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spermatogenesis

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By Targets:	Aldehyde Dehydrogenase (ALDH) (3) Androgen Receptor (2) Apoptosis (3) Aryl Hydrocarbon Receptor (1) Bacterial (3) Biochemical Assay Reagents (1) Caspase (1) CDK (1) COX (2) DNA/RNA Synthesis (1) Environmental Pollutants (3) Estrogen Receptor/ERR (2) Fungal (4) Herbicide (1) HIF/HIF Prolyl-Hydroxylase (1) Insecticide (1) Interleukin Related (4) Isotope-Labeled Compounds (2) Mitochondrial Metabolism (2) mRNA (1) nAChR (2) NF-κB (2) NO Synthase (1) Notch (1) Parasite (2) Phosphodiesterase (PDE) (2) PPAR (2) RANKL/RANK (2) Reactive Oxygen Species (ROS) (2) Reference Standards (5) TNF Receptor (2)
By Research Areas:	Cancer (5) Cardiovascular Disease (1) Endocrinology (7) Infection (4) Inflammation/Immunology (6) Metabolic Disease (6) Neurological Disease (6)
Oligonucleotides:	mRNA (1)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P9958

Denosumab 2 Publications Verification AMG-162	NF-κB Caspase Apoptosis RANKL/RANK	Endocrinology Cancer
Denosumab is a human monoclonal antibody that targets the protein RANKL. Denosumab binds to the receptor activator of nuclear factor kappa-B ligand (RANKL) and prevents its binding to the RANK receptor (K_D of 0.003 nM for human RANKL). Denosumab promotes proliferation and spermatogenesis. Denosumab prevents bone resorption through inhibition of the NF-κB pathway. Denosumab can be used in bone-related studies .

HY-W011094

Win 18446 3 Publications Verification	Aldehyde Dehydrogenase (ALDH)	Endocrinology
Win 18446 is an orally active testes-specific enzyme ALDH1a2 inhibitor, with an IC₅₀ of 0.3 μM. Win 18446 reversibly inhibits spermatogenesis in many species and inhibits Retinoic acid (HY-14649) biosynthesis from Retinol (HY-B1342) within the testes .

HY-W583749

6:2 Cl-PFAES 2 Publications Verification	Biochemical Assay Reagents	Endocrinology
6:2 Cl-PFAES is an orally effective alternative to Perfluorooctane sulfonate. 6:2 Cl-PFAES significantly inhibits the growth of zebrafish and induces reproductive toxicity. 6:2 Cl-PFAES reduces the relative weights of epididymis and testis in male BALB/c mice. 6:2 Cl-PFAES can be used in the chrome plating industry .

HY-B0823

Acetamiprid 2 Publications Verification	Environmental Pollutants nAChR	Neurological Disease
Acetamiprid is a neonicotinoid insecticide used worldwide. Acetamiprid is a nicotinic acetylcholine receptor (nAChR) agonist, and is shown to be associated with neuromuscular and reproductive disorders .

HY-B2141

Bendazol	NO Synthase HIF/HIF Prolyl-Hydroxylase	Cardiovascular Disease Others Metabolic Disease
Bendazol is an orally effective antihypertensive agent. Bendazol acts directly on vascular smooth muscle to dilate blood vessels and reduce peripheral resistance, thereby improving blood circulation. Bendazol significantly inhibits the development of myopia in rabbit models. Bendazol can regulate kidney function by increasing the activity of NO synthase in the rat model of nephrogenic hypertension. In addition, Bendazol has an effect on sexual behavior and spermatogenesis in male rats .

