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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
107 Results for "
antispasmodic
" in MedChemExpress (MCE) Product Catalog:
Products (107)
107 Results for "antispasmodic" in MCE Product Catalog:
13
Category:
Neurological Disease Anti-aging Plants Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey Infection Iridoids Terpenoids Scrophulariaceae Disease Research Fields Inflammation/Immunology Cancer
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8
8 Cited Publications
Synonyms: Vanillylacetone; Gingerone
Category:
Zingiber officinale Roscoe Monophenols Ketones, Aldehydes, Acids Metabolic Disease Phenols Plants Disease Research Fields Inflammation/Immunology Zingiberaceae
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6
6 Cited Publications
Synonyms: Immunomycin; FR-900520; FK520
Category:
Microorganisms Neurological Disease Macrolide Antibiotics Antifungal Anti-inflammation/Immunoregulatory Antibiotics Disease Research Disease Research Fields Inflammation/Immunology
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2
Category:
Cardiovascular Disease Artemisia cana Pursh Lignans Phenylpropanoids Plants Umbelliferae Disease Research Fields
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1
Category:
Monophenols Ketones, Aldehydes, Acids Asclepiadaceae Phenols Plants Periploca sepium Bunge
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1
Category:
Neurological Disease Xanthones Plants other families Gentianaceae Phenols Polyphenols Swertia chirata Disease Research Fields Inflammation/Immunology
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1
1 Cited Publications
Synonyms: Hexahydroadiphenine hydrochloride
Target:
Cholinesterase (ChE) Potassium Channel Amyloid-β TRP Channel Tau Protein NOD-like Receptor (NLR) JNK NF-κB IKK
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology
Drofenine (Cycloadiphene; Hexahydroadiphenine) hydrochloride is an brain-penetrant antispasmodic agent. Drofenine hydrochloride is a Kv2.1 channel inhibitor with human IC50 of 9.53 μM. Drofenine hydrochloride is a butyrylcholinesterase (BChE) inhibitor with Ki of 0.003 mM, and is a TRPV3 activator. Drofenine hydrochloride blocks Kv2.1-dependent potassium efflux, inhibits Kv2.1/JNK/NF-κB and IkBa/NF-kB signaling, suppresses Kv2.1 mRNA/protein expression. Drofenine suppresses oligomeric Aβ-induced microglial NLRP3 inflammasome activation and neuronal Tau hyperphosphorylation, improves cognitive impairment, promotes neurite outgrowth. Drofenine hydrochloride induces calcium influx in keratinocytes and exert cytotoxicity against keratinocytes. Drofenine hydrochloride ameliorates diabetic peripheral neuropathy -like pathology. Drofenine hydrochloride can be used for the researches of Alzheimer's disease, diabetic peripheral neuropathy and smooth muscle spasm .
Category:
Infection Zanthoxylum bungeanum Maxim. Monophenols Rutaceae Phenols Plants Disease Research Fields Zanthoxylum simulans Hance
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Synonyms: 14:0 Lyso PC; 1-myristoyl-sn-glycero-3-phosphatidylcholine
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Alimemazine hemitartrate (Trimeprazine hemitartrate) is an antagonist of the histamine (HA) receptor that can be taken orally and also acts as a partial agonist at other GPCR receptors. Alimemazine hemitartrate has effects that include anti-serotonin, antispasmodic, antihistamine, sedation, hypnotic, antiviral, and anti-nausea properties. Alimemazine hemitartrate promotes the growth of pancreatic β-cells in mice and improves diabetes in mice .
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Dicyclomine hydrochloride is a potent and orally active muscarinic cholinergic receptors antagonist. Dicyclomine hydrochloride shows high affinity for muscarinic M1 receptor subtype (Ki=5.1 nM) and M2 receptor subtype (Ki=54.6 nM) in brush-border membrane and basal plasma membranes, respectively . Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo .
Research Areas:
Cardiovascular Disease Infection Neurological Disease Cancer
Flavoxate hydrochloride (Rec-7-0040; DW61) is an orally active L-type Ca 2+ channel inhibitor and antispasmodic. Flavoxate hydrochloride inhibits cyclic adenosine monophosphate production by blocking voltage-dependent inward Ba 2+ currents, regulating the brainstem micturition center, and stimulating G protein-coupled receptors. Consequently, Flavoxate hydrochloride induces relaxation of bladder smooth muscle and inhibits isovolumetric rhythmic contractions. Flavoxate hydrochloride effectively increases bladder capacity and alleviates symptoms of urgent urination frequency and pollakiuria caused by overactive bladder. Flavoxate hydrochloride can be used in research on overactive bladder and related voiding dysfunctions .
Cat. No.: HY-N4113
CAS No.: 94805-82-0
Category:
Leguminosae Coumarins Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Cancer
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Flopropione is a 5-HT receptor antagonist and also a catechol-o-methyltransferase (COMT) inhibitor . Flopropione also as an antispasmodic agent .
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Cat. No.: HY-B0326
CAS No.: 26750-81-2
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Alibendol can be taken orally. It has anti-spasmodic properties and promotes bile secretion, making it useful for research on digestive system issues like indigestion, nausea, vomiting, and constipation .
Research Areas:
Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor and an L-type voltage-dependent calcium channel (L-VDCC) blocker, blocks the degradation of 3',5'-cyclic adenosine monophosphate. Drotaverine (hydrochloride) exhibits in vivo antispasmodic efficacy without anticholinergic effects.
Cat. No.: HY-N8117
CAS No.: 22567-36-8
Category:
Natural Products Distemonanthus benthamianus Baill. Plants Compositae Disease Research Fields Inflammation/Immunology
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Cat. No.: HY-B2078A
CAS No.: 10402-53-6
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Research Areas:
Eprazinone dihydrochloride is a gent with mucolytic, secretolytic, antitussive, and bronchial antispasmodic properties. Eprazinone dihydrochloride is a neurokinin 1 receptor (NK1R) ligand. Eprazinone dihydrochloride has the potential for chronic bronchitis treatment that improved pulmonary function and arterial partial pressure of oxygen .
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Ethaverine hydrochloride, a derivative of papaverine, inhibits cardiac L-type calcium channel. Ethaverine hydrochloride is a peripheral vasodilator and antispasmodic agent. Ethaverine hydrochloride can be used for research of peripheral vascular disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
