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TPPS

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58

Inhibitors & Agonists

2

Fluorescent Dye

8

Biochemical Assay Reagents

6

Peptides

1

Inhibitory Antibodies

1

Natural
Products

7

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-100116A
    Mitoquinone mesylate
    Maximum Cited Publications
    153 Publications Verification

    MitoQ mesylate; MitoQ10 mesylate

    		 Reactive Oxygen Species (ROS) Metabolic Disease Cancer
    Mitoquinone mesylate is a TPP-based, mitochondrially targeted antioxidant in order to protect against oxidative damage .
    Mitoquinone mesylate
  • HY-102007A
    Gamitrinib TPP hexafluorophosphate
    10+ Cited Publications

    		 HSP Cancer
    Gamitrinib TPP hexafluorophosphate is a Gamitrinib (GA) mitochondrial matrix inhibitor. Gamitrinib TPP hexafluorophosphate is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity.
    Gamitrinib TPP hexafluorophosphate
  • HY-125623
    MitoPerOx
    3 Publications Verification

    		 Fluorescent Dye Others
    MitoPerOx is a mitochondrial-targeted, lipid peroxidation-indicating fluorescent probe with BODIPY581/591 fluorophores. The triphenylphosphine cation (TPP+) of MitoPerOx can be selectively enriched in mitochondria (depending on membrane potential) and can be used to detect lipid peroxidation in the inner mitochondrial membrane. Under the action of lipid peroxides, the BODIPY581/591 fluorophores of MitoPerOx shift their emission wavelength from 590 nm (reduced state) to 520 nm (oxidized state), and ratiometric detection can be performed at an excitation wavelength of 488 nm. MitoPerOx can specifically monitor the peroxidation of mitochondrial phospholipids (especially cardiolipin) and is used in the study of oxidative stress-related diseases (such as aging, neurodegenerative diseases, and mitochondrial dysfunction)[1][2].
    MitoPerOx
  • HY-W111141
    BCN-OH

    endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne

    		 Biochemical Assay Reagents Others
    BCN-OH (endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne) is an alcohol functionalized cyclooctyne derivative. BCN-OH can act as a raw material for synthesizing other probes (such as BCN-TPP). BCN-OH is used to construct targeted probes by coupling with carboxyl-containing compounds (such as TPP-COOH). BCN-OH can be used as control reagent for BCN-TPP .
    BCN-OH
  • HY-P3139
    TPP-1

    		PD-1/PD-L1 Cancer
    TPP-1 is a potent inhibitor of the PD-1/PD-L1 interaction. TPP-1 binds specifically to PD-L1 with a high affinity (KD=95 nM). TPP-1 inhibits human tumor growth in vivo via reactivating T-cell function .
    TPP-1
  • HY-103656
    Tetraphenylporphyrin

    TPP; Tetraphenylporphine; meso-Tetraphenylporphyrin

    		 MOFs Cancer
    Tetraphenylporphyrin (TPP) is a symmetrically substituted porphyrin-based heterocyclic compound and used as a structural block for supramolecular synthesis. Tetraphenylporphyrin derivatives can be used for cancer research .
    Tetraphenylporphyrin
  • HY-DY1073
    MitoPerOx (solution)

    		Fluorescent Dye Others
    MitoPerOx (solution) is a mitochondrial-targeted, lipid peroxidation-indicating fluorescent probe with BODIPY581/591 fluorophores. The triphenylphosphine cation (TPP+) of MitoPerOx can be selectively enriched in mitochondria (depending on membrane potential) and can be used to detect lipid peroxidation in the inner mitochondrial membrane. Under the action of lipid peroxides, the BODIPY581/591 fluorophores of MitoPerOx shift their emission wavelength from 590 nm (reduced state) to 520 nm (oxidized state) , and ratiometric detection can be performed at an excitation wavelength of 488 nm. MitoPerOx can specifically monitor the peroxidation of mitochondrial phospholipids (especially cardiolipin) and is used in the study of oxidative stress-related diseases (such as aging, neurodegenerative diseases, and mitochondrial dysfunction) .
    Solvent and concentration: DMSO: 2 mM
    MitoPerOx (solution)
  • HY-102007
    Gamitrinib TPP

