Endogenous metabolite Disease Research Fields Source Classification	MOFs Endogenous Metabolite Virus Protease
Picolinic acid (PCL 016) is a topical antiviral agent, which inhibits adenovirus replication in rabbits.

HY-17470

Mizoribine 5 Publications Verification NSC 289637; HE 69	Alkaloids Microorganisms Classification of Application Fields Other Alkaloids Inflammation/Immunology Disease Research Fields Source Classification	HCV SARS-CoV Antibiotic Parasite
Mizoribine (NSC 289637), an imidazole nucleoside, inhibits HCV RNA replication with IC₅₀ of approximately 100 μM for anti-HCV activity. Immunosuppressant . Mizoribine, an IMPDH inhibitor, inhibits replication of SARS-CoV with IC₅₀s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively .

HY-N1127

Tricin 5+ Cited Publications	Infection Flavonoids Classification of Application Fields Flavones Agrostidoideae Phenols Polyphenols Plants Disease Research Fields Triticum aestivum L. Source Classification	CMV
Tricin is a natural flavonoid found in large amounts in wheat. Tricin inhibits HCMV replication by inhibiting CDK9. Tricin inhibits the proliferation and invasion of C6 glioma cells by upregulating the expression of FAK-targeting microRNA-7 .

HY-B0398

Nalidixic acid 2 Publications Verification	Infection Microorganisms Classification of Application Fields Antibiotics Resistance Selection Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial Antibiotic Topoisomerase
Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria .

HY-N1996

Chebulagic acid 5 Publications Verification	Classification of Application Fields Combretaceae Phenols Polyphenols Terminalia chebula Retz. Plants Inflammation/Immunology Disease Research Fields Source Classification	COX Lipoxygenase SARS-CoV Influenza Virus
Chebulagic acid is a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz, on angiogenesis. Chebulagic acid is a M2 serine to asparagine 31 mutation (S31N) inhibitor and influenza antiviral. Chebulagic acid also against SARS-CoV-2 viral replication with an EC₅₀ of 9.76 μM.

HY-N6769

Radicicol 4 Publications Verification Monorden	Antifungal Classification of Application Fields Marine natural products Anti-parasitic Disease Research Infection Microorganisms Macrolide Antibiotics Antibiotics Phenols Polyphenols Marine microorganism Disease Research Fields Source Classification	HSP Bacterial Antibiotic Parasite
Radicicol is an inhibitor of Hsp90 with an IC₅₀ value < 1 μM, and leads to proteasomal degradation . Radicicol exhibits inhibition on PDK with IC₅₀s of 230 μM (PDK1) and 400 μM (PDK3). Radicicol is an antifungal and antimalarial antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB . Radicicol is also an inhibitor of fat mass and obesity-associated protein (FTO), with an IC₅₀ value of 16.04 μM .

HY-I0960

Uracil 4 Publications Verification	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Drug Derivative
Uracil is a pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA. Uracil is a frequently occurring DNA base damage that results from the spontaneous or chemically induced deamination of cytosine and is mutagenic at the level of replication. Uracil could potentially alter transcriptional fidelity, resulting in production of mutant proteins .

HY-N7922

Urolithin M5 1 Publications Verification Decarboxyellagic acid	Structural Classification Canarium album (Lour.) Rauesch. Phenols Polyphenols Plants Burseraceae Source Classification	Influenza Virus p38 MAPK EGFR Akt Reactive Oxygen Species (ROS) Apoptosis
Urolithin M5 (Decarboxyellagic acid) is an orally active influenza virus neuraminidase inhibitor and neuroprotective agent, with IC₅₀ values of 174.8 μM (HK68), 191.5 μM (pdm09), 243.2 μM (WSN) and 257.1 μM (PR8) against four influenza virus neuraminidases, respectively. Urolithin M5 inhibits viral neuraminidase activity, thereby blocking influenza virus replication (including oseltamivir (HY-13317)-resistant strains), protecting infected mammals from death and improving pulmonary edema. Urolithin M5 forms a hydrogen-bond stabilized complex with IGF1R, and binds to MAPK14, AKT1, NFKB1 and EGFR. Urolithin M5 reduces reactive oxygen species production, inhibits neuronal apoptosis, restores mitochondrial transmembrane potential, and promotes neurite outgrowth of damaged neuronal cells. Urolithin M5 can be used in research related to influenza virus infection and Alzheimer's disease .

