291 Results for "

linear

" in MedChemExpress (MCE) Product Catalog:
Products (291)

291 Results for "linear" in MCE Product Catalog:

23
23 Publications Verification
Cat. No.: HY-101916
CAS No.: 9050-30-0
Heparan sulfate, a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on the cell surface and in the extracellular matrix.
loading...
    loading...
9
9 Cited Publications
Cat. No.: HY-P99045
CAS No.: 1796566-95-4
Synonyms: HRS7; hRS7

Target:  

ADC Antibodies TROP2

Research Areas:  

Cancer

Sacituzumab is a humanized IgG1 monoclonal antibody targeting Trophoblast cell surface antigen 2 (TROP2). Sacituzumab demonstrates a lack of antitumor effects alone and does not inhibit the function of TROP-2 during tumor metastasis, binding to the linear epitopes of TROP-2 protein. Sacituzumab can be used for the synthesis of antibody-drug conjugates (ADC) drug Sacituzumab govitecan (HY-132254). Sacituzumab govitecan can be used in the field of triple-negative breast cancer .
loading...
    loading...
8
8 Cited Publications
Cat. No.: HY-P3465
CAS No.: 2012558-47-1
Synonyms: Myrcludex B
Target:  

HBV

Research Areas:  

Infection

Bulevirtide (Myrcludex B) is a NTCP inhibitor, a linear lipopeptide of 47 amino acids. Bulevirtide inhibits HBV and HDV entry into liver cells, blocks HBV infection in hepatocytes, and participates in HBV transcriptional suppression. Bulevirtide can be used in HDV infection and compensated cirrhosis research .
loading...
    loading...
5
5 Cited Publications
Cat. No.: HY-P0290
CAS No.: 91037-75-1
Target:  

Integrin

Research Areas:  

Cancer

GRGDSP, a synthetic linear RGD peptide, is an integrin inhibitor.
loading...
    loading...
4
4 Cited Publications
Cat. No.: HY-122881
Purity:  99.57%
Synonyms: JTP-0819958
Target:  

IKK

Research Areas:  

Cancer

HOIPIN-1 (JTP-0819958) is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 of 2.8 μM . HOIPIN-1 suppress LUBAC-mediated NF-kB activation in vitro .
loading...
    loading...
4
4 Cited Publications
Cat. No.: HY-B2144A
CAS No.: 9012-76-4
Synonyms: Deacetylated chitin (MW 150000) (≥85% deacetylated); Poly(D-glucosamine) (MW 150000) (≥85% deacetylated)
Research Areas:  

Infection Cancer

Chitosan (MW 150000) (Deacetylated chitin (MW 150000)) is a polycationic linear polysaccharide derived from chitin with the molecular weight of 150000. Chitosan is an versatile biomaterial because of its non-toxicity, low allergenicity, biocompatibility and biodegradability. Chitosan also has antitumor, antibacterial, antifungal, and antioxidant activities .
loading...
    loading...
4
4 Cited Publications
Cat. No.: HY-122882
CAS No.: 2519537-70-1
Purity:  98.90%
Target:  

E1/E2/E3 Enzyme

Research Areas:  

Inflammation/Immunology

HOIPIN-8 is a potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) with an IC50 of 11 nM. HOIPIN-8 is a HOIPIN-1 derivative with enhanced the potency by 255-fold in the petit-LUBAC inhibition, and 10-fold and 4-fold in the LUBAC- and TNF-α-mediated NF-κB activation, respectively than HOIPIN-1. HOIPIN-1 is a promising tool to explore the cellular functions of LUBAC .
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-KE7055

RNase R is a magnesium ion-dependent 3'-5' exoribonuclease that can increase the abundance of circular RNA by degrading linear RNA in mixed RNA, thereby enriching circular RNA.

loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-P1539
CAS No.: 80451-04-3
Target:  

