Search Result

Results for "

sting

" in MedChemExpress (MCE) Product Catalog:

By Targets:	STING (223) 11β-HSD (2) ADC Payload (3) Adenylate Cyclase (1) Akt (4) Amino Acid Derivatives (1) AMPK (4) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (16) ATM/ATR (2) Autophagy (10) Bacterial (3) Bcl-2 Family (1) Biochemical Assay Reagents (2) Calcium Channel (3) Caspase (5) Cathepsin (1) CD28 (1) CXCR (5) Cyclic GMP-AMP Synthase (9) Deubiquitinase (1) DNA Stain (1) DNA/RNA Synthesis (6) Drug Derivative (2) Drug-Linker Conjugates for ADC (8) E3 Ligase Ligand-Linker Conjugates (3) EGFR (1) Endogenous Metabolite (14) Epoxide Hydrolase (1) ERK (2) Eukaryotic Initiation Factor (eIF) (1) Ferroptosis (3) G-quadruplex (1) Glutathione Peroxidase (1) Glycosyltransferase (1) Guanylate Cyclase (1) HBV (2) HPV (2) HSV (2) IFNAR (31) IKK (8) Influenza Virus (2) Integrin (1) Interleukin Related (19) Isotope-Labeled Compounds (1) Keap1-Nrf2 (4) Ligands for E3 Ligase (2) Ligands for Target Protein for PROTAC (3) Liposome (1) Mineralocorticoid Receptor (1) Mitochondrial Metabolism (1) Molecular Glues (2) mTOR (1) NF-κB (8) NO Synthase (1) p38 MAPK (2) Parasite (2) PARP (7) PD-1/PD-L1 (5) PERK (1) Phosphatase (1) Phosphodiesterase (PDE) (9) Phosphoglycerate Dehydrogenase (PHGDH) (1) PI3K (3) PPAR (1) PROTAC Linkers (1) PROTACs (13) Ras (3) Reactive Oxygen Species (ROS) (11) Reference Standards (6) SARS-CoV (2) Small Interfering RNA (siRNA) (3) Sodium Channel (1) STAT (3) TNF Receptor (5) Topoisomerase (2) VEGFR (2) Virus Protease (1)
By Research Areas:	Cancer (158) Cardiovascular Disease (4) Infection (32) Inflammation/Immunology (116) Metabolic Disease (11) Neurological Disease (9)
Click Chemistry:	DBCO (1) Azide (1) Alkynes (3)
Oligonucleotides:	CpG ODNs (2) Rat Pre-designed siRNA Sets (1) Cationic Lipids (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

264

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: STING

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112921A

*diABZI STING* agonist-1** 45+ Cited Publications	STING	Inflammation/Immunology
diABZI STING agonist-1 is a tautomerism of diABZI STING agonist-1 tautomerism (HY-112921). diABZI STING agonist-1 is a selective stimulator of interferon genes *(STING)* receptor agonist, with EC₅₀s of 130, 186 nM for human and mouse, respectively .

HY-112921B

*diABZI STING* agonist-1 trihydrochloride** 45+ Cited Publications	STING	Inflammation/Immunology Cancer
diABZI STING agonist-1 (trihydrochloride) is a selective stimulator of interferon genes *(STING)* receptor agonist, with EC₅₀s of 130, 186 nM for human and mouse, respectively.

HY-103665

STING agonist-3 5+ Cited Publications	STING	Cancer
STING agonist-3, extracted from patent WO2017175147A1 (example 10), is a selective and non-nucleotide small-molecule STING* agonist* with a pEC₅₀ and pIC₅₀ of 7.5 and 9.5, respectively. STING agonist-3 has durable anti-tumor effect and tremendous potential to improve treatment of cancer .

HY-148068

STING agonist-20	STING	Inflammation/Immunology Cancer
STING agonist-20 (compound 95) is a potent *STING* agonist used in the synthesis of XMT-2056. STING agonist-20 can be used as a vaccine adjuvant in the study of cancer and other inflammatory, immune diseases .

