2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Epigenetics
  4. Sirtuin

Sirtuin

Sirtuin

Related Products

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Sirtuin (Sir2 proteins) are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. Sirtuins regulate important biological pathways in bacteria, archaeaand eukaryotes. Sirtuins have been implicated in influencing a wide range of cellular processes like aging, transcription, apoptosis, inflammation and stress resistance, as well as energy efficiency and alertness during low-calorie situations. Sirtuins can also control circadian clocks and mitochondrial biogenesis.

Sirtuin Isoform Specific Products:

Sirtuin Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-183259
    6,7-Dimethoxy-1,3-bis(4-methoxyphenyl)isoquinoline
    		Inhibitor
    6,7-Dimethoxy-1,3-bis (4-methoxyphenyl) isoquinoline is a SIRT1 inhibitor with a KD value of 0.5 μM.
    6,7-Dimethoxy-1,3-bis(4-methoxyphenyl)isoquinoline
  • HY-N0526R
    2"-O-Galloylhyperin (Standard)
    		Inhibitor
    2"-O-Galloylhyperin (Standard) is the analytical standard of 2"-O-Galloylhyperin (HY-N0526). This product is intended for research and analytical applications. 2''-O-Galloylhyperin is an active natural compound with anti‑inflammatory, antioxidant, anti‑adipogenic, antifibrotic, and cytostatic activities. 2''-O-Galloylhyperin upregulates SIRT1/Nrf2 signaling, inhibits NF-κB and MAPK (ERK1/2, p38, JNK) phosphorylation, suppresses TSHR activation, reduces ROS accumulation, and enhances SOD and GSH-Px activities. 2''-O-Galloylhyperin protects against LPS-induced tissue injury, enhances survival, and inhibits adipogenesis and fibrosis. 2"-O-Galloylhyperin can be used for the research of sepsis, acute lung injury, and thyroid eye disease.
    2
  • HY-108986R
    JFD00244 (Standard)
    		Inhibitor
    JFD00244 (Standard) is the analytical standard of JFD00244 (HY-108986). This product is intended for research and analytical applications. JFD00244 is a sirtuin 2 (SIRT2) inhibitor, with anti-tumor effect. JFD00244 is also a Nsp-16 inhibitor against SARS-CoV-2.
    JFD00244 (Standard)
Cat. No. Product Name / Synonyms Application Reactivity
Sirtuin Isoform Comparison

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