    		HSP Cancer
    Gamitrinib TPP is a Gamitrinib (GA) mitochondrial matrix inhibitor. Gamitrinib TPP is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity.
    Gamitrinib TPP
  • HY-135869
    Mito-apocynin (C11)
    3 Publications Verification

    		 Mitochondrial Metabolism Neurological Disease
    Mito-apocynin (C11), an orally active mitochondria-targeted triphenylphosphonium (TPP)-based compound, is synthesized by conjugating the Apocynin moiety with a TPP + cation. Mito-apocynin (C11) selectively targets mitochondria, and shows neuroprotective effect. Mito-apocynin (C11) prevents hyposmia and corrects deficits in motor function .
    Mito-apocynin (C11)
  • HY-159734
    TPP-resveratrol

    		Apoptosis Cancer
    TPP-resveratrol is a conjugate of Resveratrol (HY-16561) and triphenylphosphine (TPP) with anticancer activity. TPP-resveratrol increases the potency of Resveratrol through mitochondrial-targeted delivery and induces mitochondria-mediated apoptosis .
    TPP-resveratrol
  • HY-158189
    TPP-Ce6

    		Photosensitizer Reactive Oxygen Species (ROS) Apoptosis Neurological Disease Cancer
    TPP-Ce6 is a mitochondria-targeted photosensitizer formed by the ester bond conjugation of chlorophyll e6 (Ce6) with triphenylphosphine (TPP). Under light irradiation or ultrasound exposure, TPP-Ce6 generates reactive oxygen species, induces cell apoptosis, and triggers immunogenic cell death. TPP-Ce6 can serve as a component of carrier-free co-delivery systems, undergo enzyme-induced self-assembly within tumors, and modulate tumor hypoxia. TPP-Ce6 is applicable to research on breast cancer and glioblastoma .
    TPP-Ce6
  • HY-144768
    (R)-Chol-TPP
    1 Publications Verification

    		 Liposome Others
    (R)-Chol-TPP a mitochondria targeting liposome ligand could be used in pH-redox responsive .
    (R)-Chol-TPP
  • HY-150070
    Butabindide

    UCL-1397

    		 Ser/Thr Protease Neurological Disease
    Butabindide (UCL-1397) is a potent, selective tripeptidvl peptidase II (TPP II) inhibitor with Ki values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide inhibits TPP II to protect CCK-8 against inactivation .
    Butabindide
  • HY-107759
    Butabindide oxalate
    2 Publications Verification

    UCL-1397 oxalate

    		 Ser/Thr Protease Neurological Disease
    Butabindide (UCL-1397) oxalate is a potent, selective tripeptidvl peptidase II (TPP II) inhibitor with Ki values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide oxalate inhibits TPP II to protect CCK-8 against inactivation .
    Butabindide oxalate
  • HY-W075353
    TPPS

    		Fluorescent Dye MOFs Cancer
    TPPS can be used as a non-cytotoxic probe for detecting tumor location .
    TPPS
  • HY-W582504
    Chlorotris(triphenylphosphine)copper

    CuCl(TPP)3

    		 DNA Stain Bacterial Fungal Infection Cancer
    Chlorotris(triphenylphosphine)copper (CuCl(TPP)₃) is a DNA-targeted metal complex. Chlorotris(triphenylphosphine)copper involves non-covalent interactions (such as groove binding mode) through the copper(I) center to affect DNA function, showing inhibitory activity against bacteria, fungi, and tumor cells. Chlorotris(triphenylphosphine)copper is promising for research of antibacterial, antitumor, and antioxidant agents .
    Chlorotris(triphenylphosphine)copper
  • HY-174953A
    TPP-PEG2000-Mal

    		Biochemical Assay Reagents Others
    TPP-PEG2000-Mal is a PEG derivative composed of triphenyl phosphate (TPP), PEG units, and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups .
    TPP-PEG2000-Mal
  • HY-174953B
    TPP-PEG3400-Mal