HY-106373

Adrenocorticotropic hormone 1 Publications Verification ACTH; Adrenocorticotrophic hormone	Androgen Receptor Reactive Oxygen Species (ROS) Mitochondrial Metabolism Interleukin Related TNF Receptor	Metabolic Disease Inflammation/Immunology
Adrenocorticotropic hormone (ACTH; Adrenocorticotrophic hormone) is a polypeptide tropic hormone produced by the anterior pituitary gland. Adrenocorticotropic hormone stimulates cortisol secretion from the adrenal cortex via the hypothalamic-pituitary-adrenal (HPA) axis. Adrenocorticotropic hormone regulates cortisol and androgen production. Adrenocorticotropic hormone can promote the development of spermatogenesis. Adrenocorticotropic hormone can relieve acute inflammation in gout models by inhibiting the polarization of macrophages to M1 type, inhibiting ROS and proinflammatory factor production and protecting mitochondrial function. Adrenocorticotropic hormone can be used for the researches of inflammation, endocrinology, metabolic disease, such as gout and nephrotic syndrome .

HY-P9958A

Denosumab (anti-TNFSF11) 2 Publications Verification	RANKL/RANK Apoptosis NF-κB	Neurological Disease Endocrinology Cancer
Denosumab (anti-TNFSF11) is a human monoclonal antibody that targets the protein RANKL. Denosumab binds to the receptor activator of nuclear factor kappa-B ligand (RANKL) and prevents its binding to the RANK receptor (K_D of 0.003 nM for human RANKL). Denosumab promotes proliferation and spermatogenesis. Denosumab prevents bone resorption through inhibition of the NF-κB pathway. Denosumab can be used in bone-related studies .

HY-N5012

Eurycomanone Pasakbumin A	Phosphodiesterase (PDE)	Endocrinology
Eurycomanone could increases spermatogenesis by inhibiting the activity of phosphodiesterase and aromatase in steroidogenesis.

HY-126114

Lupeol acetate 1 Publications Verification	COX Interleukin Related Bacterial Fungal Parasite	Infection Inflammation/Immunology Cancer
Lupeol acetate is a derivative of Lupeol. Lupeol acetate is an anti-inflammatory, antibacterial, anti-trypanosomic and anticancer agent with oral activity. Lupeol acetate significantly improves the symptoms of rheumatoid arthritis by down-regulating the expression of inflammatory cytokines and osteoclast production. Lupeol acetate inhibits spermatogenesis in male rats and eventually led to infertility .

HY-N6625

Chlorothalonil 1 Publications Verification	Environmental Pollutants Estrogen Receptor/ERR Fungal	Infection
Chlorothalonil is a broad-spectrum foliar fungicide with oral activity. Chlorothalonil can be used to combat fungal diseases in vegetable and crop leaves. Chlorothalonil can alter the microbial community in the soil. Chlorothalonil inhibits spermatogenesis. Chlorothalonil can cause intestinal epithelial barrier dysfunction and fetal toxicity .

HY-21197

Perfluoroenanthic acid Perfluoroheptanoic acid; Tridecafluoroheptanoic acid; PFHpA	PPAR	Neurological Disease Metabolic Disease Inflammation/Immunology
Perfluoroenanthic acid (Perfluoroheptanoic acid) is a kind of perfluoroalkyl carboxylic acid organic pollutant. Perfluoroenanthic acid has environmental persistence and bioaccumulation, and exposure can occur via oral, dermal and other routes. Perfluoroenanthic acid exhibits reproductive toxicity, neurotoxicity, hepatotoxicity, immunotoxicity and endocrine-disrupting effects. Perfluoroenanthic acid exerts definite adverse effects on development, spermatogenesis, neuronal activity and liver tissue .

HY-157567

FSI-TN42 N42	Aldehyde Dehydrogenase (ALDH)	Metabolic Disease
FSI-TN42 (N42) is a selective, orally active and irreversible ALDH1A1 inhibitor with an IC₅₀ of 23 nM. FSI-TN42 shows 800-fold more potent against ALDH1A1 than ALDH1A2 (IC₅₀

HY-114558

Resmethrin Benzofuroline; Isathrine; Resmethrin(mixture of isomers)	Environmental Pollutants Insecticide	Others
Resmethrin (Benzofuroline) is a reproductively toxic compound that inhibits spermatogenesis and induces apoptosis of germ cells in mouse testis culture in vitro, but has no significant toxicity to supporting cells and interstitial cells.

