HSP
Heat shock proteins
HSP (Heat shock proteins) are a group of proteins induced by heat shock, the most prominent members of this group are a class of functionally related proteins involved in the folding and unfolding of other proteins. HSP expression is increased when cells are exposed to elevated temperatures or other stress. This increase in expression is transcriptionally regulated. The dramatic upregulation of the heat shock proteins is a key part of the heat shock response and is induced primarily by heat shock factor (HSF). HSPs are found in virtually all living organisms, from bacteria to humans. Heat shock proteins appear to serve a significant cardiovascular role. Hsp90, Hsp84, Hsp70, Hsp27, Hsp20 and alpha B crystallin all have been reported as having roles in the cardiovasculature.
HSP Isoform Specific Products
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HSP Inhibitors
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HSP Agonists
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HSP Antagonists
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HSP Activators
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HSP Modulators
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HSP Inducers
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HSP Degraders
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HSP Pre-designed Set
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HSP Controls
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HSP Ligands
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HSP Related Products (503)
Related Products (503)
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Antibodies (46)
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HSP Isoform Comparison
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Iroxanadine hydrochloride
0 ImagesCat. No.: HY-19399DCAS No.: 276690-59-6Synonyms: (-)-BRX 005 hydrochloride; (-)-BRX 235 hydrochlorideIroxanadine (BRX 005) hydrochloride is a vasculoprotector. Iroxanadine is a p38 kinase and HSP protein dual activator. Iroxanadine hydrochloride has the potential for atherosclerosis and vascular diseases research.
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Araloside C
0 ImagesAraloside C is a natural saponin that is mainly isolated from Aralia elata. Araloside C exerts extensive anti-inflammatory properties. Araloside C exhibits protective effects against myocardial ischaemia/reperfusion injury.
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SU086
0 ImagesCat. No.: HY-200492CAS No.: 1017898-53-1SU086 is a chalcone-derived HSP90 inhibitor. SU086 interacts with HSP90, reduces HSP90 protein levels, and suppresses glycolysis in prostate cancer cells. SU086 can be used in research related to advanced prostate cancer and castration-resistant prostate cancer (CRPC).
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STA-1474 sodium
0 ImagesCat. No.: HY-13752BCAS No.: 1402907-09-8STA-1474 sodium is an orally active and highly selective HSP90 inhibitor, as well as a phosphate prodrug of the HSP90 inhibitor STA-9090 (HY-15205). STA-1474 sodium disrupts the chaperone function of HSP90 and promotes the degradation of client proteins. STA-1474 sodium inhibits the phosphorylation of Met, Akt and STAT3, thereby blocking related signaling pathways. STA-1474 sodium induces apoptosis and inhibits proliferation of osteosarcoma cells, and triggers the up-regulation of HSP70 and HSP90. STA-1474 sodium induces tumor regression and caspase-3 activation in mouse osteosarcoma xenograft models. STA-1474 sodium can be used in the research of osteosarcoma.
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Tamoxifen Citrate (Standard)
0 ImagesSynonyms: ICI 46474 (Standard); (Z)-Tamoxifen Citrate (Standard); trans-Tamoxifen Citrate (Standard)Tamoxifen (Citrate) (Standard) is the analytical standard of Tamoxifen (Citrate). This product is intended for research and analytical applications. Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells.Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively. Tamoxifen Citrate activates autophagy and induces apoptosis.Tamoxifen Citrate also can induce gene knockout of CreER(T2) transgenic mouse.
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Pochonin D
0 ImagesCat. No.: HY-N14780CAS No.: 544712-82-5Synonyms: (+)-Pochonin DPochonin D ((+)-Pochonin D) is an inhibitor of heat shock protein 90 (Hsp90) with antiviral and anti-inflammatory activities. Pochonin D inhibits Hsp90, affects the homeostasis, folding and assembly processes of viral proteins, and reduces the replication capacity of viruses. Pochonin D is a copper ion carrier that can induce cuproptosis in triple-negative breast cancer cells by targeting PRDX1. Pochonin D reduces the infiltration of inflammatory cells, decreases the secretion of inflammatory cytokines such as TNF-α and IL-1β, and alleviates inflammatory responses. Pochonin D is a promising candidate for research on human rhinovirus (HRV) infection and cancer.
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CCT251236 (Standard)
0 ImagesCCT251236 (Standard) is the analytical standard of CCT251236 (HY-101026). This product is intended for research and analytical applications. CCT251236 is an orally available pirin ligand from a heat shock transcription factor 1 (hsf1) phenotypic screen with an IC50 of 19 nM for inhibition of HSF1-mediated HSP72 induction.
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EG36
0 ImagesCat. No.: HY-181810CAS No.: 2215779-34-1EG36 is a selective E. coli DnaK inhibitor that inhibits DnaK ATPase activity at a concentration of 100 μM. EG36 directly binds to the nucleotide-binding domain (NBD) of E. coli DnaK by disrupting the DnaK-DnaJ interaction. EG36 can be used for research on bacterial infectious diseases.
