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thymus

" in MedChemExpress (MCE) Product Catalog:

58

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1

Fluorescent Dye

4

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8

Peptides

1

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1

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18

Natural
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3

Recombinant Proteins

5

Isotope-Labeled Compounds

3

Antibodies

4

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-17563
    2'-Deoxyguanosine
    5+ Cited Publications

    Deoxyguanosine; Guanine deoxyriboside

    		 Endogenous Metabolite Cancer
    2’-Deoxyguanosine (Deoxyguanosine) is a purine nucleoside with a variety of biological activities. 2’-Deoxyguanosine can induce DNA division in mouse thymus cells. 2’-Deoxyguanosine is a potent cell division inhibitor in plant cells .
    2'-Deoxyguanosine
  • HY-109517
    Calf thymus DNA
    5 Publications Verification

    DNA from calf thymus, Thymonucleic acid

    		 DNA/RNA Synthesis Inflammation/Immunology Cancer
    Calf thymus DNA (DNA from calf thymus) is high quality double-stranded template DNA isolated from the thymus of male and female calves. Calf thymus DNA can be used for the research of the interaction between DNA and agents .
    Calf thymus DNA
  • HY-NP155
    Histone (calf thymus)
    1 Publications Verification

    		 Endogenous Metabolite Others
    Histone (calf thymus) is a histone found in the deoxyribonucleoprotein of calf thymus and can be obtained by acid extraction technique .
    Histone (calf thymus)
  • HY-106033
    Edotreotide
    2 Publications Verification

    DOTATOC; SDZ-SMT 487; SMT 487

    		 Radionuclide-Drug Conjugates (RDCs) Cancer
    Edotreotide is a ligand that selectively targets SSTR2 and can competitively bind to the receptor. Edotreotide mediates the targeted delivery, while modificated with radionuclides (such as 90Y, 177Lu, and 68Ga) to SSTR-positive tumors and induces tumor cell apoptosis by releasing β rays. Edotreotide has strong tumor targeting and precise killing activity. Edotreotide is used in the synthesis of radionuclide-drug conjugates (RDCs) and is widely used in the field of neuroendocrine tumors (such as metastatic carcinoids, lung and thymus NETs) .
    Edotreotide
  • HY-B1095
    Chlormadinone acetate
    1 Publications Verification

    		 Progesterone Receptor Androgen Receptor Glucocorticoid Receptor GABA Receptor Neurological Disease Metabolic Disease
    Chlormadinone acetate is a progestogen with potent progestogenic activity and antiandrogenic effects. Chlormadinone acetate acts on glucocorticoid receptor, progesterone receptor, androgen receptor, and GABAA receptor. Chlormadinone acetate induces endometrial proliferation in estrogen-pretreated rabbits, inhibits testosterone-stimulated growth of the prostate and seminal vesicles in castrated rats, and reduces the thymus and adrenal weights in juvenile rats. Chlormadinone acetate is applicable to research related to diseases such as depression and reproductive metabolic disorders .
    Chlormadinone acetate
  • HY-13718
    Oglufanide

    H-Glu-Trp-OH; L-Glutamyl-L-tryptophan

    		 VEGFR HCV Endogenous Metabolite Infection Cardiovascular Disease Inflammation/Immunology Cancer
    Oglufanide (H-Glu-Trp-OH) is a dipeptide immunomodulator isolated from calf thymus. Oglufanide inhibits vascular endothelial growth factor (VEGF). Oglufanide can stimulate the immune response to hepatitic C virus (HCV) and intracellular bacterial infections. Oglufanide shows antitumor and anti-angiogenesis activities .
    Oglufanide
  • HY-121309
    Doxorubicinone
    2 Publications Verification

    Adriamycin aglycone; Adriamycinone

    		 NF-κB TNF Receptor Interleukin Related Drug Derivative Inflammation/Immunology Cancer
    Doxorubicinone (Adriamycin aglycone) is the aglycone of the antibiotic Doxorubicin (HY-15142A), i.e., its sugar-free parent nucleus structure. Doxorubicinone does not induce DNA damage or bind to RelA, but still downregulates the expression of pro-inflammatory cytokines (such as TNF, IL-12, etc.) regulated by the NF-κB pathway. Doxorubicinone can be used in sepsis-related research .
    Doxorubicinone
  • HY-N10424
    Brazilein
    2 Publications Verification