    		Biochemical Assay Reagents Others
    TPP-PEG3400-Mal is a PEG derivative composed of triphenyl phosphate (TPP), PEG units, and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups .
    TPP-PEG3400-Mal
  • HY-P4470
    Phe-Pro-Ala-pNA

    		Ser/Thr Protease Cancer
    Phe-Pro-Ala-pNA is a chromogenic substrate of tripeptidyl peptidase. Phe-Pro-Ala-pNA can be used to test tripeptidyl peptidase activity .
    Phe-Pro-Ala-pNA
  • HY-W854649
    [Au(TPP)]Cl

    		HSP Cancer
    [Au(TPP)]Cl inhibits the refolding activity of the Hsp60-Hsp10 complex with significant anticancer activities .
    [Au(TPP)]Cl
  • HY-151342
    Ser@TPP@CUR

    		Drug Derivative Others
    Ser@TPP@CUR is a Curcumin (HY-N0005) derivative. Ser@TPP@CUR effectively ameliorates injured renal tubular epithelial cells and improves renal functions of acute kidney injury (AKI) mice. Ser@TPP@CUR can be used for the research of AKI .
    Ser@TPP@CUR
  • HY-P3139A
    TPP-1 TFA

    		PD-1/PD-L1 Cancer
    TPP-1 TFA is a potent inhibitor of the PD-1/PD-L1 interaction. TPP-1 TFA binds specifically to PD-L1 with a high affinity (KD=95 nM). TPP-1 TFA inhibits human tumor growth in vivo via reactivating T-cell function .
    TPP-1 TFA
  • HY-186012
    TPP@CUR

    		Drug Intermediate Others
    TPP@CUR is the product formed by the esterification reaction between Curcumin (HY-N0005) and (5-hydroxy-5-oxopentyl)triphenylphosphonium bromide (TPP). TPP@CUR can be used to synthesize Ser@TPP@CUR (HY-151342), which can then be used in studies of acute kidney injury .
    TPP@CUR
  • HY-174953
    TPP-PEG1000-Mal

    		Biochemical Assay Reagents Others
    TPP-PEG1000-Mal is a PEG derivative composed of triphenyl phosphate (TPP), PEG units, and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups .
    TPP-PEG1000-Mal
  • HY-W076041
    Zinc meso-tetraphenylporphine

    Zinc(II) TPP

    		 MOFs Others
    Zinc meso-tetraphenylporphine (Zinc(II) TPP) is a metal-organic framework (MOF).
    Zinc meso-tetraphenylporphine
  • HY-W034952
    5,10,15,20-Tetraphenyl-21H,23H-porphine copper(II)

    Copper(II) TPP

    		 MOFs Others
    5,10,15,20-Tetraphenyl-21H,23H-porphine copper(II) (Copper(II) TPP) is a metal-organic framework (MOF).
    5,10,15,20-Tetraphenyl-21H,23H-porphine copper(II)
  • HY-W010252
    N-Benzylethylenediamine

    		Calcium Channel Bacterial Infection
    N-Benzylethylenediamine is a polyamine compound. N-Benzylethylenediamine can effectively release Ca 2+ from the outer membrane of Escherichia coli (ED50: 200-500 μM), but cannot induce TPP + uptake .
    N-Benzylethylenediamine
  • HY-W754527
    Allithiamine

    Allithiamin

    		 Drug Derivative Metabolic Disease
    Allithiamine is a thiamin derivative with absorption characteristics similar to fat-soluble vitamins. Allithiamine acts as a cofactor precursor for thiamin pyrophosphate (TPP), which participates in carbohydrate metabolism by supporting the pyruvate dehydrogenase (PDH) complex to facilitate pyruvate entry into the tricarboxylic acid (TCA) cycle as acetyl CoA. Allithiamine can be used for researching thiamin metabolism .
    Allithiamine
  • HY-W127806
    TPPS dihydrochloride

    		Biochemical Assay Reagents Others
    TPPS dihydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    TPPS dihydrochloride
  • HY-135868
    Mito-apocynin (C2)

