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and R5/W677

" in MedChemExpress (MCE) Product Catalog:

標的別:	11β-HSD (1) 17β-HSD (1) 5 alpha Reductase (2) 5-HT Receptor (22) ABA Receptor (1) Acetyl-CoA Carboxylase (1) Acetyl-CoA synthetase (1) Acyltransferase (1) ADC Antibody (1) ADC Linker (5) ADC Payload (1) Adenosine Receptor (5) Adenylate Cyclase (4) Adrenergic Receptor (17) AIM2 (1) Akt (26) Aldehyde Dehydrogenase (ALDH) (1) Aldose Reductase (4) Amino Acid Decarboxylase (3) Amino Acid Derivatives (1324) Aminoacyl-tRNA Synthetase (1) Aminopeptidase (3) AMPK (9) Amylin Receptor (5) Amyloid-β (3) Anaplastic lymphoma kinase (ALK) (8) Androgen Receptor (5) Angiotensin Receptor (2) Angiotensin-converting Enzyme (ACE) (6) Antibiotic (28) Antibody-Drug Conjugates (ADCs) (3) Antifolate (1) AP-1 (3) Apelin Receptor (APJ) (1) Apolipoprotein (2) Apoptosis (160) Arginase (1) Arrestin (5) ASCT (1) ATF6 (2) Atg8/LC3 (3) ATM/ATR (4) ATP Citrate Lyase (2) Aurora Kinase (2) Autophagy (26) Bacterial (85) Bcl-2 Family (24) Bcr-Abl (1) BCRP (2) Beclin1 (1) Beta-lactamase (2) Biochemical Assay Reagents (249) Bombesin Receptor (1) Bradykinin Receptor (1) Btk (3) c-Fms (1) c-Kit (3) c-Met/HGFR (6) c-Myc (5) C-type Lectin-like Receptors (CTLRs) (1) Cadherin (1) Calcium Channel (17) Calmodulin (1) Cannabinoid Receptor (6) Carbonic Anhydrase (8) Carboxylesterase (CES) (1) Carboxypeptidase (2) Casein Kinase (1) Caspase (28) Cathepsin (5) CCR (3) CD19 (1) CD276/B7-H3 (1) CD28 (4) CD38 (1) CD44 (1) CD47 (1) CDK (23) CFTR (1) CGRP Receptor (3) Checkpoint Kinase (Chk) (2) CHIKV (2) Cholecystokinin Receptor (2) Cholinesterase (ChE) (15) Claudin (1) CMV (3) Collagen (2) Complement System (4) COX (13) CRFR (2) CXCR (7) Cyclin G-associated Kinase (GAK) (2) Cyclophilin (1) Cytochrome P450 (14) DAGL (1) Dengue Virus (2) DGK (1) Dihydrofolate reductase (DHFR) (5) Dihydroorotate Dehydrogenase (1) Dipeptidyl Peptidase (5) DNA Alkylator/Crosslinker (1) DNA Methyltransferase (1) DNA Stain (1) DNA/RNA Synthesis (122) Dopamine Receptor (5) Dopamine β-hydroxylase (1) Drug Derivative (56) Drug Intermediate 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Standards (97) Renin (1) Reverse Transcriptase (3) Ribosomal S6 Kinase (RSK) (2) RIO Kinase (1) RIP kinase (2) ROS Kinase (2) RUNX (3) RXFP Receptor (1) SARS-CoV (12) Scavenger Receptor Class B type I (SR-BI） (1) Sec61 (1) Ser/Thr Kinase (1) Ser/Thr Protease (12) Serotonin Transporter (4) SGK (3) Sirtuin (7) SOD (4) Sodium Channel (7) Sodium Phosphate Cotransporter (1) Somatostatin Receptor (3) Src (7) STAT (21) Stearoyl-CoA Desaturase (SCD) (2) Steroid Sulfatase (1) STING (9) Survivin (3) Syk (1) TAM Receptor (1) Target Protein Ligand-Linker Conjugates (2) Taste Receptor (3) Telomerase (1) TGF-beta/Smad (5) TGF-β Receptor (4) Thrombin (3) Thymidylate Synthase (1) Thyroid Hormone Receptor (3) Tie (2) TNF Receptor (22) Toll-like Receptor (TLR) (9) Topoisomerase (18) Transferrin Receptor (1) Transmembrane Glycoprotein (8) Trk Receptor (1) TROP2 (1) TRP Channel (12) TrxR (2) Tryptophan Hydroxylase (1) Tyrosinase (5) Tyrosine Hydroxylase (3) ULK (1) URAT1 (1) Urease (1) Vasopressin Receptor (2) VD/VDR (1) VDAC (1) VEGFR (16) Virus Protease (2) Wee1 (1) Wnt (7) Xanthine Oxidase (1) YAP (2) Zinc Finger Protein (1) α-synuclein (1) β-catenin (8) γ-Glutamyl Transferase (GGT) (1)
研究分野別:	Cancer (600) Cardiovascular Disease (141) Endocrinology (34) Infection (198) Inflammation/Immunology (300) Metabolic Disease (182) Neurological Disease (252)
クリックケミストリー:	DBCO (1) Azide (15) Alkynes (7)
Oligonucleotides:	Guanosine (2) Nucleotide Analogs (21) Phospholipids (1) Cap Analogs (7) Other Phosphoramidite (1) Antisense Oligonucleotides (2) Guanine (3) pH Modifiers (5) Antioxidants (1) Pegylated Lipids (5) Nucleoside Analogs (10) Disintegrants (4) Cytosine (2) Cationic Lipids (1) Polymers (1) Phosphoramidites (11) Solvents (4) Adenosine (4) Preservatives (4) Thickeners (3) Inosine Nucleoside (2) Fillers (3) Thymine (1) Adenine (3) Suspending Agents (2) Solubilizing Agents (5) Binders (2) Surfactants (5) Bases (5) Cytidine Nucleotide (2) Adenine Nucleotide (2) Cytidine (2) Cholesterol (2) Guanine Nucleotide (1) Uridine (2) CpG ODNs (1) Emulsifiers (14) Uracil (1) Chelating Agents (2)

2942

阻害剤およびアゴニスト

スクリーニングライブラリ

蛍光色素

205

生化学アッセイ試薬

1747

ペプチド

阻害性抗体

191

天然物

328

組換えタンパク質

同位体標識化合物

265

抗体

クリックケミストリー

113

オリゴヌクレオチド

製品番号	製品名	Target	研究分野	構造式

HY-Y1275

N-Methylpyrrolidone NMP; 1-Methyl-2-pyrrolidinone	Environmental Pollutants Biochemical Assay Reagents	Cancer
N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an orally active organic polar solvent with teratogenicity and toxicity. N-Methylpyrrolidone is low in acute toxicity with a LD₅₀ value of 3914 mg/kg in rats and of 4050 mg/kg in mice. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals .

HY-N0681

D-Pantothenic acid hemicalcium salt 5+ Cited Publications Calcium pantothenate; Calcium D-pantothenate; Vitamin B5 calcium salt	Environmental Pollutants Apoptosis Endogenous Metabolite	Metabolic Disease Inflammation/Immunology Endocrinology
D-Pantothenic acid hemicalcium salt is an orally active vitamin that reduces patulin in apple juice. D-Pantothenic acid hemicalcium salt removes ROS. D-Pantothenic acid hemicalcium salt has antibacterial and immunomodulatory activities. D-Pantothenic acid hemicalcium salt also has the effect of improving osteoporosis and obesity .

HY-15941

5(6)-FITC 2 Publications Verification Fluorescein 5(6)-isothiocyanate; Fluorescein isothiocyanate 5- and 6- isomers	Fluorescent Dye	Others
5(6)-FITC (Fluorescein 5(6)-isothiocyanate) is an amine-reactive derivative of a fluorescent dye, characterized by high absorbance and excellent fluorescence quantum yield. The isothiocyanate group of FITC can react with various functional groups on proteins, including amines, thiols, imidazoles, tyrosines and carbonyls, enabling the labeling of proteins such as antibodies and lectins. 5(6)-FITC has a wide range of applications, including flow cytometry, immunofluorescence, protease assays and conjugation. The maximum excitation/emission wavelengths are 492/518 nm .