HY-106373A

Adrenocorticotropic hormone TFA 1 Publications Verification ACTH TFA; Adrenocorticotrophic hormone TFA	Androgen Receptor Reactive Oxygen Species (ROS) Mitochondrial Metabolism Interleukin Related TNF Receptor	Metabolic Disease Inflammation/Immunology
Adrenocorticotropic hormone (ACTH; Adrenocorticotrophic hormone) TFA is a polypeptide tropic hormone produced by the anterior pituitary gland. Adrenocorticotropic hormone TFA stimulates cortisol secretion from the adrenal cortex via the hypothalamic-pituitary-adrenal (HPA) axis. Adrenocorticotropic hormone TFA regulates cortisol and androgen production. Adrenocorticotropic hormone TFA can promote the development of spermatogenesis. Adrenocorticotropic hormone TFA can relieve acute inflammation in gout models by inhibiting the polarization of macrophages to M1 type, inhibiting ROS and proinflammatory factor production and protecting mitochondrial function. Adrenocorticotropic hormone TFA can be used for the researches of inflammation, endocrinology, metabolic disease, such as gout and nephrotic syndrome .

HY-W011094R

Win 18446 (Standard)	Reference Standards Aldehyde Dehydrogenase (ALDH)	Endocrinology
Win 18446 is an orally active testes-specific enzyme ALDH1a2 inhibitor, with an IC50 of 0.3 μM. Win 18446 reversibly inhibits spermatogenesis in many species and inhibits Retinoic acid (HY-14649) biosynthesis from Retinol (HY-B1342) within the testes .

HY-W753602

Acetamiprid-N-desmethyl-13C,d3	Isotope-Labeled Compounds	Neurological Disease
Acetamiprid-N-desmethyl- ¹³C,d3 is the ¹³C and deuterium labeled isotope of Acetamiprid-N-desmethyl( ¹³C,d3)(HY-B0823).Acetamiprid is a nAChR agonist that has been implicated in neuromuscular and reproductive disorders.

HY-N6625R

Chlorothalonil (Standard)	Reference Standards Fungal Estrogen Receptor/ERR	Infection
Chlorothalonil (Standard) is the analytical standard of Chlorothalonil. This product is intended for research and analytical applications. Chlorothalonil is a broad-spectrum foliar fungicide with oral activity. Chlorothalonil can be used to combat fungal diseases in vegetable and crop leaves. Chlorothalonil can alter the microbial community in the soil. Chlorothalonil inhibits spermatogenesis. Chlorothalonil can cause intestinal epithelial barrier dysfunction and fetal toxicity .

HY-161690

EF-4-177	CDK	Others
EF-4-177 is an orally active and allosteric CDK2 inhibitor with the IC₅₀ of 87 nM. EF-4-177 can disrupt spermatogenesis .

HY-B0823R

Acetamiprid (Standard)	Reference Standards nAChR	Neurological Disease
Acetamiprid (Standard) is the analytical standard of Acetamiprid. This product is intended for research and analytical applications. Acetamiprid is a neonicotinoid insecticide used worldwide. Acetamiprid is a nicotinic acetylcholine receptor (nAChR) agonist, and is shown to be associated with neuromuscular and reproductive disorders .

HY-B1431A

Butylparaben sodium Butyl parahydroxybenzoate sodium; Butyl 4-hydroxybenzoate sodium	DNA/RNA Synthesis Bacterial	Others
Butylparaben sodium strongly influences the later stages of the spermatogenesis in the testis through the deterioration of hormonal control and/or RNA and protein synthesis .

HY-N5012R

Eurycomanone (Standard) Pasakbumin A (Standard)	Reference Standards Phosphodiesterase (PDE)	Endocrinology
Eurycomanone (Standard) is the analytical standard of Eurycomanone. This product is intended for research and analytical applications. Eurycomanone could increases spermatogenesis by inhibiting the activity of phosphodiesterase and aromatase in steroidogenesis.

