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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
56 Results for "
super
" in MedChemExpress (MCE) Product Catalog:
Products (56)
56 Results for "super" in MCE Product Catalog:
6
3
3 Cited Publications
Synonyms: super Squalene; trans-Squalene; AddaVax
3
3 Cited Publications
Target:
Áreas de investigación:
ZXH-3-26 is a CRBN-recruiting BRD4 PROTAC degrader with a DC50/5h of approximately 5 nM. ZXH-3-26 drives the ubiquitination and degradation of BRD4 by recruiting BRD4BD1 to the CRL4 CRBN E3 ubiquitin ligase complex, thereby inhibiting the dynamic distribution of super-enhancers. ZXH-3-26 reverses TNF-α-induced impairment of the immunosuppressive function of mesenchymal stem cells, and affects RNA synthesis and the transcriptional elongation process of Pol II. ZXH-3-26 can be used in studies related to inflammatory arthritis, malignant tumors, and HIV latency .
2
2 Cited Publications
Referencia número: HY-P1728A
1
1 Cited Publications
Synonyms: AG-3-5
Target:
Áreas de investigación:
Icilin (AG-3-5) is a super-agonist of the transient receptor potential M8 (TRPM8) ion channel. Icilin activates TRPM8 in EGTA in a dose-dependent manner (EC50=1.4 μM). Icilin is a "super-cooling agent" . Icilin attenuates autoimmune neuroinflammation through modulation of the T-cell response .
1
1 Cited Publications
Synonyms: KL-2
Target:
Áreas de investigación:
SEC inhibitor KL-2 (KL-2), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-2 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 1.50 μM .
1
1
1 Cited Publications
MFH290 is an orally active, selective covalent CDK12/CDK13 inhibitor, with an IC50 of 25 nM against human CDK12 and 49 nM against human CDK13. MFH290 reduces the phosphorylation level of CTD-RNAPII-Ser2, downregulates genes related to DNA damage response (DDR), and inhibits transcription factors regulated by super-enhancers. MFH290 can be used in research related to various cancers including leukemia .
1
1 Cited Publications
Referencia número: HY-P73634
Pureza: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SNAP25; SEC9; Prev. SNAP; Synaptosomal-Associated Protein, 25kDa; SNAP-25; SUP; Synaptosomal-Associated Protein 25; Synaptosomal-Associated 25 KDa Protein; DJ1068F16.2; Synaptosome Associated Protein 25kDa; BA416N4.2; super Protein; RIC-4; DEE117; RIC4; C
Species:
Human
Source:
E. coli
Referencia número: HY-N1214S
No. CAS: 1875101-86-2
Synonyms: super Squalene-d6; trans-Squalene-d6; AddaVax-d6
Referencia número: HY-D2348A
Referencia número: HY-19625
No. CAS: 1162656-22-5
Áreas de investigación:
MCB-613 is a potent Steroid receptor coactivator SRC small molecule ‘stimulator’ (SMS), super-stimulates SRCs’ transcriptional activity.
MCB-613 increases SRCs’ interactions with other coactivators and markedly induces ER stress coupled to the generation of reactive oxygen species (ROS).
MCB-613 is a SMS that target oncogenes can be exploited as anti-cancer agents by over-stimulating the SRC oncogenic program .
Referencia número: HY-P10531
No. CAS: 2413353-86-1
Target:
Áreas de investigación:
ALFA-tag is an α-helical peptide epitope tag. ALFA-tag is recognized by the high-affinity Nb-ALFA nanobody (Kd = 26 pM). The ALFA system, composed of ALFA-tag and ALFA-Nb, is widely adopted and applied in various fields such as immunofluorescence, super-resolution microscopy, immunoblotting, and protein purification .
Referencia número: HY-D2348
No. CAS: 3058751-62-2
Referencia número: HY-148739
No. CAS: 2170679-42-0
Target:
Áreas de investigación:
dBRD 9-A is a selective BRD9 PROTAC degrader. dBRD 9-A induces near complete BRD9 degradation dependent on E3 ubiquitin ligase CRBN and BRD9 bromodomain engagement, and drives loss of BRD9 chromatin binding genome-wide. dBRD 9-A downregulates oncogenic SS18-SSX-driven transcriptional programs, super enhancer-associated gene expression, and SS18-SSX1 super enhancer binding, and depletes GBAF complex members GLTSCR1/1L from SS18-SSX complexes. dBRD 9-A induces cell cycle arrest and increases apoptosis in synovial sarcoma cells. dBRD 9-A can be used for the research of synovial sarcoma .
Referencia número: HY-W784030
No. CAS: 1380349-88-1
Target:
Áreas de investigación:
N-TCO-L-lysine is a non-canonical amino acid. N-TCO-L-lysine contains a trans-cyclooctene (TCO) bioorthogonal reactive linker. N-TCO-L-lysine undergoes a bioorthogonal click reaction with SiR-Tz to enable fluorescent labeling of endogenously expressed proteins with site-specific incorporation. When used in combination with SiR-Tz, N-TCO-L-lysine allows super-resolution and live-cell imaging of endogenous proteins .
Referencia número: HY-D2017
No. CAS: 1251752-59-6
Target:
Áreas de investigación:
ATTO 550 is a fluorescent dye in the orange spectral range, commonly used as a fluorescent probe for the labeling and detection of biomolecules. ATTO 550 can be used to label nucleic acids, proteins, and small molecules, and is widely applied in super-resolution imaging, flow cytometry, fluorescence lifetime imaging (FLIM), fluorescence resonance energy transfer (FRET), and fluorescence intensity-based cell uptake and binding assays. The excitation/emission wavelengths of ATTO 550 are approximately Ex/Em = 554/576 nm .
Referencia número: HY-W400925
No. CAS: 1481447-40-8
Target:
Áreas de investigación:
Sulfo-Cy5-N3 is an azide-functionalized sulfonated cyanine 5 Fluorescent dye and also serves as click chemistry coupling reagent. Sulfo-Cy5-N3 undergoes copper (I)-catalyzed azide-alkyne cycloaddition with alkyne-functionalized antibody constructs and peptide probes for site-selective fluorescent labeling. Sulfo-Cy5-N3 also acts as an emission dye for STORM super-resolution imaging. Sulfo-Cy5-N3 is applicable to the study of HER2-positive breast cancer .
Synonyms: super Squalene (Standard); trans-Squalene (Standard); AddaVax (Standard)
Synonyms: TRX-E-002-1
Cantrixil (TRX-E-002-1), an active enantiomer of TRX-E-002, is a second-generation super-benzopyran (SBP) compound. Cantrixil increases phosphorylated c-Jun levels resulting in caspase-mediated apoptosis in ovarian cancer cells. Cantrixil has potent pan anti-cancer activity against a broad range of cancer phenotypes .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