HY-15940

5(6)-Carboxyfluorescein 5 Publications Verification 5(6)-FAM; 5-(and-6)-Carboxyfluorescein mixed isomers	Fluorescent Dye	Cancer
5(6)-Carboxyfluorescein (5(6)-FAM) is an amine-reactive pH-sensitive green fluorescent probe. 5(6)-Carboxyfluorescein (5(6)-FAM) can be used to label proteins, peptides and nucleotides. 5(6)-Carboxyfluorescein can be used for the detection of tumour areas in vivo .

HY-B1539A

Fuchsine base monohydrochloride Magenta base monohydrochloride; Basic Fuchsin monohydrochloride; Rosaniline Base monohydrochloride	Fluorescent Dye Bacterial Fungal	Infection
Fuchsine base (Magenta base; Basic Fuchsin) monohydrochloride is a triaminotriphenylmethane dye. Fuchsine base monohydrochloride has anesthetic, bactericidal and fungicidal properties. Fuchsine base monohydrochloride can be used for the staining of collagen, muscle, mitochondria and tuberculosis. Fuchsine base monohydrochloride is commonly used as a counterstain in Gram staining .

HY-W561907

*IMipenem and* cilastatin sodium**	Antibiotic Bacterial	Infection
IMipenem and cilastatin sodium is a broad-spectrum Carbapenem Antibiotic combination. Imipenem (HY-B1369A) is a Carbapenem antibiotic. IMipenem demonstrates excellent activity against gram-positive and gram-negative aerobic and anaerobic organisms. Cilastatin (HY-A0166) is a renal Dehydropeptidase inhibitor that inhibits the metabolism of Imipenem by renal brush-border enzymes, thus increasing imipenem concentrations in urine .

HY-177451

*Glyceryl mono and* dicaprylocaprate**	Biochemical Assay Reagents	Others
Glyceryl mono and dicaprylocaprate is a mixture of glyceryl monoesters and diesters.

HY-P99274

Xentuzumab 1 Publications Verification BI 836845; Anti-Human IGF1 and IGF2 Recombinant Antibody	IGF-1R	Cancer
Xentuzumab (Anti-Human IGF1 and IGF2 Recombinant Antibody; BI836845) is a recombinant a human monoclonal antibody that targets IGF ligands IGF1 and IGF2. Xentuzumab inhibits both of IGF1 and IGF2 growth-promoting signalling and suppresses AKT activation .

HY-129566

Withanolide B	ERK Wnt β-catenin RUNX	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects .

HY-DY3003

*Tissue and* Cell Fixative (4% Paraformaldehyde, PFA)**	Biochemical Assay Reagents	Others
Tissue and Cell Fixative (4% Paraformaldehyde, PFA) is mainly composed of paraformaldehyde, phosphate, and deionized water, with a pH of 7.0-7.4. Tissue and Cell Fixative (4% Paraformaldehyde, PFA) is suitable for fixing most tissues and cells, and can effectively protect the morphology and structure of tissues and cells as well as nucleic acids.

HY-Y0537C

Potassium chloride, ≥99.99% trace metals basis Potassium chloride, suitable for the extraction and solubilization of proteins	Environmental Pollutants Biochemical Assay Reagents	Others
Potassium chloride, ≥99.99% trace metals basis (Potassium chloride, suitable for the extraction and solubilization of proteins), is an inorganic salt used in the preparation of phosphate buffers. With very low metal impurity content, it is suitable for protein extraction and dissolution.

HY-N10568

Gibberellin A9	Phytohormone	Others
Gibberellin A9 is a plant hormone that targets gibberellin receptor GID1. Gibberellin A9 binds to GID1 to form a GA-GID1-DELLA protein complex, which promotes the degradation of DELLA proteins. This relieves the inhibitory effect of DELLA proteins on plant growth, thereby promoting plant cell elongation and division, and increasing seed germination rate. Gibberellin A9 is promising for use in studies on plant growth and development, such as stem elongation and flowering induction .

HY-P991504

LAE-102	Anaplastic lymphoma kinase (ALK) TGF-β Receptor TGF-beta/Smad	Metabolic Disease Cancer
LAE-102 is the selective anti-ActRIIA (activin receptor type IIA or ACVR2) monoclonal antibody. LAE-102 increases muscle mass and reduces fat mass. LAE102 can increase serum activin A levels in vivo. LAE-102 is promising for research of obesity .

HY-136648A

2'-Deoxyadenosine-5'-triphosphate trisodium dATP trisodium	Endogenous Metabolite DNA/RNA Synthesis	Cancer
2'-Deoxyadenosine-5'-triphosphate (dATP) trisodium is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase. 2'-Deoxyadenosine-5'-triphosphate is promising for research of genetic immunodeficiency diseases adenosine deaminase deficiency and purine nucleotide phosphorylase deficiency .

HY-W007056

Fmoc-N-me-Trp(Boc)-OH	Amino Acid Derivatives Biochemical Assay Reagents Drug Intermediate	Infection
Fmoc-N-me-Trp(Boc)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize peptide antibiotics with antibacterial activity against Pseudomonas aeruginosa .

HY-W028813

Acetobromo-α-D-galactose	Biochemical Assay Reagents Drug Intermediate	Others
Acetobromo-α-D-galactose is a brominating agent, serving as an important intermediate in the synthesis of various glycosides and oligosaccharides .

HY-70027A

*p53 and* MDM2 proteins-interaction-inhibitor dihydrochloride**	MDM-2/p53 E1/E2/E3 Enzyme	Cancer
p53 and MDM2 proteins-interaction-inhibitor dihydrochloride is an inhibitor of the interaction between p53 and MDM2 proteins.

HY-103137

Zacopride hydrochloride 1 Publications Verification	5-HT Receptor	Cardiovascular Disease Neurological Disease
Zacopride hydrochloride is an orally active 5-HT₃ receptor (K_i of 0.38 nM) antagonist and 5-HT₄ receptor (K_i of 373 nM) agonist. Zacopride hydrochloride exhibits multiple activities, such as regulating gastrointestinal motility, affecting cardiac function, and exerting anxiolytic and antiemetic effects. Zacopride hydrochloride is currently mainly used in the research of gastrointestinal diseases, cardiovascular diseases, and psychiatric diseases such as anxiety .

HY-135297

*Mono-and* diglycerides**	Biochemical Assay Reagents	Others
Mono-and diglycerides is formed by triglycerides being broken down by pancreatic lipase in the gastrointestinal lumen. Mono-and diglycerides is a food additive used as a nonionic emulsifier and mainly present in food fats .

HY-P2498A

*Cathepsin D and* E FRET Substrate acetate**	Cathepsin	Cancer
Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D .

HY-146005

*Tau-aggregation and* neuroinflammation-IN-1**	Microtubule/Tubulin	Neurological Disease Inflammation/Immunology
Tau-aggregation and neuroinflammation-IN-1 is a potent tau-aggregation and neuroinflammation inhibitor. Tau-aggregation and neuroinflammation-IN-1 exhibits remarkable inhibitory activities against AcPHF6 and full-length tau aggregation. Tau-aggregation and neuroinflammation-IN-1 has a low cytotoxicity and reduced NO release in LPS-stimulated BV2 cells. Tau-aggregation and neuroinflammation-IN-1 can reverse okadaic acid-induced memory impairment in rats .

HY-139637

(±)-Silybin Silibinin (mixture of Silybin A and Silybin B)	Apoptosis	Cancer
(±)-Silybin is the racemate of Silybin (HY-N0779A). Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity .

HY-D2776

*Primary antibody and* secondary antibody eluent, specially for mIHC experiments**	Biochemical Assay Reagents	Others
Primary antibody and secondary antibody eluent, specially for mIHC experiments is an eluent used for mIHC (multiple immunohistochemistry).

HY-W067425

2-(4-Hydroxyphenyl)propionic acid	Endogenous Metabolite	Metabolic Disease
2-(4-Hydroxyphenyl)propionic acid (Compound 1) is an aromatic carboxylic acid, which can be converted into its R and S glucosyl esters and glucosides by root culture of P. ginseng (Pg-1) .