HY-174558

Human PAX5 mRNA	mRNA	Cancer
Human PAX5 mRNA encodes the human paired box 5 (PAX5) protein, a member of the paired box (PAX) family. PAX5 may play an important role in B-cell differentiation as well as neural development and spermatogenesis.

HY-126114R

Lupeol acetate (Standard)	COX Interleukin Related Bacterial Fungal Parasite Reference Standards	Infection Inflammation/Immunology Cancer
Lupeol acetate (Standard) is the analytical standard of Lupeol acetate. This product is intended for research and analytical applications. Lupeol acetate is a derivative of Lupeol. Lupeol acetate is an anti-inflammatory, antibacterial, anti-trypanosomic and anticancer agent with oral activity. Lupeol acetate significantly improves the symptoms of rheumatoid arthritis by down-regulating the expression of inflammatory cytokines and osteoclast production. Lupeol acetate inhibits spermatogenesis in male rats and eventually led to infertility .

HY-21197S

Perfluoroenanthic acid-13C4 Perfluoroheptanoic acid-¹³C₄; Tridecafluoroheptanoic acid-¹³C₄; PFHpA-¹³C₄	Isotope-Labeled Compounds PPAR	Neurological Disease Metabolic Disease Inflammation/Immunology
Perfluoroenanthic acid- ¹³C₄ (Perfluoroheptanoic acid- ¹³C₄) is the ¹³C-labeled Perfluoroenanthic acid (HY-21197). Perfluoroenanthic acid (Perfluoroheptanoic acid) is a kind of perfluoroalkyl carboxylic acid organic pollutant. Perfluoroenanthic acid has environmental persistence and bioaccumulation, and exposure can occur via oral, dermal and other routes. Perfluoroenanthic acid exhibits reproductive toxicity, neurotoxicity, hepatotoxicity, immunotoxicity and endocrine-disrupting effects. Perfluoroenanthic acid exerts definite adverse effects on development, spermatogenesis, neuronal activity and liver tissue .

HY-W714200

Neburon	Herbicide Aryl Hydrocarbon Receptor Notch Apoptosis	Others
Neburon is a phenylurea herbicide whose main mechanism of action is to inhibit photosynthetic electron transport, thereby disrupting algal growth. Neburon activates the Ahr and Notch1 signaling pathways, and induces oxidative stress and apoptosis. Long-term exposure causes significant male reproductive toxicity and cardiotoxicity in zebrafish .

Cat. No.	Product Name	Target	Research Area

HY-106373

Adrenocorticotropic hormone 1 Publications Verification ACTH; Adrenocorticotrophic hormone	Androgen Receptor Reactive Oxygen Species (ROS) Mitochondrial Metabolism Interleukin Related TNF Receptor	Metabolic Disease Inflammation/Immunology
Adrenocorticotropic hormone (ACTH; Adrenocorticotrophic hormone) is a polypeptide tropic hormone produced by the anterior pituitary gland. Adrenocorticotropic hormone stimulates cortisol secretion from the adrenal cortex via the hypothalamic-pituitary-adrenal (HPA) axis. Adrenocorticotropic hormone regulates cortisol and androgen production. Adrenocorticotropic hormone can promote the development of spermatogenesis. Adrenocorticotropic hormone can relieve acute inflammation in gout models by inhibiting the polarization of macrophages to M1 type, inhibiting ROS and proinflammatory factor production and protecting mitochondrial function. Adrenocorticotropic hormone can be used for the researches of inflammation, endocrinology, metabolic disease, such as gout and nephrotic syndrome .

