2. シグナル伝達
  3. Apoptosis
  4. Apoptosis

Apoptosis

Apoptosis

Apoptosis

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Apoptosis is a distinctive form of cell death exhibiting specific morphological and biochemical characteristics, including cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and exposure of specific phagocytosis signaling molecules on the cell surface. Cells undergoing apoptosis differ from those dying through necrosis. Necrotic cells are usually recognized by the immune system as a danger signal and, thus, resulting in inflammation; in contrast, apoptotic death is quiet and orderly.

There are two major pathways of apoptotic cell death induction: The intrinsic pathway, also called the Bcl-2-regulated or mitochondrial pathway, is activated by various developmental cues or cytotoxic insults, such as viral infection, DNA damage and growth-factor deprivation, and is strictly controlled by the BCL-2 family of proteins. The extrinsic or death-receptor pathway is triggered by ligation of death receptors (members of the tumor necrosis factor (TNF) receptor family, such as Fas or TNF receptor-1 (TNFR1)) that contain an intracellular death domain, which can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface. This recruitment causes subsequent activation of downstream (effector) caspases, such as caspase-3, -6 or -7, without any involvement of the BCL-2 family.

Studies suggest that alterations in cell survival contribute to the pathogenesis of a number of human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome). Treatments designed to specifically alter the apoptotic threshold may have the potential to change the natural progression of some of these diseases.

製品番号 製品名 製品効果 純度 構造式
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    S116836 Inducer 99.78%
    S116836, a potent, orally active BCR-ABL tyrosine kinase inhibitor, blocks both wild-type as well as T315I Bcr-Abl. S116836 arrests the cells in the G0/G1 phase of cell cycle, induces apoptosis, increases ROS production, and decreases GSH production in BaF3/WT and BaF3/T315I cells. S116836 also inhibits SRC, LYN, HCK, LCK and BLK, and receptor tyrosine kinases such as FLT3, TIE2, KIT, PDGFR-β. Antitumor activies. S116836 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    S116836
  • HY-129746
    Arylquin 1 Inducer 99.7%
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    Arylquin 1
  • HY-B0318S
    Metronidazole-13C2,15N2 Inducer 99.30%
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    Metronidazole-<sup>13</sup>C<sub>2</sub>,<sup>15</sup>N<sub>2</sub>
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    L-Glutamic acid-13C5,15N,d5 Inducer 99.9%
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    L-Glutamic acid-<sup>13</sup>C<sub>5</sub>,<sup>15</sup>N,d<sub>5</sub>
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    Cobimetinib-d<sub>4</sub> hydrochloride
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    LD-110 triTFA Inducer 99.56%
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    LD-110 triTFA
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    Flavagline FL3 Inducer 99.90%
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    Flavagline FL3
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    Olanzapine (Standard)
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    RSM3 TFA Inducer 98.83%
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    RSM3 TFA
  • HY-151939
    BLM-IN-2 Inducer
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    BLM-IN-2
  • HY-18952A
    (Z)-SU5614

    (Z)-SU5614

    		Inducer 98.09%
    (Z)-SU5614 is a potent FLT3 inhibitor and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3.
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    DMUP Inducer 98.0%
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    DMUP
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    Fascaplysin Inducer
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    Fascaplysin
  • HY-126193
    JS-K

    JS-K

    		Inducer 99.59%
    JS-K is a NO donor that reacts with glutathione to generate NO at physiological pH. JS-K induces reactive oxygen species (ROS) to mediate apoptosis. JS-K induces autophagy. JS-K inhibits invasion. JS-K has a broad spectrum anti-proliferative activity in cancer cells. JS-K reduces tumor volume and causes necrosis of implanted tumors in mice.
    JS-K
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    Diffractaic acid Activator 99.58%
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    Diffractaic acid
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    SZU-B6 Inducer 98.78%
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    SZU-B6
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    T7 Peptide TFA Inducer 98.20%
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    XPO1-IN-1
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    Benzyl salicylate-d4 Inhibitor 99.01%
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    Benzyl salicylate-d<sub>4</sub>
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    DP-15 Inducer 99.06%
    DP-15 is the degrader for GSPT1 and BRD4 with DC50s of 5.25 nM and 0.48 nM. DP-15 exhibits anti-proliferative activity of AML cells and NHL cells with an IC50 of nanomolar levels, arrests the cell cycle at G1 phase, and induces apoptosis in MOLM13. DP-15 exhibits anti-leukemia activity in MOLM-13 xenograft mouse models. (Pink: ligand for target protein JQ-1 carboxylic acid (HY-78695); Black: linker (HY-W262798); Blue: ligand for E3 ligase Cereblon Thalidomide-5-OH (HY-23095))
    DP-15
製品番号 製品名 / Synonyms Application Reactivity