HY-138682

STING-IN-2 5+ Cited Publications	STING	Inflammation/Immunology
STING-IN-2 (C-170) is a potent and covalent *STING* inhibitor. STING-IN-2 efficiently inhibits both *mouse STING* (mmSTING) and human STING (hsSTING)*. STING*-IN-2 can be used for autoinflammatory disease research .

HY-162664

STING antagonist-1	STING	Inflammation/Immunology
STING antagonist-1 is an antagonist of *STING* with an IC₅₀ of 3.8 nM. STING antagonist-1 can be used in the research of autoimmune diseases, inflammatory diseases, and others .

HY-123943

STING agonist-4 5+ Cited Publications	STING	Cancer
STING agonist-4 is an stimulator of Interferon Genes (STING) receptor agonist with an apparent inhibitory constant (IC₅₀) of 20 nM. STING agonist-4 is a two symmetry-related amidobenzimidazole (ABZI)-based compound to create linked ABZIs (diABZIs) with enhanced binding to STING and cellular function .

HY-112921

*diABZI STING* agonist-1 (tautomerism)** 2 Publications Verification	STING	Inflammation/Immunology
diABZI STING agonist-1 tautomerism is a tautomerism of diABZI STING agonist-1 (HY-112921A). diABZI STING agonist-1 tautomerism is a selective stimulator of interferon genes *(STING)* receptor agonist, with EC₅₀s of 130, 186 nM for human and mouse, respectively .

HY-19711

STING agonist-1 4 Publications Verification G10	STING Virus Protease	Infection
STING agonist-1 (G10) is human-specific *STING* agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) with IC₉₀ of 24.57 μM .

HY-143320

STING agonist-17	STING	Cancer
STING agonist-17 (compound 4a) is a potent *STING* agonist with an IC₅₀ value of 0.062 nM. STING agonist-17 has anti-cancer activity for tumor immunization .

HY-147010

STING agonist-12 2 Publications Verification	STING	Inflammation/Immunology
STING agonist-12 (Compound 53) is a potent, orally active human *STING* activator with an EC₅₀ of 185 nM .

HY-152955

STING agonist-22 1 Publications Verification	STING	Infection Inflammation/Immunology
STING agonist-22 (CF501) is a potent non-nucleotide *STING* agonist. STING agonist-22 is a adjuvant by activating STING to induce the type I interferon (IFN-I) response and proinflammatory cytokine production. STING agonist-22 can be used as an adjuvant to boost the original protein vaccine, producing potent, broad, and long-term immune protection. STING agonist-22 can be used for SARS-CoV-2 variants and sarbecovirus diseases research .

HY-114399

STING ligand-1	STING	Inflammation/Immunology
STING ligand-1 is a lead *STING* ligand with an IC₅₀ of 68 nM for HAQ STING .

HY-138683

STING-IN-3 2 Publications Verification	STING	Inflammation/Immunology
STING-IN-3 is an inhibitor of stimulator of interferon genes (STING). STING-IN-3 efficiently inhibits both hsSTING and mmSTING through covalently target the predicted transmembrane cysteine residue 91 and thereby block the activation-induced palmitoylation of STING .

HY-177338

STING agonist-45	STING Cyclic GMP-AMP Synthase IFNAR TNF Receptor Interleukin Related	Inflammation/Immunology Cancer
STING agonist-45 is a selective *STING* agonist (EC₅₀ = 0.28 μM). STING agonist-45 activates the innate immune response through the *cGAS-STING* pathway, upregulating key markers such as p-TBK1 and IRF3. STING agonist-45 exhibits robust *STING* activation in human peripheral blood mononuclear cells (PBMCs), inducing the production of type I interferons (such as IFN-β) and downstream cytokines (such as TNF-α and IL-6). STING agonist-45 enhances anti-tumor immunity, inhibits tumor growth, and increases CD8 ⁺ T cell infiltration in mouse models. STING agonist-45 is promising for the study of *STING*-related diseases .

