LXR
Liver X receptor
LXRs (Liver X Receptor α and β) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors. LXRs are oxysterol-activated transcription factors that upregulate a suite of genes that together promote coordinated mobilization of excess cholesterol from cells and from the body. The LXRs, like other nuclear receptors, are anti-inflammatory, inhibiting signal-dependent induction of pro-inflammatory genes by nuclear factor-κB, activating protein-1, and other transcription factors.
LXRα is expressed predominately in some tissues, including the liver, kidney, macrophages, and adipose tissue. However, LXRβ is ubiquitously expressed. Activating LXRα (mainly expressed in liver) results in high triglyceride production, and growing evidence suggests that selective LXRβ agonists can reduce this side effect.
All Product Categories
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LXR Related Products (92)
Related Products (92)
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Antibodies (1)
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Lipophagy inducer 1
0 ImagesCat. No.: HY-176236Lipophagy inducer 1 is a lipophagy inducer. Lipophagy inducer 1 has activity of reducing lipid droplet accumulation and rescuing cell death. Lipophagy inducer 1 exerts its effects by activating lipophagy, increasing steady-state autophagosome and regulating the LXR signaling pathway. Lipophagy inducer 1 can be used in the study of diabetic nephropathy (DKD) and other diseases related to lipid metabolism disorders.
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(20S)-Protopanaxatriol (Standard)
0 ImagesSynonyms: 20(S)-APPT (Standard); g-PPT (Standard)(20S)-Protopanaxatriol (Standard) is the analytical standard of (20S)-Protopanaxatriol. This product is intended for research and analytical applications. (20S)-Protopanaxatriol is a metabolite of ginsenoside. (20S)-Protopanaxatriol works through the glucocorticoid receptor (GR) and estrogen receptor (ER), and is also a LXRα inhibitor. (20S)-Protopanaxatriol shows a broad spectrum of antitumor effects.
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LXRβ agonist-2
0 ImagesCat. No.: HY-100469CAS No.: 1949801-52-8LXRβ agonist-2 is an orally active and selective LXRβ agonist. LXRβ agonist-2 increases high-density lipoprotein cholesterol levels without elevating plasma triglyceride levels. LXRβ agonist-2 decreases lipid accumulation area in the aortic arch. LXRβ agonist-2 can be used for the research of atherosclerosis.
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NR1H2 Human Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS09529NR1H2 Human Pre-designed siRNA Set A contains three designed siRNAs for NR1H2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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E17110
0 ImagesCat. No.: HY-115780CAS No.: 1090785-30-0E17110 is a liver X receptor β (LXRβ) agonist with an EC50 of 0.72 μM. E17110 can increase the expression of ATP-binding cassette transporter A1 (ABCA1) and G1 (ABCG1) in RAW264.7 macrophages. E17110 also reduce cellular lipid accumulation and promoted cholesterol efflux. E17110 can be used for the research of cardiovascular disease, such as atherosclerosis.
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LXRα agonist 1
0 ImagesCat. No.: HY-173393CAS No.: 1790089-97-2LXRα agonist 1 is a selective LXRα agonist, with EC50 values of 42 nM and 266 nM against purified LXRα and LXRβ, respectively. LXRα agonist 1 acts as a lipotoxicity inducer, triggering the production of toxic saturated fatty acids in tumor cells, and induces lipotoxicity-mediated cancer cell death when combined with the Raf inhibitor Sorafenib (HY-10201). LXRα agonist 1 can be used in the research of hepatocellular carcinoma.
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TFCA
0 ImagesCat. No.: HY-134969CAS No.: 895700-18-2TFCA is a liver X receptor α (LXRα) antagonist. TFCA inhibits ligand-activated LXRα coactivation and transcriptional expression of the downstream target genes involved in fatty acid synthesis. TFCA attenuates ligand-induced lipogenesis and fatty liver by selectively inhibiting LXRα in the liver.