    		Mitochondrial Metabolism Neurological Disease
    Mito-apocynin (C2), an orally active mitochondria-targeted triphenylphosphonium (TPP)-based compound, is synthesized by conjugating the Apocynin moiety with a TPP + cation. Mito-apocynin (C2) exhibits antineuroinflammatory effect .
    Mito-apocynin (C2)
  • HY-157933
    SF-C5-TPP

    		Mitochondrial Metabolism Infection
    SF-C5-TPP is an potent mitochondria-targeted protonophoric uncoupler. SF-C5-TPP has significant proton transfer activity on model planar bilayer lipid membranes. SF-C5-TPP inhibits the growth of Bacillus subtilis with a MIC of 2 μM >[1].
    SF-C5-TPP
  • HY-176775
    TPP-IOA

    		Oxidative Phosphorylation Mitochondrial Metabolism Apoptosis Neurological Disease
    TPP-IOA is a cytochrome c peroxidase inhibitor. TPP-IOA inhibits apoptosis by preventing cardiolipin oxidation and cytochrome c release to the cytosol. TPP-IOA disrupts oxidative phosphorylation in isolated mitochondria. TPP-IOA inhibits cell death in SH-SY5Y cells grown in glucose, but not galactose. TPP-IOA causes mitochondrial depolarization and network fragmentation. TPP-lOA mitigates radiation induced death in mice .
    TPP-IOA
  • HY-144831
    6BrCaQ-C10-TPP

    		HSP Cancer
    6BrCaQ-C10-TPP is a potent mitochondrial heat shock protein TRAP1 inhibitor, with antiproliferative activity in various human cancer cells (IC50=0.008-0.30 μM). 6BrCaQ-C10-TPP can also induces mitochondrial membrane disturbance .
    6BrCaQ-C10-TPP
  • HY-P10656
    Ac-DEVDD-TPP

    		Apoptosis Pyroptosis Cancer
    Ac-DEVDD-TPP is a porphyrin derivative that can be converted into D-TPP by caspase-3 cleavage and laser irradiation. The formed porphyrin nanofibers can effectively induce Apoptosis and Pyroptosis. Ac-DEVDD-TPP has antitumor activity .
    Ac-DEVDD-TPP
  • HY-173549
    CPPA-TPP

    CPPA-Triphenylphosphonium

    		 Drug Intermediate Cancer
    CPPA-TPP (CPPA-Triphenylphosphonium) is a compound conjugated to the mitochondria-targeting moiety triphenylphosphonium (TPP). CPPA-TPP can be used in the synthesis of nanoparticles that release Camptothecin (HY-16560) in a reactive oxygen species dependent manner, leading to cancer cell death .
    CPPA-TPP
  • HY-RS14942
    TPP1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    TPP1 Human Pre-designed siRNA Set A contains three designed siRNAs for TPP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    TPP1 Human Pre-designed siRNA Set A
    TPP1 Human Pre-designed siRNA Set A
  • HY-RS25466
    Tpp2 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Tpp2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tpp2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Tpp2 Rat Pre-designed siRNA Set A
    Tpp2 Rat Pre-designed siRNA Set A
  • HY-RS17753
    Tpp1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Tpp1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tpp1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Tpp1 Mouse Pre-designed siRNA Set A
    Tpp1 Mouse Pre-designed siRNA Set A
  • HY-161048
    PDH E1-IN-1

    		PDHK Others
    PDH E1-IN-1 (compound 24) is a selective TPP-competitive PDH E1 with an IC50 value of 0.99 μM .
    PDH E1-IN-1
  • HY-151404
    Antitumor agent-76

    		Apoptosis Cancer
    Antitumor agent-76 (Compound TP-P1) is an orally active, rapid-release and water-soluble Triptolide (HY-32735) proagent with antitumor activity .
    Antitumor agent-76
  • HY-144830
    6BrCaQ

    		HSP Cancer
    6BrCaQ is a potent mitochondrial heat shock protein TRAP1 inhibitor, with antiproliferative activity. 6BrCaQ can be used in the synthesis of 6BrCaQ-TPP conjugates .
    6BrCaQ
  • HY-158918
    4-CF3-TPP-DC