HY-W129233

*Dihydroartemisinin (mixture of α and* β isomers)** Dihydroartemisinin (α,β mixture)	Parasite Autophagy Apoptosis	Infection Cancer
Dihydroartemisinin (mixture of α and β isomers) is an anti-malaria and anticancer agent, as well as an active metabolite of artemisinin and its derivatives. Dihydroartemisinin exerts anticancer effects through various molecular mechanisms, such as inhibiting proliferation, inducing apoptosis, inhibiting tumor metastasis and angiogenesis, promoting immune function, inducing autophagy and endoplasmic reticulum stress .

HY-W008024

Fmoc-Dab(Boc)-OH	Amino Acid Derivatives	Others
Fmoc-Dab(Boc)-OH is an amino acid derivative with an Fmoc protecting group that can be used to synthesize somatostatin analogs that inhibit neointima formation induced by balloon injury in rats without altering growth hormone release. Fmoc-Dab(Boc)-OH can be used for the synthesis of peptides .

HY-127029A

Umbelliprenin	NO Synthase Lipoxygenase	Neurological Disease Inflammation/Immunology Cancer
Umbelliprenin, a prenylated coumarin, is an antioxidant with anticancer, anti-inflammatory and immunomodulatory effects. Umbelliprenin inhibits lipoxygenase managing the inflammation pathways. In inflammatory macrophages, Umbelliprenin suppresses nitric oxide production as well as inducible nitric oxide synthase (NO synthase) .

HY-129331

Neothramycin A	Antibiotic Bacterial Fungal	Infection Cancer
Neothramycin A is an antibiotic, which can be isolated from Streptomyces. Neothramycin A exhibits board spectrum antimicrobial activity, inhibits Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli W677, and Saccharomyces cerevisia with MIC of 25-50 μg/mL. Neothramycin A exhibits antitumor efficacy against leukemia in mouse models .

HY-W419140

AND-017	Drug Intermediate	Others
AND-017 is an important intermediate for Rocuronium Bromide (HY-17440) .

HY-150184

And1-IN-1	DNA/RNA Synthesis	Cancer
And1-IN-1 is a potent And1 inhibitor with an IC₅₀ of 2.08 μM. And1-IN-1 binds to the N-terminus of And-1 and induces a conformational change in And-1, which promotes the interaction of And-1 with E3 ligase CUL4B for ubiquitin-mediated degradation. And1-IN-1 suppresses the growth of a broad range of cancers and resensitizes platinum-resistant ovarian cancer cells to platinum agents. And1-IN-1 can be used for the studies of ovarian cancer and breast cancer .

HY-70027

*p53 and* MDM2 proteins-interaction-inhibitor (chiral)**	MDM-2/p53 E1/E2/E3 Enzyme	Cancer
p53 and MDM2 proteins-interaction-inhibitor (chiral) (Compound 32) is an inhibitor of the interaction between p53 and MDM2 proteins.

HY-W128533

*2-Octen-1-ylsuccinic anhydride,mixture of cis and* trans** 2-Octen-1-ylsuccinic anhydride	Biochemical Assay Reagents	Others
2-Octen-1-ylsuccinic anhydride, mixture of cis and trans (2-Octen-1-ylsuccinic anhydride) can be used to prepare amphiphilic pectin oligosaccharide (POS) derivatives .

HY-W655727

(-)-2-Phenylpropylamine (S)-2-Phenylpropylamine	Monoamine Oxidase	Neurological Disease
(-)-2-Phenylpropylamine ((S)-2-Phenylpropylamine) (compound 3b) is a MAO-A and MAO-B inhibitor with K_i values of 584 μM and 156 μM, respectively .

HY-P10877

Bicyclic UK18	PAI-1	Cancer
Bicyclic UK18 is a competitive inhibitor for human urokinase-type plasminogen activator (uPA) with a K_i of 53 nM .

HY-P2498

*Cathepsin D and* E FRET Substrate**	Cathepsin	Others
Cathepsin D and E FRET Substrate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D .

HY-126304A

*Glycerophosphoric acid disodium salt hydrate (α and* β mixture)** 15+ Cited Publications	Biochemical Assay Reagents	Others
Glycerophosphoric acid (disodium salt hydrate) (α and β mixture) is a complex contains α and β Glycerophosphoric acid isomers.

HY-179663B

*3M NaAc pH 5.2 Buffer,RNase and* DNase-free**	Biochemical Assay Reagents	Others
3M NaAc pH 5.2 Buffer, RNase and DNase-free is a sterile, RNase- and DNase-free sodium acetate buffer with a concentration of 3 M and a pH of 5.2.

HY-171746

F4-Trp 4,5,6,7-Tetrafluoro-L-tryptophan	nAChR	Neurological Disease
F4-Trp (4,5,6,7-Tetrafluoro-L-tryptophan) is a ligand targeting the α3β4 nicotinic acetylcholine receptor (α3β4 nAChR). F4-Trp is promising for research of neurotransmission, addiction, and related diseases, such as neurological diseases .

HY-177508

BC264	Cholecystokinin Receptor	Neurological Disease
BC264 is a highly potent and selective CCK-B agonist that crosses the blood-brain barrier. BC264 increases dopamine in the nucleus accumbens and facilitates motivation and attention in rats .

HY-156830A

(4′R)-TGR5 Receptor Agonist 4	G protein-coupled Bile Acid Receptor 1	Metabolic Disease
(4′R)-TGR5 Receptor Agonist 4 is the R enantiomer of TGR5 Receptor Agonist 4 (HY-156830). TGR5 Receptor Agonist 4 is an agonist of Bile Acid Receptor (TGR5), with EC₅₀ for hTGR5 and mTGR5 of 2 nM and 3 nM, respectively. TGR5 Receptor Agonist 4 plays important roles in hypoglycemic and weight loss .

HY-W013852

PKC-IN-6	Ser/Thr Kinase Tyrosinase PKA PKC EGFR	Cancer
PKC-IN-6 (Compound 21) is a selective inhibitor of tyrosine and serine kinases. PKC-IN-6 shows inhibitory activity against PKC-α, PKC-δ, PKA, EGF-R with IC₅₀ values of 240, >500, >500, >100 μM, respectively. PKC-IN-6 is promising for research of cancers .

HY-168131

PROTAC EZH2 Degrader-3	PROTACs Histone Methyltransferase Apoptosis	Cancer
PROTAC EZH2 Degrader-3 (compound ZJ-20) is a EZH2 PROTAC degrader. PROTAC EZH2 Degrader-3 (5 μM, 24 h) not only potently inhibits the expression of EZH2 protein, but also had a strong inhibits effect on the expression levels of other subunits of PRC2 as well as H3k27me3 protein. PROTAC EZH2 Degrader-3 shows anti-proliferative activity and blocks the cell cycle in the G0-G1 phase and induces cell apoptosis((Blue: cereblon ligand Pomalidomide (HY-10984), Black: linker HY-W361751；Pink: EZH2 inhibitor Tazemetostat (HY-13803)) .

HY-136794

SB-284851-BT	p38 MAPK Epigenetic Reader Domain	Inflammation/Immunology Cancer
SB-284851-BT is an inhibitor of BRD4/p38α/BRDT. SB-284851-BT inhibits BRD4-BD1 (IC₅₀=1.7 µM), p38α (K_d=0.47 nM), BRDT (1) (IC₅₀=18 µM) and BRD4 (1)(IC₅₀=3.7 µM). SB-284851-BT reduces IL-8 production by inhibiting p38α, as well as inhibiting BRD4 to down-regulates c-Myc and NF-κB gene pathways in cancer. SB-284851-BT can combined with the bromine domain and extra terminal (BET) .

HY-P5984

Thioether-cyclized helix B peptide, CHBP	mTOR	Others
Thioether-cyclized helix B peptide, CHBP can improve metabolic stability and renoprotective effect through inducing autophagy via inhibition of mTORC1 and activation of mTORC2 .

HY-112147

*IDO1 and* HDAC1 Inhibitor**	Indoleamine 2,3-Dioxygenase (IDO) HDAC	Cancer
IDO1 and HDAC1 Inhibitor (Compound 10) is a dual IDO1 and HDAC1 inhibitor with IC₅₀s of 69.0 nM and 66.5 nM, respectively .

