841 Results for "

spot indole testing

" in MedChemExpress (MCE) Product Catalog:
Products (841)

841 Results for "spot indole testing" in MCE Product Catalog:

46
46 Publications Verification
Cat. No.: HY-108882C
CAS No.: 9003-98-9
Target:  

DNA/RNA Synthesis

Research Areas:  

Inflammation/Immunology

DNase I is an enzyme that degrades DNA. DNase I is mainly produced by digestive system organs, such as the pancreas and parotid gland. Three types of DNase I are known in mammals: pancreatic type, parotid type, and pancreatico-parotid type. DNase I plays a key role in the cleavage of extracellular DNA, and is critical for limiting inflammatory responses and maintaining homeostasis. DNase I is responsible for digesting extracellular nucleoproteins, which may be essential for preventing autoimmune reactions. Decreased DNase I activity may be associated with the occurrence and development of systemic lupus erythematosus (SLE). DNase I (filtered) is filtered through a 0.22 μM membrane and is not tested for pyrogenicity .
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25
25 Cited Publications
Cat. No.: HY-18569
CAS No.: 87-51-4
Synonyms: indole-3-acetic acid; 3-IAA
3-Indoleacetic acid is is an IAA hormone and growth regulator that can promote plant nutritional growth through processes such as cell expansion, differentiation, morphogenesis, and organogenesis .
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25
25 Cited Publications
Cat. No.: HY-18569A
CAS No.: 6505-45-9
Synonyms: indole-3-acetic acid sodium; 3-IAA sodium
3-Indoleacetic acid sodium is is an IAA hormone and growth regulator that can promote plant nutritional growth through processes such as cell expansion, differentiation, morphogenesis, and organogenesis .
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19
19 Cited Publications
Cat. No.: HY-N0170
CAS No.: 700-06-1
Synonyms: indole-3-methanol
Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1).
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19
19 Cited Publications
Cat. No.: HY-108903A
CAS No.: 37326-33-3
Purity:  95.00%
Research Areas:  

Endocrinology

Hyaluronidase, Ovine testes is an endoglycosidase. Hyaluronidase, Ovine testes specifically degrades Hyaluronic acid (HY-B0633A) and Chondroitin sulfate (HY-B2162) by hydrolyzing β-glycosidic bonds in acidic mucopolysaccharides. Hyaluronidase, Ovine testes disperses follicular cells during fertilization by breaking down the hyaluronic acid-rich cumulus. Hyaluronidase, Ovine testes can be used in the study of fertility-related diseases .
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19
19 Cited Publications
Cat. No.: HY-107910
CAS No.: 37326-33-3
Synonyms: Hyaluronate 4-glycanohydrolase, Bovine testes; Hyaluronoglucosaminidase, Bovine testes
Target:  

NF-κB

Research Areas:  

Inflammation/Immunology Cancer

Hyaluronidase, Bovine testes (Hyaluronate 4-glycanohydrolase; Hyaluronoglucosaminidase) is an endoglycosidase that depolymerizes Hyaluronic acid (HA) (HY-B0633A) by cleavage of glycosidic bonds. Hyaluronidase degrades HA and activates membrane receptors that trigger pathways converging in NF-κB activation. Hyaluronidase is employed in the research of granulomatous foreign body reactions, soft-tissue necrosis caused by vascular compromise and uncomplicated nodules, overcorrection, inflamed nodules or tissue ischemia associated with HA filler injection .
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16
16 Cited Publications
Cat. No.: HY-113099
CAS No.: 1821-52-9
Purity:  99.99%
Synonyms: indole-3-lactic acid
Indolelactic acid (Indole-3-lactic acid) is a tryptophan (Trp) catabolite in Azotobacter vinelandii cultures. Indolelactic acid has anti-inflammation and potential anti-viral activity .
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14
14 Cited Publications
Cat. No.: HY-N0117
CAS No.: 479-41-4
Synonyms: Couroupitine B; Indigo red; Indigopurpurin
Indirubin (Couroupitine B) is a bis-indole alkaloid and has emarkable anticancer activity against chronic myelocytic leukemia .
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13
13 Cited Publications
Cat. No.: HY-B1610E
CAS No.: 6132-04-3
Synonyms: Trisodium citrate dihydrate, meets USP testing specifications
Sodium citrate (Trisodium citrate) dihydrate, meets USP testing specifications is an orally active natural product that can be found in citrus fruits. Sodium citrate dihydrate can inhibit the proliferation of tumor cells and induce apoptosis. Sodium citrate dihydrate has antibacterial, anti-tumor and antioxidant activities. Sodium citrate dihydrate can be prepared as a cosolvent or buffer .
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13
13 Cited Publications
Cat. No.: HY-W015229
CAS No.: 830-96-6
Synonyms: indole-3-propionic acid; 3-IPA
3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease.
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11
11 Cited Publications
Cat. No.: HY-P0019
CAS No.: 66216-78-2
Research Areas:  