    4-CF3-Triphenylphosphonium-DC

    		 Biochemical Assay Reagents Others
    4-CF3-TPP-DC (4-CF3-Triphenylphosphonium-DC) is an inert mitochondrial targeting carrier, that delivers target drugs and probes to mitochondria without causing mitochondrial depolarization and cytotoxicity in cell C2C12 .
    4-CF3-TPP-DC
  • HY-172342
    MitoA bromide

    		Fluorescent Dye Cardiovascular Disease
    MitoA (bromide) is a mitochondria-targeted H2S probe, which can be used to assess relative changes in mitochondrial levels of H2S in vivo. MitoA (bromide) can accumulate inside mitochondria within tissues in vivo due to tryphenylphosphonium (TPP) cation. MitoA (bromide) can be studied in research on myocardial ischemia .
    MitoA bromide
  • HY-151556
    Antifungal agent 45

    		Fungal Infection
    Antifungal agent 45 is with fungicidal activities. Antifungal agent 45 shows excellent characteristics superior to Kresoxim-methyl (HY-125776), in which the activity enhancement against Phytophthora capsici was the most remarkable, with an EC50 value of about 5 μM .
    Antifungal agent 45
  • HY-144825
    Chol-CTPP

    		Apoptosis Reactive Oxygen Species (ROS) Cancer
    Chol-CTPP is a ligand with dual targeting effect on blood-brain barrier (BBB) and glioma cells. Lip-CTPP can be gained by Chol-CTPP and another mitochondria targeting ligand (Chol-TPP). Lip-CTPP is a promising potential carrier to exert the anti-glioma effect of doxorubicin (DOX) and lonidamine (LND) collaboratively. Lip-CTPP elevates the inhibition rate of tumor cell proliferation, migration and invasion, promote apoptosis and necrosis, and interfere with mitochondrial function .
    Chol-CTPP
  • HY-102007AR
    Gamitrinib TPP hexafluorophosphate (Standard)

    		Reference Standards HSP Cancer
    Gamitrinib TPP hexafluorophosphate (Standard) is the analytical standard of Gamitrinib TPP hexafluorophosphate (HY-102007A). This product is intended for research and analytical applications. Gamitrinib TPP hexafluorophosphate is a Gamitrinib (GA) mitochondrial matrix inhibitor. Gamitrinib TPP hexafluorophosphate is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity.
    Gamitrinib TPP hexafluorophosphate (Standard)
  • HY-P992032
    TPP-9476

    BAY-943 antibody

    		 Interleukin Related Cancer
    TPP-9476 is an anti-human IL3RA (CD123) monoclonal antibody with human IL3RA Kd of 11 nM and cynomolgus monkey IL3RA Kd of 16 nM. TPP-9476 binds specifically to human and cynomolgus monkey IL3RA, undergoes target-dependent internalization into lysosomes of IL3RA-positive cells.TPP-9476 exerts antiproliferative effects in IL3RA-expressing acute myeloid leukemia and classical Hodgkin lymphoma cells, reduces tumor burden, improves survival, and induces complete tumor remission in relevant xenograft mouse models .
    TPP-9476
  • HY-RS14943
    TPP2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    TPP2 Human Pre-designed siRNA Set A contains three designed siRNAs for TPP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    TPP2 Human Pre-designed siRNA Set A
    TPP2 Human Pre-designed siRNA Set A
  • HY-183082
    Mal-GFLG-TPP-PPA

    		Drug-Linker Conjugates for ADC Drug Intermediate Cancer
    Mal-GFLG-TPP-PPA is a drug-linker conjugate for ADC, and can be used for synthesis of ADCs. Mal-GFLG-TPP-PPA is used in the synthesis of PEG-iPDPA-GFLG-Y-TPPa .
    Mal-GFLG-TPP-PPA
  • HY-RS24220
    Tpp1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Tpp1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tpp1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Tpp1 Rat Pre-designed siRNA Set A
    Tpp1 Rat Pre-designed siRNA Set A

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