HY-N0457A

L-Chicoric Acid 3 Publications Verification (-)-Chicoric acid; trans-Caffeoyltartaric acid	other families Classification of Application Fields Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Source Classification Cancer	HIV Integrase HIV Endogenous Metabolite
L-Chicoric Acid ((-)-Chicoric acid) is a dicaffeoyltartaric acid and a potent, selective and reversible HIV-1 integrase inhibitor with an IC₅₀ of ~100 nM. L-Chicoric Acid inhibits HIV-1 replication in tissue culture .

HY-113306

1-Methyladenine	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
1-Methyladenine is a gonad maturation-promoting regulator. 1-Methyladenine is produced in testes and ovarian follicle cells of starfish under the induction of gonad-stimulating substance (GSS). 1-Methyladenine promotes starfish oocyte maturation and spawning, and modifies bases that regulate DNA structure. 1-Methyladenine converts T-A base pairs in double-stranded DNA into non-disruptive T (anti)m1A (syn) Hoogsteen conformation. If this conformational base is not repaired in a timely manner, 1-Methyladenine transforms into cytotoxic DNA damage and blocks the replication process .

HY-N0227

7-epi-Taxol 4 Publications Verification 7-epi-Paclitaxel	Classification of Application Fields Terpenoids Taxaceae Diterpenoids Plants Disease Research Fields Taxus chinensis (Pilger) Rehd. Source Classification Cancer	Microtubule/Tubulin
7-epi-Taxol is an active metabolite of taxol, with activity comparable to that of taxol against cell replication, promoting microtubule bundle formation and against microtubule depolymerization.

HY-B0439

Sulfadoxine Sulphadoxine	Infection Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Parasite HIV Antibiotic Endogenous Metabolite
Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other agents, for respiratory, urinary tract and malarial infections. Sulfadoxine inhibits HIV replication in peripheral blood mononuclear cells.

HY-113074

Glycolithocholic acid 3-sulfate Glycolithocholate sulfate; Sulfolithocholylglycine; SLCG	Triterpenes Terpenoids Endogenous metabolite Source Classification	HIV Endogenous Metabolite
Glycolithocholic acid 3-sulfate (SLCG) is a cholic acid derivative and a metabolite of glycolithocholic acid. Glycolithocholic acid 3-sulfate inhibits replication of HIV-1 in vitro. Glycolithocholic acid 3-sulfate can be used for the research of HIV infection and gallbladder disease .

HY-N0923

Corydaline 1 Publications Verification (+)-Corydaline; Corydalin	Alkaloids Corydalis yanhusuo W. T. Wang Plants Isoquinoline Alkaloids Papaveraceae Source Classification	Cholinesterase (ChE) Enterovirus Opioid Receptor
Corydaline ((+)-Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an AChE inhibitor with an IC₅₀ of 226 μM. Corydaline is a μ-opioid receptor (K_i of 1.23 μM) agonist and inhibits enterovirus 71 (EV71) replication (IC₅₀ of 25.23 μM). Corydaline has anti-angiogenic, anti-allergic and gastric-emptying and antinociceptive activities .

HY-W013715A

Deoxythymidine-5'-triphosphate trisodium solution (100 mM) dTTP trisodium solution (100 mM)	Structural Classification Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Endogenous Metabolite
Deoxythymidine-5'-triphosphate (dTTP) (trisodium) solution (100 mM) is one of the raw materials used by DNA polymerase to synthesize long DNA strands during DNA replication. Deoxythymidine-5'-triphosphate (trisodium) solution (100 mM) is used in polymerase chain reaction (PCR) for DNA amplification. This product is supplied as an aqueous solution.

HY-N0093

Ancitabine hydrochloride 1 Publications Verification Cyclocytidine hydrochloride; Cyclo-CMP hydrochloride; Cyclo-C	Classification of Application Fields Disease Research Fields Cancer	Autophagy CMV DNA/RNA Synthesis
Ancitabine hydrochloride is a cytarabine derivative that inhibits viral replication. Ancitabine hydrochloride blocks vaccinia virus DNA replication, the progression of viral protein synthesis from early to late stages, and one-step growth of vaccinia virus. Ancitabine hydrochloride is applicable to research related to vaccinia virus infection, leukemia, human cytomegalovirus infection and colorectal cancer .

