2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-173213
    Antileishmanial agent-33 98%
    Antileishmanial agent-33 (4e), a hybrid compound of grandisin and machilin G, shows moderate activity on promastigotes (IC50 of 38.1 μM). Antileishmanial agent-33 (4e) shows potential as an antileishmanial agent for the research of cutaneous leishmaniasis (CL).
    Antileishmanial agent-33
  • HY-173219
    SrtA-IN-1 98%
    SrtA-IN-1 (Compound T10) is an inhibitor of Streptococcus pyogenes sortase A (SpSrtA), with an IC50 value of 0.7 μM. SrtA-IN-1 can be used in the research of the anti-infection field.
    SrtA-IN-1
  • HY-173225
    MRSA/VRE-IN-1 98%
    MRSA/VRE-IN-1 (Compound 3e) is an inhibitor against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE). The MIC/MBC of MRSA/VRE-IN-1 against VRE is 3.6/7.3 µM, and against MRSA is 7.3/14.6 µM. MRSA/VRE-IN-1 can be used in the research of the anti-infection field.
    MRSA/VRE-IN-1
  • HY-173238
    Antibacterial agent 273 98%
    Antibacterial Agent 273 (Compound 15e) is a membrane-targeting antimicrobial agent that disrupts bacterial cell membranes, exhibiting a MIC of 4 μg/mL against Staphylococcus aureus. By compromising membrane integrity, it induces leakage of intracellular nucleic acids and proteins, suppresses bacterial metabolic activity, and triggers the accumulation of reactive oxygen species (ROS). Antibacterial Agent 273 is suitable for research on infections caused by Staphylococcus aureus.
    Antibacterial agent 273
  • HY-173239
    Antibacterial agent 274 98%
    Antibacterial agent 274 (Compound 18b) is a membrane-targeting antibacterial agent that demonstrates a MIC of 8 μg/mL against Acinetobacter baumannii ATCC 17978. By disrupting bacterial membrane integrity, it induces intracellular ROS accumulation and causes leakage of DNA and proteins, thereby exhibiting potent antibacterial activity. This compound is suitable for research applications targeting Gram-negative bacterial infections.
    Antibacterial agent 274
  • HY-173240
    IPMCL-28b 98%
    IPMCL-28b is an antibacterial agent targeting the bacterial cell membrane. Its minimum inhibitory concentration (MIC) against Staphylococcus aureus ATCC 25923 is 1.56 μg/mL, and the MIC against methicillin-resistant Staphylococcus aureus (MRSA) is 6.25 μg/mL. IPMCL-28b is expected to be used in the research of the anti-infection field.
    IPMCL-28b
  • HY-173254
    MurA-IN-6 333740-13-9 98%
    MurA-IN-6 (Compound L16) is a selective MurA inhibitor with an IC50 value of 26.63 μM. MurA-IN-6 exerts antibacterial activity by blocking the activity of MurA, which is crucial in bacterial cell wall synthesis.
    MurA-IN-6
  • HY-173264
    SDH-IN-24 98%
    SDH-IN-24 (Compound 51) is an inhibitor of succinate dehydrogenase (SDH). The LC50 against the second-stage juveniles of Bursaphelenchus xylophilus (B. xylophilus) is 6.9 mg/L, and the IC50 for SDH is 15.0 μM. SDH-IN-24 exerts its nematicidal activity by inhibiting the activity of SDH to interfere with the energy metabolism of nematodes. Meanwhile, it inhibits the motility, feeding, and reproduction of nematodes, induces oxidative stress, reduces the protein content of nematodes, and impairs their antioxidant capacity. SDH-IN-24 can be used in the research related to anti-nematode fields.
    SDH-IN-24
  • HY-173270
    Antibacterial synergist 3 98%
    Antibacterial synergist 3 is a dual-acting inhibitor of biofilm (IC50 of PAO1: 0.40 μM and IC50 of PA14: 1.45 μM). Antibacterial synergist 3 reduces virulence production by inhibiting the quorum sensing (QS) system and induces iron deficiency in P. aeruginosa PAO1. Antibacterial synergist 3 enhances the efficacy of Tobramycin (HY-B0441) and Ciprofloxacin (HY-B0356) in a mouse wound infection model. Antibacterial synergist 3 can be used for the research of P. aeruginosa infections.
    Antibacterial synergist 3
  • HY-173277
    FtsZ-IN-13 914357-88-3 98%
    FtsZ-IN-13 (Compound C11) is an inhibitor of temperature-sensitive mutant Z (FtsZ), with IC50 values of 47.97, 34 μM against FtsZSa and FtsZPa, respectively. FtsZ-IN-13 has a notable antimicrobial activity against S. aureus (minimum inhibitory concentration value of 2 μg/mL), cystic fibrosis S. aureus clinical isolates, and methicillin-resistant S. aureus (MRSA) strains. FtsZ-IN-13 can be used for antimicrobial resistance study.