HY-150608

*PROTAC STING* Degrader-1** 1 Publications Verification	PROTACs STING	Inflammation/Immunology Cancer
PROTAC STING Degrader-1 is a PROTAC degrader targeting the *STING* pathway with a DC₅₀ of 3.2 μM. PROTAC STING Degrader-1 exerts high anti-inflammatory efficacy. PROTAC STING Degrader-1 can be used to study diseases such as acute kidney injury and inflammatory bowel diseases (IBDs). (Pink: STING ligand (HY-138682); Blue: CRBN ligand (HY-10984); Black: linker (HY-W015883)) .

HY-150074

STING agonist-18	STING ADC Payload	Cancer
STING agonist-18 (compound 1a) is a *STING* agonist that can be used for synthesis of antibody-drug conjugates (ADCs), such Trastuzumab (HY-P9907) conjugate .

HY-160406

SNX281	STING IFNAR Interleukin Related	Inflammation/Immunology Cancer
SNX281 is a selective *STING* agonist, with IC₅₀ values of 4.1, 4.5, 10.7, and 3.7 μM against human, mouse, rat, and monkey STING, respectively. SNX281 undergoes homodimerization at the STING binding site, triggering a conformational shift of STING from an inactive open state to an active closed state, thereby driving downstream *STING*-dependent signaling pathways. SNX281 induces type I interferons, IFN-β, TNF-α, IL-6, cytokine release, T cell responses, and long-lasting immune memory. SNX281 exhibits anti-tumor activity and is applicable to research related to colorectal cancer, melanoma, advanced solid tumors, lymphoma, and ovarian cancer .

HY-139586

Ulevostinag MK-1454	STING	Cancer
Ulevostinag (MK-1454) is a potent cyclic dinucleotide agonist stimulator of interferon genes (STING). Ulevostinag (MK-1454) acts in the intra-tumoral route by targeting the stimulator of interferon genes (STING) protein. Ulevostinag (MK-1454) can be used for immuno-tumor cancer disease research .

HY-173425

STING-IN-15	STING IFNAR TNF Receptor Interleukin Related	Inflammation/Immunology
STING-IN-15 is an orally active *STING* inhibitor, with an IC₅₀ of 116 nM against *h-STING* and an IC₅₀ of 96.3 nM against *m-STING. STING-IN-15 inhibits the STING* signaling pathway in cells, reduces the secretion of IFN-β and IP-10, downregulates the expression of ISG15, ISG56 and TNF-α, and suppresses the phosphorylation of TBK1/IRF3. STING-IN-15 alleviates systemic and renal inflammation induced by STING agonists in mice, reduces tissue damage and the expression of interferon pathway genes, and inhibits spontaneous tissue inflammation in mice. STING-IN-15 can be used for the research of acute kidney injury and autoimmune/inflammatory diseases .

HY-151970

STING-IN-4	STING	Inflammation/Immunology
STING-IN-4 (Compound 1) is a *STING* inhibitor that inhibits STING expression and hence reducing activation of STING and nuclear factor-κB (NF-κB) signaling. STING-IN-4 shows anti-inflammatory activity and can be used for the research of sepsis .

HY-143896

STING agonist-7	STING	Cancer
STING agonist-7 is a non-nucleotide *STING* agonist. STING agonist-7 binds selectively to mouse STING but not human STING. STING agonist-7 penetrates cell membrane poorly .

HY-131994

STING agonist-16 1 Publications Verification	STING	Infection Cancer
STING agonist-16 (1a) is a specific stimulator of interferon genes (STING) agonist. STING agonist-16 (1a) can be used as a potential antiviral and antitumor tool .

HY-173414

*PROTAC STING* degrader-3**	PROTACs STING NF-κB	Inflammation/Immunology
PROTAC STING degrader-3 is a STING PROTAC degrader (DC₅₀: 0.62 μM). PROTAC STING degrader-3 induces STING degradation via the ubiquitin-proteasome pathway. PROTAC STING degrader-3 exerts anti-inflammatory effects by inhibiting *STING/TBK1/NF-κB* signaling. PROTAC STING degrader-3 has renal protective effects and can be used in the study of acute kidney injury (AKI) .

HY-156449

STING-IN-7	STING IKK	Inflammation/Immunology
STING-IN-7 is a potent *STING* inhibitor with an IC₅₀ of 11.5 nM. STING-IN-7 can inhibit the phosphorylation of *STING, IRF3, and TBK1. STING*-IN-7 can be used in the research of autoimmune and inflammatory diseases .

