Potassium Channel
KcsA
Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly and selectively. Biologically, these channels act to set or reset the resting potential in many cells. In excitable cells, such asneurons, the delayed counterflow of potassium ions shapes the action potential. By contributing to the regulation of the action potential duration in cardiac muscle, malfunction of potassium channels may cause life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone.
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Potassium Channel Inhibitors
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Potassium Channel Agonists
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Potassium Channel Antagonists
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Potassium Channel Activators
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Potassium Channel Modulators
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Potassium Channel Chemical
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Potassium Channel Controls
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Potassium Channel Related Products (1155)
Related Products (1155)
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Antibodies (6)
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Related Compound Screening Libraries (1)
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(BrMT)2
0 ImagesCat. No.: HY-126106CAS No.: 622011-16-9(BrMT)2 (compound 2) is a non-peptide snail toxin that slows down the activation of Kv1.1 channels.
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Dequalinium Chloride (Standard)
0 ImagesDequalinium (Chloride) (Standard) is the analytical standard of Dequalinium (Chloride). This product is intended for research and analytical applications. Dequalinium chloride is an Apamin (HY-P0256)-sensitive potassium channel selective blocker. Dequalinium chloride is a cationic, lipophilic mitochondrial poison. Dequalinium chloride is also an antagonist pf α7 nAChR, and an anti-microbial antiseptic agent with a broad bactericidal and fungicidal activity.
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Flonicamid (Standard)
0 ImagesSynonyms: IKI220 (Standard)Flonicamid (Standard) (IKI220 (Standard)) is the analytical standard of Flonicamid (HY-119649). This product is intended for research and analytical applications. Flonicamid (IKI220) is an antifeedant Insecticide active against Hemiptera, Thysanoptera, and piercing-sucking pests including aphids of all species, developmental stages and morphs. Flonicamid inhibits the inward rectifier potassium channel NlKir1, blocking stylet penetration, salivation, sap feeding, honeydew secretion, and fluid secretion by isolated Malpighian tubules. Flonicamid reduces renal excretory function in female Culex pipiens pallens. Flonicamid rapidly disrupts insect feeding behavior without neurotoxic poisoning symptoms, induces irreversible starvation, and increases the mortality of nymph progeny of adult aphids exposed to this agent.
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Flecainide hydrochloride (Standard)
0 ImagesCat. No.: HY-W010950ARCAS No.: 57415-44-8Flecainide hydrochloride is an orally active antiarrhythmic agent. Flecainide hydrochloride can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2). Flecainide hydrochloride can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT).
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Daurisoline (Standard)
0 ImagesCat. No.: HY-N0221RCAS No.: 70553-76-3Synonyms: (R,R)-Daurisoline (Standard)Daurisoline (Standard) is the analytical standard of Daurisoline. This product is intended for research and analytical applications. Daurisoline is a bis-benzylisoquinoline alkaloid that can be isolated from Menispermum dauricum and Rhizoma Menispermi. Daurisoline exerts a blocking effect on hERG and has antiarrhythmic effects. Daurisoline is a potent autophagy blocker that can be used for the research of cancer.
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BTS 39542
0 ImagesCat. No.: HY-126038CAS No.: 57410-31-8BTS 39542 is an orally active inhibitor for Na+ K+ Cl cotransport system, that exhibits diuretic activity, and can be used in hypertension and edema research.
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(S)-PF 03716556
0 ImagesCat. No.: HY-13100ACAS No.: 928774-44-1(S)-PF 03716556 is a K+-competitive acid blocker with gastric acid pump inhibitory activity. (S)-PF 03716556 can be used to inhibit disease states mediated by acid pump inhibitory activity.
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Trimebutine (Standard)
0 ImagesTrimebutine (Standard) is the analytical standard of Trimebutine (HY-B0380). This product is intended for research and analytical applications. Trimebutine is a multi-target inhibitor and opioid receptor agonist with antimuscarinic activity. Trimebutine inhibits L-type Ca2+ channels and large-conductance calcium-activated potassium channels (BKCa channels), thereby inhibiting extracellular calcium influx and potassium ion efflux. Trimebutine also targets Toll-like receptors, inhibits Toll-like receptor 2/4/7/8/9 signals, and inhibits LPS-induced IRAK1 activation, as well as ERK1/2, JNK and NF-κB activation, thereby exerting anti-inflammatory effects. Trimebutine also induces tumor cell apoptosis by inhibiting the AKT/ERK pathway. Trimebutine also inhibits excessive contraction of smooth muscle and can be used in the study of gastrointestinal disorders such as irritable bowel syndrome (IBS).
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KCNQ2 modulator-1
0 ImagesCat. No.: HY-180873CAS No.: 462617-36-3KCNQ2 modulator-1 is a KCNQ2 modulator.
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Tifenazoxide (Standard)
0 ImagesCat. No.: HY-119322RCAS No.: 279215-43-9Synonyms: NN414 (Standard)Tifenazoxide (Standard) is the analytical standard of Tifenazoxide. This product is intended for research and analytical applications. Tifenazoxide (NN414) is a potent, orally active and SUR1/Kir6.2 selective KATP channels opener. Tifenazoxide has antidiabetic effect, can inhibit glucose stimulated insulin release in vitro and in vivo, and has a beneficial effect on glucose homeostasis.
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Mephetyl tetrazole
0 ImagesCat. No.: HY-134953CAS No.: 916923-10-9Mephetyl tetrazole is a potassium channel Kv1.5 blocker, with an IC50 of 330 nM. Mephetyl tetrazole can be used for the research of cancer.