HY-N2036

Mosloflavone 1 Publications Verification	Infection Monophenols Flavonoids Classification of Application Fields Flavones Labiatae Phenols Plants Medicago truncatula Gaertn. Disease Research Fields Source Classification	TNF Receptor Enterovirus Bacterial
Mosloflavone is a flavonoid isolated from Scutellaria baicalensis Georgi with ?anti-EV71 activity. Mosloflavone? inhibits VP2 virus replication and protein expression during the initial stage of virus infection and inhibits viral VP2 capsid protein synthesis. Mosloflavone is a promising biocide and inhibits P. aeruginosa virulence and biofilm formation.

HY-N7543

Schisantherin D	Schisandra sphenanthera Rehd. et Wils Infection Structural Classification Classification of Application Fields Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields Source Classification	HIV Endothelin Receptor
Schisantherin D is a lignan. Schisantherin D can be isolated from Kadsura interior. Schisantherin D downregulates the expression of ETBR and inhibits the secretion of ECM and ET-1. Schisantherin D alleviates EtOH + ET-1-induced hepatocyte cytotoxicity. Schisantherin D potently inhibits HIV replication in cells .

HY-136648A

2'-Deoxyadenosine-5'-triphosphate trisodium dATP trisodium	Alkaloids Structural Classification Classification of Application Fields Other Alkaloids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite DNA/RNA Synthesis
2'-Deoxyadenosine-5'-triphosphate (dATP) trisodium is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase. 2'-Deoxyadenosine-5'-triphosphate is promising for research of genetic immunodeficiency diseases adenosine deaminase deficiency and purine nucleotide phosphorylase deficiency .

HY-N3242

Moronic acid 1 Publications Verification (+)-Moronic acid	Triterpenes Terpenoids Rhus chinensis Mill. Plants Anacardiaceae Source Classification	HIV Reactive Oxygen Species (ROS) NOD-like Receptor (NLR)
Moronic Acid is a triterpenoid compound, which is an orally available anti-HIV agent with anti-inflammatory activity. Moronic Acid can inhibit viral replication, with an EC₅₀ value of <1 μg/mL. Moronic Acid can be isolated from Brazilian propolis .

HY-138616

dGTP 2'-Deoxyguanosine-5'-triphosphate	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog
dGTP (2'-Deoxyguanosine-5'-triphosphate) is one of the precursors for DNA synthesis, and serves as a direct substrate for DNA replication and repair. dGTP is prone to oxidative damage; under the action of reactive oxygen species and other factors, dGTP is oxidized to form 8-oxo-dGTP .

HY-N8533

Sodium Camptothecin	Infection Alkaloids Pyrrole Alkaloids Classification of Application Fields Quinoline Alkaloids Camptotheca acuminata Decne. Plants Nyssaceae Disease Research Fields Source Classification	DNA/RNA Synthesis
Sodium Camptothecin is a plant alkaloid, with antitumor activity. Sodium Camptothecin is a reversible inhibitor of RNA synthesis. Sodium Camptothecin is an effective inhibitor of adenovirus replication. Sodium Camptothecin inhibits DNA synthesis and causes breaks in intracellular preformed viral DNA .

HY-125713

Ganoderic acid Y	Infection Triterpenes Classification of Application Fields Terpenoids Polyporaceae Plants Disease Research Fields Source Classification	Glycosidase Enterovirus
Ganoderic acid Y is a α-glucosidase inhibitor with an IC₅₀ of 170 μM for yeast α-glucosidase. Ganoderic acid Y inhibits enterovirus 71 (EV71) replication through blocking EV71 uncoating .

HY-13629R

Etoposide (Standard) 1 Publications Verification VP-16 (Standard); VP-16-213 (Standard)	Structural Classification Monophenols Sinopodophyllum hexandrum (Royle) Ying Lignans Phenols Phenylpropanoids Plants Berberidaceae Source Classification	Reference Standards Topoisomerase Autophagy Mitophagy Bacterial Apoptosis Antibiotic
Etoposide (Standard) is the analytical standard of Etoposide. This product is intended for research and analytical applications. Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy .

HY-116887

N6-Methyladenine	Structural Classification Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite Nucleoside Antimetabolite/Analog DNA/RNA Synthesis
N6-Methyladenine is a DNA epigenetic modification that involves the addition of a methyl group to the sixth position of adenine. N6-Methyladenine plays an important role in distinguishing host DNA from exogenous DNA and controls many biological functions, such as DNA replication, transcription, mismatch repair, and chromosome replication. N6-Methyladenine can be used for the kidney diseases .

HY-N1150R

Thymidine (Standard) DThyd (Standard); NSC 21548 (Standard)	Structural Classification Natural Products Immune System Disorder Microorganisms Disease markers Endogenous metabolite Source Classification	Reference Standards DNA/RNA Synthesis Endogenous Metabolite Orthopoxvirus
Thymidine (Standard) is the analytical standard of Thymidine. This product is intended for research and analytical applications. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication .

HY-I0736

Isonicotinic acid	Alkaloids Aloe africana Liliaceae Other Diseases Pyridine Alkaloids Plants Disease Research Fields Source Classification	MOFs Drug Metabolite Drug Intermediate
Isonicotinic acid is an Isoniazid (HY-B0329) metabolite. The Isonicotinic acid derivative Enisamium inhibits the replication of multiple subtypes of influenza A virus .

HY-136648

2'-Deoxyadenosine-5'-triphosphate dATP	Structural Classification Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite DNA/RNA Synthesis
2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase .

HY-108398B

11(Z),14(Z),17(Z)-Eicosatrienoic acid	Microorganisms Ketones, Aldehydes, Acids Source Classification	Endogenous Metabolite
11(Z),14(Z),17(Z)-Eicosatrienoic acid is an unsaturated fatty acid that can maintain the continued replication of functional mitochondria in Saccharomyces cerevisiae (KD115) .

HY-N1060

Yatein	Infection Cupressaceae Classification of Application Fields Chamaecyparis obtusa (Siebold & Zucc.) Endl. Lignans Phenylpropanoids Plants Disease Research Fields Source Classification	HSV Apoptosis
Yatein is a lignan isolated from A. chilensis, with antiproliferative activity . Yatein suppresses herpes simplex virus type 1 (HSV-1 ) replication by interruption the immediate-early gene expression .

HY-I0660R

Picolinic acid (Standard) PCL 016 (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Virus Protease
Picolinic acid (Standard) is the analytical standard of Picolinic acid. This product is intended for research and analytical applications. Picolinic acid (PCL 016) is a topical antiviral agent, which inhibits adenovirus replication in rabbits.

HY-149049

Cajaninstilbene acid Cajanine	Simple Phenylpropanols Leguminosae Phenylpropanoids Plants Cajanus cajan (L.) Millsp. Source Classification	HCV
Cajaninstilbene acid is a potent HCV inhibitor with an IC₅₀ of 3.17 μM. Cajaninstilbene acid inhibits HCV replications via down-regulates a cellular protein chondroitin sulfate N-acetylgalactosaminyltransferase 1 .

HY-W060316

β-Thujaplicinol 3-Hydroxy-5-isopropyltropolone	Cupressaceae Ketones, Aldehydes, Acids Plants Source Classification	HBV DNA/RNA Synthesis
β-Thujaplicinol (3-Hydroxy-5-isopropyltropolone) is an inhibitor of hepatitis B virus (HBV) ribonuclease H. β-Thujaplicinol inhibits RNAseHs of HBV genotypes D and H with IC₅₀ values of 5.9 and 2.3 μM, respectively .

HY-N0365R

Sennoside A (Standard) 5+ Cited Publications	Infection Quinones Classification of Application Fields Plants Disease Research Fields Source Classification	Reference Standards HIV
Sennoside A (Standard) is the analytical standard of Sennoside A. This product is intended for research and analytical applications. Sennoside A is an anthraquinone glycoside, found in Senna (Cassia angustifolia) . Sennoside A is a HIV-1 inhibitor effective on HIV-1 replication .

HY-N6795

Leptomycin A	Infection Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	CRM1 HIV Antibiotic
Leptomycin A, a Streptomyces metabolite, is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A suppresses HIV-1 replication. Less potent than Leptomycin B .