HY-W423345R

*Decanoic acid compound with octanoic acid and* propane-1,2-diol (1:1:1) (Standard)** Xincapricacidpropyleneglycolester (Standard)	Reference Standards
Decanoic acid compound with octanoic acid and propane-1,2-diol (1:1:1) (Standard) is the analytical standard of Decanoic acid compound with octanoic acid and propane-1,2-diol (1:1:1). This product is intended for research and analytical applications.

HY-149514

BC-05	Proteasome	Cancer
BC-05 is an orally active and potent inhibitor of CD13 and proteasome. BC-05 has an IC₅₀ value of 0.13 μM for human CD13 and an IC₅₀ value of 1.39 μM for the 20S proteasome. BC-05 can be used in multiple myeloma research .

HY-P11250

HVF18-a3-d	Bacterial NO Synthase Interleukin Related Reactive Oxygen Species (ROS) Toll-like Receptor (TLR) ERK JNK p38 MAPK	Infection Inflammation/Immunology
HVF18-a3-d is an antimicrobial peptide. HVF18-a3-d reduces NO production. HVF18-a3-d inhibits the production of TNF-α and IL-6, reduces ROS production, and suppresses the TLR4 signaling pathway, as well as LPS-induced phosphorylation of ERK, JNK, and p38 MAPK. HVF18-a3-d exhibits antimicrobial activity against a variety of bacteria by disrupting their outer and inner membranes. HVF18-a3-d protects mice from fatal septic shock induced by Acinetobacter baumannii resistant to Carbapenem. HVF18-a3-d shows anti-inflammatory and antioxidant effects .

HY-170477

Δ8-THCP Δ8-Tetrahydrocannabiphorol; n-Heptyl ∆8-THC	Cannabinoid Receptor	Others
Δ8-THCP (Δ8-Tetrahydrocannabiphorol; n-Heptyl Δ8-THC) (Compound 1a) is a semisynthetic cannabinoid that serves as an analytical reference standard and exhibits affinity for the CB1 receptor .

HY-W101419

Ibuprofenamide	Epoxide Hydrolase	Cardiovascular Disease Cancer
Ibuprofenamide (Compound 136) is a potent microsomal epoxide hydrolase (mEH) inhibitor with an IC₅₀ value of 96 μM. Ibuprofenamide is promising for research of preeclampsia, hypercholanemia and cancer .

製品番号	製品名	Category	Target	構造式

HY-Y0520

Itaconic acid 2 Publications Verification Methylenesuccinic acid	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite Ferroptosis
Itaconic acid, a precursor of polymers, chemicals, and fuels, can be synthesized by many fungi. Itaconic acid also is a macrophage-specific metabolite. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors. Itaconic acid has anti-inflammatory, anti-microbial and immunomodulatory effect .

HY-N0680

Thiamine hydrochloride 1 Publications Verification Thiamine chloride hydrochloride; Vitamin B1 hydrochloride	Structural Classification 天然物 Human Gut Microbiota Metabolites Endogenous metabolite	Endogenous Metabolite Keap1-Nrf2 Toll-like Receptor (TLR) NF-κB
Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes.Thiamine hydrochloride activates NrF-2/HO-1 and inhibits TLR4, NF-κB. Thiamine hydrochloride has neuroprotective and anti-inflammatory effects. Thiamine hydrochloride can be used in the studys of diabetic complications, neurological diseases, cancers, and colitis .

HY-N0681

D-Pantothenic acid hemicalcium salt 5+ Cited Publications Calcium pantothenate; Calcium D-pantothenate; Vitamin B5 calcium salt	Structural Classification 天然物 other families Classification of Application Fields Other Diseases Plants Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Apoptosis Endogenous Metabolite
D-Pantothenic acid hemicalcium salt is an orally active vitamin that reduces patulin in apple juice. D-Pantothenic acid hemicalcium salt removes ROS. D-Pantothenic acid hemicalcium salt has antibacterial and immunomodulatory activities. D-Pantothenic acid hemicalcium salt also has the effect of improving osteoporosis and obesity .

HY-135005A

Biliverdin 1 Publications Verification	Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite
Biliverdin, a tetrapyrrolic pigment, is a product of heme catabolism. Heme is broken down into Biliverdin and carbon monoxide and iron by heme oxidase. Biliverdin is then quickly broken down to bilirubin by Biliverdin reductase. Biliverdin can mediate the protective effects of HO-1 in many disease models including IRI and organ transplantation. Biliverdin exhibits anti-mutagenic, an antioxidant, anti-inflammatory, and immunosuppressant properties .

HY-B1472

Deoxycorticosterone acetate 2 Publications Verification 11-Deoxycorticosterone acetate; DOC acetate; Cortexone acetate	Structural Classification Classification of Application Fields Endogenous metabolite Disease Research Fields Endocrinology Steroids Source Classification	Mineralocorticoid Receptor Endogenous Metabolite
Deoxycorticosterone acetate (DOCA) is an adrenocortin, acts as a precursor to aldosterone. Deoxycorticosterone acetate is a mineralocorticoid receptor agonist. Deoxycorticosterone acetate can cause severe renal injury, including inflammation, fibrosis, glomerular damage, and proteinuria .

HY-N0270

Ononin 10+ Cited Publications Ononoside; Formononetin 7-O-β-D-glucopyranoside	Structural Classification Flavonoids other families Classification of Application Fields Leguminosae Other Diseases Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Isoflavones Source Classification	ERK JNK p38 MAPK PI3K Akt mTOR Apoptosis
Ononin is an orally active isoflavone. Ononin inhibits the ERK/JNK/p38 and PI3K/Akt/mTOR pathways. Ononin regulates Apoptosis. Ononin has anti-tumor effects on laryngeal cancer and lung cancer. Ononin has neuroprotective effects. Ononin alleviates endoplasmic reticulum stress and diabetic nephropathy .

HY-B1907

Rifamycin sodium 2 Publications Verification Rifamycin SV sodium	Infection Microorganisms Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Antibiotic Bacterial DNA/RNA Synthesis
Rifamycin sodium (Rifamycin SV monosodium) is an orally active ansamycin antibiotic. Rifamycin sodium inhibits DNA-dependent RNA synthesis. Rifamycin sodium has antibacterial activity against Mycobacterium tuberculosis. Rifamycin sodium interferes with hepatic bile acid metabolism. Rifamycin sodium has anti-inflammatory effects. Rifamycin sodium can be used in the study of Mycobacterium tuberculosis, Bacteroides fragilis infection, and Lipopolysaccharide (HY-D1056B3)-induced inflammation .

HY-W050044

L-Azetidine-2-carboxylic acid 1 Publications Verification	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite PERK Atg8/LC3 Autophagy Bcl-2 Family Apoptosis Eukaryotic Initiation Factor (eIF) ATF6
L-Azetidine-2-carboxylic acid is a proline analog. L-Azetidine-2-carboxylic acid upregulates the lipid autophagy marker LC3-II via activation of the PERK pathway. L-Azetidine-2-carboxylic acid increases pro-apoptotic BAX protein. L-Azetidine-2-carboxylic acid induces ATF6 cleavage and upregulates phosphorylated eIF2α levels. L-Azetidine-2-carboxylic acid induces ER stress, inducing protein misfolding and aggregation. L-Azetidine-2-carboxylic acid shows teratogenic, pro-inflammatory and pro-apoptotic effects .

HY-N0621

Morin 5+ Cited Publications	Flavonols Structural Classification Flavonoids other families Classification of Application Fields Phenols Polyphenols Plants Disease Research Fields Source Classification Cancer	Environmental Pollutants Reactive Oxygen Species (ROS) Phosphatase Insulin Receptor Apoptosis
Morin is an orally active plant-derived flavonoid. Morin inhibits ROS generation. Morin induces Apoptosis. Morin inhibits PTP1B (IC₅₀ of 15 μM) and activates the insulin receptor. Morin has a detoxifying effect. Morin can be used in diabetes, leukemia, colon cancer, cervical cancer, Parkinson's disease and hypertension research .