Bacterial Antibiotic

Cecropin A is a linear 37-residue antimicrobial polypeptide, with anticancer and anti-inflammatory activity.
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-30152
CAS No.: 2009-24-7
Synonyms: 8-Hydroxypsoralen
Xanthotoxol (8-Hydroxypsoralen) It is a kind of fragrant bean substance, and it is a CYP450 inhibitor. Xanthotoxol has anti-inflammatory, anti-inflammatory, and 5-HT antagonistic and protective effects. Xanthotoxol inhibited CYP3A4 sum CYP1A2 IC50s separation 7.43 μM sum 27.82 μM. Xanthotoxol can pass through MAPK and NF-κB, inhibiting inflammation.
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-N6708
CAS No.: 27061-78-5
Alamethicin is a linear 20-amino acid antibiotic, which can induce voltage-gated conductance in model and cell membranes. Alamethicin exhibits antimicrobial activity against Gram-positive bacteria, but not Gram-negative bacteria. Alamethicin can form an amphipathic α-helical structure in biological membranes .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-W1048553B
Mal-PEG3400-NH2 TFA is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-D1668
Biotin-11-dCTP is a biotinylated deoxynucleoside triphosphate and an important DNA labeling reagent. In random primer DNA labeling reactions, Biotin-11-dCTP incorporates into newly synthesized DNA strands to generate labeled DNA probes suitable for hybridization applications. In addition, Biotin-11-dCTP can serve as a substrate for terminal deoxynucleotidyl transferase to end-label oligonucleotides for telomere sequence detection, or to label the cut ends of linearized DNA molecules, thereby supporting streptavidin-based electron microscopy analysis. For example, Biotin-11-dCTP can label the cut ends of linearized DNA molecules under the action of dGTP and avian myeloblastosis virus reverse transcriptase .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-B2144B
CAS No.: 9012-76-4
Synonyms: Deacetylated chitin (MW 30000) (≥85% deacetylated); Poly(D-glucosamine) (MW 30000) (≥85% deacetylated)
Research Areas:  

Infection Cancer

Chitosan (MW 30000) (Deacetylated chitin (MW 30000)) is a polycationic linear polysaccharide derived from chitin with the molecular weight of 30000. Chitosan is an versatile biomaterial because of its non-toxicity, low allergenicity, biocompatibility and biodegradability. Chitosan also has antitumor, antibacterial, antifungal, and antioxidant activities .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-156591
CAS No.: 3032600-90-8
Purity:  99.76%
Research Areas:  

Others

PROTAC MLKL Degrader-1 is a selective MLKL PROTAC degrader with a DC50 of 2.4 μM. PROTAC MLKL Degrader-1 blocks necroptosis without modulating the phosphorylation of RIPK1 or RIPK3, and exhibits a linear correlation between MLKL levels and necroptotic cell death .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-151507
CAS No.: 2322290-93-5
Purity:  ≥98.0%
306Oi10 is a branched ionizable lipid that can be used to construct lipid nanoparticles (LNPs) for delivering messenger RNA. The surface ionization of lipid nanoparticles is related to the effectiveness of mRNA delivery. The tail of 306Oi10 has a one-carbon branch, which provides it with stronger surface ionization compared to lipids with linear tails, thereby enhancing its mRNA delivery efficacy. 306Oi10 can be used in research related to mRNA delivery .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-128425A
CAS No.: 13184-27-5
Purity:  ≥98.0%
Synonyms: L-Ureidosuccinic acid
N-Carbamoyl-L-aspartic acid (L-Ureidosuccinic acid) is an important pyrimidine metabolic precursor and intermediate metabolite. N-Carbamoyl-L-aspartic acid reverses the growth inhibition of Ura + strains induced by 2-thiouracil (with growth rate increasing linearly with its concentration), but fails to support the growth of uracil-requiring Ura - strains. N-Carbamoyl-L-aspartic acid inhibits the cell growth of *Saccharomyces cerevisiae* by suppressing the purine biosynthetic pathway at a pre-step of 5-aminoimidazole nucleotide synthesis. The growth inhibitory effect of N-Carbamoyl-L-aspartic acid on yeast can be alleviated by purines, and the sensitivity of strains is closely related to the activity level of dihydroorotase .
loading...
    loading...
Cat. No.: HY-D1005A
CAS No.: 9003-11-6
Synonyms: PEG-PPG-PEG, 8800 (Average Mn)
Poloxamer 188 is a nonionic linear copolymer with surfactant properties. Poloxamer 188 exhibits anti-thrombotic, anti-inflammatory, and cytoprotective activities in various tissue injury models. Poloxamer 188 can be used for drug delivery .
loading...
    loading...
Cat. No.: HY-D1005H
CAS No.: 9003-11-6
Synonyms: PEG-PPG-PEG, 8400(Average Mn)
Poloxamer 188 is a nonionic linear copolymer with surfactant properties. Poloxamer 188 exhibits anti-thrombotic, anti-inflammatory, and cytoprotective activities in various tissue injury models .
loading...
    loading...
Cat. No.: HY-B1620B
CAS No.: 9003-39-8
Synonyms: PVP K15; Polyvidone K15; Povidone K15
Polyvinylpyrrolidone K15 is a linear non-ionic polymer devises vigorous bright crystalline layers and has adhesive, cohesive and dispersive properties .
loading...
    loading...