HY-N14780

Pochonin D (+)-Pochonin D	Structural Classification Natural Products Microorganisms Source Classification	HSP Interleukin Related Enterovirus
Pochonin D ((+)-Pochonin D) is an inhibitor of heat shock protein 90 (Hsp90) with antiviral and anti-inflammatory activities. Pochonin D inhibits Hsp90, affects the homeostasis, folding and assembly processes of viral proteins, and reduces the replication capacity of viruses. Pochonin D reduces the infiltration of inflammatory cells, decreases the secretion of inflammatory cytokines such as TNF-α and IL-1β, and alleviates inflammatory responses. Pochonin D is a promising candidate for research on human rhinovirus (HRV) infection and cancer .

HY-122920

Soyasaponin II	Triterpenes Classification of Application Fields Leguminosae Terpenoids Plants Inflammation/Immunology Disease Research Fields Glycine soja Sieb. Et Zucc. Source Classification	HSV CMV Influenza Virus HIV NOD-like Receptor (NLR) YB-1
Soyasaponin II is a saponin with antiviral activity. Soyasaponin II inhibits the replication of HSV-1, HCMV, influenza virus, and HIV-1. Soyasaponin II shows potent inhibition on HSV-1 replication. Soyasaponin II serves as a inhibitor for YB-1 phosphorylation and NLRP3 inflammasome priming and could protect mice against LPS/GalN induced acute liver failure .

HY-17470R

Mizoribine (Standard) NSC 289637 (Standard); HE 69 (Standard)	Alkaloids Structural Classification Microorganisms Other Alkaloids Source Classification	Reference Standards HCV SARS-CoV Antibiotic Parasite
Mizoribine (Standard) is the analytical standard of Mizoribine. This product is intended for research and analytical applications. Mizoribine (NSC 289637), an imidazole nucleoside, inhibits HCV RNA replication with IC₅₀ of approximately 100 μM for anti-HCV activity. Immunosuppressant . Mizoribine, an IMPDH inhibitor, inhibits replication of SARS-CoV with IC₅₀s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively .

HY-113053

Prostaglandin A1	Animals Ketones, Aldehydes, Acids Source Classification	Endogenous Metabolite Apoptosis
Prostaglandin A1 is a dehydration derivate of Prostaglandin E1. Prostaglandin A1 exhibits inhibitory activities against tumor growth, inflammation, virus replication, platelet aggregation and excitotoxin-induced neurons apoptosis .

Cat. No.	Product Name	Chemical Structure

HY-N7434S1

N-Nitrosodiethylamine-d10

N-Nitrosodiethylamine-d₁₀ is the deuterium labeled N-Nitrosodiethylamine . N-Nitrosodiethylamine (Diethylnitrosamine) is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. N-Nitrosodiethylamine is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. N-Nitrosodiethylamine results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.

HY-15005S1

Sofosbuvir-d6 1 Publications Verification
Sofosbuvir-d₆ is the deuterium labeled Sofosbuvir. Sofosbuvir (PSI-7977) is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.

HY-B0330S

Levofloxacin-d8
Levofloxacin-d₈ is the deuterium labeled Levofloxacin. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.

HY-N1150S11

Thymidine-13C10
Thymidine- ¹³C₁₀ (DThyd- ¹³C₁₀; NSC 21548- ¹³C₁₀) is ¹³C-labeled Thymidine (HY-N1150). Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication.

HY-N1150S8

Thymidine-13C10,15N2
Thymidine- ¹³C₁₀, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Thymidine[1]. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[2][3][4].

HY-N1150S9

Thymidine-15N2
Thymidine- ¹⁵N₂ is the ¹⁵N labeled Thymidine . Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication .

HY-13637S

Ganciclovir-d5

Ganciclovir-d₅ is the deuterium labeled Ganciclovir. Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC₅₀ of 5.2 μM for feline herpesvirus type-1 (FHV-1) .

HY-W011834S

2'-O-Methylcytidine-d3
2'-O-Methylcytidine-d₃ is deuterium labeled 2'-O-Methylcytidine (HY-W011834). 2'-O-Methylcytidine is a 2'-substituted nucleoside as a inhibitor of HCV replication. 2'-O-Methylcytidine inhibits RNA-dependent RNA polymerase (NS5B)-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate.