HY-N6033

Ferruginol (+)-Ferruginol	Cupressaceae Terpenoids Diterpenoids Thuja standishii (Gord.) Carr. Plants	EBV HSV Apoptosis
Ferruginol ((+)-Ferruginol), a natural diterpenoid, is an inhibitor of the activation of Epstein-Barr virus early antigen (EBV-EA). Ferruginol inhibits the growth of thyroid cancer cells through the induction of mitochondrial apoptosis. Ferruginol has antitumor, cardioprotective, antioxidant, gastroprotective, and neuroprotective activities .

HY-135005

Biliverdin hydrochloride 1 Publications Verification	Alkaloids Pyrrole Alkaloids Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite
Biliverdin hydrochloride, a tetrapyrrolic pigment, is a product of heme catabolism. Heme is broken down into Biliverdin and carbon monoxide and iron by heme oxidase. Biliverdin hydrochloride is then quickly broken down to bilirubin by Biliverdin reductase. Biliverdin hydrochloride is anti-mutagenic, an antioxidant, anti-inflammatory, and immunosuppressant .

HY-113168

Butyrylcarnitine 1 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Butyrylcarnitine is an endogenous metabolite found in plasma. Elevated levels of Butyrylcarnitine are closely associated with abnormalities in lipid and energy metabolism. Butyrylcarnitine can serve as a diagnostic and prognostic indicator for certain diseases, such as heart failure and head and neck cancer .

HY-59291

Levacetylleucine N-Acetyl-L-leucine	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Amino Acid Derivatives
Levacetylleucine (N-acetyl-L-leucine), an orally bioavailable and brain-penetrant compound, is an acetylated derivative of amino acid Leucine. Levacetylleucine is the active form of N-acetyl-leucine (NAL). Levacetylleucine attenuates neuronal death and neuroinflammation in the cortical tissue of mice. Levacetylleucine also potentially improves ameliorates lysosomal and metabolic dysfunction. Levacetylleucine improves compensation of postural symptoms after unilateral chemical labyrinthectomy (UL) in rats. Levacetylleucine is promising for research of neurological manifestations of Niemann-Pick disease type C, traumatic brain injury and neurodegeneration prevention .

HY-N0563

Alizarin 1 Publications Verification	Quinones Classification of Application Fields Anthraquinones Rubiaceae Other Diseases Phenols Polyphenols Plants Disease Research Fields Rubia cordifolia L. Source Classification	AMPK VEGFR PI3K Akt NF-κB Cytochrome P450
Alizarin is a natural dye. Alizarin can be extracted from the roots of madder plant. Alizarin activates AMPK and VEGFR2/eNOS pathway. Alizarin regulates PI3K/Akt and inhibits NF-κB pathway. Alizarin enhances CYP1A1 enzyme activity. Alizarin has protective effects on hypertension and vascular endothelial dysfunction. Alizarin has anti-tumor activity against multiple cancers including pancreatic cancer, breast cancer, osteosarcoma and liver cancer. Alizarin has been widely used as a pigment in textile fabrics and paintings .

HY-113107

3-Hydroxydodecanoic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
3-Hydroxydodecanoic acid is a medium-chain fatty acid. 3-Hydroxydodecanoic acid activates GPR84 and promotes IL-12 production. 3-Hydroxydodecanoic acid has anticancer activity against colon cancer, lung cancer, and melanoma .

HY-N0921

Dihydromethysticin (+)-Dihydromethysticin	天然物 other families Classification of Application Fields Plants Inflammation/Immunology Disease Research Fields Source Classification	Carboxylesterase (CES) NOD-like Receptor (NLR) Apoptosis
Dihydromethysticin is an orally active natural active ingredient. Dihydromethysticin can be extracted from Piper methysticum. Dihydromethysticin inhibits carboxylesterase 1 (K_i = 68.2 μM) and CYP2A5. Dihydromethysticin upregulates NLRC3 and induces Apoptosis. Dihydromethysticin exhibits anticancer activity against colorectal cancer and lung adenoma .

HY-N2406

Dihydrocaffeic acid 2 Publications Verification 3,4-Dihydroxy-benzenepropanoic acid	Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Phenols Polyphenols Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	p38 MAPK Endogenous Metabolite Reactive Oxygen Species (ROS) NO Synthase
Dihydrocaffeic acid is a microbial metabolite of flavonoids. Dihydrocaffeic acid scavenges intracellular ROS and increases nitric oxide synthase activity. Dihydrocaffeic acid reduces phosphorylation of MAPK p38 and prevent UVB-induced skin damage. Dihydrocaffeic acid has antioxidant, anti-inflammatory and anti-cartilage degradation activities .

HY-34431

Purine 7H-Imidazo(4,5-d)pyrimidine	天然物 Microorganisms Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite PARP
Purine is an endogenous metabolite. Purine bases are the building blocks of the nucleic acids. Purine inhibits the activation of PARP. Purine protects against oxidant-induced cell injury. Purine can be used in the research of cancer and nervous system diseases .

HY-N6866

Gomisin N	Neurological Disease Classification of Application Fields Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Inflammation/Immunology Disease Research Fields Source Classification Cancer	Apoptosis AMPK Akt PERK Keap1-Nrf2 Caspase PARP GSK-3 NO Synthase Interleukin Related
Gomisin N is an orally active lignan compound. Gomisin N can be isolated from Schisandra chinensis. Gomisin N induces Apoptosis in a variety of cells. Gomisin N activates AMPK, Akt, MAPK/ERK, Nrf2, caspase-3 and PARP-1. Gomisin N inhibits GSK3β, nitric oxide (NO), and proinflammatory cytokines (IL-1β, IL-6, TNF-α). Gomisin N has anti-inflammatory, antioxidant, anti-obesity, anti-diabetic, and anti-melanogenesis activities. Gomisin N has anti-tumor activity against cervical cancer and liver cancer. Gomisin N improves Alzheimer's disease .

HY-B1513

α-Cyclodextrin 2 Publications Verification	Structural Classification Zea mays L. Polysaccharides Classification of Application Fields Gramineae Other Diseases Plants Disease Research Fields Saccharides Source Classification	Environmental Pollutants SARS-CoV Microtubule/Tubulin
α-Cyclodextrin (α-CD) is a soluble fiber derived from corn. α-Cyclodextrin can deplete sphingolipids and phospholipids from cell membranes. α-Cyclodextrin interacts with tubulin. α-Cyclodextrin improves defenses against SARS-CoV-2 infection. α-Cyclodextrin enhances the anticancer efficacy of Crcumin (HY-N0005) against breast, lung and cervical cancer. α-Cyclodextrin has beneficial effects on body weight and blood lipids .

HY-N7112

Leucomycin 1 Publications Verification Kitasamycin	Infection Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Source Classification	Bacterial Antibiotic
Leucomycin (Kitasamycin) is an orally active macrolide antibiotic produced by Streptomyces kitasatoensis. Leucomycin has broad-spectrum antibacterial activities against gram-positive and gram-negative bacteria, mycoplasma, leptospira, spirochaetes, rickettsiae and some larger viruses .

HY-129566

Withanolide B	Neurological Disease Classification of Application Fields Metabolic Disease Withania somnifera Solanaceae Plants Inflammation/Immunology Disease Research Fields Steroids Source Classification	ERK Wnt β-catenin RUNX
Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects .

HY-N7575

Lacto-N-fucopentaose II LNFP II	Polysaccharides Classification of Application Fields Disease markers Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides Cancer Source Classification	Endogenous Metabolite
Lacto-N-fucopentaose II (LNFP II) is a sialyl-Lewis, hapten of human Lewis bloodgroup determinant. Lacto-N-fucopentaose II monosialo-ganglioside/glycolipid and sialyl derivative, CA 19-9, is a molecular tumour markers (TM) for biliopancreatic malignancy .

HY-114519

Helenalin acetate 2 Publications Verification	Sesquiterpenes Derris robusta Plants Compositae Source Classification	Histone Demethylase NF-κB
Helenalin acetate, a natural NF-κB inhibitor, is a potent C/EBPβ inhibitor. Helenalin acetate has anti-inflammatory and anticancer activities .