HY-106373A

Adrenocorticotropic hormone TFA 1 Publications Verification ACTH TFA; Adrenocorticotrophic hormone TFA	Androgen Receptor Reactive Oxygen Species (ROS) Mitochondrial Metabolism Interleukin Related TNF Receptor	Metabolic Disease Inflammation/Immunology
Adrenocorticotropic hormone (ACTH; Adrenocorticotrophic hormone) TFA is a polypeptide tropic hormone produced by the anterior pituitary gland. Adrenocorticotropic hormone TFA stimulates cortisol secretion from the adrenal cortex via the hypothalamic-pituitary-adrenal (HPA) axis. Adrenocorticotropic hormone TFA regulates cortisol and androgen production. Adrenocorticotropic hormone TFA can promote the development of spermatogenesis. Adrenocorticotropic hormone TFA can relieve acute inflammation in gout models by inhibiting the polarization of macrophages to M1 type, inhibiting ROS and proinflammatory factor production and protecting mitochondrial function. Adrenocorticotropic hormone TFA can be used for the researches of inflammation, endocrinology, metabolic disease, such as gout and nephrotic syndrome .

Cat. No.	Product Name	Target	Research Area	Image

HY-P9958

Denosumab 2 Publications Verification AMG-162	NF-κB Caspase Apoptosis RANKL/RANK	Endocrinology Cancer
Denosumab is a human monoclonal antibody that targets the protein RANKL. Denosumab binds to the receptor activator of nuclear factor kappa-B ligand (RANKL) and prevents its binding to the RANK receptor (K_D of 0.003 nM for human RANKL). Denosumab promotes proliferation and spermatogenesis. Denosumab prevents bone resorption through inhibition of the NF-κB pathway. Denosumab can be used in bone-related studies .

HY-P9958A

Denosumab (anti-TNFSF11) 2 Publications Verification	RANKL/RANK Apoptosis NF-κB	Neurological Disease Endocrinology Cancer
Denosumab (anti-TNFSF11) is a human monoclonal antibody that targets the protein RANKL. Denosumab binds to the receptor activator of nuclear factor kappa-B ligand (RANKL) and prevents its binding to the RANK receptor (K_D of 0.003 nM for human RANKL). Denosumab promotes proliferation and spermatogenesis. Denosumab prevents bone resorption through inhibition of the NF-κB pathway. Denosumab can be used in bone-related studies .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N5012

Eurycomanone Pasakbumin A	other families Classification of Application Fields Terpenoids Diterpenoids Plants Disease Research Fields Endocrinology Source Classification	Phosphodiesterase (PDE)
Eurycomanone could increases spermatogenesis by inhibiting the activity of phosphodiesterase and aromatase in steroidogenesis.

HY-126114

Lupeol acetate 1 Publications Verification	Triterpenes Classification of Application Fields Terpenoids Umbelliferae Plants Inflammation/Immunology Disease Research Fields Carphephorus corymbosus (Nutt.) Torr. & A.Gray Source Classification	COX Interleukin Related Bacterial Fungal Parasite
Lupeol acetate is a derivative of Lupeol. Lupeol acetate is an anti-inflammatory, antibacterial, anti-trypanosomic and anticancer agent with oral activity. Lupeol acetate significantly improves the symptoms of rheumatoid arthritis by down-regulating the expression of inflammatory cytokines and osteoclast production. Lupeol acetate inhibits spermatogenesis in male rats and eventually led to infertility .

HY-N5012R

Eurycomanone (Standard) Pasakbumin A (Standard)	Structural Classification other families Terpenoids Diterpenoids Plants Source Classification	Reference Standards Phosphodiesterase (PDE)
Eurycomanone (Standard) is the analytical standard of Eurycomanone. This product is intended for research and analytical applications. Eurycomanone could increases spermatogenesis by inhibiting the activity of phosphodiesterase and aromatase in steroidogenesis.

HY-126114R

Lupeol acetate (Standard)	Triterpenes Structural Classification Terpenoids Umbelliferae Plants Carphephorus corymbosus (Nutt.) Torr. & A.Gray Source Classification	COX Interleukin Related Bacterial Fungal Parasite Reference Standards
Lupeol acetate (Standard) is the analytical standard of Lupeol acetate. This product is intended for research and analytical applications. Lupeol acetate is a derivative of Lupeol. Lupeol acetate is an anti-inflammatory, antibacterial, anti-trypanosomic and anticancer agent with oral activity. Lupeol acetate significantly improves the symptoms of rheumatoid arthritis by down-regulating the expression of inflammatory cytokines and osteoclast production. Lupeol acetate inhibits spermatogenesis in male rats and eventually led to infertility .