HY-17393S

Carboplatin-d4
Carboplatin-d₄ is the deuterium labeled Carboplatin. Carboplatin (NSC 241240) is a DNA synthesis inhibitor which binds to DNA, inhibits replication and transcription and induces cell death. Carboplatin (NSC 241240) is a derivative of CDDP and a potent anti-cancer agent.

HY-N1150S2

Thymidine-13C
Thymidine- ¹³C is the ¹³C labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication

HY-N1150S

Thymidine-d3
Thymidine-d₃ is the deuterium labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication .

HY-106254S

Vapendavir-d5
Vapendavir-d5 is the deuterium labeled Vapendavir. Vapendavir (BTA798) is a potent enteroviral capsid binder (CB). Vapendavir (BTA798) possesses potent antiviral activity for enterovirus 71 (EV71) replication, with EC₅₀ values of 0.5-1.4 μM in different EV71 strains .

HY-136648S5

2'-Deoxyadenosine-5'-triphosphate-13C10 dilithium
2'-Deoxyadenosine-5'-triphosphate- ¹³C₁₀ (dATP- ¹³C₁₀) dilithium is ¹³C-labeled 2'-Deoxyadenosine-5'-triphosphate (HY-136648). 2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase.

HY-136648S1

2'-Deoxyadenosine-5'-triphosphate-13C10,15N5 dilithium
2'-Deoxyadenosine-5'-triphosphate- ¹³C₁₀, ¹⁵N₅ (dATP- ¹³C₁₀, ¹⁵N₅) dilithium is ¹³C and ¹⁵N-labeled 2'-Deoxyadenosine-5'-triphosphate (HY-136648). 2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase.

HY-N7434S

N-Nitrosodiethylamine-d4

N-Nitrosodiethylamine-d₄ is the deuterium labeled N-Nitrosodiethylamine . N-Nitrosodiethylamine (Diethylnitrosamine) is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. N-Nitrosodiethylamine is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. N-Nitrosodiethylamine results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.

HY-N0488S

Vincristine-d3 sulfate

Vincristine-d₃ sulfate is the deuterium labeled Vincristine sulfate. Vincristine sulfate (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a K_i of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine sulfate inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine sulfate upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine sulfate is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas .

HY-113308S1

Taurolithocholic acid-d4

Taurolithocholic acid-d₄ is deuterium labeled Taurolithocholic acid. Taurolithocholic acid is an orally active bile acid and antiviral agent. Taurolithocholic acid upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV-induced ferroptosis, viral replication and viral entry of HBV/HDV, while reducing the release of IL-1β, lipid ROS and LDH. While exerting antiviral protective effects, Taurolithocholic acid also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic acid serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic acid shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic acid not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis .

HY-N1150S10

Thymidine-d14
Thymidine-d₁₄ (DThyd-d₁₄; NSC 21548-d₁₄) is deuterium labeled Thymidine (HY-N1150). Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication.

HY-N1150S6

Thymidine-d2
Thymidine-d₂ is the deuterium labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1

HY-B0497S1

Niclosamide-13C6
Niclosamide- ¹³C₆ is the ¹³C₆ labeled Niclosamide. Niclosamide (BAY2353) is an orally bioavailable chlorinated salicylanilide, with anthelmintic and potential antineoplastic activity. Niclosamide (BAY2353) inhibits STAT3 with IC50 of 0.25 μM in HeLa cells and inhibits DNA replication in a cell-free assay.

HY-109025AS

Baloxavir-d5
Baloxavir-d₅ is deuterium labeled Baloxavir. Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity .

HY-10046S

Plerixafor-d4
Plerixafor-d₄ is the deuterium labeled Plerixafor. Plerixafor (AMD 3100) is a selective CXCR4 antagonist with an IC₅₀ of 44 nM. Plerixafor, an immunostimulant and a hematopoietic stem cell (HSC) mobilizer, is an allosteric agonist of CXCR7. Plerixafor inhibits HIV-1 and HIV-2 replication with an EC₅₀ of 1-10 nM .