HY-152959

STING agonist-26	STING	Infection Cancer
STING agonist-26 (CF508) is a non-nucleotide small-molecule *STING* agonist. STING agonist-23 activates STING, increases phosphorylation of *STING, TBK1* and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains .

HY-103665A

STING agonist-3 trihydrochloride 5+ Cited Publications	STING	Cancer
STING agonist-3 trihydrochloride, extracted from patent WO2017175147A1 (example 10), is a selective and non-nucleotide small-molecule *STING* agonist with a pEC₅₀ and pEC₅₀ of 7.5 and 9.5, respectively. STING agonist-3 trihydrochloride has durable anti-tumor effect and tremendous potential to improve treatment of cancer .

HY-175714

STING agonist-46	STING	Inflammation/Immunology Cancer
STING agonist-46 is an orally active STING agonist. STING agonist-46 activates the STING signaling pathway, promoting phosphorylation of TBK1 and IRF3, and secretion of IFN-β and IP-10. STING agonist-46 directly binds to STING and increases its thermal stability. STING agonist-46 demonstrates potent anti-tumor efficacy in B16F10, CT26, and 4T1 mouse models. STING agonist-46 can be used for cancer immunotherapy studies .

HY-RS13916

STING1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
STING1 Human Pre-designed siRNA Set A contains three designed siRNAs for STING1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

STING1 Human Pre-designed siRNA Set A STING1 Human Pre-designed siRNA Set A

HY-148346

STING agonist-20-Ala-amide-PEG2-C2-NH2	Drug-Linker Conjugates for ADC STING	Cancer
STING agonist-20-Ala-amide-PEG2-C2-NH2 is an active scaffold comprising a stimulator of interferon genes (STING). STING agonist-20-Ala-amide-PEG2-C2-NH2 can be used to synthesize immune-stimulating antibody conjugate (ISAC). STING agonist-20-Ala-amide-PEG2-C2-NH2 can be used for the research of cancer .

HY-170949

STING-IN-11	STING Interleukin Related	Inflammation/Immunology
STING-IN-11 (Compound 42) is an orally active *STING* inhibitor with an IC₅₀ of 37.8 nM. STING-IN-11 can block the palmitoylation of the *STING* protein and *STING* downstream signaling, and inhibit *STING*-mediated inflammation. STING-IN-11 has good in vivo safety and can be used for the research of *STING*-related inflammatory and autoimmune diseases .

HY-139179

STING agonist-14	STING	Infection Cancer
STING agonist-14 (compound 12b) is a potent *STING* agonist that is efficacious across species. STING agonist-14 could activate the pathway by directly binding human STING. STING agonist-14 can be used for the research of tumours or viral infections .

HY-152956

STING agonist-23	STING	Infection Cancer
STING agonist-23 (CF502) is a non-nucleotide small-molecule *STING* agonist. STING agonist-23 activates STING, increases phosphorylation of *STING, TBK1* and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains .

HY-148644

STING antagonist-2	STING	Inflammation/Immunology
STING antagonist-2 (Compound 50) is a potent *STING* antagonist with a pIC₅₀ of 8.9. STING antagonist-2 has the potential for immunity research .

HY-176809

Parent CDN	STING	Cancer
Parent CDN is a cyclic dinucleotide and a *STING* agonist. Parent CDN exhibits anti-tumor activity .

HY-157570

Anti-inflammatory agent 70 1 Publications Verification	PROTACs STING	Infection
Anti-inflammatory agent 70 (N-Me-SP23) is a *STING* protein PROTAC degrader and inhibits the STING signaling pathway. Anti-inflammatory agent 70 has anti-inflammatory activity. (Pink: STING inhibitor (HY-47709); Black: linker (HY-W008296); Blue: CRBN Ligand (HY-W460193)) .