Cat. No.	Product Name	Chemical Structure

HY-W753602

Acetamiprid-N-desmethyl-13C,d3
Acetamiprid-N-desmethyl- ¹³C,d3 is the ¹³C and deuterium labeled isotope of Acetamiprid-N-desmethyl( ¹³C,d3)(HY-B0823).Acetamiprid is a nAChR agonist that has been implicated in neuromuscular and reproductive disorders.

HY-21197S

Perfluoroenanthic acid-13C4
Perfluoroenanthic acid- ¹³C₄ (Perfluoroheptanoic acid- ¹³C₄) is the ¹³C-labeled Perfluoroenanthic acid (HY-21197). Perfluoroenanthic acid (Perfluoroheptanoic acid) is a kind of perfluoroalkyl carboxylic acid organic pollutant. Perfluoroenanthic acid has environmental persistence and bioaccumulation, and exposure can occur via oral, dermal and other routes. Perfluoroenanthic acid exhibits reproductive toxicity, neurotoxicity, hepatotoxicity, immunotoxicity and endocrine-disrupting effects. Perfluoroenanthic acid exerts definite adverse effects on development, spermatogenesis, neuronal activity and liver tissue .

Perfluoroenanthic acid-13C4

Perfluoroenanthic acid- ¹³C₄ (Perfluoroheptanoic acid- ¹³C₄) is the ¹³C-labeled Perfluoroenanthic acid (HY-21197). Perfluoroenanthic acid (Perfluoroheptanoic acid) is a kind of perfluoroalkyl carboxylic acid organic pollutant. Perfluoroenanthic acid has environmental persistence and bioaccumulation, and exposure can occur via oral, dermal and other routes. Perfluoroenanthic acid exhibits reproductive toxicity, neurotoxicity, hepatotoxicity, immunotoxicity and endocrine-disrupting effects. Perfluoroenanthic acid exerts definite adverse effects on development, spermatogenesis, neuronal activity and liver tissue .

Host:	Mouse (1) Rabbit (2)
Reactivity:	Human (3) Rat (1)
Application:	IHC-P (3) ICC/IF (1) WB (1) FC (1)
Isotype:	IgG (2) IgG1 (1)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P87369

	SPATA5L1 Antibody (YA7052) FLJ12286 antibody; MGC5347 antibody; SPA5L_HUMAN antibody; SPATA5L1 antibody; spermatogenesis-associated protein 5-like protein 1 antibody	WB, ICC/IF, IHC-P, FC	Human, Rat
	SPATA5L1 Antibody (YA7052) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SPATA5L1.

HY-P81511

	PBK Antibody (YA1256) PBK; TOPK; Lymphokine-activated killer T-cell-originated protein kinase; Cancer/testis antigen 84; CT84; MAPKK-like protein kinase; Nori-3; PDZ-binding kinase; spermatogenesis-related protein kinase; SPK; T-LAK cell-originated protein kinas	IHC-P	Human
	PBK Antibody (YA1256) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PBK.

HY-P81511A

	PBK Antibody (YA1256)(PBS only) PBK; TOPK; Lymphokine-activated killer T-cell-originated protein kinase; Cancer/testis antigen 84; CT84; MAPKK-like protein kinase; Nori-3; PDZ-binding kinase; spermatogenesis-related protein kinase; SPK; T-LAK cell-originated protein kinas	IHC-P	Human
	PBK Antibody (YA1256) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PBK.

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HY-174558

Human PAX5 mRNA		mRNA
Human PAX5 mRNA encodes the human paired box 5 (PAX5) protein, a member of the paired box (PAX) family. PAX5 may play an important role in B-cell differentiation as well as neural development and spermatogenesis.

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spermatogenesis

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

NaturalProducts

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Natural
Products