HY-B0439S1

Sulfadoxine D3

Sulfadoxine-d₃ is a deuterium labeled Sulfadoxine (HY-B0439). Sulfadoxine is a sulfonamide that is used, usually in combination with Pyrimethamine(HY-18062), for multidrug-resistant Plasmodium falciparum and P. vivax inhibition. Unlike PYR, Sulfadoxine has no impact on HIV replication or MT-2 cell cycle progression. But also Sulfadoxine exhibits suppression on respiratory, and urinary tract infections .

HY-N0168AS1

(Rac)-Hesperetin-13C,d3

(Rac)-Hesperetin- ¹³C,d₃ is the ¹³C- and deuterium labeled (Rac)-Hesperetin. (Rac)-Hesperetin is the racemate of Hesperetin (HY-N0168), an orally active multi-target inhibitor. (Rac)-Hesperetin exhibits significant anti-tumor and anti-inflammatory activities by blocking the TGF-β1-mediated Fyn/RhoA signaling axis and the TLR4-MyD88-NF-κB inflammatory pathway. (Rac)-Hesperetin inhibits the formation of actin stress fibers and the migration and invasion of cancer cells, and is suitable for triple-negative breast cancer research. In inflammation models, (Rac)-Hesperetin effectively alleviates lung injury by reducing the release of pro-inflammatory mediators and regulating the activity of oxidative stress enzymes, and is suitable for acute lung injury research. (Rac)-Hesperetin also interferes with the entry and early replication processes of channel catfish virus, inhibits viral gene expression and progeny virus production, thereby protecting cells from virus-induced cytopathic effects .

HY-10241S

Simeprevir-13C,d3

Simeprevir- ¹³C,d₃ is the ¹³C- and deuterium labeled Simeprevir. Simeprevir is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a K_i of 0.36 nM. Simeprevir inhibits HCV replication with an EC₅₀ of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (Mpro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses .

HY-15005S

Sofosbuvir-13C,d3
Sofosbuvir- ¹³C,d₃ is the deuterium labeled Sofosbuvir. Sofosbuvir (PSI-7977) is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.

HY-17371S

Oxaliplatin-d10
Oxaliplatin-d₁₀ is a deuterium labeled Oxaliplatin (HY-17371). Oxaliplatin is a DNA synthesis inhibitor. Oxaliplatin causes DNA crosslinking damage, prevents DNA replication and transcription and induces apoptosis. Oxaliplatin can be used for cancer research .

HY-N1150S1

Thymidine-d4
Thymidine-d₄ is the deuterium labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication .

HY-N1150S3

Thymidine-13C-1
Thymidine- ¹³C-1 is the ¹³C labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication

HY-10572S1

Efavirenz-13C6
Efavirenz- ¹³C₆ is the ¹³C-labeled Efavirenz. Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a K_i of 2.93 nM and exhibits an IC₉₅ of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture .

HY-B0398S

Nalidixic Acid-d5

Nalidixic Acid-d₅ is the deuterium labeled Nalidixic acid. Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria .

HY-W744243

Etoposide-d4
Etoposide-d₄ (VP-16-d₄; VP-16-213-d₄) is the deuterium labeled Etoposide (HY-13629). Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy .

HY-B0497S2

Niclosamide-d3
Niclosamide-d₃ (BAY2353-d₃) is deuterium labeled Niclosamide. Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research . Niclosamide is a STAT3 inhibitor with an IC₅₀ of 0.25 μM in HeLa cells . Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells .

HY-10572S

Efavirenz-d5

Efavirenz-d₅ (DMP 266-d₅) is the deuterium labeled Efavirenz. Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a K_i of 2.93 nM and exhibits an IC₉₅ of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture . Efavirenz-d₅ is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W751835

Baloxavir-d4

Baloxavir-d₄ (Baloxavir acid-d₄; S-033447-d₄) is the deuterium-labeled Baloxavir (HY-109025A). Baloxavir-d₄ (Baloxavir-d₄ acid), derived from the proagent Baloxavir-d₄ marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir-d₄ inhibits viral RNA transcription and replication and has potently antiviral activity .

HY-B0268S1

Enoxacin-d8 hydrochloride

Enoxacin-d₈ (hydrochloride) is deuterium labeled Enoxacin. Enoxacin (AT 2266), a fluoroquinolone, interferes with DNA replication and inhibits bacterial DNA gyrase (IC₅₀=126 μg/ml) and topoisomerase IV (IC₅₀=26.5 μg/ml). Enoxacin is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. Enoxacin has potent activities against gram-positive and -negative bacteria. Enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2 (TRBP)-mediated microRNA processing .