HY-N2067

Vanillyl alcohol 1 Publications Verification p-(Hydroxymethyl)guaiacol	Structural Classification Monophenols Gastrodia elata Bl. Classification of Application Fields Orchidaceae Other Diseases Phenols Plants Disease Research Fields Source Classification	Reactive Oxygen Species (ROS) Bcl-2 Family
Vanillyl alcohol (p-(Hydroxymethyl)guaiacol) is an orally active phenolic alcohol. Vanillyl alcohol reduces ROS generation. suppresses Bax, increases Bcl-2. Vanillyl alcohol has anti-angiogenic, anti-inflammatory, anti-nociceptive and neuroprotective effects. Vanillyl alcohol is used as a flavoring agent in foods and beverages .

HY-N0766

Isorhynchophylline 2 Publications Verification	Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Classification of Application Fields Rubiaceae Other Diseases Plants Disease Research Fields Indole Alkaloids Source Classification	SOD NF-κB
Isorhynchophylline is an alkaloid isolated from Crocus sativus with anticancer, antihypertensive, anti-inflammatory, and neuroprotective properties. Isorhynchophylline can be applied to cardiovascular and neurological disorders, and cancer studies .

HY-Y0946

Acetamide	Structural Classification 天然物 Human Gut Microbiota Metabolites Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Environmental Pollutants
Acetamide is used as an intermediate in the synthesis of methylamine, thioacetamide, and insecticides, and as a plasticizer in leather, cloth and coatings. Acetamide has carcinogenicity. Acetamide derivatives may has antioxidant activity and potential anti-inflammatory activity. Acetamide holds promise for research in the fields of anti-inflammatory and cancer studies .

HY-N10568

Gibberellin A9	Malvaceae Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Plants Endogenous metabolite Source Classification	Phytohormone
Gibberellin A9 is a plant hormone that targets gibberellin receptor GID1. Gibberellin A9 binds to GID1 to form a GA-GID1-DELLA protein complex, which promotes the degradation of DELLA proteins. This relieves the inhibitory effect of DELLA proteins on plant growth, thereby promoting plant cell elongation and division, and increasing seed germination rate. Gibberellin A9 is promising for use in studies on plant growth and development, such as stem elongation and flowering induction .

HY-136648A

2'-Deoxyadenosine-5'-triphosphate trisodium dATP trisodium	Alkaloids Structural Classification Classification of Application Fields Other Alkaloids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite DNA/RNA Synthesis
2'-Deoxyadenosine-5'-triphosphate (dATP) trisodium is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase. 2'-Deoxyadenosine-5'-triphosphate is promising for research of genetic immunodeficiency diseases adenosine deaminase deficiency and purine nucleotide phosphorylase deficiency .

HY-Y1819

2-Acetonaphthone 1 Publications Verification	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Reactive Oxygen Species (ROS) Mitochondrial Metabolism
2-Acetonaphthone is a synthetic fragrance material. 2-Acetonaphthone increases ROS under UVA/sunlight, leading to endoplasmic reticulum stress and decreased mitochondrial membrane potential. 2-Acetonaphthone can be used as an adulterant in a variety of cosmetics. 2-Acetonaphthone can be used for the study of skin keratinization

HY-N3847

Eriodictyol-7-O-glucoside Eriodictyol 7-O-β-D-glucoside	Flavonoids Classification of Application Fields Labiatae Flavonones Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Petalostemun purpureum Source Classification	Keap1-Nrf2
Eriodictyol-7-O-glucoside (Eriodictyol 7-O-β-D-glucoside), a flavonoid, is an Nrf2 activator. Eriodictyol-7-O-glucoside exhibits significant scavenging effects on both hydroxyl radicals and superoxide anions, with IC₅₀ values of 0.28 mM and 0.30 mM, respectively. Eriodictyol-7-O-glucoside increases the nuclear localization of Nrf2 and induces the expression of the Nrf2/ARE-dependent genes. Eriodictyol-7-O-glucoside provides protection against oxygen and glucose deprivation (OGD)-induced oxidative insult. Eriodictyol-7-O-glucoside demonstrates neuroprotective efficacy in a rat model of focal cerebral ischemia (MCAO). Eriodictyol-7-O-glucoside can be used for the study of stroke .

HY-N2541

Gymnemic acid I	Triterpenes Classification of Application Fields Terpenoids Asclepiadaceae Metabolic Disease Plants Disease Research Fields Gymnema sylvestre (Retz.) Schult. Source Classification	Taste Receptor mTOR Autophagy Apoptosis
Gymnemic acid I is a bioactive triterpene saponin found in Gymnema sylvestre. Gymnemic acid I is an antisweetness inhibitor via human sweet receptor type 1 receptor 2 (T1R2) and T1R3. Gymnemic acid I is a ribosomal protein biosynthesis inhibitor. Gymnemic acid I has antidiabetic effects. Gymnema acid I induces autophagy-protected MIN-6 cells from apoptosis under high glucose stress by inhibiting the phosphorylation activity of mTOR .

HY-N1401

20(R)-Ginsenoside Rh2 2 Publications Verification	Panax ginseng C. A. Meyer Infection Triterpenes Human Gut Microbiota Metabolites Classification of Application Fields Terpenoids Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields Araliaceae Source Classification	MMP Apoptosis HSV DNA/RNA Synthesis NO Synthase Prostaglandin Receptor Reactive Oxygen Species (ROS) Akt
20(R)-Ginsenoside Rh2 is an orally active protopanaxadiol-type saponin with multiple biological activities. 20(R)-Ginsenoside Rh2 exerts a significant inhibitory effect on non-small cell lung cancer and liver cancer by inducing cell cycle arrest and promoting apoptosis. 20(R)-Ginsenoside Rh2 exerts anti-γ-herpesvirus effects by inhibiting viral DNA replication. 20(R)-Ginsenoside Rh2 inhibits inflammatory mediators by reducing the levels of NO, PGE2, and ROS; it can delay skin photoaging by reducing ROS and inhibiting MMP-9/2 activity. 20(R)-Ginsenoside Rh2 accelerates the recovery after muscle injury by activating the Akt1/PKB signaling pathway. 20(R)-Ginsenoside Rh2 can inhibit osteoclast formation and exert an anti-osteoporosis effect .

HY-N11576

Secalonic acid D	天然物 Microorganisms Classification of Application Fields Sunscreen Cosmetic Research Disease Research Fields Cancer Source Classification	Apoptosis GSK-3 c-Myc β-catenin
Secalonic acid D is a toxic compound against tumor cells. Secalonic acid D can be isolated from the metabolites of Aspergillus aculeatus. Secalonic acid D activates GSK3-β, and degrades β-catenin. Thus, Secalonic acid D down-regulates c-Myc expression, arrests cell cycle at G1 phase, induces cell apoptosis .

HY-107245

Segetalin B 2 Publications Verification	Vaccaria segetalis (Neck.) Garcke Classification of Application Fields Cyclopeptides Metabolic Disease Plants Disease Research Fields Caryophyllaceae Source Classification	Estrogen Receptor/ERR Sirtuin RUNX
Segetalin B, an orally active cyclopentapeptide found in Vaccaria segetalis, possesses estrogen-like activity. Segetalin B promotes mineralization of ovariectomized rat-derived bone marrow mesenchymal stem cells (BMSCs) in vitro and increases the level of osteocalcin, BMP-2, ALP, and SIRT1 activity. Segetalin B is promising for research of post-menopausal osteoporosis (PMOP) .

HY-N3883

Euxanthone	Flavonoids Garcinia oblongifolia Champ. ex Benth. Guttiferae Plants Other Flavonoids Source Classification	Autophagy
Euxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress and apoptosis by triggering autophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities .

HY-139637

(±)-Silybin Silibinin (mixture of Silybin A and Silybin B)	Structural Classification Flavanonols Flavonoids Cyamopsis tetragonoloba (L.) Taub. Plants Compositae Source Classification	Apoptosis
(±)-Silybin is the racemate of Silybin (HY-N0779A). Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity .

HY-127029A

Umbelliprenin	天然物 Umbelliferae Carpesium faberi C. Winkl. Plants Source Classification	NO Synthase Lipoxygenase
Umbelliprenin, a prenylated coumarin, is an antioxidant with anticancer, anti-inflammatory and immunomodulatory effects. Umbelliprenin inhibits lipoxygenase managing the inflammation pathways. In inflammatory macrophages, Umbelliprenin suppresses nitric oxide production as well as inducible nitric oxide synthase (NO synthase) .