    		 Na+/K+ ATPase Apoptosis Interleukin Related NO Synthase Bacterial Parasite Cardiovascular Disease Infection Neurological Disease Inflammation/Immunology
    Brazilein is a compound with anti-inflammatory and neuroprotective activities, with an IC50 of 500 μM against guinea pig Na +,K +-ATPase. Brazilein reduces iNOS mRNA expression, thereby inhibiting nitric oxide production in immune cells. Brazilein suppresses inflammatory responses by reducing the mRNA expression of TNF-α and IL-6, but has no effect on IL-1β expression. Brazilein reduces the cerebral infarction volume and improves the neurological function scores of rats with cerebral ischemia-reperfusion injury. Brazilein induces apoptosis of splenic lymphocytes in mice. Brazilein inhibits humoral immune responses in mice, and causes thymus and spleen atrophy as well as body weight loss in mice. Brazilein also possesses antimalarial and antibacterial activities. Brazilein is also a red dye. Brazilein can be used in studies related to the infection, nervous system, cardiovascular system and inflammatory diseases .
    Brazilein
  • HY-W020955
    Triphenylphosphinechlorogold

    Chloro(triphenylphosphine)gold(I)

    		 Biochemical Assay Reagents Apoptosis DNA Alkylator/Crosslinker Lipoxygenase Cancer
    Triphenylphosphinechlorogold (Chloro(triphenylphosphine)gold(I)) is a gold complex, Apoptosis inducer, and catalyst. Triphenylphosphinechlorogold exhibits high LOX inhibitory activity. Triphenylphosphinechlorogold induces cell cycle arrest and apoptosis. Triphenylphosphinechlorogold catalyzes the peroxidation of linoleic acid. A weak interaction exists between Triphenylphosphinechlorogold and DNA. Triphenylphosphinechlorogold displays antiproliferative activity against breast cancer cells .
    Triphenylphosphinechlorogold
  • HY-N6801
    Nivalenol

    		Caspase Apoptosis Bcl-2 Family Infection Inflammation/Immunology Cancer
    Nivalenol, a trichothecene mycotoxin that can be produced by Fusarium graminearum, is a fungal metabolite present in agricultural product. Nivalenol modulates apoptotic pathway, cell cycle regulation, Bax, ERK, caspase-3, and poly-ADP-ribose synthase activity in macrophages. Nivalenol inhibits ribosomal peptidyltransferase site, protein synthesis, DNA synthesis, and cell proliferation. Nivalenol induces late-stage apoptotic morphological changes, reduces cellular metabolism, and decreases cell proliferation in erythroleukemia cells. Nivalenol induces lymphocyte apoptosis in murine thymus, spleen, and Peyer's patches. Nivalenol can be used for the research of erythroleukemia .
    Nivalenol
  • HY-P0070
    Thymus peptide C

    		Endogenous Metabolite Inflammation/Immunology
    Thymus peptide C is a hormonal agent derived from the thymus glands of young calves, which works as a substitute for the physiological functions of the thymus.
    Thymus peptide C
  • HY-153118
    Deoxyribonucleic acid sodium, from calf thymus, Type I, fibers
    5 Publications Verification

    ctDNA sodium, Type I, fibers; DNA sodium, from calf thymus, Type I, fibers; Thymonucleic acid sodium, Type I, fibers

    		 Biochemical Assay Reagents Others Cancer
    Deoxyribonucleic acid sodium, from calf thymus, Type I, fibers is the sodium salts form of Calf thymus DNA (HY-109517). Calf thymus DNA is a double-stranded template DNA isolated from calf thymus. It can be used to study the interaction between DNA and DNA binding agents, as well as the structure and function of DNA, for DNA quantification and used as a substrate for DNA polymerase analysis, etc​ .
    Deoxyribonucleic acid sodium, from calf thymus, Type I, fibers
  • HY-N8593
    Undecane