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HSP70-IN-5
0 ImagesCat. No.: HY-160145CAS No.: 302948-38-5HSP70-IN-5 is a HSP70 inhibitor. HSP70-IN-5 exhibits IC₅₀ value for HSP70/DnaJ-mediated luciferase reconstitution of 0.6 μM. HSP70-IN-5 can be used as a biochemical probe to study the role of HSP70/DnaJ in various biological processes.
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19-epi-Scholaricine
0 Images19-epi-Scholaricine is an orally active indole alkaloid. 19-epi-Scholaricine downregulates the expression of profibrotic/apoptotic proteins (HRAS, HSP90AA1, KDR) and upregulates the expression of cell cycle-related protein (CDK2). 19-epi-Scholaricine suppresses ROS production and reduces the release of inflammatory mediators, thereby attenuating podocyte apoptosis, renal inflammation and oxidative stress by inhibiting AKT/mTOR. 19-epi-Scholaricine can be used in the research of chronic glomerulonephritis and membranous nephropathy.
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Caesappanin C
0 ImagesCaesappanin C, a biphenyl dimer from the ethanolic extract of the heartwood of Indonesian Caesalpinia sappan L., shows strong proliferation stimulating activity against the primary osteoblastic cells in vitro. Caesappanin C has the potential to stimulate bone formation and regeneration. Caesappanin C can effectively deactivate HSV particles and bind HSV surface glycoprotein B (gB) to inhibit membrane fusion.
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Hsp90-IN-34
0 ImagesCat. No.: HY-167827CAS No.: 439588-33-7
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CYP51/Hsp90-IN-1
0 ImagesCat. No.: HY-170816CYP51/Hsp90-IN-1 (Compound MM4) is a dual CYP51/Hsp90 inhibitor. CYP51/Hsp90-IN-1 shows antifungal activity against Candida albicans and effectively inhibits important fungal virulence factors. CYP51/Hsp90-IN-1 is promising for research of invasive candidiasis.
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ML189
0 ImagesCat. No.: HY-127179CAS No.: 337328-21-9ML189 is an HSP90 inhibitor. ML189 can be used in the research of infectious diseases such as candidiasis.
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DCZ3112
0 ImagesCat. No.: HY-187653CAS No.: 2556837-25-1DCZ3112 is a Hsp90/Cdc37 protein-protein interaction inhibitor, with a Kd value of 4.98 µM against human Hsp90. DCZ3112 binds to the N-terminal domain of Hsp90, disrupts the Hsp90-Cdc37 interaction, and does not inhibit the ATPase activity of Hsp90. DCZ3112 induces G1 phase cell cycle arrest, apoptosis, reduces the phosphorylation levels of AKT and ERK, and inhibits the proliferation of HER2-positive breast cancer cells. DCZ3112 can be used in breast cancer-related research.
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Derrubone
0 ImagesCat. No.: HY-187645CAS No.: 22044-58-2Derrubone is a prenylated isoflavone Hsp90 inhibitor that binds to the C-terminal ATP site of Hsp90α, stabilizes the Hsp90-client protein co-chaperone complex, and induces client protein degradation, thereby inhibiting cancer cell proliferation. Derrubone can be used for research on breast cancer, colon cancer, Alzheimer's disease, and type 2 diabetes.
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SNX-2112 (Standard)
0 ImagesCat. No.: HY-10214RCAS No.: 908112-43-6Synonyms: PF-04928473 (Standard)SNX-2112 (Standard) is the analytical standard of SNX-2112 (HY-10214). This product is intended for research and analytical applications. SNX-2112 (PF 04928473) is an orally active Hsp90 inhibitor, with a Kd of 16 nM for Hsp90 and IC50s of 30 nM, 30 nM for Hsp90 α and Hsp90 β, also induces Her-2 degradation, and inhibits Grp94 and Trap-1, with IC50s of 10 nM, 4.275 μM and 0.862 μM, respectively. SNX-2112 (PF 04928473) binds Hsp90 isoforms Hsp90α, Hsp90β and Hsp90b1/Grp94 with Kds of 4 nM, 6 nM and 484 nM, respectively.
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BIIB021 (Standard)
0 ImagesCat. No.: HY-10212RCAS No.: 848695-25-0Synonyms: CNF2024 (Standard)BIIB021 (Standard) is the analytical standard of BIIB021. This product is intended for research and analytical applications. BIIB021 (CNF2024) is an orally active, fully synthetic inhibitor of HSP90 with a Ki and an EC50 of 1.7 nM and 38 nM, respectively.
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KNK437 (Standard)
0 ImagesSynonyms: Heat Shock Protein Inhibitor I (Standard)