HY-N0867

13-Oxyingenol-13-dodecanoate	Structural Classification Classification of Application Fields Terpenoids Gramineae Other Diseases Diterpenoids Leptochloa chinensis (Linn.) Nees Plants Disease Research Fields Source Classification	HIV ULK Bcl-2 Family
13-Oxyingenol-dodecanoate (13OD) is a tumor suppressor agent. 13-Oxyingenol-dodecanoate has anti-HIV-1 activity with EC₅₀ value of 33.7 nM .13-Oxyingenol-dodecanoate can induce the expression of ULK1 to effect mitochondrial dysfunction and cellular autophagy. 13-Oxyingenol-dodecanoate also increases the expression of BAX and suppresses the expression of BCL-2 to effect apoptosis .

HY-N3831

Epimedokoreanin B	Flavonoids Flavones Epimedium koreanum Nakai Plants Berberidaceae Source Classification	Bacterial Apoptosis
Epimedokoreanin B is a natural flavonoid with anticancer, anti-inflammatory and antibacterial effects. Epimedokoreanin B inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated apoptosis accompanied by autophagosome accumulation. Epimedokoreanin B is an anti-periodontitis agent that inhibits gingipains and *Porphyromonas gingivalis* growth and biofilm formation .

HY-129331

Neothramycin A	Microorganisms Antibiotics Source Classification	Antibiotic Bacterial Fungal
Neothramycin A is an antibiotic, which can be isolated from Streptomyces. Neothramycin A exhibits board spectrum antimicrobial activity, inhibits Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli W677, and Saccharomyces cerevisia with MIC of 25-50 μg/mL. Neothramycin A exhibits antitumor efficacy against leukemia in mouse models .

HY-N6927

Isoforskolin Coleonol B	Classification of Application Fields Terpenoids Labiatae Diterpenoids Plants Inflammation/Immunology Disease Research Fields Pueraria montana (Lour.) Merr. Source Classification	TNF Receptor Interleukin Related
Isoforskolin is the principle active component of C. forskohlii native to China. Isoforskolin reduces the secretion of lipopolysaccharide (LPS)-induced cytokines, namely TNF-α, IL-1β, IL-6 and IL-8, in human mononuclear leukocytes. Isoforskolin acts as an anti-inflammatory agent for the treatment of Lyme arthritis .

HY-W010203

2-Decanone	Structural Classification Ketones, Aldehydes, Acids Humulus lupulus L. Plants Moraceae Source Classification	Fungal
2-Decanone is an antifungal agent. 2-Decanone inhibits pathogen mycelial growth, spore germination, and appressorium formation. 2-Decanone downregulates spore germination-related genes (MfBmp1) and penetration structure formation genes (MfPls1), inducing reactive oxygen species (ROS) accumulation to trigger mitochondrial damage and subsequent spore apoptosis. 2-Decanone is promising for research of postharvest disease control in fruits and vegetables .

HY-N11845

Sigmoidin B	Flavonoids Flavones Leguminosae Plants Erythrina latissima E. Mey. Source Classification	Lipoxygenase
Sigmoidin B, a prenylated flavanone, is a selective 5-lipoxygenase inhibitor. Sigmoidin B is a potent scavenger of the DPPH radical. Sigmoidin B has antigenotoxic activity that inhibits genotoxicity induced by Aflatoxin B1 (HY-N6615), with an IC₅₀ of 18.7 μg/mL. Sigmoidin B has anti-inflammatory activity and antioxidant properties .

HY-113110R

Cysteinylglycine (Standard) L-Cysteinylglycine (Standard); Cys-Gly (Standard); H-Cys-Gly-OH (Standard)	天然物 Human Gut Microbiota Metabolites Microorganisms Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Reactive Oxygen Species (ROS) DNA/RNA Synthesis
Cysteinylglycine (Standard) is the analytical standard of Cysteinylglycine. This product is intended for research and analytical applications. Cysteinylglycine is a dipeptide formed by the peptide bond linkage between cysteine (Cysteine) and glycine (Glycine). Cysteinylglycine is an important metabolic intermediate in the human body, mainly derived from the degradation of glutathione (GSH). Cysteinylglycine reduces ferric iron to ferrous iron, drives the redox cycle of iron, generates reactive oxygen species (ROS), stimulates oxidative reactions, induces lipid peroxidation of human plasma LDL lipoproteins, and causes oxidative damage to DNA bases. Cysteinylglycine can be used as a biomarker to evaluate ischemic heart disease, breast cancer and other conditions .

HY-N15533

(S)-Menthiafolic acid	Ketones, Aldehydes, Acids Piperaceae Piper crocatum Ruiz & Pav. Plants Source Classification	Drug Metabolite
(S)-Menthiafolic acid is a component found in wines and grape juices. (S)-Menthiafolic acid can be generated from the grape-derived (S)-menthiafolic acid glucose ester during alcoholic and malolactic fermentation, thereby influencing the aroma components of wine .

HY-W713570

Nectandrin B	Monophenols Saururaceae Saururus chinensis (Lour.) Baill. Phenols Plants Source Classification	Topoisomerase
Nectandrin B is an inhibitor of DNA topoisomerases I and II, which is found in Saururus chinensis. Nectandrin B is promising for research of cancers .

HY-W712539

Homodihydrocapsaicin II	Structural Classification Monophenols Capsicum annuum L. Phenols Solanaceae Plants Source Classification	Drug Derivative
Homodihydrocapsaicin II is a capsaicinoid with analgesic and anti-inflammatory effects, which is found in capsicum fruits. Homodihydrocapsaicin II is promising for research of inflammatory diseases and neuropathic pain .

HY-121711

5-OH-HxMF	Flavonoids Flavones Rutaceae Plants Citrus reticulata Blanco Source Classification	Apoptosis
5-OH-HxMF is a hydroxylated polymethoxyflavone that has anti-inflammatory, anticancer, neurotrophic and neuroprotective activities .

HY-W050044R

L-Azetidine-2-carboxylic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite PERK Atg8/LC3 Autophagy Bcl-2 Family Apoptosis Eukaryotic Initiation Factor (eIF) ATF6
L-Azetidine-2-carboxylic acid is a proline analog. L-Azetidine-2-carboxylic acid upregulates the lipid autophagy marker LC3-II via activation of the PERK pathway. L-Azetidine-2-carboxylic acid increases pro-apoptotic BAX protein. L-Azetidine-2-carboxylic acid induces ATF6 cleavage and upregulates phosphorylated eIF2α levels. L-Azetidine-2-carboxylic acid induces ER stress, inducing protein misfolding and aggregation. L-Azetidine-2-carboxylic acid shows teratogenic, pro-inflammatory and pro-apoptotic effects .

製品番号	製品名	構造式

HY-Y0882S1

Hydroxylamine-d3 hydrochloride

Hydroxylamine-d₃ (hydrochloride) is the deuterium labeled Hydroxyamine hydrochloride. Hydroxylamine hydrochloride is a selective Monoamine oxidase (MAO) inhibitor used for inhibiting of platelet aggregation. Hydroxylamine hydrochloride is an intermediate of nitrogen cycle in aerobic ammonium oxidizers microorganisms, such as ammonium oxidizing bacteria (AOB), ammonium oxidizing archaea (AOA) and complete ammonium oxidizing bacteria (comammox). Hydroxylamine hydrochloride impacts NO and N₂O emissions by aerobic ammonium oxidizers microorganisms and inhibits nitrite oxidizing bacteria (NOB) activity .

HY-17479BS

Amfenac-d5 sodium
Amfenac-d₅ sodium is deuterated-labeled Amfenac sodium. Amfenac Sodium is an orally active and potent anti-inflammatory compound possessing antipyretic and analgesic properties. Amfenac Sodium can be used for the research of acute and chronic inflammation .

HY-17479S

Amfenac-d5
Amfenac-d₅ is the deuterium labeled Amfenac. Amfenac is an orally active and potent anti-inflammatory compound possessing antipyretic and analgesic properties. Amfenac can be used for the research of acute and chronic inflammation .