    		Environmental Pollutants p38 MAPK TNF Receptor NF-κB Interleukin Related Histamine Receptor PKA Inflammation/Immunology Endocrinology
    Undecane is a potent cAMP agonist with anti-allergic and anti-inflammatory activities. Undecane inhibits degranulation and the secretion of histamine and TNF-α. Undecane reverses the increased levels of p38 phosphorylation, NF-κB transcriptional activity and target cytokine/chemokine genes, including thymus and activation-regulated chemokine (TARC), macrophage-derived chemokine (MDC) and interleukin-8 (IL-8). Undecane can be used for the study of skin inflammatory disorders, such as atopic dermatitis .
    Undecane
  • HY-17563R
    2'-Deoxyguanosine (Standard)

    Deoxyguanosine (Standard); Guanine deoxyriboside (Standard)

    		 Reference Standards Endogenous Metabolite Cancer
    2'-Deoxyguanosine (Standard) is the analytical standard of 2'-Deoxyguanosine. This product is intended for research and analytical applications. 2’-Deoxyguanosine (Deoxyguanosine) is a purine nucleoside with a variety of biological activities. 2’-Deoxyguanosine can induce DNA division in mouse thymus cells. 2’-Deoxyguanosine is a potent cell division inhibitor in plant cells . In Vitro: 2'-Deoxyguanosine inhibits the clonal growth of HL-60 and K562 leukemia cells with IC50 values of 50 and 80 μM, respectively .
    2'-Deoxyguanosine (Standard)
  • HY-N12851
    4-OHE

    (E)-4-Oxo-2-hexenal

    		 Bacterial Apoptosis Infection
    4-OHE ((E)-4-Oxo-2-hexenal) is a mutagen formed by omega-3 lipid peroxidation. 4-OHE reacts with deoxyguanosine, deoxycytidine and 5-methyldeoxycytidine to form covalent adducts. 4-OHE induces apoptosis and exhibits genotoxicity. 4-OHE inhibits the growth of Gram-positive and Gram-negative bacteria, which correlates with its electrophilic reactivity towards nucleophilic biomolecules. 4-OHE is a chemical defense component of Dolycoris baccarum (sloe bug), and acts as a deterrent and toxin against insect predators .
    4-OHE
  • HY-147385
    CCR4 antagonist 3

    		CCR Inflammation/Immunology
    CCR4 antagonist 3 is a potent chemokine receptor 4 (CCR4) antagonist with an IC50 value of 1.7 μM for [ 125I]TARC (thymus and activation regulated chemokine). CCR4 antagonist 3 inhibits binding of radiolabeled TARC and macrophage-derived chemokine (MDC) to CCR4 receptors on the surface of CEM cells. CCR4 antagonist 3 also inhibits the in vitro migration of CEM cells mediated by TARC (IC50 = 6.4 μM) .
    CCR4 antagonist 3
  • HY-N17260
    Phellandral

    		Bacterial Infection
    Phellandral is an aldehyde compound that can be found in Eucalyptus camaldulensis and Thymus seravschanicus. The phellandral-containing eucalyptus essential oil exhibits significant inhibitory effects on various plant pathogenic fungi, especially on Aspergillus flavus. Phellandral, together with other oxygenated monoterpenoids, constitutes an important basis for the antibacterial activity of the essential oil .
    Phellandral
  • HY-18164
    TASP0277308

    		LPL Receptor Inflammation/Immunology
    TASP0277308 is a highly selective S1P1 antagonist. TASP0277308 possesses immunomodulatory activities, including lymphopenia, a block in T cell egress from the thymus, marginal zone B cell displacement, and the upregulation of CD69 expression on lymphocytes. TASP0277308 can be used for the research of collagen-induced arthritis in mice .
    TASP0277308
  • HY-N6801S
    Nivalenol-13C15

    		Isotope-Labeled Compounds Caspase Apoptosis Bcl-2 Family Infection Inflammation/Immunology Cancer
    Nivalenol- 13C15 is the 13C labeled Nivalenol (HY-N6801) . Nivalenol, a trichothecene mycotoxin that can be produced by Fusarium graminearum, is a fungal metabolite present in agricultural product. Nivalenol modulates apoptotic pathway, cell cycle regulation, Bax, ERK, caspase-3, and poly-ADP-ribose synthase activity in macrophages. Nivalenol inhibits ribosomal peptidyltransferase site, protein synthesis, DNA synthesis, and cell proliferation. Nivalenol induces late-stage apoptotic morphological changes, reduces cellular metabolism, and decreases cell proliferation in erythroleukemia cells. Nivalenol induces lymphocyte apoptosis in murine thymus, spleen, and Peyer's patches. Nivalenol can be used for the research of erythroleukemia.
    Nivalenol-13C15
  • HY-NP155A
    Histone H1 (calf thymus)

    		Endogenous Metabolite Others
    Histone H1 (calf thymus) is a linker histone subtype found in the deoxyribonucleoprotein of calf thymus and can be obtained by separation and purification from total calf thymus histones .
    Histone H1 (calf thymus)
  • HY-B1265
    Hydrocortisone 17-valerate

    Cortisol 17-valerate

    		 Glucocorticoid Receptor Neurological Disease Inflammation/Immunology
    Hydrocortisone 17-valerate (Cortisol 17-valerate) is a 17α-ester derivative of Hydrocortisone (HY-N0583), an endogenous glucocorticoid with anti-inflammatory activity. Hydrocortisone 17-valerate can be used for research on skin inflammation .
    Hydrocortisone 17-valerate
  • HY-W339331
    Flubendiamide

    NNI-0001

    		 Insecticide Calcium Channel Reactive Oxygen Species (ROS) Apoptosis Infection Metabolic Disease
    Flubendiamide (NNI-0001) is an orally active phthalic diamide insecticide that acts by targeting insect ryanodine receptors (RyRs), causing insect muscle dysfunction, paralysis and death. Flubendiamide disrupts molting, metamorphosis and reproductive processes, induces oxidative stress by increasing the levels of ROS/RNS, MDA and 8OHdG and decreasing the levels of SOD, CAT and GST, activates the CncC/Maf apoptosis pathway, impairs calcium homeostasis, promotes adipogenesis, increases triglyceride accumulation, and upregulates the expression of regulatory factors for adipocyte differentiation and adipogenesis .
    Flubendiamide
  • HY-146350
    TrxR-IN-4

    		TrxR Reactive Oxygen Species (ROS) Apoptosis Cancer
    TrxR-IN-4 is a thioredoxin reductase (TrxR) inhibitor with a rat IC50 of 0.37 μM. TrxR-IN-4 inhibits TrxR activity, elevates reactive oxygen species (ROS) and induces apoptosis. TrxR-IN-4 mediates endoplasmic reticulum stress and induces mitochondrial dysfunction. TrxR-IN-4 can be used for the research of hepatocellular carcinoma .
    TrxR-IN-4
  • HY-N3409
    Ladanein

    		Others Others
    Ladanein is a flavonoids compound isolated from Thymus piperella .
    Ladanein
  • HY-P3963
    Thymus Factor

    		ERK Inflammation/Immunology
    Thymus Factor (Thymulin) is a key factor responsible for the maturation of humoral immunological faculty . Thymulin is an inhibitor of ERK .
    Thymus Factor
  • HY-N6801R
    Nivalenol (Standard)

    		Reference Standards Caspase Apoptosis Bcl-2 Family Infection Inflammation/Immunology Cancer
    Nivalenol (Standard) is the analytical standard of Nivalenol (HY-N6801). This product is intended for research and analytical applications. Nivalenol, a trichothecene mycotoxin that can be produced by Fusarium graminearum, is a fungal metabolite present in agricultural product. Nivalenol modulates apoptotic pathway, cell cycle regulation, Bax, ERK, caspase-3, and poly-ADP-ribose synthase activity in macrophages. Nivalenol inhibits ribosomal peptidyltransferase site, protein synthesis, DNA synthesis, and cell proliferation. Nivalenol induces late-stage apoptotic morphological changes, reduces cellular metabolism, and decreases cell proliferation in erythroleukemia cells. Nivalenol induces lymphocyte apoptosis in murine thymus, spleen, and Peyer's patches. Nivalenol can be used for the research of erythroleukemia.
    Nivalenol (Standard)
  • HY-121782
    A 65281

    		Bacterial DNA/RNA Synthesis Infection
    A 65281 is a potent DNA gyrase inhibitor with an IC50 value of 0.1 µg/mL. A 65281 induces DNA breakage mediated by calf thymus topoisomerase II. A 65281 inhibits P4 DNA unknotting with an IC50 value of 8 µg/mL .
    A 65281
  • HY-P0001
    Thymus factor X

    TFX-Jelfa

    		 Biochemical Assay Reagents Inflammation/Immunology
    Thymic factor X (TFX-Jelfa) is an aqueous extract from juvenile calf thymuses and a natural stimulator of lymphocyte function .
    Thymus factor X
  • HY-135181
    Daunosamnyl-daunorubicin

    		Antibiotic Bacterial Inflammation/Immunology
    Daunosamnyl-daunorubic, an antibiotic, can bind calf thymus DNA .
    Daunosamnyl-daunorubicin
  • HY-N12919
    (E)-3-Dodecenol

    		Others Endocrinology
    (E)-3-Dodecenol is a termite trail pheromone that can be isolated from the whole body and thymus extracts of termite workers. (E)-3-Dodecenol induces orientational and recruitment behavior effects, but its induction effect is weaker than (Z)-Dodecenol or natural thymus extracts .
    (E)-3-Dodecenol
  • HY-120747
    A-65282

    		Bacterial DNA/RNA Synthesis Infection
    A-65282 is an antibacterial agent. A-65282 inhibits P4 DNA unknotting with an IC50 value of 8 µg/mL. A 65281 induces DNA breakage mediated by calf thymus topoisomerase II .
    A-65282
  • HY-174554
    Human PAX9 mRNA

    		mRNA Cancer
    Human PAX9 mRNA encodes the human paired box 9 (PAX9) protein, a member of the paired box (PAX) family. PAX9 is required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.
    Human PAX9 mRNA
  • HY-174766
    Human CCL17 mRNA

    		mRNA Inflammation/Immunology
    Human CCL17 mRNA encodes the human C-C motif chemokine ligand 17 (CCL17) protein, a cytokine that displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. CCL17 plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells.
    Human CCL17 mRNA
  • HY-171460
    Win 45164

    		Glucocorticoid Receptor Neurological Disease Inflammation/Immunology
    Win 45164 is an orally active glucocorticoid receptor (Glucocorticoid Receptor) ligand with the activity of inhibiting the pituitary - adrenal axis. It can promote liver glycogen deposition and thymus involution in adrenalectomized male rats. Meanwhile, Win 45164 has anti - inflammatory effects. It can be used in the research of inflammatory and neurological diseases .
    Win 45164
  • HY-174764
    Human CCL19 mRNA

    		mRNA Inflammation/Immunology
    Human CCL19 mRNA encodes the human C-C motif chemokine ligand 19 (CCL19) protein, a cytokine that may play a role in normal lymphocyte recirculation and homing. CCL19 also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs.
    Human CCL19 mRNA
  • HY-13718A
    Oglufanide disodium

    H-Glu-Trp-OH disodium; L-Glutamyl-L-tryptophan disodium

    		 VEGFR HCV Endogenous Metabolite Infection Cardiovascular Disease Inflammation/Immunology Cancer
    Oglufanide (H-Glu-Trp-OH) disodium is a dipeptide immunomodulator isolated from calf thymus. Oglufanide disodium inhibits vascular endothelial growth factor (VEGF). Oglufanide disodium can stimulate the immune response to hepatitic C virus (HCV) and intracellular bacterial infections. Oglufanide disodium shows antitumor and anti-angiogenesis activities .
    Oglufanide disodium
  • HY-B1095S1
    Chlormadinone acetate-d6-1

    		Isotope-Labeled Compounds Progesterone Receptor Neurological Disease Metabolic Disease
    Chlormadinone acetate-d6-1 is deuterium labeled Chlormadinone acetate (HY-B1095). Chlormadinone acetate is a progestogen with potent progestogenic activity and antiandrogenic effects. Chlormadinone acetate acts on glucocorticoid receptor, progesterone receptor, androgen receptor, and GABAA receptor. Chlormadinone acetate induces endometrial proliferation in estrogen-pretreated rabbits, inhibits testosterone-stimulated growth of the prostate and seminal vesicles in castrated rats, and reduces the thymus and adrenal weights in juvenile rats. Chlormadinone acetate is applicable to research related to diseases such as depression and reproductive metabolic disorders .
    Chlormadinone acetate-d6-1
  • HY-B1095R
    Chlormadinone acetate (Standard)

    		Reference Standards Progesterone Receptor Neurological Disease Metabolic Disease
    Chlormadinone acetate (Standard) is the analytical standard of Chlormadinone acetate (HY-B1095). This product is intended for research and analytical applications. Chlormadinone acetate is a progestogen with potent progestogenic activity and antiandrogenic effects. Chlormadinone acetate acts on glucocorticoid receptor, progesterone receptor, androgen receptor, and GABAA receptor. Chlormadinone acetate induces endometrial proliferation in estrogen-pretreated rabbits, inhibits testosterone-stimulated growth of the prostate and seminal vesicles in castrated rats, and reduces the thymus and adrenal weights in juvenile rats. Chlormadinone acetate is applicable to research related to diseases such as depression and reproductive metabolic disorders.
    Chlormadinone acetate (Standard)
  • HY-B1095S2
    Chlormadinone acetate-d3

    		Isotope-Labeled Compounds Progesterone Receptor Neurological Disease Metabolic Disease
    Chlormadinone acetate-d3 is the deuterium labeled Chlormadinone acetate (HY-B1095). Chlormadinone acetate is a progestogen with potent progestogenic activity and antiandrogenic effects. Chlormadinone acetate acts on glucocorticoid receptor, progesterone receptor, androgen receptor, and GABAA receptor. Chlormadinone acetate induces endometrial proliferation in estrogen-pretreated rabbits, inhibits testosterone-stimulated growth of the prostate and seminal vesicles in castrated rats, and reduces the thymus and adrenal weights in juvenile rats. Chlormadinone acetate is applicable to research related to diseases such as depression and reproductive metabolic disorders .
    Chlormadinone acetate-d3
  • HY-17563S
    2'-Deoxyguanosine-13C,15N2

    Deoxyguanosine-13C,15N2; Guanine deoxyriboside-13C,15N2

    		 Isotope-Labeled Compounds Endogenous Metabolite Cancer
    2'-Deoxyguanosine- 13C, 15N2 (Deoxyguanosine- 13C, 15N2; Guanine deoxyriboside- 13C, 15N2) is the 13C- and 15N-labeled labeled 2'-Deoxyguanosine (HY-17563). 2’-Deoxyguanosine (Deoxyguanosine) is a purine nucleoside with a variety of biological activities. 2’-Deoxyguanosine can induce DNA division in mouse thymus cells. 2’-Deoxyguanosine is a potent cell division inhibitor in plant cells .
    2'-Deoxyguanosine-13C,15N2
  • HY-N8593R
    Undecane (Standard)

    		Reference Standards Histamine Receptor p38 MAPK NF-κB TNF Receptor Interleukin Related Inflammation/Immunology Endocrinology
    Undecane (Standard) is an analytical standard of Undecane (HY-N8593).Undecane is a potent cAMP agonist with anti-allergic and anti-inflammatory activities. Undecane inhibits degranulation and the secretion of histamine and TNF-α. Undecane reverses the increased levels of p38 phosphorylation, NF-κB transcriptional activity and target cytokine/chemokine genes, including thymus and activation-regulated chemokine (TARC), macrophage-derived chemokine (MDC) and interleukin-8 (IL-8). Undecane can be used for the study of skin inflammatory disorders, such as atopic dermatitis .
    Undecane (Standard)
  • HY-N8593S
    Undecane-d24

    		Isotope-Labeled Compounds PKA Histamine Receptor p38 MAPK NF-κB TNF Receptor Interleukin Related Inflammation/Immunology Endocrinology
    Undecane-d24 is the deuterium labeled Undecane (HY-N8593).Undecane is a potent cAMP agonist with anti-allergic and anti-inflammatory activities. Undecane inhibits degranulation and the secretion of histamine and TNF-α. Undecane reverses the increased levels of p38 phosphorylation, NF-κB transcriptional activity and target cytokine/chemokine genes, including thymus and activation-regulated chemokine (TARC), macrophage-derived chemokine (MDC) and interleukin-8 (IL-8). Undecane can be used for the study of skin inflammatory disorders, such as atopic dermatitis .
    Undecane-d24
  • HY-N8501
    Emestrin

