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Cat. No.: HY-181976

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dHTC3

dHTC3 is a selective BRD4 molecular glue degrader. dHTC3 selectively binds to BRD4 BD1 to form a BRD4-dHTC3 complex, which cooperatively recruits the SCF^FBXO3 E3 ubiquitin ligase and mediates the degradation of BRD4 via the ubiquitin-proteasome pathway. dHTC3 induces proteasome- and CRL-dependent BRD4 degradation with no hook effect. dHTC3 can be used in related research on acute myeloid leukemia.

For research use only. We do not sell to patients.

Formula: C₃₁H₄₂N₆O₄S₂
Molecular Weight:626.83

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Please store the product under the recommended conditions in the Certificate of Analysis.

dHTC3 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
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Biological Activity

Description

IC₅₀ & Target

^[1]

BRD4 (BD1)

All Epigenetic Reader Domain Isoforms :

In Vitro

dHTC3 (1 nM-100 μM; 12-16 h) degrades BRD4 in MV4;11 BRD4-HiBiT cells, and pretreatment with JQ1 (HY-13030), MLN4924 (HY-70062), and Carfilzomib (HY-10455) blocks this degradation^[1].
dHTC3 does not exhibit the hook effect in both BRD4 degradation and ternary complex formation assays^[1].
dHTC3 (1 nM-100 μM; 1-16 h) selectively degrades BRD4 in MV4;11, HEK293T and NALM6 cells via SCF^FBXO3 mediation, and its degradation activity is completely abolished after FBXO3 knockout^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 626.83
Formula C₃₁H₄₂N₆O₄S₂
SMILES

O=C(OC(C)(C)C)C[C@H]1C2=NN=C(C)N2C3=C(C(C)=C(C)S3)C(C4=CC=C(NS(=O)(NCC5C(CC)(CC)C5)=O)C=C4)=N1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Shaum J B, et al. High-throughput ligand diversification to discover chemical inducers of proximity[J]. Nature chemical biology, 2026: 1-13.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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dHTC3

All Epigenetic Reader Domain Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

dHTC3 Related Classifications

HY-181976 Related Classifications

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