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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
31 Results for "
VGSCs
" in MedChemExpress (MCE) Product Catalog:
Products (31)
31 Results for "VGSCs" in MCE Product Catalog:
8
8 Publications Verification
Synonyms: 5,5-Diphenylhydantoin
Target:
Áreas de investigación:
Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na + channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice .
8
8 Publications Verification
Synonyms: 5,5-Diphenylhydantoin sodium salt
Target:
Áreas de investigación:
Phenytoin sodium (5,5-Diphenylhydantoin sodium salt) is a potent Voltage-gated Na + channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice .
5
5 Cited Publications
Referencia número: HY-17385
No. CAS: 82248-59-7
Synonyms: Tomoxetine hydrochloride; (R)-Tomoxetine hydrochloride; LY 139603
Áreas de investigación:
Atomoxetine (Tomoxetine) hydrochloride is a selective noradrenaline reuptake inhibitor with Ki values of 5 nM, 77 nM and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride is a potent Na + channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research .
5
5 Cited Publications
Referencia número: HY-107370
No. CAS: 83015-26-3
Synonyms: Tomoxetine; (R)-Tomoxetine
Target:
Áreas de investigación:
Atomoxetine (Tomoxetine) is a selective noradrenaline reuptake inhibitor with Ki values of 5, 77 and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine (Tomoxetine) increases of DAEX and NEEX in the PFC and enhances catecholaminergic neurotransmission. Atomoxetine (Tomoxetine) is a potent Na + channels (VGSCs) blocker. Atomoxetine (Tomoxetine) can be used for attention-deficit hyperactivity disorder (ADHD) research .
4
Target:
1
Target:
1
Target:
Áreas de investigación:
DPI 201-106 (SDZ 201106) is a cardiotonic agent with a synergistic sarcolemmal and intracellular mechanism of action. DPI 201-106 shows cardioselective modulation of voltage-gated sodium channels (VGSCs) resulting in a positive inotropic effect .
Referencia número: HY-B0448S
No. CAS: 65854-97-9
Synonyms: 5,5-Diphenylhydantoin-d10
Referencia número: HY-17612
No. CAS: 1092977-61-1
Synonyms: NW-3509
Target:
Áreas de investigación:
Evenamide (NW-3509) is an orally available voltage-gated sodium channel (VGSC) blocker (Ki=0.4 µM) for the research of schizophrenia. Evenamide shows efficacy in a broad spectrum of rodent models of psychosis, mania, depression, and aggressiveness .
Referencia número: HY-16723
No. CAS: 1259933-16-8
Synonyms: TV 45070; XEN402; FX301
Target:
Áreas de investigación:
Funapide (TV 45070; XEN402) is an orally active inhibitor of voltage-gated sodium channels (VGSC) in the peripheral nervous system with IC50 values ??of 84 nM and 54 nM for Nav1.5 and Nav1.7, respectively. Funapide has analgesic effects .
Referencia número: HY-B0448AR
No. CAS: 630-93-3
Synonyms: 5,5-Diphenylhydantoin sodium salt (Standard)
Áreas de investigación:
Phenytoin (sodium) (Standard) is the analytical standard of Phenytoin (sodium). This product is intended for research and analytical applications. Phenytoin sodium (5,5-Diphenylhydantoin sodium salt) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice .
Áreas de investigación:
Phenytoin (Standard) is the analytical standard of Phenytoin. This product is intended for research and analytical applications. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na + channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice .
Referencia número: HY-P5807A
Synonyms: β-Mammal toxin Cn2 TFA
Target:
Áreas de investigación:
Referencia número: HY-W031620
No. CAS: 1204296-79-6
Target:
Áreas de investigación:
VGSCs-IN-1 (compound 14), a 2-piperazine analog of Riluzole (HY-B0211), is a human voltage-gated sodium channels (VGSCs) inhibitor. VGSCs-IN-1 shows great Nav1.4 blocking activity. VGSCs-IN-1 has a pKa of 7.6 and a cLog P of 2.4. VGSCs-IN-1 can be used for cell excitability disorders research .
Referencia número: HY-P1219
No. CAS: 925463-91-8
Synonyms: β-TRTX-Cj1α
Target:
Áreas de investigación:
Referencia número: HY-B0448S2
Synonyms: 5,5-Diphenylhydantoin-d5
Target:
Referencia número: HY-107370A
No. CAS: 82857-40-7
Synonyms: (Rac)-Tomoxetine hydrochloride; (Rac)-LY 139603
Target:
Áreas de investigación:
(Rac)-Atomoxetine hydrochloride ((Rac)-Tomoxetine (hydrochloride); (Rac)-LY 139603) is the racemic mixture of Atomoxetine hydrochloride (HY-17385). Atomoxetine hydrochloride is a selective noradrenaline reuptake inhibitor with Ki values of 5, 77 and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride increases of DAEX and NEEX in the PFC and enhances catecholaminergic neurotransmission. Atomoxetine hydrochloride is a potent Na + channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research .
Referencia número: HY-126005
No. CAS: 2230472-55-4
Target:
Áreas de investigación:
VGSC blocker-1 is a potent and small molecule blocker of neonatal isoform of the VGSC subtype, Nav1.5 (nNav1.5). VGSC blocker-1 blocks INa peak currents 34.9% at 1 μM and inhibits cell invasion 0.3% at 1 μM in human breast cancer cell line MDA-MB-231, without affecting the cell viability .
Referencia número: HY-P5772
Target:
Áreas de investigación:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
