1443 Results for "

polymerization

" in MedChemExpress (MCE) Product Catalog:
Products (1443)

1443 Results for "polymerization" in MCE Product Catalog:

388
388 Publications Verification
Cat. No.: HY-B0015
CAS No.: 33069-62-4
Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy .
loading...
    loading...
238
238 Cited Publications
Cat. No.: HY-15534
CAS No.: 3520-43-2
Purity:  98.71%
Synonyms: CBIC2
JC-1 (CBIC2) is an ideal fluorescent probe widely used to detect mitochondrial membrane potential. JC-1 accumulates in mitochondria in a potential dependent manner and can be used to detect the membrane potential of cells or purified mitochondria. In normal mitochondria, JC-1 aggregates in the mitochondrial matrix to form a polymer, which emits strong red fluorescence (Ex=585 nm, Em=590 nm); When the mitochondrial membrane potential is low, JC-1 cannot aggregate in the matrix of mitochondria and produce green fluorescence (ex=510 nm, em= 527 nm) .
loading...
    loading...
212
212 Cited Publications
Cat. No.: HY-Y0873
CAS No.: 25322-68-3
Synonyms: Polyethylene glycol 300
PEG300 (Polyethylene glycol 300), a neutral polymer of molecular weight 300, is a water-soluble, low immunogenic and biocompatible polymer formed by repeating units of ethylene glycol .
loading...
    loading...
115
115 Cited Publications
Cat. No.: HY-112735
CAS No.: 28728-55-4
Purity:  99.69%
Synonyms: Polybrene; 1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide
Hexadimethrine bromide (Polybrene) is a cationic polymer used routinely to enhance the efficiency of retrovirus vector-mediated gene transfer .
loading...
    loading...
100
100 Cited Publications
Cat. No.: HY-N6682
CAS No.: 22144-77-0
Synonyms: Zygosporin A; NSC 209835
Cytochalasin D (Zygosporin A) is a potent actin polymerization inhibitor, could be derived from fungus. Cytochalasin D has cell-permeable activity. Cytochalasin D inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of Yap .
loading...
    loading...
77
77 Cited Publications
Cat. No.: HY-N0488A
CAS No.: 57-22-7
Synonyms: Leurocristine; NSC-67574; 22-Oxovincaleukoblastine
Vincristine (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a Ki of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas .
loading...
    loading...
77
77 Cited Publications
Cat. No.: HY-N0488
CAS No.: 2068-78-2
Synonyms: Leurocristine sulfate; NSC-67574 sulfate; 22-Oxovincaleukoblastine sulfate
Vincristine (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) sulfate is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a Ki of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine sulfate inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine sulfate upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine sulfate is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas .
loading...
    loading...
73
73 Cited Publications
Cat. No.: HY-16569
CAS No.: 64-86-8
Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research .
loading...
    loading...
61
61 Cited Publications
Cat. No.: HY-15162
CAS No.: 474645-27-7
Purity:  99.97%
Synonyms: MMAE; SGD-1010
Research Areas:  

Cancer

Monomethyl auristatin E (MMAE; SGD-1010) is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types.
loading...
    loading...
47
47 Cited Publications
Cat. No.: HY-16928
CAS No.: 14930-96-2
Synonyms: Phomin
Cytochalasin B is a cell-permeable mycotoxin binding to the barbed end of actin filaments, disrupting the formation of actin polymers, with Kd value of 1.4-2.2 nM for F-actin. Cytochalasin B blocks cell migration.
loading...
    loading...
41
41 Cited Publications
Cat. No.: HY-K1014

MCE PolyFast Transfection Reagent consists of cationic polymers and can introduce nucleic acids (DNA or RNA) into eukaryotic cells efficiently, including some hard-to-transfect cells.

loading...
    loading...
17
17 Cited Publications
Cat. No.: HY-Y0479
CAS No.: 79-33-4
Synonyms: (S)-2-Hydroxypropanoic acid
L-Lactic acid is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid. L-Lactic acid has antiproliferative activity .
loading...
    loading...
17
17 Cited Publications
Cat. No.: HY-W040233
CAS No.: 867-56-1
Synonyms: (S)-2-Hydroxypropanoic acid sodium
L-lactate Sodium (Sodium (S)-2-hydroxypropanoate) is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid. L-Lactic acid Sodium has antiproliferative activity .
loading...
    loading...
16
16 Cited Publications
Cat. No.: HY-142979
CAS No.: 892144-24-0
Purity:  99.95%
Synonyms: (C2H4O)nC42H82NO10P
DSPE-PEG 2000 is a PEG polymer containing DSPE and amine end groups. DSPE-PEG 2000 can be used to form micelles as nanoparticles for drug delivery .
loading...
    loading...
14
14 Cited Publications
Cat. No.: HY-K2017

MCE siRNA/miRNA Transfection Reagent is a novel cationic polymer transfection reagent for siRNA and miRNA transfection. The 1 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

loading...
    loading...
13
13 Cited Publications
Cat. No.: HY-16929
CAS No.: 76343-93-6
Synonyms: LAT-A
Latrunculin A (LAT-A), found in the red sea sponge Latrunculia magnifica, is a G-actin polymerization inhibitor. Latrunculin A binds to actin monomers and inhibits polymerization of actin with Kds of 0.1, 0.4, 4.7 μM and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin and G-actin, respectively. Latrunculin A has effective anti-metastatic properties for cancer research. Latrunculin A blocks cell migration .
loading...
    loading...
12
12 Cited Publications
Cat. No.: HY-W105639
CAS No.: 865717-20-0
Target:  

Drug Intermediate

Research Areas:  

Others

L-Lactic acid calcium hydrate is the calcium salt of L-Lactic acid. L-Lactic acid calcium hydrate is a building block that can be used as a precursor for the production of bioplastic polymer polylactic acid .
loading...
    loading...
12
12 Cited Publications
Cat. No.: HY-D0884
CAS No.: 27848-80-2
Synonyms: (S)-2-Hydroxypropanoic acid lithium
L-Lactic acid lithium ((S)-2-Hydroxypropanoic acid lithium) is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid. L-Lactic acid lithium has antiproliferative activity .
loading...
    loading...
10
10 Cited Publications
Cat. No.: HY-16931
CAS No.: 340316-62-3
Target:  

Arp2/3 Complex

Research Areas:  

Cancer

SMIFH2 is a formin specific inhibitor. SMIFH2 inhibits actin polymerization by Formins and affects the actin cytoskeleton .
loading...
    loading...
10
10 Cited Publications
Cat. No.: HY-116282C
CAS No.: 9011-18-1
Synonyms: DSS (MW 35000-45000); DXS (MW 35000-45000)
Target:  

Apoptosis

Dextran sulfate sodium salt (DSS) (MW 35000-45000) is a polymer of dehydrated glucose with a molecular weight of approximately 35000-45000. DSS with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (DSS) (MW 35000-45000) is a potent inducer of colitis. Dextran sulfate sodium salt (DSS) (MW 35000-45000) can be used to induce model acute colitis, chronic colitis, and colitis-related colon cancer. Dextran sulfate sodium salt (DSS) (MW 35000-45000) may be related to macrophage dysfunction, intestinal flora dysbiosis, and is particularly toxic to the colonic epithelium .
loading...
    loading...