119 Results for "

Xanthine oxidase inhibitors

" in MedChemExpress (MCE) Product Catalog:
Products (119)

119 Results for "Xanthine oxidase inhibitors" in MCE Product Catalog:

39
39 Publications Verification
Cat. No.: HY-N0196
CAS No.: 491-67-8
Synonyms: 5,6,7-Trihydroxyflavone
Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor with an IC50 value of 3.12 μM.
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13
13 Cited Publications
Cat. No.: HY-14268
CAS No.: 144060-53-7
Purity:  99.94%
Synonyms: TEI 6720; TMX 67
Febuxostat (TEI 6720) is a potent, selective and non-purine xanthine oxidase (XO) inhibitor with a Ki value of 0.6 nM. Febuxostat has the potential for the research of hyperuricemia and gout .
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13
13 Cited Publications
Cat. No.: HY-B0219
CAS No.: 315-30-0
Allopurinol is a potent and orally active xanthine oxidase inhibitor with an IC50 value of 0.2-50 μM. Allopurinol can be used in the research of hyperuricemia and gout. Allopurinol decreases the expression of HIF-1α and HIF-2α protein. Allopurinol shows anti-depressant and anti-nociception activity. Anti-leishmanial effect .
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13 Cited Publications
Cat. No.: HY-B0219A
CAS No.: 17795-21-0
Allopurinol sodium is a potent and orally active xanthine oxidase inhibitor with an IC50 value of 0.2-50 μM. Allopurinol sodium can be used in the research of hyperuricemia and gout. Allopurinol sodium decreases the expression of HIF-1α and HIF-2α protein. Allopurinol sodium shows anti-depressant and anti-nociception activity. Anti-leishmanial effect .
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4
4 Cited Publications
Cat. No.: HY-N0327
CAS No.: 129277-38-9
Lobetyolin, a bioactive compound, is derived from Codonopsis pilosula. Lobetyolin has anti-inflammatory, anti-oxidative and xanthine oxidase inhibiting activities. Lobetyolin also induces the apoptosis via the inhibition of ASCT2-mediated glutamine metabolism . Lobetyolin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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4 Cited Publications
Cat. No.: HY-N0778
CAS No.: 55033-90-4
Isorhamnetin-3-O-neohespeidoside is a flavonoid. Isorhamnetin-3-O-neohespeidoside can be isolated from Typha angustifolia. Isorhamnetin-3-O-neohespeidoside inhibits xanthine oxidase activity with an IC50 of 48.75 μg mL. Isorhamnetin-3-O-neohespeidoside has antioxidant and osteoclastogenic activities. Isorhamnetin-3-O-neohespeidoside can be used in research of bone .
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3
3 Cited Publications
Cat. No.: HY-D0837
CAS No.: 288-32-4
Synonyms: Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene
Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CL Pro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease .
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2
2 Cited Publications
Cat. No.: HY-N0244
CAS No.: 28543-07-9
Theaflavin-3'-gallate is a monomer of theaflavins found in black tea, which has anti-UVB damage activity and inhibits cell apoptosis and necroptosis. Theaflavin-3'-gallate acts as a pro-oxidant and induces oxidative stress in cancer cells, inhibiting xanthine oxidase (OX), with an IC50 of 7.6 μM .
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2
2 Cited Publications
Cat. No.: HY-N3101
CAS No.: 22384-63-0
Pedalitin is a tyrosinase and α-glucosidase inhibitor with IC50 values of 0.28 mM and 0.29 mM, respectively, and can be isolated and extracted from Rabdosia serra. Pedalitin is a xanthine oxidase (Xanthine Oxidase) (IC50 = 3.7 µM) and myeloperoxidase (MPO) (IC50 = 3.8 nM) inhibitor. Pedalitin ameliorates NAFLD by downregulating the EGFR/IRS1/AKT1/FOXO1 signaling pathway and related inflammatory and lipid metabolism factors. Pedalitin reduces the risk of urinary tract infection and stones by inhibiting the expression of the urease UreC gene in Proteus mirabilis. Pedalitin also exhibits antifungal activity, with a MIC of 3.9 mg/L against Cryptococcus neoformans. Pedalitin can be used for research on non-alcoholic fatty liver disease, chronic kidney disease, kidney stones, cryptococcosis, and abdominal pain .
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1
1 Cited Publications
Cat. No.: HY-N4136
CAS No.: 25694-72-8
Synonyms: Veronicastroside