    FtsZ-IN-13
  • HY-173278
    AIC263282 98%
    AIC263282 is a potent Hepatitis B Virus (HBV) capsid assembly modulator with an EC50 of 3.8 nM. AIC263282 shows an IC50 of 61 nM for hERG. AIC263282 exhibits activity against viral replication and hepatitis B surface antigen (HBsAG) on primary human hepatocytes.
    AIC263282
  • HY-173283
    Antifungal agent 129 98%
    Antifungal agent 129 (Compound 4g) is an inhibitor targeting Rhizoctonia solani, with an EC50 value of 4.27 mg/L. It has a good control effect against rice sheath blight in in vitro and in vivo experiments. Preliminary exploration through scanning electron microscopy, molecular docking, enzyme activity determination, and cytotoxicity experiments has revealed that Antifungal agent 129 may exert its inhibitory activity by affecting the cell structure or physiological processes of Rhizoctonia solani. Antifungal agent 129 can be used in the research of plant diseases in the agricultural field, such as rice sheath blight, which are caused by Rhizoctonia solani.
    Antifungal agent 129
  • HY-173285
    SARS-CoV-2 Mpro-IN-38 98%
    SARS-CoV-2 Mpro-IN-38 (2-5a) is a SARS-CoV‑2 Mpro inhibitor, with an IC50 of 0.0435 μM.
    SARS-CoV-2 Mpro-IN-38
  • HY-173305
    Mpro/PLPro-IN-2 98%
    Mpro/PLPro-IN-2 (Compound 22l) is a non-covalent competitive dual inhibitor of the papain-like protease and main protease of SARS-CoV-2, with a Ki of 0.2 μM for the papain-like protease and a Ki of 1.1 μM for the main protease. Mpro/PLPro-IN-2 can be used in the research field of anti-SARS-CoV-2.
    Mpro/PLPro-IN-2
  • HY-173312
    Antimalarial agent 49 98%
    Antimalarial agent 49 is an orally active antimalarial compound. Antimalarial agent 49 inhibits growth of Pf3D7 and PfK1 strains (IC50: 0.84 μM and 0.4 μM respectively). Antimalarial agent 49 has antimalarial activity and inhibits the development of P. berghei liver stages. Antimalarial agent 49 can be used in the study of Plasmodium infection.
    Antimalarial agent 49
  • HY-173318
    Anti-MRSA agent 25 98%
    Anti-MRSA agent 25 (Compound 10c) is an antibacterial agent with a MIC of 0.25 μg/mL against methicillin-resistant Staphylococcus aureus (MRSA). Anti-MRSA agent 25 exerts its antibacterial activity by inhibiting biofilm formation, disrupting the cell wall (interacting with peptidoglycan and lipoteichoic acids), acting on the cell membrane (causing depolarization, increasing permeability, and disrupting integrity), reducing metabolic activity, interfering with cellular redox homeostasis, and binding to DNA. Anti-MRSA agent 25 is expected to be used in the research of the anti-infection field.
    Anti-MRSA agent 25
  • HY-173335
    PLA2-IN-1 98%
    PLA2-IN-1 (Compound 7) is a potent and selective inhibitor of phospholipase A2 (PLA2) with an IC50 value of 1 nM PLA2-IN-1 inhibits PLA2-induced coagulopathy in vitro. PLA2-IN-1 is promising for research of snakebite envenomation caused by cobra venom.
    PLA2-IN-1
  • HY-173338
    MSRV-IN-1 1438403-50-9 98%
    MSRV-IN-1 (Compound M3) is an inhibitor targeting aquatic rhabdoviruses (such as MSRV, SVCV and IHNV). Its IC50 values for inhibiting MSRV, SVCV and IHNV are 0.92 μM, 2.92 μM and 2.78 μM respectively. MSRV-IN-1 does not act directly on the virions but rather inhibits viral replication by altering the cell cycle arrest state in the S phase induced by the virus and disrupting the viral replication environment. When administered intraperitoneally at a dose of 20 mg/kg, MSRV-IN-1 can significantly increase the survival rate of largemouth bass infected with MSRV by 35.98% and reduce the viral loads in the liver, spleen and kidney. MSRV-IN-1 can be used in the research of diseases related to rhabdoviruses in aquaculture.
    MSRV-IN-1
  • HY-173342
    Neocryptolepine-Cl 1150313-15-7 98%
    Neocryptolepine-Cl (compound Z24) is an inhibitor of Bcthi4 and exhibits excellent antifungal activity against B. cinerea with EC50 value of 0.56 μg/mL.
    Neocryptolepine-Cl
  • HY-173354
    hDHODH-IN-17 98%
    hDHODH-IN-17 (Compound 10) is a human dihydroorotate dehydrogenase (hDHODH) inhibitor, with an IC50 of 0.188 μM. hDHODH-IN-17 is in good agreement with the hDHODH activity pocket and interacted well with amino acid residues. hDHODH-IN-17 is the potential broad-spectrum antiviral agent.
    hDHODH-IN-17
Cat. No. Product Name / Synonyms Application Reactivity