2. Signaling Pathways
  3. JAK/STAT Signaling
    Stem Cell/Wnt
  4. STAT
  5. STAT6 Isoform
  6. STAT6 Degrader

STAT6 Degrader

STAT6 Degraders (12):

Cat. No. Product Name Effect Purity
  • HY-169179
    AK-1690
    		Degrader 99.91%
    AK-1690 is a selective PROTAC degrader targeting STAT6 (DC50=1 nM) with a Ki of 6 nM against human STAT6. AK-1690 degrades STAT6 via the interaction of STAT6 with cereblon and a ubiquitin-like process. AK-1690 effectively depletes STAT6 protein in mouse liver and lung tissues, and is applicable to research related to leukemia, Hodgkin's lymphoma, follicular lymphoma, etc..
  • HY-183733
    STAT6 degrader-4
    		Degrader
    STAT6 degrader-4 (Compound I-197) is a STAT6 degrading agent with a DC50 value ranging from 1 to 10 μM. STAT6 degrader-4 can be used in cancer research.
  • HY-169360
    SD-436
    		Degrader 98.27%
    SD-436 is a highly selective and efficacious STAT3 PROTAC degrader (DC50: 0.5 μM), with IC50 of 19 nM (STAT3), 270 nM (STAT1), 360 nM (STAT4), >10 μM (STAT5) and >10 μM (STAT6). SD-436 promotes ubiquitination and degradation of STAT3, and induces tumor regression. SD-436 can be used for tumor research, such as leukemia and lymphoma (Pink: STAT3 ligand (HY-169361); Blue: E3 ligase ligand (HY-43722); Black: linker (HY-147052).
  • HY-176857
    PROTAC STAT6 degrader-1
    		Degrader 99.55%
    PROTAC STAT6 degrader-1 (Compound I-2) is a potent STAT6 PROTAC degrader with a DC50 <1 nM. PROTAC STAT6 degrader-1 inhibits STAT6 activity with an IC50 of <0.1 pM. PROTAC STAT6 degrader-1 can be used for inflammatory and cancers research, such as non-small cell lung cancer (NSCLC).
  • HY-177456
    STAT6 degrader-3
    		Degrader 99.26%
    STAT6 degrader-3 (Compound I-1) is a potent and selective STAT6 degrader with a DC50 of <1 nM. STAT6 degrader-3 can be used in the research of Type 2 immune and allergic responses.
  • HY-183834
    PROTAC STAT6 degrader-7
    		Degrader
    PROTAC STAT6 degrader-7 (Compound I-981) is a STAT6 PROTAC degrader with an IC50 of <0.1 μM. PROTAC STAT6 degrader-7 promotes ubiquitination and degradation of STAT6. PROTAC STAT6 degrader-7 can be used in cancer research.
  • HY-183837
    PROTAC STAT6 degrader-8
    		Degrader
    PROTAC STAT6 degrader-8 is a STAT6 PROTAC degrader with a DC50 value >0.1 μM and a DCmax value > 0.01 μM. PROTAC STAT6 degrader-8 has the potential for application in inflammation-related diseases.
  • HY-183839
    PROTAC STAT6 degrader-9
    		Degrader
    PROTAC STAT6 degrader-9 is a STAT6 PROTAC degrader with a DC50 value >1 μM and a DCmax value > 0.1 μM. PROTAC STAT6 degrader-9 has the potential for application in inflammation-related diseases.
  • HY-171441
    STAT6 degrader-1
    		Degrader
    STAT6 degrader-1 (Compound 21) is a bifunctional molecular glue degrader of STAT6 that recruits E3 ubiquitin ligase. STAT6 degrader-1 induces proteasomal degradation of STAT6. STAT6 degrader-1 is applicable to the research of cancer, inflammatory diseases and colorectal cancer.
  • HY-179233
    PROTAC STAT6 degrader-2
    		Degrader
    PROTAC STAT6 degrader-2 is a highly efficient PROTAC degrader targeting STAT6. PROTAC STAT6 degrader-2 has a DC50 value of 1-10 nM for STAT6 in human PBMC cells and a DC50 value of less than 100 nM for STAT6 in HEK293-HIBiT-STAT6 cells. PROTAC STAT6 degrader-2 can be used for STAT6-mediated diseases.
  • HY-183847
    PROTAC STAT6 degrader-10
    		Degrader
    PROTAC STAT6 degrader-10 is a STAT6 PROTAC degrader with a DC50 value >1 μM and a DCmax value >0.1 μM. PROTAC STAT6 degrader-10 has the potential for application in inflammation-related diseases.
  • HY-181901
    PROTAC STAT6 degrader-4
    		Degrader
    PROTAC STAT6 degrader-4 (Compound 3u247) is a STAT6 PROTAC degrader with a DC50 of 0.04 nM. PROTAC STAT6 degrader-4 promotes the ubiquitination and degradation of STAT6, and is applicable to the research of immune diseases.