Lonicerin (Veronicastroside) is a flavonoid with multiple biological activities. Lonicerin inhibits xanthine oxidase with an IC50 of 37.4 µg/mL. Lonicerin inhibits alginate secretion protein (AlgE). Lonicerin inhibits P. aeruginosa and C. albicans. Lonicerin has anti-inflammatory, anti-arthritic, antioxidant, antifungal, anti-bacterial, and neuroprotective properties .
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1
1 Cited Publications
Cat. No.: HY-N3220
CAS No.: 15648-86-9
Myricetin 3-O-galactoside inhibits xanthine oxidase (XO) activity, lipid peroxidation and scavenges the free radical. Myricetin 3-O-galactoside inhibits lipid peroxidation with an IC50 of 160 μg/mL. Antioxidant activity .
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1
1 Cited Publications
Cat. No.: HY-N0358
CAS No.: 1182-34-9
Synonyms: 1,4-DCQA
1,4-Dicaffeoylquinic acid (1,4-DCQA) is a phenylpropanoid compound that can be isolated from Xanthii fructus and an inhibitor of xanthine oxidase (IC50: 7.36 μM). 1,4-Dicaffeoylquinic acid has anti-inflammatory activity and can inhibit the production of TNF-α induced by LPS (HY-D1056) .
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1
1 Cited Publications
Cat. No.: HY-N0814A
CAS No.: 123408-98-0
Synonyms: Inositol hexaphosphate dodecasodium hydrate; SNF472 dodecasodium hydrate
Phytic acid (Inositol hexaphosphate) dodecasodium hydrate is a phosphorus storage compound of seeds and cereal grains. Phytic acid dodecasodium hydrate is known as a food inhibitor, which has a strong ability to chelate multivalent metal ions, specially zinc, calcium, iron and as with protein residue. Phytic acid dodecasodium hydrate inhibits the enzymatic superoxide source xanthine oxidase (XO), and has antioxidative, neuroprotective, anti-inflammatory effects .
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1
1 Cited Publications
Cat. No.: HY-N8600
CAS No.: 3440-24-2
7,8,3′,4′-Tetrahydroxyflavone (compound 2) is a potent xanthine oxidase (XOD) inhibitor with an IC50 value of 10.488 µM .
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Cat. No.: HY-19657
CAS No.: 2465-59-0
Synonyms: Oxipurinol
Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout .
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Cat. No.: HY-W047187
CAS No.: 117405-51-3
Lavandoside is an ABTS ?+ free radical scavenger and a moderate inhibitor of xanthine oxidase (XO), with an IC50 of 71.6 μM for inhibiting NO production in LPS-induced macrophages. Lavandoside exerts its antioxidant and potential anti-inflammatory effects by directly scavenging free radicals and inhibiting XO activity, a mechanism related to the hydroxyl groups in its molecular structure. Lavandoside can be isolated from lavender and can be used in the development of natural antioxidants and in research on oxidative stress-related diseases and inflammation-related diseases .
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Cat. No.: HY-14268S1
CAS No.: 1285539-74-3
Synonyms: TEI 6720-d7; TMX 67-d7
Febuxostat-d7 is deuterium labeled Febuxostat. Febuxostat (TEI 6720) is selective xanthine oxidase inhibitor with a Ki of 0.6 nM .
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Cat. No.: HY-116442
CAS No.: 13539-59-8
Azapropazone is an orally active nonsteroidal anti-inflammatory agent. Azapropazone inhibits Xanthine oxidase activity with an IC50 of 70-140 μg/mL. Azapropazone exerts significant cardiomyocyte protective effects on dogs with ischemia-reperfusion injury . Azapropazone reduces arthritis. Azapropazone inhibits Adrenaline-induced platelet aggregation. Azapropazone can be used for the research of myocardial ischemia and reperfusion injury, adjuvant arthritis, and gouty arthritis .
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Cat. No.: HY-B0051
CAS No.: 70724-25-3
Carbazeran is a phosphodiesterase inhibitor. Carbazeran is oxidized by aldehyde oxidase/AOX1 to 4-oxo-carbazeran/hydroxycarbazeran, serving as an AOX1 probe and competitively inhibiting xanthine oxidase. Carbazeran can be used in research on congestive heart failure and chronic heart failure .
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Cat. No.: HY-113978
CAS No.: 712-30-1
Purity:  ≥98.0%
6-Formylpterin is an inhibitor of Xanthine Oxidase. 6-Formylpterin induces intracellular ROS generation and apoptosis in HL-60 cells. 6-Formylpterin suppresses cell proliferation in PanC-1 cells .
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