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Quinidine (15% dihydroquinidine) (Standard)
0 ImagesQuinidine (15% dihydroquinidine) (Standard) is the analytical standard of Quinidine (15% dihydroquinidine) (HY-B1751). This product is intended for research and analytical applications. Quinidine (15% dihydroquinidine) is an orally active antiarrhythmic agent. Quinidine (15% dihydroquinidine) reduces the expression level of P-gp, inhibits P-gp-mediated efflux, increases the intracellular accumulation of P-gp substrates, induces PARP cleavage and Caspase-3 activation, and elevates the proportion of Apoptotic cells at the sub-G1 phase. Quinidine (15% dihydroquinidine) exerts sustained block and open-channel block effects on IK(f). Quinidine (15% dihydroquinidine) alters the urinary metabolic ratio of Amphetamine, modulates the Pentylenetetrazol-induced seizure threshold, and regulates the anticonvulsant effect of Dextromethorphan. Quinidine (15% dihydroquinidine) can be used in studies related to uterine sarcoma and seizures.
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ML402 (Standard)
0 ImagesCat. No.: HY-104027RCAS No.: 298684-44-3
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Cisapride (Standard)
0 ImagesSynonyms: R 51619 (Standard); (±)-Cisaprid (Standard)Cisapride (R 51619) (Standard) is the analytical standard of Cisapride (HY-14149). This product is intended for research and analytical applications. Cisapride (R 51619) is an orally active, selective 5-HT4 receptor agonist with an EC50 of 140 nM. Cisapride also acts as an hERG potassium channel blocker with an IC50 of 9.4 nM. Cisapride exerts gastrointestinal prokinetic effects by activating 5-HT4 receptors, but it also blocks the hERG potassium channel responsible for the repolarization phase of cardiac action potentials, delaying repolarization and thus prolonging the action potential duration. Cisapride can be used in research related to gastrointestinal dysfunction, gastroesophageal reflux disease, functional dyspepsia, chronic gastritis, gastroparesis, ulcerative colitis and necrotizing enterocolitis.
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SKP-451
0 ImagesCat. No.: HY-171469CAS No.: 181137-41-7SKP-451 is an ATP-sensitive potassium (K+) channel agonist. SKP-451 activates the ATP-sensitive K+ channels, promotes the efflux of K+, causes membrane hyperpolarization, and inhibits the influx of Ca2+, thereby relaxing the vascular smooth muscle. SKP-451 relaxs the canine coronary artery, rabbit basilar artery, and vertebral artery. SKP-451 also reduces the mean arterial blood pressure of conscious spontaneously hypertensive rats (SHR). SKP-451 is promising for research of cardiovascular diseases.
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1,2,4-Trihydroxybenzene (Standard)
0 ImagesSynonyms: Hydroxyhydroquinone (Standard)1,2,4-Trihydroxybenzene (Hydroxyhydroquinone) (Standard) is the analytical standard of 1,2,4-Trihydroxybenzene (HY-W010451). This product is intended for research and analytical applications. 1,2,4-Trihydroxybenzene (Hydroxyhydroquinone) is an ER stress inducer that targets proteins such as PKR-like ER kinase PERK to induce cytotoxicity. 1,2,4-Trihydroxybenzene selectively activates eIF2α phosphorylation, activates the PERK-eIF2α signaling pathway and induces stress granule formation. 1,2,4-Trihydroxybenzene subsequently exacerbates oxidative stress and causes DNA double-strand breaks, destroying organelles such as mitochondria and ER, and inducing cell death. 1,2,4-Trihydroxybenzene also has the potential to exhibit anti-tumor effect, increase blood pressure, and relieve spasm.
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NS8593 hydrochloride (Standard)
0 ImagesCat. No.: HY-110105RCAS No.: 875755-24-1NS8593 hydrochloride (Standard) is the analytical standard of NS8593 (hydrochloride) (HY-110105). This product is intended for research and analytical applications. NS8593 hydrochloride is a potent and selective small conductance Ca2+-activated K+ channels (SK channels) inhibitor. NS8593 hydrochloride reversibly inhibits SK3-mediated currents with a Kd value of 77 nM. NS8593 hydrochloride inhibits all the SK1-3 subtypes Ca2+-dependently (Kds of 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca2+), and does not affect the Ca2+-activated K+ channels of intermediate and large conductance (hIK and hBK channels, respectively).
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Astemizole (Standard)
0 ImagesSynonyms: R 43512 (Standard)Astemizole (Standard) is the analytical standard of Astemizole. This product is intended for research and analytical applications. Astemizole (R 43512), a second-generation antihistamine agent to diminish allergic symptoms with a long duration of action, is a histamine H1-receptor antagonist, with an IC50 of 4 nM. Astemizole also shows potent hERG K+ channel blocking activity with an IC50 of 0.9 nM. Astemizole has antipruritic effects.
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ML 297 (Standard)
0 ImagesCat. No.: HY-110192RCAS No.: 1443246-62-5Synonyms: VU 0456810 (Standard); CID 56642816 (Standard)ML 297 (Standard) is the analytical standard of ML 297 (HY-110192). This product is intended for research and analytical applications. ML 297 (VU 0456810) is a potent and selective GIRK1/2 activator, with an EC50 of 0.16 μM. ML 297 can cross the blood-brain barrier with brain-to-plasma ratio of 0.2 in mice model (i.p.). ML 297 is potential for the treatment of epilepsy.
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UK-78282 hydrochloride
0 ImagesUK-78282 hydrochloride is a KV1.3 channel inhibitor with an IC50 value of 0.20 μM and a Kd of 0.39 μM. UK-78282 hydrochloride also inhibits the Kv1.4 Potassium Channel. UK-78282 hydrochloride blocks KV1.3 in a use-dependent manner and inhibits human T lymphocyte activation by regulating the cell cycle. UK-78282 hydrochloride can be used in research related to mental disorders, such as depression and schizophrenia.