HY-174136

STING Degrader-2	STING IFNAR	Inflammation/Immunology
STING Degrader-2 is an orally active *STING* degrader that promotes proteasome-independent degradation of STING. STING Degrader-2 inhibits cGAMP-induced STING activation, suppresses STING oligomerization, and inhibits phosphorylation of STING and interferon regulatory factor 3 (IRF3). STING Degrader-2 reduces serum IFN-β and CXCL-10 levels in a cGAMP-induced autoimmune disease mouse model. STING Degrader-2 can be used for the research of autoimmune diseases .

HY-144329

STING agonist-11	STING	Inflammation/Immunology Cancer
STING agonist-11 (Compound 92) is a potent small molecule cyclic urea activator of *STING* with EC₅₀ of 18 nM. Activation of STING is a highly promising approach in immunotherapy .

HY-RS13917

Sting1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sting1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sting1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sting1 Mouse Pre-designed siRNA Set A Sting1 Mouse Pre-designed siRNA Set A

HY-148606

STING modulator-3	STING	Cancer
STING modulator-3 is a *STING* inhibitor. STING modulator-3 inhibits R232 STING with an K_i value of 43.1 nM in scintillation proximity assay. STING modulator-3 has no effect on IRF-3 activation or TNF-β induction in THP-1 cells .

HY-158036

*PROTAC STING* Degrader-2**	PROTACs STING	Others Inflammation/Immunology
PROTAC STING degrader-2 is a protein Degrader that targets Stimulator of interferon genes (STING) (DC₅₀=0.53 μM). PROTAC STING Degrader-2 is combined with *STING* protein and E3 ubiquitin ligase in a covalent manner to induce the degradation of *STING* protein. PROTAC STING Degrader-2 can be used to investigate the role of *STING* in autoinflammation and autoimmune diseases (PINK: STING binder (HY-145009); Blue: VHL ligand (HY-164043); Black: linker) .

HY-47709

STING ligand-3	Ligands for Target Protein for PROTAC STING	Inflammation/Immunology
STING ligand-3 is a Ligand for Target Protein for PROTAC activity control. STING ligand-3 can be used to synthesize Anti-inflammatory agent 70 (HY-157570) .

HY-150074A

STING agonist-18 diTFA	STING ADC Payload	Cancer
STING agonist-18 (compound 1a) diTFA is a *STING* agonist that can be used for synthesis of antibody-drug conjugates (ADCs), such Trastuzumab (HY-P9907) conjugate .

HY-149781

STING agonist-34	STING	Cancer
STING agonist-34 (Compound 12L) is a potent *STING* agonist with an IC₅₀ value of 1.15 μM and an EC₅₀ of 0.38 μM in THP1 cells. STING agonist-34 could be used in cancer research .

HY-162331

STING Degrader-1	Molecular Glues STING	Inflammation/Immunology Cancer
STING Degrader-1 (compound 2), a molecular glue, is a potent *STING* degrader that covalently binds to STING and E3 ligase. STING Degrader-1 exhibits a "hook effect", that degrades 75% STING protein at 10 μM, and degrades ca. 30% STING protein at 30 μM .

HY-175210

STING-IN-16	STING Interleukin Related IFNAR Reactive Oxygen Species (ROS) Apoptosis	Inflammation/Immunology
STING-IN-16 is a *STING* inhibitor with IC₅₀ values of 44 nM (human) and 32 nM (mice) for cellular *STING* inhibition. STING-IN-16 effectively inhibits the activation of the *STING* axis in both human and murine cells. STING-IN-16 can restore renal mitochondrial function, suppress reactive oxygen species (ROS) production, and reduce cell apoptosis. STING-IN-16 shows robust anti-inflammatory efiicacy in vivo. STING-IN-16 can be used for the study of autoimmune and autoinflammatory diseases .

HY-178338

STING agonist-47	STING	Cancer
STING agonist-47 is a *STING* agonist with an EC₅₀ of 0.72 μM and a K_d of 176 nM. STING agonist-47 is a dimer of MSA-2 (HY-136927). STING agonist-47 can be used for the research of cancer, such as breast cancer .

