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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
100 Results for "
hypothalamic
" in MedChemExpress (MCE) Product Catalog:
Products (100)
100 Results for "hypothalamic" in MCE Product Catalog:
223
Metformin (1,1-Dimethylbiguanide) inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Metformin also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, Metformin regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo .
223
223 Publications Verification
別名: 1,1-Dimethylbiguanide hydrochloride
Metformin (1,1-Dimethylbiguanide) hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, Metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo .
31
31
31 Cited Publications
別名: α-Hypophamine acetate; Oxytocic hormone acetate
14
Target:
研究分野:
7
7 Cited Publications
製品番号: HY-B1811
CAS 番号: 11000-17-2
別名: Arginine vasopressin; Antidiuretic hormone
Target:
5
5 Cited Publications
別名: Clomifene; (Z/E)-Enclomiphene; (Z/E)-Enclomifene
Target:
研究分野:
Clomiphene (Clomifene; (Z/E)-Enclomiphene; (Z/E)-Enclomifene) is an orally active ovulation-inducing agent. Clomiphene binds to hypothalamic estrogen receptors to elevate FSH levels, and exhibits antiestrogenic or estrogenic properties. Clomiphene can induce erturbations during meiotic maturation and cytogenetic abnormalities in mouse oocytes. Clomiphene ameliorates memory impairment in PCOS models. Clomiphene mobilizes cytosolic calcium and reduces viability in prostate cancer cells. Clomiphene can be used for the research of polycystic ovary syndrome (PCOS) and prostate cancer .
3
Category:
Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Other Diseases Microorganism Endogenous metabolite Disease Research Fields
Target:
2
Target:
(R)-Nimodipine ((R)-BAY-e 9736) is an orally active, blood-brain barrier-permeable L-type calcium channel blocker with an IC50 of 5 nM. (R)-Nimodipine inhibits corticosterone release by blocking calcium channels on the hypothalamic-pituitary-adrenal axis, thereby reversing immobilization stress-induced memory impairment and behavioral abnormalities. (R)-Nimodipine is widely used in studies related to aneurysmal subarachnoid hemorrhage, cerebral ischemia, epilepsy, age-related degenerative neurological diseases, and alcohol intoxication .
1
Category:
Cardiovascular Disease Rutaceae Extract Other Monoterpenes Plant Terpenoids Disease Research Fields Citrus Extract
Target:
1
1 Cited Publications
別名: ACTH; Adrenocorticotrophic hormone
1
Target:
1
1 Cited Publications
製品番号: HY-P2278
CAS 番号: 597578-70-6
研究分野:
1
1
1 Cited Publications
製品番号: HY-P3641A
Target:
1
1
1 Cited Publications
製品番号: HY-P1205
CAS 番号: 128315-56-0
別名: Melanin-concentrating hormone(human, mouse, rat)
Target:
1
1 Cited Publications
製品番号: HY-P2278A
研究分野:
1
1 Cited Publications
製品番号: HY-P70248
純度: ≥ 90%, as determined by reducing SDS-PAGE.
別名: ESR1; Estrogen Receptor Alpha Delta 4*,5,6,7*/654 Isoform; Prev. ESR; Estrogen Receptor Alpha 3*,4,5,6,7,8*/1032 Isoform; ER-Alpha; Estrogen Receptor Alpha 3*,4,5,6,7,8*/1068 Isoform; ER; Estrogen Receptor Alpha 3*,4,5,6,7,8*/984 Isoform; Nuclear Receptor Subfamily 3 Group A Member 1; Hippocampal Estrogen Receptor Alpha Isoform TADDI; Estradiol Receptor; Estrogen Receptor Alpha 2*,3,4,5,6,7*,8* Isoform; NR3A1; Estrogen Receptor Alpha 3*,4,5,6,7*/765 Isoform; Estrogen Receptor; Estrogen Receptor Alpha 3*,4,5,6,7*/822 Isoform; Era; Estrogen Receptor Alpha Delta 3*4,5*,7 Isoform; Oestrogen Receptor Alpha; Estrogen Receptor Alpha Delta 4,5,6,7 Isoform; Estrogen Receptor Alpha; Estrogen Receptor Alpha Delta 3*4*,7 Isoform; E2 Receptor Alpha; Estrogen Receptor Alpha E1-N2-E2-1-2 Variant; Estrogen Receptor Alpha Delta 2*,3,4,5,6,7*/834 hypothalamic Isoform; Estrogen Receptor Alpha Delta 4,5,7 Isoform; Estrogen Receptor Alpha Delta 3*,4,5,6,7*/775 hypothalamic Isoform; Estrogen Receptor Alpha Delta 4 +49 Isoform; Estrogen Receptor Alpha Delta 1*,2,3*/663 Choroid Plexus Isoform; Estrogen Receptor Alpha E1-N1-E2-1 Variant; Estrogen Receptor Alpha Delta 4,7*,8*/581 hypothalamic Isoform; Estrogen Receptor Alpha E1-N2-E2-2 Variant; Estrogen Receptor Alpha Delta 4*,5,6*/481 hypothalamic Isoform; Estrogen Receptor Alpha Delta 6,7 Isoform; Estrogen Receptor Alpha Delta 3*,4,5,6,7*, 8*/912 Isoform; Estrogen Receptor Alpha E1-E2-1-2 Variant; Estrogen Receptor Alpha Delta 3*,4,5,6,7*,8*/941 Isoform; Estrogen Receptor Alpha E1-E2-2 Variant; Estrogen Receptor Alpha Delta 3*,4,5,6,7,8*/1029 Isoform; Estrogen Receptor Alpha Splice Variant; Estrogen Receptor Alpha Delta 3*,4,5,6,7*/819-2 Isoform; Estrogen Receptor Alpha E1-1-2 Variant; Estrogen Receptor Alpha Delta 3*,4,5,6,7,8*/969 Isoform; Estrogen Receptor Alpha E1-N2-E2-1-2; Estrogen Receptor Alpha Delta 3*,4,5,6,7,8*/984 Isoform; Estrogen Receptor Alpha E1-2 Variant; Estrogen Receptor Alpha Delta 2*,3,4,5,6,7*/963 Isoform; Estrogen Receptor Alpha E1-E2-1-2; Estrogen Receptor Alpha Superior Frontal Gyrus Isoform; Estrogen Nuclear Receptor Alpha; Estrogen Receptor Alpha Delta 4*,5,6,7,8*/918 Isoform; Estrogen Receptor Protein; Estrogen Receptor Alpha Delta 4*,5,6,7,8*/885 Isoform; Alternative Protein ESR1; Estrogen Receptor Alpha Delta 4*,5,6,7,8*/901 Isoform; ESTRR; Estrogen Receptor Alpha Delta 4*,5,6,7*/633 Isoform; ESRA; Estrogen Receptor 1; Estrogen Receptor Alpha Delta 2*,3,4,5,6,7 Isoform
Species:
Human
Source:
E. coli
製品番号: HY-106203
CAS 番号: 752253-39-7
別名: SSR-125543
Target:
研究分野:
Crinecerfont (SSR-125543) is an orally effective corticotropin-releasing factor receptor type-1 (CRHR1) antagonist. Crinecerfont blocks CRHR1 signaling to reduce adrenocorticotropic hormone secretion. Crinecerfont improves hypothalamic-pituitary-adrenal axis negative feedback sensitivity in chronically stressed mice. Crinecerfont can be used for the research of chronic stress conditions and classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency . Crinecerfont is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