HY-B2221S1

U-13C Cellulose from chicory

U- ¹³C Cellulose from chicory is the ¹³C labeled Cellulose (HY-B2221). Cellulose (Pectin glycosidase) is a natural high molecular weight polysaccharide found in many plants and organisms. It is widely used in manufacturing industries, such as in paper making, textiles, food and medicine, etc. As a renewable resource, Cellulose is biodegradable and sustainable, and can also be used to manufacture chemicals such as Cellulose Esters, Cellulose Acetate and Cellulose Nitrate. In addition, Cellulose is often used as a food additive to increase the stability and quality of food .

HY-B2221S

U-13C Cellulose high DP from potato

U- ¹³C Cellulose high DP from potato is the ¹³C labeled Cellulose (HY-B2221). Cellulose (Pectin glycosidase) is a natural high molecular weight polysaccharide found in many plants and organisms. It is widely used in manufacturing industries, such as in paper making, textiles, food and medicine, etc. As a renewable resource, Cellulose is biodegradable and sustainable, and can also be used to manufacture chemicals such as Cellulose Esters, Cellulose Acetate and Cellulose Nitrate. In addition, Cellulose is often used as a food additive to increase the stability and quality of food .

HY-P11431

Cyclo(Gly-Pro)
Cyclo(Gly-Pro) is a cyclic dipeptide. Cyclo(Gly-Pro) can be derived from the Nterminus of the IGF-1. Cyclo(Gly-Pro) attenuates nociceptive behaviour and inflammatory response in mice .

HY-132485S

*N-Methyl Pantoprazole-d3 (Mixture of 1 and* 3 isomers)**
N-Methyl Pantoprazole-d₃ (Mixture of 1 and 3 isomers) is the deuterium labeled N-Methyl Pantoprazole (Mixture of 1 and 3 isomers) .

HY-108226S1

*Regorafenib N-oxide and* N-desmethyl (M5)-13C6**
Regorafenib N-oxide and N-desmethyl (M5)- ¹³C₆ is the ¹³C-labeled Regorafenib N-oxide and N-desmethyl (M5) .

HY-108226S

*Regorafenib N-oxide and* N-desmethyl (M5)-d3**
Regorafenib N-oxide and N-desmethyl (M5)-d₃ is deuterium labeled Regorafenib N-oxide and N-desmethyl (M5).

HY-W709612

*Regorafenib N-oxide and* N-desmethyl (M5)-d3-1**
Regorafenib N-oxide and N-desmethyl (M5)-d₃-1 (N-Desmethyl regorafenib N-oxide-d₃-1) is the deuterium labeled Regorafenib N-oxide and N-desmethyl (M5) (HY-108226). Regorafenib N-oxide and N-desmethyl (M5) (N-Desmethyl regorafenib N-oxide) is an active metabolite of Sorafenib (HY-10201) and can be metabolized by CYP3A4 .

HY-P0090S

Calcitonin-13C6,15N4 (salmon) TFA
Calcitonin- ¹³C₆, ¹⁵N₄ (salmon) (Salmon calcitonin- ¹³C₆, ¹⁵N₄) TFA is ¹³C and ¹⁵N-labeled Calcitonin (salmon) (HY-P0090). Calcitonin (salmon) , a calcium regulating hormone, is a dual-action amylin and calcitonin receptor agonist, could stimulate bone formation and inhibit bone resorption .

HY-Y0921S3

(±)-1,2-Propanediol-13C3
(±)-1,2-Propanediol- ¹³C₃ is ¹³C labeled (±)-1,2-Propanediol (HY-Y0921). (±)-1, 2-propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol that is often used as an excipient in many active molecular preparations to increase the solubility and stability of the active molecule. (±)-1, 2-propanediol can affect the neurobehavior of zebrafish .

HY-B0168AS

Milnacipran-d5 hydrochloride

Milnacipran-d₅ hydrochloride is deuterium labeled Milnacipran hydrochloride (HY-B0168A). Milnacipran hydrochloride is an orally active Serotonin (HY-B1473A) and Norepinephrine (HY-13715) reuptake inhibitor. Milnacipran hydrochloride inhibits monoamine transporters, especially the norepinephrine transporter and the serotonin transporter (K_i values of 31 and 8.5 nM, respectively). Milnacipran hydrochloride inhibits pERK1/2 activation. Milnacipran hydrochloride has antidepressant, anxiolytic and analgesic properties. Milnacipran hydrochloride inhibits biting behavior in mice. Milnacipran hydrochloride can be used in the study of major depressive disorder, anxiety disorders, and neuropathic pain (e.g., fibromyalgia) .

HY-W585933S

Fructose-alanine-13C6

Fructose-alanine- ¹³C₆ is ¹³C labeled Fructose-alanine. Fructose-alanine, an amadori compound, is an aroma precursor that formed in the initial phase of the Maillard reaction (MR). Fructose-alanine can be isolated from tobacco, miso and white wine. Fructose-alanine significantly induces oxidative browning and correlates with Maillard product (furfuryl alcohol) with a roasted and sweet aroma. Fructose-alanine can be used for food industry and tobacco processing research .

HY-B1234S

Octinoxate-13C,d3

Octinoxate-13C,d3 is the deuterium labeled Octinoxate (HY-W245806). Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo .

HY-B2221S3

U-13C Cellulose high DP from maize

U- ¹³C Cellulose high DP from maize is the ¹³C labeled Cellulose (HY-B2221). Cellulose (Pectin glycosidase) is a natural high molecular weight polysaccharide found in many plants and organisms. It is widely used in manufacturing industries, such as in paper making, textiles, food and medicine, etc. As a renewable resource, Cellulose is biodegradable and sustainable, and can also be used to manufacture chemicals such as Cellulose Esters, Cellulose Acetate and Cellulose Nitrate. In addition, Cellulose is often used as a food additive to increase the stability and quality of food .

HY-P3252AS

Pegcetacoplan-13C3,15N TFA

Pegcetacoplan- ¹³C₃, ¹⁵N TFA is the ¹³C- and ¹⁵N-labeled Pegcetacoplan TFA. Pegcetacoplan is a pegylated complement C3/C3b inhibitor. Pegcetacoplan acts by specifically binding to and inhibiting C3 and C3b, thereby suppressing the complement cascade at its proximal stage. Pegcetacoplan is not a known inhibitor or inducer of CYP450 isoenzymes. Pegcetacoplan can be used for the research of complement-mediated diseases, including paroxysmal nocturnal hemoglobinuria (PNH) and age-related macular degeneration (AMD).

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Species:	Human (256) Marmoset (1) Rhesus Macaque (2) Bovine (1) Rat (7) Mouse (46) E.coli (2) Cynomolgus (10) Canine (1)
Tag:	GFP (1) SUMO (6) His (233) Strep (17) Tag Free (43) Avi (16) TAT (1) Myc (7) GST (22) B2M (1) Flag (10) Fc (45)
Source:	HEK293 (158) E. coli Cell-free (3) CHO (1) sf9 insect cells (4) CHO (2) P. pastoris (2) Sf9 insect cells (52) E. coli (105) sf9 insect cells (1)


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Size	* This product has been "discontinued". Optimized version of product available: / 在庫あり - + カートに追加お問い合わせ

Host:	Rat (1) Mouse (87) Rabbit (177)
Reactivity:	Human (235) Bovine (2) rat (8) Rat (128) Escherichia coli (1) Monkey (5) Rabbit (1) Pig (1) Transfected (2) mouse (8) Mouse (144) Dog (3) human (19) Hamster (4)
Application:	WB IHC-P ICC/IF (1) IHC-P (151) ICC/IF (137) mIHC (1) IF-Tissue (34) IP (80) IHC-F (24) WB (225) ChIP (2) FC (55) ELISA (68)
Isotype:	IgG3 (2) IgG (177) IgG2b,IgG/Kappa (1) IgG1 (31) IgG2a (8) IgG/Kappa (8) IgG2b (10) IgM (2)
Conjugation:	Non-conjugated (264) Biotin (18)
Clonality:	Polyclonal (11) polyclonal (2) Monoclonal (191) Recombinant (114)
Modification:	Phosphorylated (24) Unmodified (200)


Products	在庫あり - + カートに追加
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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / 在庫あり - + カートに追加お問い合わせ