HY-148346A

STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA	Drug-Linker Conjugates for ADC STING	Cancer
STING agonist-20-Ala-amide-PEG2-C2-NH2 (Compound 30b) TFA is an active scaffold comprising a stimulator of interferon genes (STING). STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA can be used to synthesize immune-stimulating antibody conjugate (ISAC). STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA can be used for the research of cancer .

HY-143321

STING agonist-13	STING	Cancer
STING agonist-13 is a stimulator of interferon genes (STING) agonist, for cancer immunity via STING-mediated immune activation. STING agonist-13 can stimulate *STING* downstream signaling and promoting type I interferon immune responses. STING agonist-13 significantly decreases tumor volume and shows immunological memory-derived cancer inhibition .

HY-152961

STING agonist-28	STING	Infection
STING agonist-28 (CF510) is a non-nucleotide small-molecule *STING* agonist. STING agonist-23 activates STING, increases phosphorylation of *STING, TBK1* and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-100564

2',3'-cGAMP Maximum Cited Publications 33 Publications Verification 2'-3'-cyclic GMP-AMP	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite STING IFNAR
2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP binds to *STING* with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm .

HY-100564A

2',3'-cGAMP sodium Maximum Cited Publications 33 Publications Verification 2'-3'-cyclic GMP-AMP sodium	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite STING IFNAR
2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP sodium binds to *STING* with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP sodium is produced in mammalian cells in response to DNA in the cytoplasm .

HY-12326A

c-di-AMP disodium 15+ Cited Publications Cyclic diadenylate disodium; Cyclic-di-AMP disodium	Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	STING Bacterial Endogenous Metabolite
c-di-AMP (Cyclic diadenylate) sodium is a *STING* agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP sodium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

HY-110382

Cyclic-di-GMP disodium 5+ Cited Publications c-di-GMP disodium; cyclic diguanylate disodium; 5GP-5GP disodium	Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	STING Endogenous Metabolite
Cyclic-di-GMP disodium is a *STING* agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP disodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP disodium can be used in cancer research .

HY-12326

c-di-AMP Cyclic diadenylate; Cyclic-di-AMP	Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	STING Bacterial Endogenous Metabolite
c-di-AMP (Cyclic diadenylate) is a *STING* agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP (Cyclic diadenylate) is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP (Cyclic diadenylate) acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

HY-P1680

Astin C Asterin	Natural Products Plants Compositae Erythrina latissima E. Mey. Source Classification	STING HSV
Astin C (Asterin) is a cyclopeptide that can be extracted from Aster tataricus. Astin C has anti-inflammatory and anti-cancer activities. Astin C can specifically inhibit the *cGAS-STING* signaling pathway, block the recruitment of IRF3 to the *STING* signalosome, and thus inhibit the innate inflammatory response. Astin C can be used in the research of autoimmune diseases and cancers .

HY-110385

cGAMP disodium 25+ Cited Publications Cyclic GMP-AMP disodium; 3',3'-cGAMP disodium	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	STING Endogenous Metabolite
cGAMP (Cyclic GMP-AMP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes *(STING)*, which activates a signaling cascade leading to the production of type I interferons and other immune mediators .

HY-N0660

Jujuboside B	Cardiovascular Disease Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Plants Disease Research Fields Source Classification	Apoptosis PARP Caspase AMPK Autophagy VEGFR Keap1-Nrf2 STING 11β-HSD Ferroptosis PI3K Akt p38 MAPK ERK
Jujuboside B is a bioactive saponin component isolated from Ziziphi Spinosae Semen (sour jujube seed), with oral efficacy and blood-brain barrier permeability. Jujuboside B induces acute leukemia cell death and drives necroptosis apoptosis by activating the RIPK1/RIPK3/MLKL pathway. Jujuboside B upregulates the expression of NOXA, PARP and caspase-3, activates AMPK, inhibits the proliferation of breast cancer cells, and induces cell apoptosis and autophagy. Jujuboside B inhibits angiogenesis and tumor growth by blocking the VEGFR-2 signaling pathway. Jujuboside B alleviates liver injury in mice by regulating the *Nrf2-STING* signaling pathway . Jujuboside B alleviates liver injury by regulating anti-inflammatory responses and downregulating the expression of 11β-HSD2. Jujuboside B induces ferroptosis and overcomes radioresistance in non-small cell lung cancer via the PPARγ-ATF3-Gpx4 signaling pathway. Jujuboside B exerts inhibitory effects on platelet aggregation. Jujuboside B inhibits febrile seizures by suppressing the activity of AMPA receptors. Jujuboside B reverses chronic unpredictable mild stress-promoted tumor progression by blocking the PI3K/Akt and MAPK/ERK pathways and dephosphorylating CREB signaling. Jujuboside B is applicable to related studies on acute leukemia, breast cancer, PM_2.5-induced lung injury, hepatotoxicity, liver injury, colorectal cancer, non-small cell lung cancer, thromboembolic diseases, cardiovascular diseases associated with high platelet aggregation, febrile seizures, and depressive-like phenotypes .