HY-13238S1

Dolutegravir-d3

Dolutegravir-d₃ is the deuterium labeled Dolutegravir. Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC₅₀ of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC₅₀ of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC₅₀=3.6-5.8 nM) .

HY-13238S2

Dolutegravir-d5

Dolutegravir-d₅ is deuterium labeled Dolutegravir. Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC₅₀ of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC₅₀ of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC₅₀=3.6-5.8 nM) .

HY-N0488S2

Vincristine-d6 sulfate

Vincristine-d₆ (sulfate) is the deuterium labeled Vincristine sulfate. Vincristine sulfate (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a K_i of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine sulfate inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine sulfate upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine sulfate is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas .

HY-N0488S1

Vincristine-d3-1 sulfate

Vincristine-d₃ sulfate is the deuterium labeled Vincristine sulfate. Vincristine-1 sulfate (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a K_i of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine-1 sulfate inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine-1 sulfate upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine-1 sulfate is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas .

HY-113308AS1

Taurolithocholic Acid-d5 sodium salt

Taurolithocholic Acid-d₅ (sodium) is the deuterium labeled Taurolithocholic acid sodium salt. Taurolithocholic Acid sodium salt is an orally active bile acid and antiviral agent. Taurolithocholic Acid sodium salt upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV-induced ferroptosis, viral replication and viral entry of HBV/HDV, while reducing the release of IL-1β, lipid ROS and LDH. While exerting antiviral protective effects, Taurolithocholic Acid sodium salt also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic Acid sodium salt serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic Acid sodium salt shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic Acid sodium salt not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis .

HY-30234S

Clemizole-d4
Clemizole-d4 is a deuterium labeled Clemizole. Clemizole is an H1 histamine receptor antagonist, is found to substantially inhibit HCV replication .

HY-14588S2

Lopinavir-d7

Lopinavir-d₇ is deuterated labeled Lopinavir (HY-14588). Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with K_is of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity . Lopinavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 14.2 μM .

HY-B0330S1

(S)-Ofloxacin-d3
(S)-Ofloxacin-d₃ is the deuterium labeled Levofloxacin. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.

HY-B0017S

Telbivudine-d4
Telbivudine-d₄ is deuterium labeled Telbivudine. Telbivudine (Epavudine), an orally active thymidine nucleoside analog, is a potent antiviral inhibitor of hepatitis B virus (HBV) replication .

HY-135389S

Desmethyl Levofloxacin-d8 hydrochloride
Desmethyl Levofloxacin-d8 hydrochloride is the deuterium labeled Desmethyl Levofloxacin. Desmethyl Levofloxacin is a metabolite of Levofloxacin. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication .

HY-N0285S

Imperatorin-d6
Imperatorin-d6 (Ammidin-d6) is the deuterium labeled Imperatorin. Imperatorin is a BChE inhibitor and HIV-1 replication inhibitor. Imperatorin shows mild activity against Gram-negative bacteria .

HY-135389S1

Desmethyl Levofloxacin-d8
Desmethyl Levofloxacin-d₈ is deuterium labeled Desmethyl Levofloxacin. Desmethyl Levofloxacin is a metabolite of Levofloxacin. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication .

HY-B0338S

Rimantadine-d4 hydrochloride
Rimantadine-d₄ (hydrochloride) is the deuterium labeled Rimantadine hydrochloride. Rimantadine is an orally active inhibitor for M2 protein, that blocks the hydrogen ion channel activity, prevents the entry and replication of the virus, and exhibits board-spectrum antiviral activity .

HY-B0439S

Sulfadoxine-d4
Sulfadoxine-d₄ is the deuterium labeled Sulfadoxine. Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other agents, for respiratory, urinary tract and malarial infections. Sulfadoxine inhibits HIV replication in peripheral blood mononuclear cells.

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0497G

Niclosamide BAY2353	Antibiotic Parasite STAT	Cancer
Niclosamide (GMP) is Niclosamide (HY-B0497) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research . Niclosamide is a STAT3 inhibitor with an IC₅₀ of 0.25 μM in HeLa cells . Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells .

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