Cardiovascular Disease

Z-Gly-Gly-Arg-AMC is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP) (Ex/Em = 390/480 nm) .
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11
11 Cited Publications
Cat. No.: HY-P0019A
CAS No.: 2070009-61-7
Research Areas:  

Others

Z-Gly-Gly-Arg-AMC acetate is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP) (Ex/Em = 390/480 nm) .
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11
11 Cited Publications
Cat. No.: HY-N6778
CAS No.: 57186-25-1
Paxilline is an indole alkaloid mycotoxin derived from Penicillium paxilli, which effectively inhibits the BK channel through a channel-blocking mechanism. Paxilline also inhibits sarco/endoplasmic reticulum Ca 2+-stimulated ATPase (SERCA), with IC50 values ranging from 5 μM to 50 μM for different SERCA isoforms. Paxilline exhibits significant anticonvulsant and neuroprotective effects, as well as certain antioxidant activity .
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10
10 Cited Publications
Cat. No.: HY-131328
CAS No.: 2101700-15-4
Purity:  99.88%
Synonyms: LOXO-305
Target:  

Btk

Research Areas:  

Cancer

Pirtobrutinib (LOXO-305), a highly selective and non-covalent next generation BTK inhibitor, inhibits diverse BTK C481 substitution mutations. Pirtobrutinib causes regression of BTK-dependent lymphoma tumors in mouse xenograft models. Pirtobrutinib is also more than 300-fold selective for BTK versus 370 other kinases tested and shows no significant inhibition of non-kinase off-targets at 1 μM .
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8
8 Cited Publications
Cat. No.: HY-12449
CAS No.: 1421438-81-4
Purity:  99.01%
Synonyms: LY3039478
Target:  

Notch γ-secretase

Research Areas:  

Cancer

Crenigacestat (LY3039478) is an orally active Notch and γ-secretase inhibitor, with an IC50 of 1 nM in most of the tumor cell lines tested .
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8
8 Cited Publications
Cat. No.: HY-147216A
Purity:  99.68%
AXKO-0046 dihydrochloride, indole derivative, is an uncompetitive Lactate dehydrogenase B (LDHB) selective inhibitor. AXKO-0046 dihydrochloride has LDHB inhibitory activity with an EC50 value of 42 nM. AXKO-0046 dihydrochloride can be used for the research of cancer metabolism .
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8
8 Cited Publications
Cat. No.: HY-147216
CAS No.: 3103525-82-9
Purity:  99.77%
Target:  

Lactate Dehydrogenase

Research Areas:  

Cancer

AXKO-0046, indole derivative, is an uncompetitive Lactate dehydrogenase B (LDHB) selective inhibitor.AXKO-0046 has LDHB inhibitory activity with an EC50 value of 42 nM.AXKO-0046 can be used for the research of cancer metabolism .
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8
8 Cited Publications
Cat. No.: HY-N6607
CAS No.: 13220-57-0
Tryptanthrin is an indole quinazoline that could be an alkaloid from indigo-bearing plants. Tryptanthrin is a potent and orally active cellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin has anticancer activity. Tryptanthrin suppresses the expression levels of NOS1, COX-2, and NF-κB and regulates the expression levels of IL-2, IL-10, and TNF-α .
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7
7 Cited Publications
Cat. No.: HY-112730
CAS No.: 6266-66-6
Purity:  99.70%
Synonyms: 2-(1H-Indol-3-yl)-4-oxo-4-phenyl-butyric acid
Target:  

Phytohormone

Research Areas:  

Others

PEO-IAA is an indole-3-acetic acid (IAA) antagonist. PEO-IAA is an auxin antagonist that binds to transport inhibitor response 1/auxin signaling F-box proteins (TIR1/AFBs).
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7
7 Cited Publications
Cat. No.: HY-N6771
CAS No.: 18172-33-3
Cyclopiazonic acid is an endoplasmic reticulum calcium ATPase (ECAs) inhibitor and human respiratory syncytial virus (RSV) inhibitor (EC50 value of 4.13 μ M), which can reduce the antagonistic effect of 5-HT receptors in rat thoracic aorta, induce p53 dependent cell apoptosis and reproductive toxicity in mouse testes, and inhibit the biological activation of aflatoxin B [1][4][5].
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