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STO-609

37 Cited Publications
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Based on 37 publication(s) in Google Scholar

STO-609 is a selective and cell-permeable inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK), with Ki values of 80 and 15 ng/mL for recombinant CaM-KKα and CaM-KKβ, respectively. STO-609 inhibits AMP-activated protein kinase kinase (AMPKK) activity in HeLa cell lysates with an IC50 ~0.02 g/ml.

For research use only. We do not sell to patients.

  • Purity: 98.20%
  • CAS No.: 52029-86-4
  • Formula: C19H10N2O3
  • Molecular Weight:314.29
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • STO-609 Chemical Structure
    STO-609 Chemical Structure
  • Experimental Validation Results for STO-609
  • Experimental Validation Results for STO-609
  • Experimental Validation Results for STO-609
  • Experimental Validation Results for STO-609
  • Experimental Validation Results for STO-609
CAS No.: 52029-86-4
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • STO-609 Chemical Structure
    STO-609 Chemical Structure
    1/16
  • 1/16

    STO-609 purchased from MedChemExpress. Usage Cited in: Nat Aging. 2025 Jun;5(6):1097-1113. [Abstract]

    Customer Validation
     Primary WT mouse neurons were treated with exendin-4 with or without STO-609, a CaMKK2 inhibitor. STO-609 significantly attenuated the effect of exendin-4 on AMPK phosphorylation.

  • 1/16

    STO-609 purchased from MedChemExpress. Usage Cited in: Nat Metab. 2022 Sep;4(9):1185-1201. [Abstract]

    Customer Validation
     Mouse primary hepatocytes were incubated with 13C acetate (1 mM) containing vehicle control (PBS), ORM2 (100 ng ml−1) and STO-609 (5 μM) for 6 h. STO-609 markedly abolished suppression of DNL rate by ORM2 in primary hepatocytes from C57BL/6J healthy mice.

  • 1/16

    STO-609 purchased from MedChemExpress. Usage Cited in: Nat Metab. 2022 Sep;4(9):1185-1201. [Abstract]

    Customer Validation
     MPHs were pre-incubated with palmitic acid (200 μM) for 12 hr, and then treated with ORM2 protein (100 ng/ml) or vehicle control (PBS) for 6 h, in the presence or absence of STO-609 (5 μM). STO-609 largely blocked the inhibitory effects of ORM2 on cellular TG accumulation and lipogenic gene expression.

  • 1/16

    STO-609 purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2021 Jan 25;6(1):29. [Abstract]

    Customer Validation
     Cells were pretreated with STO-609 (10 μM; 1 h) followed by exposure to NM (20 μM) for an additional 24 h. STO-609 markedly inhibited NM-induced AMPK and ULK1 activation.

  • 1/16

    STO-609 purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2021 Jan 25;6(1):29. [Abstract]

    Customer Validation
     Cells were treated with STO-609 (10 µM; 1 h) following the addition of NM (20 µM) for another 24 h. Total cell lysates were collected and the levels of indicated proteins were detected by western blotting. STO-609 treatment markedly inhibited NM-induced ULK1 activation and autophagy induction but had no obvious effect on NM-induced pmTOR expression in keratinocytes.

  • STO-609