HY-N2616

Vomicine 1 Publications Verification	Alkaloids Monophenols Strychnos nux-vomica Linn. Classification of Application Fields Phenols Loganiaceae Metabolic Disease Plants Disease Research Fields Indole Alkaloids Source Classification	STING
Vomicine modulates *cGAS-STING-TBK1* signaling pathway, and exhibits anti-inflammatory activity. Vomicine is an alkaloid that can be isolated from Strychnos nux-vomica seeds .

HY-107780

Cyclic-di-GMP c-di-GMP; cyclic diguanylate; 5GP-5GP	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	STING Endogenous Metabolite
Cyclic-di-GMP is a *STING* agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP can be used in cancer research .

HY-12326B

c-di-AMP diammonium 15+ Cited Publications Cyclic diadenylate diammonium; Cyclic-di-AMP diammonium	Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	STING Bacterial Endogenous Metabolite
c-di-AMP diammonium is a *STING* agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP diammonium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP diammonium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

HY-107780B

Cyclic-di-GMP diammonium 5+ Cited Publications c-di-GMP diammonium; cyclic diguanylate diammonium; 5GP-5GP diammonium	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	STING Endogenous Metabolite
Cyclic-di-GMP diammonium is a *STING* agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP diammonium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP diammonium can be used in cancer research .

HY-Z15849

Caffeoylmalic acid	Nasturtium officinale R.Br. ex W.T.Aiton Ketones, Aldehydes, Acids Plants Brassicaceae Source Classification	Others
Caffeoylmalic acid is an orally active hydroxycinnamoyl-malate ester found in stinging nettle (Urtica dioica). Caffeoylmalic acid exhibits anti-diabetic, anti-inflammation and anti-oxidant effects. Caffeoylmalic acid shows cytotoxicity to cancer cells. Caffeoylmalic acid can be used for the researches of cancer, inflammation and metabolic disease, such as colon cancer and diabetes .

HY-110385A

cGAMP diammonium 25+ Cited Publications Cyclic GMP-AMP diammonium; 3',3'-cGAMP diammonium	Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	STING Endogenous Metabolite
cGAMP (Cyclic GMP-AMP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes *(STING)*, which activates a signaling cascade leading to the production of type I interferons and other immune mediators .

HY-N15159

Cladophorol A	Structural Classification Marine algae Marine natural products Phenols Polyphenols Source Classification	Cyclic GMP-AMP Synthase STING Parasite
Cladophorol A is a cyclic GMP-AMP synthase (cGAS) inhibitor. Cladophorol A binds to the conserved adenosine nucleobase binding site within the cGAS active site to inhibit its catalytic activity. Cladophorol A effectively inhibits the overactivation of the *cGAS-STING* pathway with an IC₅₀ of 370 nM. Cladophorol A inhibits asexual blood-stage Plasmodium falciparum with an EC₅₀ of 0.7 μg/mL. Cladophorol A can be used for the researches of inflammatory disease and malaria .

HY-N8107

Matairesinol monoglucoside 2 Publications Verification	Structural Classification Monophenols other families Classification of Application Fields Lignans Other Diseases Phenols Phenylpropanoids Plants Disease Research Fields Source Classification	STING IFNAR HBV
Matairesinol monoglucoside is a *STING* activator. Matairesinol monoglucoside modulates the *STING-TBK1-IRF3* signaling axis, promotes STING transcriptional expression, increases TBK1 and IRF3 phosphorylation. Matairesinol monoglucoside induces IFN-α and IFN-β production, reduces HBV DNA, HBsAg, and HBeAg expression. Matairesinol monoglucoside can be used for the research of hepatitis b virus (hbv) infection .