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UAB116
0 ImagesCat. No.: HY-177890CAS No.: 3031463-59-6UAB116 is a Liver X Receptor (LXR)/Retinoid X Receptor (RXR) agonist. UAB116 can decreases metastatic phenotype in hepatoblastoma by inhibiting the Wnt/β-Catenin pathway via upregulation of TRIM29. UAB116 can reduce proliferation, stemness and invasiveness of metastatic hepatoblastoma cells.
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LXR agonist 4
0 ImagesCat. No.: HY-179278LXR agonist 4 is a selective LXR inverse agonist with IC50 values of 7.6 (LXRα) and 2.9 μM (LXRβ), respectively. LXR agonist 4 exhibits selectivity over RORα and FXR. LXR agonist 4 robustly suppresses SREBP1c expression without altering ABCA1 or APOE. LXR agonist 4 displays antilipogenic properties and resolves fatty acid-induced steatosis. LXR agonist 4 can be used for the research of atherosclerosis and metabolic dysfunction-associated steatotic liver disease (MASLD).
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NR1H3 Human Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS09530NR1H3 Human Pre-designed siRNA Set A contains three designed siRNAs for NR1H3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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12R,13S-Dihydroxyfumitremorgin C
0 ImagesCat. No.: HY-N12619CAS No.: 111427-99-712R,13S-Dihydroxyfumitremorgin C (compound 1) is a LXRα agonist.
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LXRβ agonist-3
0 ImagesCat. No.: HY-146275CAS No.: 2416049-12-0LXRβ agonist-3 (compound 4-13) is a potent and selective LXRβ (liver X receptor β) agonist, with an EC50 of 0.095 μM. LXRβ agonist-3 efficiently inhibits U87EGFRvIII cell, with an IC50 of 3.75 μM. LXRβ agonist-3 shows antitumor activity, and can inhibit glioblastoma.
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25(S)-27-Hydroxy cholesterol
0 ImagesCat. No.: HY-139067CAS No.: 56845-83-125(S)-27-Hydroxy cholesterol is a metabolite of CYP27A1 mediated cholesterol hydroxylation. 25(S)-27-Hydroxy cholesterol inhibits melanoma cell proliferation.
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Saikosaponin A (Standard)
0 ImagesCat. No.: HY-N0246RCAS No.: 20736-09-8Saikosaponin A (Standard) is the analytical standard of Saikosaponin A. This product is intended for research and analytical applications. Saikosaponin A is the main active ingredient in Bupleurum chinense, which can regulate lipid metabolism and promote cholesterol efflux in early atherosclerosis. In addition, Saikosaponin A may also act as a potential peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist, significantly promoting the expression of PPAR-γ. Saikosaponin A can be used in the study of hyperlipidemic pancreatitis.
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27-Hydroxycholesterol (Standard)
0 ImagesCat. No.: HY-N2371RCAS No.: 20380-11-4Synonyms: 27-OHC (Standard)27-Hydroxycholesterol (27-OHC) is a selective estrogen receptor modulator and an agonist of the liver X receptor.
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24-Hydroxycholesterol (Standard)
0 ImagesCat. No.: HY-N2370RCAS No.: 30271-38-624-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors LXR.
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Ethyl 2,4,6-trihydroxybenzoate
0 ImagesCat. No.: HY-N3867CAS No.: 90536-74-6Synonyms: Benzoic acid, 2,4,6-trihydroxy-, ethyl esterEthyl 2,4,6-trihydroxybenzoate (Benzoic acid, 2,4,6-trihydroxy-, ethyl ester) is a Triterpenoids product that can be isolated from the herbs of Pueraria lobata.
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Larsucosterol ammonium
0 ImagesCat. No.: HY-139576CCAS No.: 2655654-16-1Synonyms: DUR-928 ammoniumLarsucosterol (DUR-928) ammonium, a cholesterol metabolite, is a potent liver X receptor (LXR) antagonist. Larsucosterol ammonium as a potent endogenous regulator decreases lipogenesis. Larsucosterol ammonium inhibits the cholesterol biosynthesis via decreasing mRNA levels and inhibiting the activation of SREBP-1.
