Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
50 Results for "
cPLA2
" in MedChemExpress (MCE) Product Catalog:
Products (50)
50 Results for "cPLA2" in MCE Product Catalog:
8
8 Publications Verification
Target:
Research Areas:
CAY10650 is a highly potent cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC50 value of 12 nM. CAY10650 suppresses lipid droplets formation and PGE2 secretion [2].
6
6 Cited Publications
Synonyms: Arachidonyl trifluoromethyl ketone
Target:
Research Areas:
AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeant trifluoromethyl ketone analog of arachidonic acid. AACOCF3 is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). AACOCF3 blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets. AACOCF3 has the potential for the research of cardiovascular disease [2] .
5
5 Cited Publications
Synonyms: Methyl Arachidonyl Fluorophosphonate
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease
MAFP (Methyl Arachidonyl Fluorophosphonate) is an selective, active-site directed and irreversible inhibitor of cPLA2 and iPLA2. MAFP is also a potent irreversible inhibitor of anandamide amidase.
5
Category:
Labiatae Terpenoids Samanea saman (Jacq.) Merr. Diterpenoids Plants Disease Research Fields Cancer
Target:
4
4 Cited Publications
Target:
Research Areas:
Pyrrophenone is a potent and specific cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC50 value of 4.2 nM .
1
Target:
1
1 Cited Publications
Cat. No.: HY-18540
CAS No.: 1402612-55-8
Research Areas:
KT109 is a potent and an isoform-selective inhibitor of diacylglycerol lipase-β (DAGLβ) with an IC50 of 42 nM. KT109 has ~60-fold selectivity for DAGLβ over DAGLα. KT109 shows inhibitory activity against PLA2G7 (IC50=1 µM). KT109 shows negligible activity against FAAH, MGLL, ABHD11, and cytosolic phospholipase A2 (cPLA2 or PLA2G4A). KT109 perturbs a lipid network involved in macrophage inflammatory responses and lowers 2-Arachidonoylglycerol (HY-W011051), Arachidonic acid (HY-109590) and eicosanoids in mouse peritoneal macrophages .
1
1 Cited Publications
Cat. No.: HY-N10549
CAS No.: 83088-28-2
1
1 Cited Publications
Target:
Research Areas:
ASB14780 is a 4-phenoxy derivative, the cytosolic Phospholipase A2α (cPLA2α) inhibitor, with an IC50 value of 20 nM .
1
1 Cited Publications
Cat. No.: HY-P71707
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: 60kDa Tat interactive protein; cPLA2 interacting protein; ESA1; Histone acetyltransferase HTATIP; HTATIP1; K(lysine) acetyltransferase 5; PLIP; Tat interacting protein, 60kDa; TIP; Tip60
Cat. No.: HY-N2600
CAS No.: 76472-87-2
Cat. No.: HY-173371
Target:
Research Areas:
BRI-50460 is an inhibitor of cytosolic calcium-dependent phospholipase A2 (cPLA2) that has the ability to penetrate the blood-brain barrier, with an IC50 of 0.88 nM. BRI-50460 exerts the activities of regulating neuroinflammation and restoring lipid homeostasis by inhibiting cPLA2, regulating the downstream inflammatory lipid signaling pathway, and alleviating the effects of amyloid β42 oligomers on the activation of cPLA2, the hyperphosphorylation of tau protein, and the reduction of synapses and dendrites. BRI-50460 can be applied to the research in the fields of Alzheimer's disease and other neurodegenerative diseases .
Synonyms: PLA-695
Target:
Research Areas:
Giripladib (PLA-695) is a indole-based inhibitor of cytosolic phospholipase A2 (cPLA2). Giripladib can be used for osteoarthritis and breast cancer research [2].
Cat. No.: HY-106253
CAS No.: 381683-94-9
Target:
Research Areas:
Efipladib is a potent, selective and orally active cPLA2α inhibitor with an IC50 of 0.04 μM and a Kd of 0.067 μM .
Cat. No.: HY-W654264
Target:
Cat. No.: HY-W127380
CAS No.: 146797-82-2
Cat. No.: HY-D1647
CAS No.: 161180-12-7
Cat. No.: HY-W019838S
CAS No.: 1246304-35-7
Synonyms: Sphinganine (d18:0)-d7
Cat. No.: HY-U00037
CAS No.: 381683-92-7
Synonyms: PLA 725
Target:
Research Areas:
Ecopladib is a sub-micromolar inhibitor of cytosolic phospholipase A2α (cPLA2α), with IC50s of 0.15 μM and 0.11 μM in the GLU micelle and rat whole blood assays, respectively.
Target:
Research Areas:
CAY10502 is a potent, calcium-dependent cytosolic phospholipase A2 α (cPLA2α) inhibitor with an IC50 of 4.3 nM for isolated enzyme. CAY10502 can be used in the research of retinopathy and inflammatory diseases [2] .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