HY-107780A

Cyclic-di-GMP sodium c-di-GMP sodium; cyclic diguanylate sodium; 5GP-5GP sodium	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	STING Endogenous Metabolite
Cyclic-di-GMP sodium is a *STING* agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP sodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP sodium can be used in cancer research .

HY-N12507

Eupenicisirenin C	Microorganisms Ketones, Aldehydes, Acids Marine natural products Marine microorganism Source Classification	STING NF-κB
Eupenicisirenin C (compound 1) is a sirenin derivative. Eupenicisirenin C has strong NF-κB inhibitory activities. Eupenicisirenin C suppresses effects on *cGAS-STING* pathway. Eupenicisirenin C inhibits RANKL-induced osteoclast differentiation in bone marrow macrophage cells .

HY-N2616R

Vomicine (Standard)	Alkaloids Structural Classification Monophenols Strychnos nux-vomica Linn. Phenols Loganiaceae Plants Indole Alkaloids Source Classification	Reference Standards STING
Vomicine (Standard) is the analytical standard of Vomicine. This product is intended for research and analytical applications. Vomicine modulates *cGAS-STING-TBK1* signaling pathway, and exhibits anti-inflammatory activity. Vomicine is an alkaloid that can be isolated from Strychnos nux-vomica seeds .

HY-N0660R

Jujuboside B (Standard)	Triterpenes Structural Classification other families Terpenoids Plants Source Classification	Reference Standards ERK p38 MAPK Akt PI3K 11β-HSD STING VEGFR Ferroptosis Autophagy Apoptosis Keap1-Nrf2 Caspase PARP AMPK
Jujuboside B (Standard) is the analytical standard of Jujuboside B. This product is intended for research and analytical applications. Jujuboside B is a bioactive saponin component isolated from Ziziphi Spinosae Semen (sour jujube seed), with oral efficacy and blood-brain barrier permeability. Jujuboside B induces acute leukemia cell death and drives necroptosis apoptosis by activating the RIPK1/RIPK3/MLKL pathway. Jujuboside B upregulates the expression of NOXA, PARP and caspase-3, activates AMPK, inhibits the proliferation of breast cancer cells, and induces cell apoptosis and autophagy. Jujuboside B inhibits angiogenesis and tumor growth by blocking the VEGFR-2 signaling pathway. Jujuboside B alleviates liver injury in mice by regulating the *Nrf2-STING* signaling pathway . Jujuboside B alleviates liver injury by regulating anti-inflammatory responses and downregulating the expression of 11β-HSD2. Jujuboside B induces ferroptosis and overcomes radioresistance in non-small cell lung cancer via the PPARγ-ATF3-Gpx4 signaling pathway. Jujuboside B exerts inhibitory effects on platelet aggregation. Jujuboside B inhibits febrile seizures by suppressing the activity of AMPA receptors. Jujuboside B reverses chronic unpredictable mild stress-promoted tumor progression by blocking the PI3K/Akt and MAPK/ERK pathways and dephosphorylating CREB signaling. Jujuboside B is applicable to related studies on acute leukemia, breast cancer, PM_2.5-induced lung injury, hepatotoxicity, liver injury, colorectal cancer, non-small cell lung cancer, thromboembolic diseases, cardiovascular diseases associated with high platelet aggregation, febrile seizures, and depressive-like phenotypes.

Cat. No.	Product Name	Chemical Structure

HY-110382S

Cyclic-di-GMP-13C20,15N10 disodium

¹³C20, ¹⁵N10-Cyclic di-GMP ( ¹³C20, ¹⁵N10-c-di-GMP) is ¹³C and ¹⁵N labeled Cyclic-di-GMP (disodium). Cyclic-di-GMP disodium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP disodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP disodium can be used in cancer research .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks