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  3. ZEN-3862

ZEN-3862 is a BET inhibitor with IC50s of 0.16 and 0.13 μM for BRD4(BD1) and BRD4(BD2) , respectively. ZEN-3862 can be used to form PROTACs to induce degradation of BRD4.

For research use only. We do not sell to patients.

ZEN-3862 Chemical Structure

ZEN-3862 Chemical Structure

CAS No. : 1952264-33-3

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1 mg USD 120 In-stock
5 mg USD 280 In-stock
10 mg USD 430 In-stock
25 mg USD 760 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

ZEN-3862 is a BET inhibitor with IC50s of 0.16 and 0.13 μM for BRD4(BD1) and BRD4(BD2) , respectively. ZEN-3862 can be used to form PROTACs to induce degradation of BRD4[1].

IC50 & Target[1]

BRD4 (BD1)

0.16 μM (IC50)

BRD4 (BD2)

0.13 μM (IC50)

Molecular Weight

340.35

Formula

C19H17FN2O3

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C=CC(C1=C(C)ON=C1C)=C2)N2CC3=CC(F)=C(C4OC4)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (244.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9382 mL 14.6908 mL 29.3815 mL
5 mM 0.5876 mL 2.9382 mL 5.8763 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9382 mL 14.6908 mL 29.3815 mL 73.4538 mL
5 mM 0.5876 mL 2.9382 mL 5.8763 mL 14.6908 mL
10 mM 0.2938 mL 1.4691 mL 2.9382 mL 7.3454 mL
15 mM 0.1959 mL 0.9794 mL 1.9588 mL 4.8969 mL
20 mM 0.1469 mL 0.7345 mL 1.4691 mL 3.6727 mL
25 mM 0.1175 mL 0.5876 mL 1.1753 mL 2.9382 mL
30 mM 0.0979 mL 0.4897 mL 0.9794 mL 2.4485 mL
40 mM 0.0735 mL 0.3673 mL 0.7345 mL 1.8363 mL
50 mM 0.0588 mL 0.2938 mL 0.5876 mL 1.4691 mL
60 mM 0.0490 mL 0.2448 mL 0.4897 mL 1.2242 mL
80 mM 0.0367 mL 0.1836 mL 0.3673 mL 0.9182 mL
100 mM 0.0294 mL 0.1469 mL 0.2938 mL 0.7345 mL
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ZEN-3862 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
ZEN-3862
Cat. No.:
HY-111978
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