    		Bacterial Infection
    Emestrin is a mycotoxin originally isolated from E. striata that has antimicrobial, immunomodulatory, and cytotoxic activities. It is active against the fungi C. albicans and C. neoformans, as well as the bacteria E. coli, S. aureus, and methicillin-resistant S. aureus (MRSA; IC50s=3.94, 0.6, 2.21, 4.55, and 2.21 μg/mL, respectively).2 Emestrin is a chemokine (C-C motif) receptor 2 (CCR2) antagonist (IC50=5.4 μM in a radioligand binding assay using isolated human monocytes).3 Emestrin (0.1 μg/mL) induces apoptosis in HL-60 cells. It induces heart, thymus, and liver tissue necrosis in mice when administered at doses ranging from 18 to 30 mg/kg.
    Emestrin
  • HY-185452
    N4-Acetyldeoxycytidine triphosphate

    		Drug Intermediate Others
    N4-Acetyldeoxycytidine triphosphate is a terminal deoxynucleotidyl transferase substrate. N4-Acetyldeoxycytidine triphosphate acts as a substrate for calf thymus terminal deoxynucleotidyl transferase and undergoes polymerization to form extended polydeoxynucleotide chains .
    N4-Acetyldeoxycytidine triphosphate
  • HY-N17505
    (1S,2R,4S)-Borneol β-D-glucopyranoside

    		Others Others
    (1S,2R,4S)-Borneol β-D-glucopyranoside (Compound 10) is a monoterpenoid glucoside.(1S,2R,4S)-Borneol β-D-glucopyranoside can be found in the leaf of Thymus vulgaris .
    (1S,2R,4S)-Borneol β-D-glucopyranoside
  • HY-181519
    ALR2/α-GLY-IN-1

    		DNA Alkylator/Crosslinker Aldose Reductase Glycosidase Metabolic Disease Inflammation/Immunology
    ALR2/α-GLY-IN-1 is a potent dual-target inhibitor that targets aldose reductase ALR2 and α-glucosidase (IC50 values are 0.72 μM and 0.82 μM, respectively; Ki values are 1.67 μM and 1.37 μM, respectively). ALR2/α-GLY-IN-1 also acts as a DNA binder, which stably interacts with calf thymus double-stranded DNA through non-covalent interactions such as groove-binding mode and water-bridged hydrogen bonds. ALR2/α-GLY-IN-1 can be used in studies related to diabetes and its complications .
    ALR2/α-GLY-IN-1
  • HY-N17549
    9-Acetoxythymol

    		Drug Derivative Others
    9-Acetoxythymol is a natural product that can be found in Thymus mongolicus?(Ronniger)?.
    9-Acetoxythymol
  • HY-182945
    IKZF2-degrader 5

    		Molecular Glues IKZF Family HOXA Interleukin Related NF-κB Cancer
    IKZF2-degrader 5 is a highly efficient, highly selective, rapidly acting, and orally active IKZF2 molecular glue degrader. IKZF2-degrader 5 induces IKZF2 degradation via the Cullin-CRBN-dependent pathway. IKZF2-degrader 5 promotes the production of pro-inflammatory IL-2. IKZF2-degrader 5 attenuates the immunosuppressive function of regulatory T cells (Tregs). IKZF2-degrader 5 triggers rapid, significant, and sustained IKZF2 degradation in the spleen and thymus of mice. IKZF2-degrader 5 inhibits tumor growth. IKZF2-degrader 5 can be used for the research of B16F melanoma .
    IKZF2-degrader 5
  • HY-119050
    Anti-inflammatory agent 87

    		CCR Inflammation/Immunology
    Anti-inflammatory agent 87 (compound 72) is a potential anti-inflammatory agent, whose precursor is an inhibitor targeting the binding of thymus and activation-regulated chemokine (TARC/CCL17) to Hut78 cells. Anti-inflammatory agent 87 can be used in the research of allergic diseases, autoimmune diseases, transplant rejection and other conditions .
    Anti-inflammatory agent 87
  • HY-N2062
    10-Nitrocamptothecin

    		Topoisomerase Cancer
    10-Nitrocamptothecin is a topoisomerase I inhibitor with an IC50 of 0.64 μM. 10-Nitrocamptothecin interferes with the formation of cleavable complexes, thereby inhibiting the activity of Topoisomerase I. 10-Nitrocamptothecin is applicable for cancer research .
    10-Nitrocamptothecin

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